| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 一种抗肿瘤的药物果聚糖羧酸酯及其合成方法 | CN201710513686.8 | 2017-06-29 | CN107383225A | 2017-11-24 | 张剑波; 时春娟; 陈莉; 周永达; 丁泽坤 |
| 本发明公开了一种抗肿瘤的药物果聚糖羧酸酯及其合成方法，其特点将采用三种合成方法将中药怀牛膝中提取的牛膝多糖与酰化试剂和催化剂在0～50℃下进行多糖衍生物的合成反应，反应产物经有机溶剂溶解后用水进行膜透析和冷冻干燥，分别制得具有抗肿瘤的药物果聚糖羧酸酯。本发明与现有技术相比具有合成工艺简单，反应条件温和，操作方便，原料丰富，生产成本低等优点，其合成产物具有抗肿瘤的活性，是一种很有应用前景的抗肿瘤分子，绿色环保、经济高效。 | ||||||
| 2 | 以菊芋为原料生产低聚果糖的方法 | CN201610504176.X | 2016-07-01 | CN105950684A | 2016-09-21 | 李志文; 李向东; 李兵; 张琴 |
| 本发明涉及一种以菊芋为原料生产低聚果糖的方法，具体工艺为（1）清洗，（2）切丝，（4）清净，（5）脱色，（6）脱盐，（7）超滤膜分级，（8）菊粉酶酶解，（9）一次浓缩，（10）色谱分离，（11）二次浓缩，（12）干燥。采用三步法纯化分级技术生产低聚果糖，工艺容易控制，利用超滤膜分级技术将聚合度小于9的低聚果糖提前分离，辟免在酶解过程中会将聚合度小的菊粉(果聚糖)分解为单糖。产品收率达到90%、纯度可达到95%左右。 | ||||||
| 3 | 一种玉竹多糖和平菇多糖的同步提取方法 | CN201610531365.6 | 2016-07-06 | CN105949340A | 2016-09-21 | 张红萍 |
| 本发明提供一种利用双水相萃取技术同步高收率提取玉竹多糖和平菇多糖的方法，以玉竹和平菇为原料得到玉竹和平菇的混合粗提取液，将其经过低分子醇/盐双水相体系提取分离，再经分离纯化得到玉竹多糖和平菇多糖萃取液。以及将玉竹多糖和平菇多糖混合萃取液应用于皮肤外用剂中，以起到美容、保湿的护肤作用。 | ||||||
| 4 | 羧甲基果聚糖的碱金属盐的浓缩水溶液的制备方法 | CN201380008852.9 | 2013-02-07 | CN104302672A | 2015-01-21 | 帕特里克·皮埃尔·诺特; 阿尔贝特·菲尔明·德沃 |
| 本发明涉及用于制备羧甲基果聚糖的碱金属盐的水溶液的新方法。更具体地，本发明涉及用于制备水溶液的新方法，所述水溶液包含按重量计至少20％的具有至少1.2的羧甲基取代度的羧甲基果聚糖的碱金属盐。 | ||||||
| 5 | 利用玉竹下脚料进行玉竹多糖和洗胰清糖素的制备方法 | CN201710596587.0 | 2017-07-17 | CN107501425A | 2017-12-22 | 向华 |
| 本发明提供利用玉竹下脚料进行玉竹多糖和洗胰清糖素的制备方法，粉碎玉竹，乙醇萃取，水提，酶解，醇沉得玉竹多糖；醇溶性成分与桑叶提取物在乙醇溶液反应，过滤，滤液减压浓缩，上大孔树脂层析，用40～60％乙醇溶液洗脱得到，减压浓缩至干得洗胰清糖素。本发明充分利用了玉竹资源，获得了玉竹多糖和洗胰清糖素功能性成分。通过添加桑叶提取物的方式，有效地降低了洗胰清糖素生产成本，缩短了生产工艺流程。 | ||||||
| 6 | 用于加工膳食纤维的方法和组合物 | CN201580033651.3 | 2015-06-24 | CN106795478A | 2017-05-31 | 罗宾·丹尼斯; 阿兰·迪里厄; 克里斯蒂安·富尼 |
| 本发明涉及用于加工包含果聚糖和蔗糖的组合物的方法，其包括将包含果聚糖和蔗糖，优选地菊粉和蔗糖的组合物与选自由酵母菌属和克鲁维酵母属组成的组中的至少一种酵母培育的步骤。利用这些酵母的培育导致游离糖的分解，从而获得纯化的果聚糖组合物。 | ||||||
| 7 | 含果聚糖微粒的水分散液，制备方法及其应用 | CN200980114699.1 | 2009-04-21 | CN102007148B | 2012-11-14 | 金·玛莎·约瑟法·弗罗宁恩克斯; 弗朗索瓦·爱丽丝·阿方索·赫罗福瑟 |
| 本发明涉及一种含果聚糖微粒的水分散液，其中该含果聚糖微粒的D50介于2μm-50μm之间，且水分散液中的固体含量在总体上介于61wt.％-80wt.％之间。本发明进一步涉及含果聚糖微粒的水分散液的制备方法，包括：a)将果聚糖和水进行混合以形成混合物的步骤；b)可选的水解步骤，其混合物中的一部分果聚糖被水解，使得经过步骤b)，混合物中所有果聚糖的5wt.％-25wt.％在室温下基本不溶解；c)可选的纯化步骤，其混合物与净化剂接触，随后从混合物中除去该净化剂；d)浓缩步骤，其混合物被浓缩，使得固体含量介于61-80％之间，从而形成该水分散液。 | ||||||
| 8 | 含果聚糖微粒的水分散液，制备方法及其应用 | CN200980114699.1 | 2009-04-21 | CN102007148A | 2011-04-06 | 金·玛莎·约瑟法·弗罗宁恩克斯; 弗朗索瓦·爱丽丝·阿方索·赫罗福瑟 |
| 本发明涉及一种含果聚糖微粒的水分散液，其中该含果聚糖微粒的D50介于2μm-50μm之间，且水分散液中的固体含量在总体上介于61wt.％-80wt.％之间。本发明进一步涉及含果聚糖微粒的水分散液的制备方法，包括：a)将果聚糖和水进行混合以形成混合物的步骤；b)可选的水解步骤，其混合物中的一部分果聚糖被水解，使得经过步骤b)，混合物中所有果聚糖的5wt.％-25wt.％在室温下基本不溶解；c)可选的纯化步骤，其混合物与净化剂接触，随后从混合物中除去该净化剂；d)浓缩步骤，其混合物被浓缩，使得固体含量介于61-80％之间，从而形成该水分散液。 | ||||||
| 9 | 低聚果糖糖单体分离纯化的方法 | CN201611122476.8 | 2016-12-08 | CN106632526A | 2017-05-10 | 李莉莉; 秦松; 武敏 |
