子分类：
- C08B37/0009： ..{α-D-葡聚糖,例如聚葡萄糖、交替糖、糖原;(α-1,4)(α-1,6)-D-葡聚糖;(α-1,3)(α-1,4)-D-葡聚糖,例如异地衣多糖或黑曲霉多糖;(α-1,4)-D-葡聚糖;(α-1,3)-D-葡聚糖,例如假黑曲多糖;它们的衍生物}
- C08B37/0024： ..{β-D-葡聚糖;(β-1,3)-D-葡聚糖,例如裸藻淀粉、云芝多糖、核盘菌多糖、茯苓多糖、胼胝质、硬葡聚糖、裂褶多糖、海带多糖、香菇多糖或可得然胶;(β-1,6)-D-葡聚糖,如石耳;(β-1,4)-D-葡聚糖;(β-1,3)(β-1,4)-D-葡聚糖,例如地衣多糖;它们的衍生物}
- C08B37/0036： ..{半乳聚糖;其衍生物}
- C08B37/0045： ..{α-D-半乳糖醛酸,例如(α-1,4)连接的D-半乳糖醛酸单元的甲基酯;果胶或α-1,4 - 连接的D-半乳糖醛酸单元的甲基酯的水解产物,即果胶酯酸;其衍生物}
- C08B37/0051： ..{β-D-呋喃果聚糖,例如β-2,6-呋喃果聚糖,即果聚糖;其衍生物}
- C08B37/0057： ..{ β-D-木聚糖,例如阿拉伯木聚糖,戊聚糖;(β-1,3)(β-1,4)- D-木聚糖,例如rhodymenans;纤维素;其衍生物}
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Fractionation of charged polysaccharide | JP2014105234 | 2014-05-21 | JP2014169451A | 2014-09-18 | JAIN SANJAY; PAPAIOANNOU IOANNIS; PETER LAING |
| PROBLEM TO BE SOLVED: To provide methods for fractionating and separating a polydisperse and charged polysaccharide.SOLUTION: An aqueous solution of the polydisperse polysaccharides is contacted with an ion exchange resin in a column and the polysaccharides are subjected to selective elution by aqueous elution buffer. The selective elution consists of at least 3 sequential elution buffers having different and constant ionic strength and/or pH and in which the subsequent buffers have ionic strength and/or pH than those of the preceding step. A polysialic acid has a polydispersity of specific molecular weight. The new preparations are particularly suitable for the production of PSA-derivatized therapeutic agents intended for use in humans and animals. | ||||||
| 122 | Resin composition having reducibility and molded article thereof | JP2010224935 | 2010-10-04 | JP2013253119A | 2013-12-19 | KITAGAWA TAKANORI; MAEDA AKIRA; WATANABE SHIGETOSHI |
| PROBLEM TO BE SOLVED: To provide: a reducing resin composition mixed with polysaccharide derived from organism, particularly with waste yeast; a resin molded article obtained by heating, pressurizng and molding the resin composition; a method for production of the resin composition; and a soil improving agent composition containing the resin composition.SOLUTION: There is provided a resin composition prepared by mixing polysaccharide derived from organism using a yeast obtained as a surplus waste from brewing industries such as beer, Sake, fermented soybean paste or soy sauce with the resin materials such as polyethylene terephthalate, polyethylene, polypropylene or urea resin. There is also provided a soil improving agent composition prepared by adding to the resin composition, a humic acid resource used for soil improvement, zeolite, diatom earth, vermiculite and peat moss. | ||||||
| 123 | Polysaccharides containing a carboxyl functional group which is substituted by a hydrophobic alcohol derivative | JP2011530586 | 2009-10-06 | JP2012504697A | 2012-02-23 | シヤルベ，リシヤル; スーラ，オリビエ; スーラ，ジエラル; スーラ，レミ |
| 【課題】疎水性アルコール誘導体により置換されたカルボキシル官能基を含有する多糖類を提供する。
