| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | Improved chemiluminescent 1,2-dioxetanes | EP01104600.0 | 1994-05-06 | EP1120423A1 | 2001-08-01 | Bronstein, Irena; Edwards, Brooks; Sparks, Alison |
Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T½, -etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of the ring bears an alkoxy, aryloxy, or arylalkoxy substituent, and either a phenyl or naphthyl ring, this aromatic ring bearing, at the meta position on the phenyl group, or a nonconjugated position on the naphthyl ring, an OX moiety wherein X is an enzyme-cleavable group, which when removed from the dioxetane, leaves the oxyanion which decomposes with chemiluminescence, the aryl ring further bearing an electron-active substituent Z. The nature and placement of the Z substituent, at a position not adjacent the point of attachment to the dioxetane ring, strongly influences the properties of the dioxetane. Assays, as well as kits for the performance of those assays, include the dioxetane, an enzyme capable of cleaving the X group, and in certain cases, membranes and chemiluminescent enhancement agents. |
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| 102 | Improved chemiluminescent 1,2-dioxetanes | EP01104599.4 | 1994-05-06 | EP1120422A1 | 2001-08-01 | Bronstein, Irena; Edwards, Brooks; Sparks, Alison |
Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T½, etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of the ring bears an alkoxy, aryloxy, or arylalkoxy substituent, and either a phenyl or naphthyl ring, this aromatic ring bearing, at the meta position on the phenyl group, or a nonconjugated position on the naphthyl ring,an OX moiety wherein X is an enzyme-cleavable group, which when removed from the dioxetane, leaves the oxyanion which decomposes with chemiluminescence, the aryl ring further bearing an electron-active substituent Z. The nature and placement of the Z substituent, at a position not adjacent the point of attachment to the dioxetane ring, strongly influences the properties of the dioxetane. Assays, as well as kits for the performance of those assays, include the dioxetane, an enzyme capable of cleaving the X group, and in certain cases, membranes and chemiluminescent enhancement agents. |
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| 103 | OXIDIZED OLIGOSACCHARIDES | EP97928373.6 | 1997-06-27 | EP0907664B1 | 2000-08-23 | HARVEY, Wilson; SAFERSTEIN, Lowell; WISEMAN, David; WATT, Paul, William; LIGHT, Nicholas |
| 104 | 1,2 CHEMILUMINESCENT DIOXETANES OF IMPROVED PERFORMANCE | EP96935803.5 | 1996-10-17 | EP1019390A1 | 2000-07-19 | BRONSTEIN, Irena; EDWARDS, Brooks; SPARKS, Alison |
| A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or chemical trigger admixed with the dioxetane. The polycyclic stabilizing group is preferably spiroadamantane. The group further bears an alkoxy, aryloxy, aralkyloxy or cycloalkyloxy moiety which is partially or completely substituted with halogens, particularly fluorine and chlorine. Proper selection of electron active groups on the stabilizing moiety, the aryl group and the OR group yields enhanced enzyme kinetics, superior light intensity and excellent detection sensitivity in various assays. | ||||||
| 105 | R-글루코시드, 당 알코올, 환원 당 알코올 및 환원 당 알코올의 퓨란 유도체의 합성 | KR1020167031058 | 2014-04-10 | KR1020160146787A | 2016-12-21 | 스텐스러드,케네스; 마,치-쳉; 마틴,케빈 |
| C5 및 C6 당알코올또는 R 글리코시드로부터 1,2,5,6-헥산테트롤(HTO), 1,6-헥산디올(HDO) 및기타환원폴리올을합성하는방법이본 설명에개시된다. 이러한방법은출발물질보다 2 내지 3개더 적은하이드록시기를가지는환원폴리올을형성하기에충분한시간, 온도및 압력으로수소와함께당 알코올또는 R-글리코시드를구리촉매, 가장바람직하게는레이니구리촉매와접촉시키는것을포함한다. 출발화합물이소르비톨과같은 C6 당알코올이거나메틸글루코시드와같은 C6 당의 R-글리코시드일때, 주된생성물은 HTO이다. 동일한촉매가 HTO를 HDO로더 환원시키는데에이용될수 있다. | ||||||
| 106 | 환원 당 알코올, 퓨란 유도체의 합성 | KR1020167031059 | 2014-04-10 | KR1020160143760A | 2016-12-14 | 스텐스러드,케네스; 마,치-쳉 |
| C5 및 C6 당알코올또는 R 글리코시드로부터 1,2,5,6-헥산테트롤(HTO), 1,6-헥산디올(HDO) 및기타환원폴리올을합성하는방법이본 설명에개시된다. 이러한방법은출발물질보다 2 내지 3개더 적은하이드록시기를가지는환원폴리올을형성하기에충분한시간, 온도및 압력으로수소와함께당 알코올또는 R-글리코시드를구리촉매, 가장바람직하게는레이니구리촉매와접촉시키는것을포함한다. 출발화합물이소르비톨과같은 C6 당알코올이거나메틸글루코시드와같은 C6 당의 R-글리코시드일때, 주된생성물은 HTO이다. 동일한촉매가 HTO를 HDO로더 환원시키는데에이용될수 있다. | ||||||
| 107 | 개선된 화학 발광성 1,2-디옥세탄 | KR1019950700026 | 1994-05-06 | KR100154209B1 | 1998-11-16 | 아이레나브론스테인; 브룩스에드워즈; 앨리슨스팍스 |
| Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T1/2 , etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of the ring bears an alkoxy, aryloxy, or arylalkoxy substituent, and either a phenyl or naphthyl ring, this aromatic ring bearing, at the meta position on the phenyl group, or a nonconjugated position on the naphthyl ring,an OX moiety wherein X is an enzyme-cleavable group, which when removed from the dioxetane, leaves the oxyanion which decomposes with chemiluminescence, the aryl ring further bearing an electron-active substituent Z. The nature and placement of the Z substituent, at a position not adjacent the point of attachment to the dioxetane ring, strongly influences the properties of the dioxetane. Assays, as well as kits for the performance of those assays, include the dioxetane, an enzyme capable of cleaving the X group, and in certain cases, membranes and chemiluminescent enhancement agents. | ||||||
| 108 | SYNTHESIS OF R-GLUCOSIDES, SUGAR ALCOHOLS, REDUCED SUGAR ALCOHOLS, AND FURAN DERIVATIVES OF REDUCED SUGAR ALCOHOLS | EP14888904 | 2014-04-10 | EP3129341A4 | 2017-12-06 | STENSRUD KENNETH; MA CHI-CHENG; MARTIN KEVIN |
| Disclosed herein are methods for synthesizing 1,2,5,6-hexanetetrol (HTO), 1,6 hexanediol (HDO) and other reduced polyols from C5 and C6 sugar alcohols or R glycosides. The methods include contacting the sugar alcohol or R-glycoside with a copper catalyst, most desirably a Raney copper catalyst with hydrogen for a time, temperature and pressure sufficient to form reduced polyols having 2 to 3 fewer hydoxy groups than the starting material. When the starting compound is a C6 sugar alcohol such as sorbitol or R-glycoside of a C6 sugar such as methyl glucoside, the predominant product is HTO. The same catalyst can be used to further reduce the HTO to HDO. | ||||||
| 109 | SYNTHESIS OF R-GLUCOSIDES, SUGAR ALCOHOLS, REDUCED SUGAR ALCOHOLS, AND FURAN DERIVATIVES OF REDUCED SUGAR ALCOHOLS | EP14888904.1 | 2014-04-10 | EP3129341A1 | 2017-02-15 | STENSRUD, Kenneth; MA, Chi-Cheng; MARTIN, Kevin |
| Disclosed herein are methods for synthesizing 1,2,5,6-hexanetetrol (HTO), 1,6 hexanediol (HDO) and other reduced polyols from C5 and C6 sugar alcohols or R glycosides. The methods include contacting the sugar alcohol or R-glycoside with a copper catalyst, most desirably a Raney copper catalyst with hydrogen for a time, temperature and pressure sufficient to form reduced polyols having 2 to 3 fewer hydoxy groups than the starting material. When the starting compound is a C6 sugar alcohol such as sorbitol or R-glycoside of a C6 sugar such as methyl glucoside, the predominant product is HTO. The same catalyst can be used to further reduce the HTO to HDO. | ||||||
| 110 | METHOD OF CONTINUOUS ACID HYDROLYSIS OF CELLULOSE CONTAINING SUBSTANCES | EP08873364 | 2008-03-17 | EP2265625A4 | 2011-05-04 | CHERNYAVSKAYA NINA ANDREEVNA |
| 111 | Improved chemiluminescent 1,2-dioxetanes | EP01104600.0 | 1994-05-06 | EP1120423B1 | 2007-03-14 | Bronstein, Irena; Edwards, Brooks; Sparks, Alison |
| 112 | Improved chemiluminescent 1,2-dioxetanes | EP01104599.4 | 1994-05-06 | EP1120422B1 | 2006-08-02 | Bronstein, Irena; Edwards, Brooks; Sparks, Alison |
| 113 | WATER-SOLUBLE ESTERIFIED HYDROCOLLOIDS | EP02728398.5 | 2002-03-05 | EP1365773A1 | 2003-12-03 | WARD, Florian, M. |
| Emulsifiers based on the reaction product of hydrocolloid and dicarboxylic anhydrides, especially useful in the preparation of oil-in-water emulsions. | ||||||
| 114 | 1,2 CHEMILUMINESCENT DIOXETANES OF IMPROVED PERFORMANCE | EP96935803.5 | 1996-10-17 | EP1019390B1 | 2002-07-24 | BRONSTEIN, Irena; EDWARDS, Brooks; SPARKS, Alison |
| A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or chemical trigger admixed with the dioxetane. The polycyclic stabilizing group is preferably spiroadamantane. The group further bears an alkoxy, aryloxy, aralkyloxy or cycloalkyloxy moiety which is partially or completely substituted with halogens, particularly fluorine and chlorine. Proper selection of electron active groups on the stabilizing moiety, the aryl group and the OR group yields enhanced enzyme kinetics, superior light intensity and excellent detection sensitivity in various assays. | ||||||
| 115 | 1,2 CHEMILUMINESCENT DIOXETANES OF IMPROVED PERFORMANCE | EP96935803 | 1996-10-17 | EP1019390A4 | 2000-07-19 | BRONSTEIN IRENA; EDWARDS BROOKS; SPARKS ALISON |
