| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Chemical amplification for the synthesis of patterned arrays | US09578282 | 2000-05-25 | US06770436B1 | 2004-08-03 | Jody E. Beecher; Martin J. Goldberg; Glenn H. McGall |
| Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers. | ||||||
| 162 | Arrays with modified oligonucleotide and polynucleotide compositions | US10417350 | 2003-04-17 | US20040121352A1 | 2004-06-24 | Roderic M.K. Dale |
| The present invention provides arrays having associated modified oligonucleotides that selectively bind to DNA or RNA, methods of making such arrays, assays for using such arrays, and the like. In one embodiment, the arrays of the invention exhibit an increased binding affinity with complementary nucleic acids, and in particular with complementary RNA. In another embodiment, the associated nucleic acids of the array of the invention exhibit substantial acid resistance, allowing the arrays to be treated with low pH solutions. In another embodiment, the modified associated nucleic acids of the array of the invention exhibit substantial resistance to nuclease degradation. | ||||||
| 163 | Fluorous triphase and other multiphase systems | US09877944 | 2001-06-08 | US06734318B2 | 2004-05-11 | Dennis P. Curran; Stephen G. Weber; Hiroyuki Nakamura; Bruno Linclau; Lifang Sun |
| A method of reacting a first compound to produce a second compound includes the step of contacting a first non-fluorous phase including the first compound with a first fluorous phase at a first phase interface. The first compound distributes between the first fluorous phase and the first non-fluorous phase. The method further includes the steps of contacting the first fluorous phase with a second non-fluorous phase at a second phase interface and including at least a third compound in the second non-fluorous phase that reacts with the first compound to produce the second compound. The second compound has a distribution coefficient less than the first compound. This method can, for example be used to separate the second compound from unreacted first compound wherein, for example, the first compound is of a fluorous nature and distributes more readily into (or transports more quickly through) the fluorous phase than does the second compound. In general, the fluorous phase serves as a barrier to prevent the two non-fluorous phases from mixing, but molecules that can migrate through the fluorous phase can pass from one side to the other. | ||||||
| 164 | Multiphasic microchannel reactions | US10279090 | 2002-10-22 | US20040082804A1 | 2004-04-29 | John H. Brophy; Bruce F. Monzyk |
| Multiphasic reactions, especially those reactions using a phase transfer catalyst, are conducted in microchannel apparatus. Advantageously, these reactions can be conducted with two, planar microlayers of reactants in adjacent laminar flow streams. Microchannel apparatus and methods for conducting unit operations such as reactions and separations in microchannel apparatus is also described. Microchannel apparatus can provide advantages for controlling reactions and separating products, solvents or reactants in multiphase reactions. | ||||||
| 165 | Method for producing molecular compound | US10432758 | 2003-05-28 | US20040030123A1 | 2004-02-12 | Masato Amaike; Seiji Sasaoka; Shigeru Kawamuko; Yasuaki Hashimoto; Eiji Takemura |
| A method for producing a molecular compound which comprises mixing and kneading a solid host compound and a solid or liquid guest compound by using a kneader and optionally followed by extruding and granulating, wherein the method further comprises one or more of the steps of holding the product at a temperature which is 50null C. or higher and not higher than the emission temperature for the guest compound, washing the formed molecular compound with a solvent capable of dissolving the guest compound, pulverizing in advance the solid host compound, and adding a poor solvent such as water prior to mixing and kneading. The method allows the production of a molecular compound having improved stability. | ||||||
| 166 | Process and unit for carrying out a reaction on an organic feed, such as dimerization or metathesis, in the presence of a polar phase containing a catalyst | US09779649 | 2001-02-09 | US06630112B2 | 2003-10-07 | Helene Olivier; Dominique Commereuc; Alain Forestiere; Francois Hugues |
| A process for carrying out a reaction on an organic feed, for example dimerization, co-dimerization, oligomerization or metathesis of olefins, as described in which the catalyst is a catalytic metal compound dissolved in a non-aqueous ionic medium which is not or is only slightly miscible with hydrocarbons. The reaction is carried out in a system comprising at least two treatment loops each comprising at least one reaction zone and at least one zone for separating the organic and polar phases between which the polar medium containing the catalytic metal compound, and the organic phase circulate. Fresh polar phase is injected into the second loop and used polar phase is eliminated from the first loop. The hydrocarbon to be transformed is injected into the first loop and the products are withdrawn from the second loop. The invention also concerns a unit for carrying out the process. | ||||||