【解決手段】本発明は、少なくとも１つが疎水性アルコール誘導体により置換された複数のカルボキシル官能基を含有する多糖類に関する。 本発明はまた、本発明の多糖類の１種及び少なくとも１種の活性成分を含有する医薬組成物にも関する。 本発明はさらに、前記活性成分が、タンパク質、糖タンパク質、ペプチド及び非ペプチド治療用分子からなる群より選択されることを特徴とする医薬組成物にも関する。 本発明はまた、上記医薬組成物を製造するための、本発明の官能化された多糖類の使用にも関する。 【選択図】なし |
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| 124 | Manufacturing system and method of an organic material with biomass material | JP2008023185 | 2008-02-01 | JP4524351B2 | 2010-08-18 | 良介 上原; 剛 坂木; 則行 山田; 直人 橋本; 康弘 波佐; 稔 源田; 謹也 藤田; 勝一 齋藤 |
| An organic material production system includes: a pretreatment device (12) that pulverizes a biomass material (11); a hydrothermal decomposition apparatus (14) that hydrothermally decomposes a pulverized biomass (13) by causing it to countercurrently contact with hot compressed water (15), elutes lignin components and hemicellulose components into the hot compressed water (15), and separates the lignin components and the hemicellulose components from a biomass solid residue; a first enzymatic hydrolysis device (19-1) that treats cellulose in a biomass solid residue (17), discharged from the hydrothermal decomposition apparatus, with an enzyme (18) to enzymatically hydrolyze it to a sugar solution containing hexose; a fermenter (21) that produces ethanol by fermentation using a sugar solution (20) obtained by the first enzymatic hydrolysis device (19-1); and a refiner 25 that refines an alcohol fermentation liquid (22), so as to separate it into ethanol (23) and a residue (24). | ||||||
| 125 | Composition having a body fat reducing action | JP2004271412 | 2004-09-17 | JP4488852B2 | 2010-06-23 | 賢一 中室; 和人 尾崎; 俊行 松島; 勝仁 武藤; 一朗 浅野; 繁佳 藤井; 和泉 高尾 |
| A mannooligosaccharide composition is provided that is effective for providing a body fat reducing effect and for reducing body weight. The mannooligosaccharide composition is provided by hydrolysis of mannan material. The mannooligosaccharide includes from about 1 to about 10 monosaccharides with at least about 60 weight percent of the monosaccharides being mannose. | ||||||
| 126 | Reduction of endotoxin in polysialic acid | JP2009551274 | 2008-02-28 | JP2010520320A | 2010-06-10 | グレゴリー グレゴリアディス; サンジェイ ジャイン; ピーター ライング |
| 本発明は、ポリシアル酸及びエンドトキシンを含む発酵ブロス試料のエンドトキシン含有量を低減させる方法であって、（ｉ）ｐＫａが少なくとも１２である塩基を該試料に添加し、ｐＨが少なくとも１２である塩基性溶液を形成すると共に、該溶液を所定の温度で所定の時間インキュベーションする工程と、（ｉｉ）ＰＳＡの回収工程であって適切には（ｉｉｉ）陰イオン交換カラムに上記試料を通過させることによりイオン交換樹脂にポリシアル酸を吸収させること、（ｉｖ）該カラムを１種類の洗浄緩衝液で洗浄することにより該イオン交換樹脂にポリシアル酸が吸収されたままにすること、及び（ｖ）溶出緩衝液を使用して上記カラムから上記ポリシアル酸を溶出させることであって、エンドトキシン含有量が低減したポリシアル酸の生成物溶液を提供する、溶出させることによる（ｉｉ）ＰＳＡの回収工程との連続する工程を含む、方法に関する。
【選択図】なし |
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| 127 | Sulfated fucan | JP2003562280 | 2003-01-17 | JP4262601B2 | 2009-05-13 | 郁之進 加藤; 勝重 猪飼; 武 酒井; ひとみ 餘目 |
| 128 | Fractionation | JP2007525353 | 2005-08-12 | JP2008510024A | 2008-04-03 | サンジャイ ジャイン; イオアニス パパイオアンノー; ピーター レイン |
| 多分散系で電荷を有する多糖が、各々は分子量の狭い範囲内のスピーシーズを含む低多分散性の分画(好ましくはpd <1.1を有する)に分別される。 多分散多糖の水性溶液はカラムのイオン交換樹脂と接触し、多糖は水性溶出バッファーによる選択的溶出にかけられる。 選択的溶出は異なる一定のイオン強度及び/又はpHを有する少なくとも3種類の連続の溶出バッファーからなり、その次のバッファーは直前の段階のバッファーよりイオン強度及び/又はpHを有している。 新しい調製は人間や動物での使用を意図したPSA誘導体化治療剤に特に適している。 | ||||||