| A new class of stable dioxetanes bears a polycyclic stabilizing group and aryloxy moiety, the oxygen atom of which is provided with a protective group which can be removed by an enzymatic or chemical trigger admixed with the dioxetane. The polycyclic stabilizing group is preferably spiroadamantane. The group further bears an alkoxy, aryloxy, aralkyloxy or cycloalkyloxy moiety which is partially or completely substituted with halogens, particularly fluorine and chlorine. Proper selection of electron active groups on the stabilizing moiety, the aryl group and the OR group yields enhanced enzyme kinetics, superior light intensity and excellent detection sensitivity in various assays. | ||||||
| 116 | APPARATUS AND METHODS FOR ARRAYING SOLUTION ONTO A SOLID SUPPORT | EP98935886.6 | 1998-07-21 | EP0996500A1 | 2000-05-03 | MOYNIHAN, Kristen; VAN NESS, Jeffrey; TABONE, John, C. |
| A method for depositing biomolecule onto a solid support, the method including the steps of: immersing a tip of a spring probe into a solution of biomolecule; removing said tip from said solution to provide biomolecule solution adhered to said tip; and contacting said biomolecule solution with a solid support to thereby transfer biomolecule solution from said tip to said solid support. The spring probe has a planar tip but it is otherwise identical to commercial spring probes. The solution of biomolecule contains a thickening agent in addition to biomolecule, where oligonucleotide is a preferred biomolecule. | ||||||
| 117 | CYCLITOL CONTAINING CARBOHYDRATES FROM HUMAN TISSUE WHICH REGULATE GLYCOGEN METABOLISM | EP97919168.1 | 1997-09-11 | EP0925304B1 | 2000-04-26 | RADEMACHER, Thomas, William; CARO, Hugo |
| The present invention provides for an isolated P-type substance having a structure identical to a P-type substance obtained from human liver or placenta, which is a cyclitol containing carbohydrate comprising Mn2+ and Zn2+ and related compositions. | ||||||
| 118 | CYCLITOL CONTAINING CARBOHYDRATES FROM HUMAN TISSUE WHICH REGULATE GLYCOGEN METABOLISM | EP97919168.0 | 1997-09-11 | EP0925304A1 | 1999-06-30 | RADEMACHER, Thomas, William; CARO, Hugo |
| The present invention provides for an isolated P-type substance having a structure identical to a P-type substance obtained from human liver or placenta, which is a cyclitol containing carbohydrate comprising Mn2+ and Zn2+ and related compositions. | ||||||
| 119 | IMPROVED CHEMILUMINESCENT 1,2-DIOXETANES | EP94915887.0 | 1994-05-06 | EP0649417A1 | 1995-04-26 | BRONSTEIN, Irena; EDWARDS, Brooks; SPARKS, Alison |
| Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T1/2, etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of the ring bears an alkoxy, aryloxy, or arylalkoxy substituent, and either a phenyl or naphthyl ring, this aromatic ring bearing, at the meta position on the phenyl group, or a non-conjugated position on the naphthyl ring, an OX moiety wherein X is an enzyme-clevable group, which when removed from the dioxetane, leaves the oxyanion which decomposes with chemiluminescence, the aryl ring further bearing an electron-active substituent Z. The nature and placement of the Z substituent, at a position not adjacent the point of attachment to the dioxetane ring, strongly influences the properties of the dioxetane. Assays, as well as kits for the performance of those assays, include the dioxetane, an enzyme capable of cleaving the X group, and in certain cases, membranes and chemiluminescent enhancement agents. | ||||||
| 120 | IMPROVED CHEMILUMINESCENT 1,2-DIOXETANES. | EP94915887 | 1994-05-06 | EP0649417A4 | 1995-02-27 | BRONSTEIN IRENA; EDWARDS BROOKS; SPARKS ALISON |
| Novel 1,2-dioxetanes with improved chemiluminescent properties, such as signal intensity, S/N ratio, T1/2, etc. are provided by spiroadamantyl 1,2-dioxetanes, wherein the remaining carbon atom of the ring bears an alkoxy, aryloxy, or arylalkoxy substituent, and either a phenyl or naphthyl ring, this aromatic ring bearing, at the meta position on the phenyl group, or a non-conjugated position on the naphthyl ring, an OX moiety wherein X is an enzyme-clevable group, which when removed from the dioxetane, leaves the oxyanion which decomposes with chemiluminescence, the aryl ring further bearing an electron-active substituent Z. The nature and placement of the Z substituent, at a position not adjacent the point of attachment to the dioxetane ring, strongly influences the properties of the dioxetane. Assays, as well as kits for the performance of those assays, include the dioxetane, an enzyme capable of cleaving the X group, and in certain cases, membranes and chemiluminescent enhancement agents. | ||||||
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