| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 1*2*44oxadiazolinee55one derivative* its manufacture and drug composition containing same | JP14066880 | 1980-10-09 | JPS5661375A | 1981-05-26 | KAARUMAAN TAKAACHIYU; KISU AIZERUTO; ANTARU SHIMAI; PEETERU RITERAATEI NAJI; HETEIEI PATSUPU; ECHIERII PUSHIYUKAASHIYU; RAASURO SEKERESHIYU; JIYURA PATSUPU; SHIAANDORU BIRAAGU; EBUA UDOUBUARUDEI |
| 2 | 1,2,4-Oxadiazolin-5-one derivatives, process for their preparation and pharmaceutical compositions containing them | US196583 | 1980-10-14 | US4365064A | 1982-12-21 | Kalman Takacs; Ilona Kiss nee Ajzert; Antal Simay; Peter Literati Nagy; Maria Hetyey nee Papp; Marian Ecsery nee Puskas; Laszlo Szekeres; Gyula Papp; Sandor Viragh; Eva Udvardy |
| The invention concerns new compounds of the formula (I) ##STR1## wherein R.sup.1 is hydrogen, phenyl or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro;R.sup.2 is alkyl having 1 to 4 carbon atoms, cycloalkyl having 5 to 7 carbon atoms, phenyl, or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro;R.sup.3 is alkoxy having 1 to 4 carbon atoms or hydrogen,R.sup.4 is hydrogen, alkyl having 1 to 4 carbon atoms unsubstituted or substituted with alkoxy having 1 to 4 carbon atoms, benzyloxy or cyano, phenyl, or phenyl substituted with at least one alkyl having 1 to 4 carbon atoms, halogen, alkoxy having 1 to 4 carbon atoms or nitro, or phenyl-(C.sub.1-4 alkyl)-alkyl, in which the phenyl moiety may bear an alkoxy substituent having 1 to 4 carbon atoms or a halogen;m and n are each 0, 1 or 2 or a pharmaceutically acceptable acid addition or quaternary salt thereof.The compounds are potent vasodilators and exert a favorable influence on the extremital blood flow. They also show a heart function influencing activity.Methods for the preparation of said compounds and pharmaceutical compositions containing them are also the subject of the invention. | ||||||
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