| 129 | Synthesis of high molecular weight iron-saccharidic complex | JP2006515004 | 2004-05-28 | JP2006526643A | 2006-11-24 | コワルスキー，ジョン; ベック，ロバート・エイ; マテア，ロバート・エイ，ジュニア |
| （１）反応混合物を生成するために（ｉ）Ｆｅ（ＩＩＩ）イオンおよび（ＯＨ） -イオン、ならびに（ｉｉ）少なくとも１つのサッカリド、を含む水溶液もしくは水性分散液を供するステップであって、（ｉ）：（ｉｉ）のモル比が約３０：１〜約１：３０であり；前記反応混合物の温度およびｐＨが複合体集合点（ＣＡＰ）以上であるステップと；（２）約２５，０００ダルトン以上の分子量を有する鉄サッカリド複合体を形成するために十分な期間にわたって温度およびｐＨをＣＡＰ、または好ましくはＣＡＰより上方で維持するステップと、を含む非経口用鉄サッカリド複合体を調製するための方法、および生成された複合体。 温度およびｐＨの制御により、効率的に高分子量複合体が生成される。 前記複合体は、沈降、透析および／またはカラム分別によって分離することができ、ならびに所望であれば、乾燥する、例えば凍結乾燥またはスプレー乾燥することができる。 前記方法によると、様々な分子量および／または化学組成、特別にはグルコン酸第二鉄ナトリウムおよび水酸化第二鉄スクロースの複合体を制御可能に合成することができる。 | ||||||
| 130 | 硫酸化フカン | JP2003562280 | 2003-01-17 | JPWO2003062412A1 | 2005-05-19 | 酒井 武; 武 酒井; ひとみ 餘目; 勝重 猪飼; 加藤 郁之進; 郁之進 加藤 |
| 糖鎖工学的に有用なヒバマタ目褐藻類由来硫酸化フカンを分解する酵素、該酵素の製造方法、及び硫酸化フカンに該酵素を作用させて得られるオリゴ糖及びその製造。 | ||||||
| 131 | Polysaccharide bound nitric oxide - nucleophile adduct | JP53112896 | 1996-04-10 | JPH11503456A | 1999-03-26 | ケイ． キーファー、ラリー; ジェイ． スミス、ダニエル; チャクラヴァティ、デバシィーシュ |
| (57)【要約】 高分子に結合しているニトリックオキサイド放出Ｎ 2 Ｏ 2 -官能基を含む多糖を含有する、ニトリックオキサイド放出が可能な高分子組成物、該高分子組成物を含む医薬組成物、およびニトリックオキサイドの投与が治療となる生物学的障害を治療する方法。 該組成物はインプラント、注射可能な製剤、コンドーム、プロテーゼコーティング、パッチ等として、および／またはそれらに取り込ませて広範囲の医療適用の用途に使用することができる。 | ||||||
| 132 | Polysaccharide derivative and a drug carrier | JP51587694 | 1994-02-28 | JP2610792B2 | 1997-05-14 | 和泓 井上; 正洋 加治木; 哲 奥野; 敬司 山本; 洋 浜名; 敏朗 矢野; 州一 菅原; 秀夫 野草; 信一 鹿島 |
| 133 | Therapeutic agent of human immune deficiency virus | JP20630090 | 1990-08-02 | JPH0491027A | 1992-03-24 | HOSHINO HIROO |
| PURPOSE: To provide a medical preparation effective for the prevention of HIV infection and for the prevention and treatment of AIDS and a syndrome ARC relating thereto, and capable of being administered for long period without causing adverse effects by compounding a polyfucose sulfuric acid originated from Holothurian or a salt thereof. CONSTITUTION: The subject agent contains as an active ingredient a Holothurian-originated polyfucose sulfuric acid and/or a pharmaceutically permissible salt thereof, the polyfucose sulfuric acid having the following physicochemical characteristics; nature: white amorphous strongly hygroscopic fine powder; mol.wt.: approximately 20000 to 200000 (by a polyacrylamide electrophoresis method); weight composition: 1-7wt.% of hexosamine; 45-65wt.% of fucose and 25-42wt.% of sulfuric acid groups. The active ingredient is obtained by decomposing and extracting the body wall of an invertebrate animal Holothurian (especially Stichopus) by an alkali decomposition method or with an enzyme such as pancreatin and subsequently separating from the extract. The compound is administered at a dose of 10-1000mg/day, preferably 50-200mg/day. COPYRIGHT: (C)1992,JPO&Japio | ||||||
| 134 | Aqueous dispersion of fructan-containing particles, method of preparation and use | US12922418 | 2009-04-21 | US10150819B2 | 2018-12-11 | Kim Martha Jozefa Frooninckx; Francois Alice Alphonso Heroufosse |