| 本发明提供一种低聚果糖糖单体分离纯化的方法，通过包含菊糖或低聚果糖的原溶液，通过Bio‑Gel‑P4色谱柱一级分离后进行组分浓缩，再通过Bio‑Gel‑P2色谱柱对浓缩液进行二级分离，最终制备得纯度95％以上的低聚果糖Fn型糖单体，上述低聚果糖糖单体分离纯化的方法工艺简单，分离后得到的Fn型低聚果糖糖单体纯度高。 | ||||||
| 10 | 一种牡蒿均一多糖及其制备方法和应用 | CN201610304006.7 | 2016-05-10 | CN105949336A | 2016-09-21 | 王顺春; 李宁; 施松善; 施晨晨; 苏娟; 刘睿敏 |
| 本发明公开了一种牡蒿均一多糖及其制备方法和应用，所述的牡蒿均一多糖是由牡蒿全草经水提醇沉后、柱层析分离纯化得到，是由果糖通过1,2连接的末端含葡萄糖基的菊糖型果聚糖，不含糖醛酸，且重均分子量为1～20kDa。实验结果表明：本发明提供的牡蒿均一多糖能明显降低胶原诱导关节炎小鼠的脚肿胀程度和小鼠血清中的炎症因子IL‑6和IL‑17A水平，可望作为主要或唯一活性成分用于制备预防或/和治疗类风湿性关节炎的保健食品或药物制剂，对研究开发具有临床应用价值的牡蒿物制剂具有重要意义；另外，本发明制备方法简单，可以得到高纯度的牡蒿均一多糖，适于规模化生产，实用性好。 | ||||||
| 11 | 一种玉竹多糖的制备方法 | CN201610462062.3 | 2016-06-23 | CN105924539A | 2016-09-07 | 吴迪; 张明; 孟浩影 |
| 本发明公开了一种玉竹多糖的制备方法，属于多糖制备技术领域。本发明以玉竹茎为原料，经酶解得玉竹酶解液，置于离心机中，离心得上清液加入硫酸铵，搅拌过滤，得滤液，再向滤液中加入活性炭、海泡石以及D001树脂，得含有玉竹多糖的滤液，加入马来酸以及麻黄碱，混合置于冰水浴中，过滤得玉竹多糖溶液，通过减压蒸馏，干燥处理，从而得到玉竹多糖的制备方法。实例证明，本发明工艺简便，反应条件温和，且在提取的过程中未加入任何有机溶剂，克服了传统工艺导致多糖产品质量不稳定的缺陷，最终使得制得的玉竹多糖得率为35％以上，纯度高达95％以上，具有广阔的市场前景。 | ||||||
| 12 | 党参均一多糖COP-1及其制备方法及应用 | CN201610300038.X | 2016-05-09 | CN105906735A | 2016-08-31 | 余兰; 刘章泉 |
| 本发明公开了一种党参均一多糖COP?1及其制备方法及应用。本发明从党参中发现的一种新的中性均一多糖，经丙烯酰胺葡聚糖凝胶（Sephacryl S?200HR）和葡聚糖凝胶（Sephadex G?25）纯化得到该多糖，获得途径方便；其产品可以进一步衍生化如硫酸化或硝酸化衍生，而且还具有增强免疫力的作用以及具有抗Ⅰ型单纯疱疹病毒的作用，具有很高的临床应用价值及保健功能。本方法简单、科学合理，只需要经过葡聚糖凝胶柱就可以快速得到高纯度的产品。 | ||||||
| 13 | 党参均一多糖COP-2及其制备方法及应用 | CN201610300021.4 | 2016-05-09 | CN105906734A | 2016-08-31 | 余兰; 刘章泉 |
| 本发明公开了一种党参均一多糖COP?2及其制备方法及应用。本发明从党参中发现的一种新的中性均一多糖，经丙烯酰胺葡聚糖凝胶（Sephacryl S?200HR）和葡聚糖凝胶（Sephadex G?25）纯化得到该多糖，获得途径方便；其产品可以进一步衍生化如硫酸化或硝酸化衍生，而且还具有增强免疫力的作用以及具有抗Ⅰ型单纯疱疹病毒的作用，具有很高的临床应用价值及保健功能。本方法简单、科学合理，只需要经过葡聚糖凝胶柱就可以快速得到高纯度的产品。 | ||||||
| 14 | Aqueous dispersion of fructan-containing particles, method of preparation and use | US12922418 | 2009-04-21 | US10150819B2 | 2018-12-11 | Kim Martha Jozefa Frooninckx; Francois Alice Alphonso Heroufosse |
| An aqueous dispersion of fructan-containing particles, wherein the D50 of the fructan-containing particles lies between 2 μm and 50 μm and the solids content of the aqueous dispersion lies between 61 wt. % and 80 wt. %. Also described is a process for the preparation of an aqueous dispersion of fructan-containing particles comprising: bringing fructan and water together to form a mixture; optionally hydrolyzing a portion of the fructans in the mixture, such that at the end of this step between 5 wt. % and 25 wt. % of all fructans in the mixture are essentially non-soluble at room temperature; optionally bring the mixture into contact with a purification agent, followed by removal of the purification agent from the mixture; and concentrating the mixture such that the solids content lies between 61 and 80%. | ||||||
