METHODS FOR EFFICIENT PRODUCTION OF POLYUNSATURATED FATTY ACIDS (PUFA) IN RHODOSPORIDIUM AND RHODOTORULA SPECIES |
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| 申请号 | EP15840158 | 申请日 | 2015-08-21 | 公开(公告)号 | EP3191577A4 | 公开(公告)日 | 2018-03-21 |
| 申请人 | TEMASEK LIFE SCIENCES LABORATORY LTD; | 发明人 | LIU YANBIN; KOH CHONG MEI; JI LIANGHUI; | ||||
| 摘要 | The present invention relates to the field of fungal biotechnology, more particularly to genetic engineering methods for the production of polyunsaturated fatty acids (PUFA) in fungal hosts selected from Rhodosporidium and Rhodotorula genera. The present invention further relates to a modified fungal host cell having reduced native aldehyde dehydrogenase (ALD 1) enzyme activity, and methods for producing omega-3 and omega-6 fatty acids and triacylglycerides, by growing said fungal host cell under suitable conditions. | ||||||
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