| 167 | Fluorous triphase and other multiphase systems | US09877944 | 2001-06-08 | US20030078444A1 | 2003-04-24 | Dennis P. Curran; Stephen G. Weber; Hiroyuki Nakamura; Bruno Linclau; Lifang Sun |
| A method of reacting a first compound to produce a second compound includes the step of contacting a first non-fluorous phase including the first compound with a first fluorous phase at a first phase interface. The first compound distributes between the first fluorous phase and the first non-fluorous phase. The method further includes the steps of contacting the first fluorous phase with a second non-fluorous phase at a second phase interface and including at least a third compound in the second non-fluorous phase that reacts with the first compound to produce the second compound. The second compound has a distribution coefficient less than the first compound. This method can, for example be used to separate the second compound from unreacted first compound wherein, for example, the first compound is of a fluorous nature and distributes more readily into (or transports more quickly through) the fluorous phase than does the second compound. In general, the fluorous phase serves as a barrier to prevent the two non-fluorous phases from mixing, but molecules that can migrate through the fluorous phase can pass from one side to the other. | ||||||
| 168 | Method of lithiating five membered heterocycles | US09830424 | 2001-07-20 | US06509474B1 | 2003-01-21 | Uwe Lischka; Dieter Hauk; Peter Rittmeyer; Ulrich Wietelmann |
| The invention relates to a method of lithiating CH-acidic five-membered heterocycles whereby the five-membered heterocycle is reacted with metallic lithium in an ether-containing solvent in the presence of an H acceptor. | ||||||
| 169 | Reaction method using metallic ion catalyst and anion exchanger, separation method of the metallic ion catalyst, and reutilization method | US10104054 | 2002-03-25 | US20020198403A1 | 2002-12-26 | Takafumi Kubo |
| The subject for the invention is to efficiently use, recover, and reuse a soluble metallic catalyst with great ease at low cost in various liquid-phase reactions using the soluble metallic catalyst. The invention provides a method of liquid-phase reaction using a soluble metallic catalyst in which the soluble metallic catalyst is caused to coexist with an anion-exchange resin during the reaction and the reaction is conducted under such conditions that 50% or more of the soluble metallic catalyst is adsorbed onto the anion-exchange resin. The anion-exchange resin having the soluble metallic catalyst adsorbed thereon is separated from the liquid reaction mixture to thereby recover the soluble metallic catalyst and reuse it in a liquid-phase reaction. | ||||||
| 170 | Ethyllithium in dibutyl ether | US09862988 | 2001-05-22 | US06495064B2 | 2002-12-17 | Wilfried Weiss; Rainer Aul; Ute Emmel; Peter Rittmeyer |
| This patent describes a solution of ethyllithium in dibutyl ether, a non-pyrophoric solution of ethyllithium in dibutyl ether in a concentration of 7 to 8%, a non-pyrophoric solution of ethyllithium in dibutyl ether and in a hydrocarbon in a concentration of 2 to 8%, process for preparing the solutions and the use of the solutions. | ||||||
| 171 | Polarization switching to control crystal form | US09965751 | 2001-09-28 | US20020120105A1 | 2002-08-29 | Allan S. Myerson; Bruce A. Garetz |
| A method to select and prepare polymorphs of materials by switching the polarization state of light employing non-photochemical laser-induced nucleation. | ||||||
| 172 | Method for creating physiologically active compounds | US09816658 | 2001-03-26 | US20020062155A1 | 2002-05-23 | Akiko Itai; Koichi Shudo |
| A method for creating physiologically active compounds, comprising the following steps: (1) generating a compound database storing molecular structures covering all the combinations of at least one substitution site selected from substitutable sites existing on a basic molecular skeleton and utilizable substituents; and (2) extracting molecular structures satisfying requirements for exhibiting the physiological activity from the compound database. | ||||||
| 173 | Method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group | US09700467 | 2001-01-24 | US06384273B1 | 2002-05-07 | Virginie Pevere; Jean Roger Desmurs; Charles Mioskowski; Alain Wagner; Arnaud Gissot |
| The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amount of at least one alkaline metal in the presence of a compound of formula (I): RX, wherein: R represents a hydrocarbon radical having 1 to 20 carbon atoms which can be a saturated or unsaturated, linear or branched, acyclic aliphatic radical; a saturated or unsaturated, monocyclic or polycyclic cycloaliphatic radical; a saturated or unsaturated, linear or branched aliphatic radical bearing a cyclic substituent; and X represents a bromine or chlorine atom. | ||||||
| 174 | Pharmacophore fingerprinting in primary library design | US09877797 | 2001-06-07 | US20020052694A1 | 2002-05-02 | Malcolm J. McGregor; Steven M. Muskal |
