| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 作为酪氨酸激酶调节剂的化合物 | CN201080048268.2 | 2010-09-03 | CN102686577A | 2012-09-19 | X·郭; Z·朱 |
| 本发明涉及式(I)的新型化合物。本发明化合物是有效的酪氨酸激酶调节剂，并且适用于治疗和预防与酪氨酸激酶受体异常的活性相关的疾病和病症。 | ||||||
| 2 | 作为酪氨酸激酶调节剂的化合物 | CN201080038952.2 | 2010-09-03 | CN102498114A | 2012-06-13 | 郭霞凌; 朱振 |
| 本发明涉及式(I)的新型化合物。本发明的化合物是有效的酪氨酸激酶调节剂，并且适于治疗和预防和酪氨酸激酶受体的异常活性有关的疾病和病症。 | ||||||
| 3 | Ｎ−スルホニルホモセリンラクトン誘導体、その調製方法及び使用 | JP2016569948 | 2015-05-25 | JP2017516809A | 2017-06-22 | ソーン リー; ジュインハイ シヤオ; チイ スゥン; ウー ジョーン; リーリー ワーン; ジービーン ジュヨン; ユインドーァ シエ; シーンジョウ リー; シンボー ジョウ; シヤオクイ ワーン; ルイユエン ツァオ |
| 本発明は、式Iのホモセリンラクトン誘導体、その調製方法及び使用に関する。当該化合物は菌体密度感知の制御作用を有し、細菌の感染によって引き起こされる疾患を予防し及び/又は治療するのに有用である。 | ||||||
| 4 | Imidazole hydrazone derivative | JP890381 | 1981-01-23 | JPS56150069A | 1981-11-20 | PIITAA JIYON FUERUNAA; BURENDAN JIEEMUSU HAMIRU; POORU UIRIAMU MANRII |
| 5 | Compounds as tyrosine kinase modulators | JP2012528089 | 2010-09-03 | JP2013503903A | 2013-02-04 | シャリン グオ; ジェン ジュ |
| 【課題】チロシンキナーゼモジュレーターである新規化合物を提供する。
【解決手段】本発明は、式（Ｉ）の新規化合物を対象とする。 本発明の化合物は、強力なチロシンキナーゼモジュレーターであり、チロシンキナーゼ受容体の異常な活性に関連する疾患および状態を治療および予防するのに適している。 【選択図】なし【化１】 |
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| 6 | Compounds as tyrosine kinase modulating agent | JP2012528084 | 2010-09-03 | JP2013503901A | 2013-02-04 | シャリン グオ; ジェン ジュ |
| 【課題】強力なチロシンキナーゼ調節物質であり、チロシンキナーゼ受容体の異常な活性が関与する疾患及び状態の治療及び予防に適切である新規化合物を提供する。
【解決手段】本発明は、式Ｉの新規化合物に関する。 【化１】 【選択図】なし |
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| 7 | N-sulfonyl homoserine lactone derivatives, preparation method and use thereof | US15314888 | 2015-05-25 | US10071994B2 | 2018-09-11 | Song Li; Junhai Xiao; Qi Sun; Wu Zhong; Lili Wang; Zhibing Zheng; Yunde Xie; Xingzhou Li; Xinbo Zhou; Xiaokui Wang; Ruiyuan Cao |
| The invention relates to a homoserine lactone derivative of Formula I, preparation method and use thereof. The compound has an effect of regulatory of bacterial quorum sensing, and is useful for preventing and/or treating a disease caused by infection of a bacterium | ||||||
| 8 | N-Sulfonyl Homoserine Lactone Derivatives, Preparation Method and Use Thereof | US15314888 | 2015-05-25 | US20180179193A1 | 2018-06-28 | Song LI; Junhai XIAO; Qi SUN; Wu ZHONG; Lili WANG; Zhibing ZHENG; Yunde XIE; Xingzhou Li; Xinbo ZHOU; Xiaokui WANG; Ruiyuan CAO |
| The invention relates to a homoserine lactone derivative of Formula I, preparation method and use thereof. The compound has an effect of regulatory of bacterial quorum sensing, and is useful for preventing and/or treating a disease caused by infection of a bacterium. | ||||||
| 9 | Compounds as tyrosine kinase modulators | US15269612 | 2016-09-19 | US09725433B2 | 2017-08-08 | Xialing Guo; Zhen Zhu |
| The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors. | ||||||
| 10 | Pyridine Derivatives With Umami Flavour | US14306725 | 2014-06-17 | US20140295045A1 | 2014-10-02 | Yili WANG; Andrew DANIHER; Adri DE KLERK; Cornelis WINKEL |
| A compound (including salts thereof) according to Formula I in which R1 is H, methyl or ethyl; R2 is H, OH, fluorine, C1-C4 linear or branched alkyl, C1-C6 alkoxy wherein the alkyl group is linear or branched, or a C3-C5 cycloalkyl moiety; R3 is H, methoxy, methyl or ethyl; or R2 and R3 together form a bridging moiety —O—CH2—O— between the phenyl carbon atoms to which they are connected; R4 is OH or methoxy; and R5 and R6 are independently H or methyl; R1, R2, R3, R4, R5 and R6 are such that, (i) when R2 and R3 together form a bridging moiety —O—CH2—O— between the phenyl carbon atoms to which they are connected, R1, R5, R6 are H, and R4 is OH; and (ii) when R4 is OH and R1-R3 are H, at least one of R5, R6 is methyl, which compound or salt thereof provides umami flavour. | ||||||