| An aqueous dispersion of fructan-containing particles, wherein the D50 of the fructan-containing particles lies between 2 μm and 50 μm and the solids content of the aqueous dispersion lies between 61 wt. % and 80 wt. %. Also described is a process for the preparation of an aqueous dispersion of fructan-containing particles comprising: bringing fructan and water together to form a mixture; optionally hydrolyzing a portion of the fructans in the mixture, such that at the end of this step between 5 wt. % and 25 wt. % of all fructans in the mixture are essentially non-soluble at room temperature; optionally bring the mixture into contact with a purification agent, followed by removal of the purification agent from the mixture; and concentrating the mixture such that the solids content lies between 61 and 80%. | ||||||
| 135 | METHODS FOR MAKING SACCHARIDE-PROTEIN GLYCOCONJUGATES | US15977754 | 2018-05-11 | US20180334515A1 | 2018-11-22 | Allan James SAUL; Francesca MICOLI |
| The invention provides a process for the reductive amination of a carbonyl group at the reducing terminus of a polysaccharide, wherein the reductive amination is carried out at a pH between 4 and 5. The invention also provides a process for preparing a conjugate of a polysaccharide and a carrier molecule, comprising the steps of: (a) coupling the polysaccharide to a linker, to form a polysaccharide-linker compound in which the free terminus of the linker is an ester group; and (b) reacting the ester group with a primary amine group in the carrier molecule, to form a polysaccharide-linker-carrier molecule conjugate in which the linker is coupled to the carrier molecule via an amide linkage. The invention also provides a process for reducing contamination of a polysaccharide-linker compound with unreacted linker, comprising a step of precipitating unreacted linker under aqueous conditions at a pH of less than 5. The invention also provides polysaccharide-linker-carrier molecule conjugates and intermediate compounds obtained or obtainable by these processes. | ||||||
| 136 | FUCAN-DENDRIMER BASED COMPOUNDS AND COMPLEXES | US15970472 | 2018-05-03 | US20180251574A1 | 2018-09-06 | Christopher Michael Kevin Springate |
| Compositions, systems, methods, etc., related to fucan-dendrimer complexes wherein a fucan molecule is linked or otherwise attached to a dendrimer. For example, the current compositions can comprise fucan covalently linked, conjugated, attached, tagged, adducted, bound, etc., to a dendrimer. These fucan-dendrimer complexes include fucan-hyperbranched polyglycerol, fucan-hyperbranched poly(glycerol ester), fucan-hyperbranched poly(1,3-diether), fucan-poly(3-ethyl-3-(hydroxymethyl)oxetane), fucan-hyperbranched polyesters, fucan-hyperbranched polyethylene, fucan-hyperbranched polystyrene, fucan-hyperbranched poly(urea-urethanes), fucan-hyperbranched polyethyleneimine, fucan-hyperbranched poly(amido amine)s, fucan-hyperbranched polyphosphates, fucan-hyperbranched polypeptides, fucan-hyperbranched polysaccharides, fucan-hyperbranched polyacrylates and fucan-hyperbranched beta-cyclodextrin. These fucan-dendrimer complexes may be used in medically and/or pharmaceutically effective compositions, for a plurality of applications, including the treatment of fibrous adhesions. In some embodiments, the fucan is fucoidan. | ||||||