| Specialized apparatus and methods may be used for identifying, representing, and productively using high activity regions of chemical structure space. At least two representations of chemical structure space provide valuable information. A first representation has many dimensions representing members of a pharmacophore basis set and one or more additional dimensions representing defined chemical activity (e.g., pharmacological activity). A second representation has many fewer dimensions, each of which represents a principle component obtained by transforming the first representation via principal component analysis used on pharmacophore fingerprint/activity data for a collection of compounds. When the collection of compounds has the defined chemical activity, that activity will be reflected as a nullhigh activitynull region of chemical space in the second representation. A nulltransformationnull procedure may convert between the first and second representations. If pharmacophore fingerprints for an nullinvestigationnull set of compounds is transformed to the second representation of chemical space, those compounds can be nullscreenednull for high activity. Those compounds residing in the region of high activity may likely have the desired activity. Those compounds residing outside the region probably do not have the desired activity. The compounds falling within high activity region may be selected for a primary library or a more constrained library, depending upon the specificity of the high activity region. | ||||||
| 175 | Gene pen devices for array printing | US09109915 | 1998-07-02 | US06235473B1 | 2001-05-22 | Mitchell Friedman; Yu-Hui Rogers; Michael Boyce-Jacino |
| The invention concerns an apparatus for printing arrays of molecules and methods for printing these arrays. More particularly, the invention relates to a gene pen apparatus that may be used for delivering arrays of oligonucleotides on solid supports from a multiplicity of reagent reservoirs through flow controlling means. The flow controlling means may for example, be either a pin valve means or a wicking means. | ||||||
| 176 | Plasma discharge reactors for the preparation of bioactive compounds | US09339315 | 1999-06-23 | US06221319B1 | 2001-04-24 | Bruce M. Johnson; Walter C. Babcock; James B. West; Dwayne T. Friesen |
| Plasma discharge reactors of various designs are disclosed; the reactors are capable of synthesizing large numbers of bioactive compounds of great chemical diversity. | ||||||
| 177 | Process for preparation of aromatic and heteroaromatic molecules | US09125233 | 1998-08-13 | US06180718B2 | 2001-01-30 | Terri L. Boehm; John C. Hodges; Howard D. H. Showalter |
| A process for the attachment of aromatic or heteroaromatic rings to a polymeric support via a silyl ether linkage is described. Such process involves the synthesis of a chlorodialkyl aryl or heteroarylsilane which is then coupled to a polymeric support via a hydroxyl functionality to form a polymer-bound silyl ether. Further modification provides a polymer-bound small organic molecule that is cleaved from the polymeric support under mild conditions to give an aryl or heteroaryl silanol or a compound in which the aryl or heteroaryl carbon-silicon bond is replaced with a carbon-hydrogen, carbon-halogen, carbon-hydroxyl, carbon-sulfur, or carbon—carbon bond. Such methods are useful for the preparation of a library of diverse aromatic and heteroaromatic compounds by both manual and automated synthesis. | ||||||
| 178 | Method for influencing the dispersibility, emulsifiability solubility and/or reactivity of low molecular weight solids containing alkyl groups | US913603 | 1998-02-27 | US6133334A | 2000-10-17 | Steffen Berger |
| A method for influencing the dispersibility, emulsifiability, solubility and/or reactivity of low molecular weight solids containing alkyl groups wherein low molecular weight solids containing alkyl groups are subjected to a plasma treatment in a frequency range of from 10 kHz to 10 GHz. | ||||||
| 179 | Arrays with modified oligonucleotide and polynucleotide compositions | US408088 | 1999-09-29 | US6087112A | 2000-07-11 | Roderic M. K. Dale |
| The present invention provides arrays having associated modified oligonucleotides, e.g., 2'-O-R oligonucleotides, methods of making such arrays, assays for using such arrays, and kits containing such arrays. In one embodiment, the arrays of the invention exhibit an increased binding affinity with complementary nucleic acids, and in particular with complementary RNA. In another embodiment, the associated nucleic acids of the array of the invention exhibit substantial acid resistance, allowing the arrays to be treated with low pH solutions. In another embodiment, the modified associated nucleic acids of the array of the invention exhibit substantial resistance to nuclease degradation. | ||||||
| 180 | Process for the chemical modification of solids containing alkyl groups | US836916 | 1997-05-23 | US5989477A | 1999-11-23 | Steffen Berger |
| The invention relates to a process for the chemical modification of solids containing alkyl groups. It is provided that the solids containing alkyl groups are heated to temperatures above their melting point and subjected to a plasma treatment in a frequency range from 10 kHz to 10 GHz. | ||||||
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