专利检索_ 含有碳氢卤素或氧的正系甾族化合物具有1个与环戊烷并专利检索_ 含有碳氢卤素或氧的正系甾族化合物具有1个与环戊烷并专利检索查询

子分类：

序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
141	Manufacture of 2-brom-6 beta-fluoro-1,4- pregnadien-3,20-diones	JP18124082	1982-10-15	JPS5877900A	1983-05-11	MARIO RIBA; RUSHIANO TOSUKANO

142	17 alphaaacyloxyy5 beta and 5 alphaacorticoids	JP1178381	1981-01-30	JPS56122398A	1981-09-25	DONARUDO EMORII EIYAA; KAARU ARUBIN SUKURAAGERU

143	JPS5442973B2 -	JP13094778	1978-10-24	JPS5442973B2	1979-12-17

144	4*66dihalosteroids	JP4041179	1979-04-05	JPS54135762A	1979-10-22	FURANSHISUKO ESU ARUBARESU
4-Halo-pregn-4-enes of the formula: wherein X<1> is fluoro or chloro; X<2> is hydrogen, fluoro or chloro; X<3> is hydrogen, fluoro, chloro or bromo; X<4> is =C=O or or may be when X<3> is chloro; R<1> is hydrogen, fluoro, chloro, bromo, hydroxy or methoxy; R<2> is fluoro, chloro, hydroxy or alkanoyloxy of 2 to 6 carbon atoms when R<1> is hydrogen or R<2> is the same as R<1> when R<1> is fluoro, chloro, hydroxy or methoxy; R<3> is hydroxy or alkanoyloxy of 2 to 6 carbon atoms when R<4> is alpha -methyl or beta -methyl or R<3> and R<4> together are and the solid and broken lines between the 1- and 2-positions in the A ring of the steroid nucleus represents a single or a double bond; have topical anti-inflammatory activity in mammals. They can be prepared by contacting the corresponding DELTA <5> compound with a base. The 17 alpha -alkanoyloxy compound can be prepared by esterifying the corresponding 17 alpha -hydroxy compound.
145	Corticosteroid antiiinflammatry drug	JP4041579	1979-04-05	JPS54132563A	1979-10-15	MAIKERU MAAKUSU; DENISU JIEI KAATESUZU
Corticosteroids of the formulae wherein: R<1><6> is methyl; and R<1><7> independently is hydrogen, or C2 to C6 linear or branched acyl or R<1><6> and OR<1><7> taken together are the radical (IV) where R<3> is hydrogen, C1 to C6 linear or branched alkyl, and R<4> is the same or different than R<3> as defined above or is C1 to C6 linear or branched alkoxy or R<3> and R<4> taken together with the carbon atom of said radical is C4 to C9 heterocyclic alkyl having one heterocyclic atom that is oxygen, R<2><1> independently is C1 to C6 linear or branched alkyl or C4 to C9 heterocyclic alkyl having one heterocyclic atom that is oxygen; or OR<1><7> and OR<2><1> taken together are the radical (IV) where R<3> is defined above and R<4> is C1 to C6 linear or branched alkoxy; Y is selected from the group methyl, halomethyl, and the radical -CH2OC(O)R where R is C2 to C6 linear or branched alkyl; Z independently is C1 to C7 linear or branched acyloxy, hydroxy or halo or Z and OR<1><7> taken together are the radical (IV) where R<3> and R<4> is defined above; are useful as anti-inflammatory agents. Compounds III can be prepared from compounds I through compounds II.
146	Method of manufacturing novel steroids	JP13094678	1978-10-24	JPS5484566A	1979-07-05	TEIBOORU KEKEJII; ZABORUKUSU ZEBERENII; GIYORUGII BEERU; ANTAARU DODASU; GIYORUGII HAYOSU; RASUZURO ZUPORUNII; EBA ZAYURIKU NE KUSHIZERU

147	17betaahydroxyy44androstenn33one process for preparing same and diuretic agent containing same	JP5812478	1978-05-16	JPS53141258A	1978-12-08	RUUDORUFU BUITSUHIERUTO; DEIITAA BITSUTORAA; URURITSUHI KERUPU; YORUGE KAZARUSU SHIYUTENTSUERU; BUORUFUGANGU ROOZERUTO