| 15 | Aqueous dispersion of fructan-containing particles, method of preparation and use | US14550374 | 2014-11-21 | US09801401B2 | 2017-10-31 | Kim Martha Jozefa Frooninckx; Francois Alice Alphonso Heroufosse |
| An aqueous dispersion of fructan-containing particles, wherein the D50 of the fructan-containing particles lies between 2 μm and 50 μm and the solids content of the aqueous dispersion lies between 61 wt. % and 80 wt. %. Also described is a process for the preparation of an aqueous dispersion of fructan-containing particles comprising: bringing fructan and water together to form a mixture; optionally hydrolyzing a portion of the fructans in the mixture, such that at the end of this step between 5 wt. % and 25 wt. % of all fructans in the mixture are essentially non-soluble at room temperature; optionally bring the mixture into contact with a purification agent, followed by removal of the purification agent from the mixture; and concentrating the mixture such that the solids content lies between 61 and 80%. | ||||||
| 16 | NEW ULTRAHIGH EFFICIENCY, SUPERFICIALLY POROUS PARTICLE (SPP) CHIRAL PHASES FOR LIQUID CHROMATOGRAPHY | US15326911 | 2015-07-17 | US20170197156A1 | 2017-07-13 | Daniel W. ARMSTRONG; Zachary S BREITBACH |
| The present invention relates to a novel stationary phase support for liquid chromatographic chiral separations. The specific combination of the special underlying support material and certain classes of known chiral selectors according to the invention produces far superior chiral (enantiomeric) separations than those obtained on any conventionally known supports. These chiral (enantiomeric) separations are enhanced in terms of significantly higher efficiencies (theoretical plate numbers), higher resolutions (Rs), shorter retention times and either equivalent or slightly higher selectivities than those obtained on conventional supports. | ||||||
| 17 | AQUEOUS DISPERSION OF FRUCTAN-CONTAINING PARTICLES, METHOD OF PREPARATION AND USE | US14550374 | 2014-11-21 | US20150079245A1 | 2015-03-19 | Kim Martha Jozefa Frooninckx; Francois Alice Alphonso Heroufosse |
| An aqueous dispersion of fructan-containing particles, wherein the D50 of the fructan-containing particles lies between 2 μm and 50 μm and the solids content of the aqueous dispersion lies between 61 wt. % and 80 wt. %. Also described is a process for the preparation of an aqueous dispersion of fructan-containing particles comprising: bringing fructan and water together to form a