| 11 | COMPOUNDS AS TYROSINE KINASE MODULATORS | US14054444 | 2013-10-15 | US20140100212A1 | 2014-04-10 | Xialing Guo; Zhen Zhu |
| The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors. | ||||||
| 12 | COMPOUNDS AS TYROSINE KINASE MODULATORS | US12875223 | 2010-09-03 | US20110053973A1 | 2011-03-03 | Xialing Guo; Zhen Zhu |
| The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors. | ||||||
| 13 | Phosphoramidate derivatives of FAU | US12092999 | 2006-11-09 | US07888330B2 | 2011-02-15 | Anthony F. Shields; Jiri Zemlicka; Sridhar Nimmagadda |
| The present invention provides phosphoramidate derivatives of a furanosyluracil analog, FAU, that can effectively deliver FAU monophosphate, or a derivative thereof, intracellularly. FAU-Phosphoramidate diesters can bypass the first step of phosphorylation and be activated intracellularly so as to be converted to nucleoside monophosphates. This results in improved formation of nucleoside triphosphates, and higher incorporation into DNA. The compounds of the invention can be used to treat cancer. | ||||||
| 14 | COMPOUNDS AS TYROSINE KINASE MODULATORS | US15269612 | 2016-09-19 | US20170066738A1 | 2017-03-09 | Xialing Guo; Zhen Zhu |
| The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors. | ||||||
| 15 | Compounds as tyrosine kinase modulators | US14793913 | 2015-07-08 | US09475801B2 | 2016-10-25 | Xialing Guo; Zhen Zhu |
| The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors. | ||||||
| 16 | 1-ARYL-3-ALKYLPYRAZOLE INSECTICIDES | US15036958 | 2014-11-20 | US20160280660A1 | 2016-09-29 | Omar Khaled Ahmad; Thomas Francis Pahutski, JR. |
| Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q is and Z, R1, R2a, R2b, R2c, R2d, J1, J2 and M are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the invention. | ||||||
| 17 | Compounds as tyrosine kinase modulators | US12875223 | 2010-09-03 | US08809534B2 | 2014-08-19 | Xialing Guo; Zhen Zhu |
| The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors. | ||||||
| 18 | Pyridine Derivatives With Umami Flavour | US13381393 | 2010-07-09 | US20120121783A1 | 2012-05-17 | Yili Wang; Andrew Daniher; Adri De Klerk; Cornelis Winkel |
| A compound (including salts thereof) according to Formula I in which R1 is H, methyl or ethyl; R2 is H, OH, fluorine, C1-C4 linear or branched alkyl, C1-C6 alkoxy wherein the alkyl group is linear or branched, or a C3-C5 cycloalkyl moiety; R3 is H, methoxy, methyl or ethyl; or R2 and R3 together form a bridging moiety —O—CH2—O— between the phenyl carbon atoms to which they are connected; R4 is OH or methoxy; and R5 and R6 are independently H or methyl; R1, R2, R3, R4, R5 and R6 are such that, (i) when R2 and R3 together form a bridging moiety —O—CH2—O— between the phenyl carbon atoms to which they are connected, R1, R5, R6 are H, and R4 is OH; and (ii) when R4 is OH and R1—R3 are H, at least one of R5, R6 is methyl. | ||||||
| 19 | COMPOUNDS AS TYROSINE KINASE MODULATORS | US12875218 | 2010-09-03 | US20110053905A1 | 2011-03-03 | Xialing Guo; Zhen Zhu |
| The present invention is directed to novel compounds of Formula I. The compounds of the present invention are potent tyrosine kinase modulators, and are suitable for the treatment and prevention of diseases and conditions related to abnormal activities of tyrosine kinase receptors. | ||||||
| 20 | Certain 2-(2,3-and 4-pyridyl)-benzofuran and derivatives thereof | US3470192D | 1965-11-12 | US3470192A | 1969-09-30 | BINON FERNAND; ZIEGLER HERBERT; INION HENRI |
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