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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	Process for preparing an optically active cyclobutane nucleoside	US451664	1989-12-18	US5064961A	1991-11-12	Gregory S. Bisacchi; Toomas Mitt
A process for the preparation of the optically active compound [IR-(1.alpha., 2.beta., 3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one, represented by the formula: ##STR1## and novel intermediates are described.
2	Intermediates for an optically active cyclobutane nucleoside	US91389	1993-07-15	US5306837A	1994-04-26	Gregory S. Bisacchi; Toomas Mitt
Novel intermediates useful in the preparation of the optically active antiviral compound [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-1,9-dihydro-6H-purin-6-one are described.
3	Method of controlling the growth of microorganisms by a composition containing isolated or in vitro synthesized nitrosoamides	US13319870	2010-05-11	US08728442B2	2014-05-20	Jorge I. Jimenez; Jonathan S. Margolis; John Kenneth Baird; Sarah F. Lego
The present invention relates to novel compounds and compositions and the use of them for the control of fungal and bacterial pathogens, insect pests, acari, nematodes and other invertebrate pests including, but not limited to post-harvest and soil diseases, building mold remediation, and seed and grain sanitation.
4	COMPOUNDS DERIVED FROM MUSCODOR FUNGI	US13319870	2010-05-11	US20120058058A1	2012-03-08	Jorge I. Jimenez; Jonathan S. Margolis; John Kenneth Baird; Sarah F. Lego
The present invention relates to novel compounds and compositions and the use of them for the control of fungal and bacterial pathogens, insect pests, acari, nematodes and other invertebrate pests including, but not limited to post-harvest and soil diseases, building mold remediation, and seed and grain sanitation.
5	Intermediates for the preparation of optically active cyclobutane nucleoside	US975256	1992-11-12	US5256806A	1993-10-26	Gregory S. Bisacchi; Toomas Mitt
Novel intermediates useful in the preparation of the optically active antiviral compound [1R-(1.alpha.,2.beta.,3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-1,9-dihydro-6H-purin-6-one are described.
6	Optically active cyclobutane nucleoside and intermediates, therefor	US770390	1991-10-03	US5198583A	1993-03-30	Gregory S. Bisacchi; Toomas Mitt
The optically active antiviral compound [1R-(1.alpha., 2.beta., 3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)-cyclobutyl]-1,9-dihydro-6H-purin-6-one and novel intermediates useful in its preparation are described.
7	Preparation of optically active cyclobutane nucleoside	JP41201090	1990-12-18	JPH05178857A	1993-07-20	GUREGORII ESU BISATSUCHI; TOOMASU MITSUTO
PURPOSE: To prepare the compound useful as an antiviral agent by allowing a specific racemic compound to successively react with an alkali, a chiral primary amine, a nitrosylating agent, a reducing agent, an acid catalyst, a sulfonylating agent and guanine. CONSTITUTION: This preparation comprises: allowing a racemic compound represented by the formula I (wherein each of R ¹ and R ² is a lower alkyl group) to react with an alkali; allowing the reaction product to react with a chiral primary amine represented by the formula R ³NH ₂ (wherein R ³ is a (substituted) alkyl group) in the presence of a coupling agent, to obtain a diastereomer mixture; after separating the mixture and protecting its OH groups, allowing the resulting mixture to react with a nitrosylating agent to obtain a compound represented by the formula II (wherein R ^3a is a group for protecting the group R ³); treating the compound represented by the formula II with a reducing agent to allow the protecting groups to react with the agent; allowing the treated compound to react with an acid catalyst to obtain a compound represented by the formula III (wherein R ⁴ is a protecting group); allowing the compound represented by the formula III to react with a sulfonylating agent; then, allowing the sulfonylated compound to further react with (protected) guanine; and thereafter, removing the protected group of the reaction product thus obtained, to prepare the objective optically active compound represented by the formula IV, i.e., (1R(1α,2β,3α))-2- amino-9-(2,3-bis(hydroxymethyl)cyclobutyl)-6H-purin-6-one. COPYRIGHT: (C)1993,JPO
8	Process for preparing an optically active cyclobutane nucleoside	EP90124123.2	1990-12-13	EP0433897B1	1997-10-01	Bisacchi, Gregory S.; Mitt, Toomas

9	Process for preparing an optically active cyclobutane nucleoside	EP90124123.2	1990-12-13	EP0433897A3	1992-08-05	Bisacchi, Gregory S.; Mitt, Toomas
A process for the preparation of the optically active compound [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one, represented by the formula: and novel intermediates are described.
10	Process for preparing an optically active cyclobutane nucleoside	EP90124123.2	1990-12-13	EP0433897A2	1991-06-26	Bisacchi, Gregory S.; Mitt, Toomas
A process for the preparation of the optically active compound [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one, represented by the formula: and novel intermediates are described.
11	COMPOUNDS DERIVED FROM MUSCODOR FUNGI	PCT/US2010034456	2010-05-11	WO2010132509A3	2011-09-15	JIMENEZ JORGE I; MARGOLIS JONATHAN S; BAIRD JOHN; LEGO SARAH F
The present invention relates to novel compounds and compositions and the use of them for the control of fungal and bacterial pathogens, insect pests, acari, nematodes and other invertebrate pests including, but not limited to post-harvest and soil diseases, building mold remediation, and seed and grain sanitation.
12	SOLUBLE DIAZOALKANE PRECURSORS	PCT/GB2007003713	2007-10-01	WO2008040947A3	2008-07-31	MOODY DAVID
The present invention relates to compounds useful in the preparation of diazoalkanes in general (such as diazomethane, diazoethane, diazopropane, diazobutane and homologues) and to diazomethane (CH₂=N=N) in particular. The compounds chosen as the diazomethane source according to the invention also have the advantage of being water soluble. They are capable of being decomposed to diazomethane or another diazoalkane (which is allowed to bubble out of the vessel to another vessel containing a solution of reactant) and are converted to by-products that are also water-soluble.

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