mixture; optionally hydrolysing a portion of the fructans in the mixture, such that at the end of this step between 5 wt. % and 25 wt. % of all fructans in the mixture are essentially non-soluble at room temperature; optionally bring the mixture into contact with a purification agent, followed by removal of the purification agent from the mixture; and concentrating the mixture such that the solids content lies between 61 and 80%. | ||||||
| 18 | AQUEOUS DISPERSION OF FRUCTAN-CONTAINING PARTICLES, METHOD OF PREPARATION AND USE | US12922418 | 2009-04-21 | US20110020510A1 | 2011-01-27 | Kim Martha Jozefa Frooninckx; Francois Alice Alphonso Heroufosse |
| The invention relates to an aqueous dispersion of fructan-containing particles, wherein the D50 of the fructan-containing particles lies between 2 μm and 50 μm and the solids content of the aqueous dispersion as a whole lies between 61 wt. % and 80 wt. %. The invention further relates to a process for the preparation of an aqueous dispersion of fructan-containing particles, comprising: a) the step of bringing fructan and water together to form a mixture; b) optionally a hydrolysis step, wherein a portion of the fructans in the mixture is hydrolysed, such that at the end of this step b) between 5 wt. % and 25 wt. % of all fructans in the mixture are essentially non-soluble at room temperature; c) optionally a purification step, wherein the mixture is brought into contact with a purification agent, followed by removal of the purification agent from the mixture; d) a concentrating step, wherein the mixture is concentrated, such that the solids content lies between 61 and 80%, whereby the aqueous dispersion is formed. | ||||||
| 19 | Derivatized polysaccharide polymer | US11282501 | 2005-11-18 | US20060111263A1 | 2006-05-25 | Euen Gunn; Alvino Gabbianelli; Regan Crooks; Krishnamurthy Shanmuganandamurthy |
| Derivatized polysaccharide polymers that contain a fructan polymer substrate bearing one or more cationic substituent groups are useful in home and fabric care applications, in oilfield applications, and in emulsion polymerization applications. | ||||||
| 20 | Fluorescent isothiocyanate (fitc) sinistrin, its production and use | US10276025 | 2003-08-11 | US20040022730A1 | 2004-02-05 | Heinz-Michael Hein; Uwe Kraemer; Rudolf Reiter; Norbert Gretz; Carsten Deus |
| The invention concerns fluorescein isothiocyanate-sinistrin (FITC-sinistrin), a method for its production, its use as a marker substance in a diagnostic agent and a corresponding diagnostic agent. | ||||||
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