| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | NOSCAPINOID-PRODUCING MICROBES AND METHODS OF MAKING AND USING THE SAME | US15517761 | 2015-11-16 | US20170253898A1 | 2017-09-07 | Christina D. SMOLKE; Yanran LI |
| Engineered non-plant cells that produce a benzylisoquinoline alkaloid product that is a derivative of canadine along a metabolic pathway that converts canadine, or an analog of canadine, to a noscapinoid product are provided. Methods of culturing engineered non-plant cells that produce a noscapinoid product and pharmaceutical compositions are also provided. | ||||||
| 2 | NOSCAPINOID-PRODUCING MICROBES AND METHODS OF MAKING AND USING THE SAME | EP15861129.3 | 2015-11-16 | EP3221461A1 | 2017-09-27 | SMOLKE, Christina D.; LI, Yanran |
| Engineered non-plant cells that produce a benzylisoquinoline alkaloid product that is a derivative of canadine along a metabolic pathway that converts canadine, or an analog of canadine, to a noscapinoid product are provided. Methods of culturing engineered non-plant cells that produce a noscapinoid product and pharmaceutical compositions are also provided. | ||||||
| 3 | ノスカピノイド産生微生物ならびにその作製及び使用方法 | JP2017520348 | 2015-11-16 | JP2018500002A | 2018-01-11 | スモルク クリスティーナ ディー.; リ ヤンラン |
| カナジンまたはカナジンの類縁体をノスカピノイド生成物に変換する代謝経路に沿って、カナジンの誘導体であるベンジルイソキノリンアルカロイド生成物を産生する、遺伝子操作された非植物細胞を提供する。ノスカピノイド生成物を産生する遺伝子操作された非植物細胞の培養方法と、医薬組成物も提供する。 | ||||||
| 4 | 노스캐피노이드-생산 미생물 그리고 이의 제조 방법 및 사용 방법 | KR1020177014869 | 2015-11-16 | KR1020170083568A | 2017-07-18 | 스몰크,크리스티나디.; 리,얀란 |
| 카나딘, 또는카나딘의유사체를, 노스캐피노이드생성물로전환시키는대사경로를따라카나딘의유도체인벤질이소퀴놀린알칼로이드생성물을생산하는조작된비-식물세포가제공된다. 노스캐피노이드생성물을생산하는조작된비-식물세포의배양방법및 약학적조성물이또한제공된다. | ||||||
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