148	JPS5330710B1 -	JP5278771	1971-07-15	JPS5330710B1	1978-08-29
6,7-alpha-difluoromethylene-20-spirox-4-ene-3-one (I) may be prepd. from the corresp. 4,6-diene-3-one by three novel routes : (a) direct reaction with Me3SnCF3 at 20-110 degrees; (b) protection of the ketone e.g. by ketalisation, followed by reaction with CHF2CO2Na; (c) epoxidation with m-chloroperbenzoic acid and reaction of the epoxide with Ph3 . PCF2.
149	Production of novel corticoid and pharmaceutical composition containin the same with effective antiiinflammatory action	JP11940177	1977-10-04	JPS5359655A	1978-05-29	KURAUSU ANNEN; HENRII ROORENTO; HERUMUUTO HOOFUMAISUTAA; RUUDORUFU BUIIHIERUTO; HANSU BUENTO; YOAHIMU FURIITORITSUHI KATSUPU
Novel corticoids of formula I (I), wherein X is beta -hydroxymethylene, beta -fluoromethylene or carbonyl; Y is fluorine, chlorine, hydroxy, or acyloxy of 1-10 carbon atoms; and R1 is acyloxy of 1-10 carbon atoms, possess strong anti-inflammatory activity when administered topically and display only minor systemic side effects.
150	Novel derivatives of 99 chlorpredonisolone * production of same and pharmaceutical agent containing the same with strong antiiinflammatory acti1on	JP11940077	1977-10-04	JPS5359654A	1978-05-29	KURAUSU ANNEN; HENRII ROORENTO; HERUMUUTO HOOFUMAISUTAA; RUUDORUFU BUIIHIERUTO; HANSU BUENTO; YOAHIMU FURIITORITSUHI KATSUPU
Derivatives of 9-chloroprednisolone of the formula in which R1 is alkanoyl with 1 to 8 carbon atoms or benzoyl, and X is fluorine, chlorine, hydroxyl, alkanoyloxy with 1 to 8 carbon atoms or benzoyloxy, are prepared. These compounds are obtained by adding HOCl onto the corresponding DELTA <9,11>-prednisolones. The compounds can be used for the treatment of inflammations.
151	Production of novel steroid having oxygen containing functional group at 19 position	JP11909677	1977-10-05	JPS5346952A	1978-04-27	GEORUGU ANNERU; HERUMUUTO UEBERUBUATSUSERU; MISHIERU BIORA; PEETA BUIIRANTO
Novel 19-oxygenated steroids of the 20-spiroxane series of the formula in which R3 is a lower alkyl radical carrying an oxygen-containing functional group and R4 is two hydrogen atoms or an oxo group, and which carry a double bond or a methylene group in the 6,7-position or carry a lower alkanoylthio group in the 7 alpha -position, and the corresponding 17 beta -hydroxy-21-carboxylic acids of the formula
152	Steroids	JP6287977	1977-05-31	JPS52148062A	1977-12-08	HENRII REON REBINSUKII; HAUSHIYANGU TORABII; DAANII FURANSHISU MOUROO

153	Novel polyhalogenoosteroid and preparation thereof	JP14932676	1976-12-11	JPS5289662A	1977-07-27	YAROSURAFU KARUFUODA; GEORUGU ANNERU

154	Production of spiro compound of steroid series	JP4563476	1976-04-23	JPS51128959A	1976-11-10	GEORUGU ANNERU; ADORIAN MARUKUSERU; KARURESU MAISUTORE; HANSUURI BEERURI

155	4*55 sekosuteroidoruinoseiho	JP13559475	1975-11-08	JPS5175054A	1976-06-29	KURISUTOFUAA MITSUCHERU SHIMAR

156	JPS517664B1 -	JP2867370	1970-04-06	JPS517664B1	1976-03-10

157	JPS4972243A -	JP11699873	1973-10-19	JPS4972243A	1974-07-12

158	JPS4943962A -	JP8536973	1973-07-28	JPS4943962A	1974-04-25

159	JPS4840762A -	JP9728772	1972-09-29	JPS4840762A	1973-06-15

160	ＣＮＳ障害を処置するための組成物および方法	JP2017520471	2015-10-16	JP2017531019A	2017-10-19	ボテーラ，ガブリエルマルティネス; フランセスコジー．サリトゥロ，; アルバートジーンロビチャウド，; ボイドエル．ハリソン，
式(I):の神経刺激性ステロイドまたはその薬学的に受容可能な塩が本明細書中に記載され、式(I)において、(II)、A、R1、R2、R3a、R4a、R4b、R5、R7a、およびR7bは、本明細書中に定義されるとおりである。特定の実施形態において、このような化合物は、GABA調節因子として作用すると想定される。本発明はまた、本発明の化合物を含む薬学的組成物、ならびに使用および処置の(例えば、鎮静および/または麻酔を誘導するための)方法を提供する。

3 4 5 6 7 8 9 10 11 12

个人版

专业版

企业版