| 137 | PHARMACEUTICAL COMPOSITIONS COMPRISING MODIFIED FUCANS AND METHODS RELATING THERETO | US15717681 | 2017-09-27 | US20180230240A1 | 2018-08-16 | Christopher Michael Kevin Springate |
| Compositions and methods relating to fucan agents useful for the treatment, prevention, inhibition, etc., of fibrous adhesions or other diseases. | ||||||
| 138 | SUBSTITUTED POLYESTERS BY THIOL-ENE MODIFICATION: RAPID DIVERSIFICATION FOR THERAPEUTIC PROTEIN STABILIZATION | US15394483 | 2016-12-29 | US20180112034A1 | 2018-04-26 | Heather D. Maynard |
| Structures and methods of making biodegradable trehalose co-polymers are disclosed. Specifically, biodegradable trehalose co-polymers consist of the general structure R5—[R1R2C—CR3R4]n-[DG]m—R6, wherein R1-R4 are independently selected from hydrogen or a side chain comprising at least one carbon atom, and wherein at least one of R1-R4 is a side chain comprising -L-trehalose, wherein L is a linker molecule that links trehalose to the monomer through at least one of the trehalose hydroxyl groups (—OH), wherein DG is a biodegradable group, and wherein R5 and R6 are end groups. | ||||||
| 139 | Polysialic acid and use for treatment of neurodegenerative and neuroinflammatory diseases | US14779800 | 2014-03-18 | US09944721B2 | 2018-04-17 | Harald Neumann; Jens Kopatz; Anahita Shahraz; Marcus Karlstetter; Thomas Langmann |
| The present invention relates to a branched or unbranched free or glycosidically bound polysialic acid according to general formula (1) as given as follows poly-(α(2→8 or 2→9)Neu5Ac)n (1) wherein Neu5Ac is N-acetylneuraminic acid, and n is an integer in the range from 14 to 26 and/or pharmaceutically acceptable salts thereof, a polysaccharide composition comprising the polysialic acid (1), and the use as a medicament, particularly in the therapeutic and/or prophylactic treatment of degenerative, demyelinating and inflammatory diseases of the central nervous system, and degenerative or inflammatory retinal diseases. | ||||||
| 140 | Polysialic acid derivatives | US14791468 | 2015-07-05 | US09920137B2 | 2018-03-20 | Dale Howard Hreczuk-Hirst; Sanjay Jain; Peter Laing; Gregory Gregoriadis; Ioannis Papaioannou |
| A polysialic acid compound is reacted with a hetero-bifunctional reagent to introduce a pendant functional group for site-specific conjugation to sulfhydryl groups, for instance side chains of cysteine units in drugs, drug delivery systems, proteins or peptides. The functional group is, for instance, an N-maleimide group. | ||||||
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