| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | COMPOSITIONS FOR MODULATING MECP2 EXPRESSION | US15554409 | 2016-03-03 | US20180036335A1 | 2018-02-08 | Susan M. Freier |
| Disclosed herein are compounds and methods for decreasing methyl CpG binding protein 2 (MECP2) mRNA and protein expression. Such compounds and methods are useful to treat, prevent, or ameliorate MECP2 associated disorders and syndromes. Such MECP2 associated disorders include MECP2 duplication syndrome. In certain embodiments, compounds useful for modulating expression and amount of MECP2 mRNA and protein are antisense compounds. In certain embodiments, the antisense compounds are modified antisense oligonucleotides. In certain embodiments, the antisense compounds are single-stranded antisense oligonucleotides. In certain embodiments, the antisense compounds are not siRNA compounds. | ||||||
| 122 | Apparatus and methods for the automated synthesis of small molecules | US14996479 | 2016-01-15 | US09862733B2 | 2018-01-09 | Martin D. Burke; Eric P. Gillis; Steven G. Ballmer |
| Provided are methods for purifying N-methyliminodiacetic acid (MIDA) boronates from solution. Also provided are methods for deprotection of boronic acids from their MIDA ligands. The purification and deprotection methods can be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chemical compounds of interest. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated synthesis of small molecules using iterative cycles of deprotection, coupling, and purification in accordance with methods of the invention. Coupling and other reactions embraced by the invention include, without limitation, Suzuki-Miyaura coupling, oxidation, Swern oxidation, “Jones reagents” oxidation, reduction, Evans' aldol reaction, HWE olefination, Takai olefination, alcohol silylation, desilylation, p-methoxybenzylation, iodination, Negishi cross-coupling, Heck coupling, Miyaura borylation, Stille coupling, and Sonogashira coupling. | ||||||
| 123 | ZEOLITE, MANUFACTURING METHOD OF THE SAME, AND CATALYTIC CRACKING CATALYST OF PARAFFIN | US14793428 | 2015-07-07 | US20170368539A1 | 2017-12-28 | Yoshihiro Kubota; Satoshi Inagaki; Raita Komatsu; Keiji Itabashi; Tatsuya Okubo; Toyohiko Hieda |
| Provided is a beta-type zeolite which has a high catalytic activity and is not easily deactivated.The beta-type zeolite of the invention has a substantially octahedral shape, has a Si/Al ratio of 5 or more, and is a proton-type zeolite. The Si/Al ratio is preferably 40 or more. This beta-type zeolite is preferably obtained by transforming a raw material beta-type zeolite synthesized without using a structure directing agent into an ammonium-type zeolite through ion exchange, then, exposing the beta-type zeolite to water vapor, and subjecting the exposed beta-type zeolite to an acid treatment. | ||||||
| 124 | METHOD FOR PREPARING CATALYST | US15532929 | 2015-12-16 | US20170341070A1 | 2017-11-30 | Yukiko NOMURA |
| [Problem to be Solved]To provide a method for preparing a catalyst that has high activity and exhibits high durability with reduced elution of a catalyst metal when a liquid-phase oxidation reaction is brought about without combined use of an alkali; and a method for producing an oxide highly efficiently by use of the catalyst.The method for preparing a catalyst has the following Steps 1, 2 and 3.Step 1: preparing an aqueous dispersion of a catalyst carrying Pt on activated carbon;Step 2: preparing an aqueous solution containing Bi in an ionic state; andStep 3: adding the aqueous dispersion obtained in Step 1 to the aqueous solution obtained in Step 2. | ||||||
| 125 | METHOD AND APPARATUS FOR SYNTHESIZING HYDROCARBON | US15536190 | 2015-06-10 | US20170327434A1 | 2017-11-16 | Tadayuki Imanaka; Tadashi Takemoto |
| A method for synthesizing a hydrocarbon by reducing carbon dioxide in water, said method comprising supplying oxygen to water containing carbon dioxide to generate oxygen nanobubbles, irradiating the water containing the oxygen nanobubbles with ultraviolet light in the presence of a photocatalyst to generate active oxygen, and reducing carbon dioxide in the presence of the active oxygen. | ||||||
| 126 | METHOD FOR PRODUCING FLUOROPOLYETHER | US15525323 | 2015-07-28 | US20170321006A1 | 2017-11-09 | Tsuyoshi SHIMIZU |
| A process for preparing a low-molecular weight fluoropolyether containing an acid fluoride by decomposing a triflate or trifluoroacetate of a fluoropolyether having a hydroxyl group in the presence of a Lewis acid. | ||||||
| 127 | METHOD FOR PRODUCING EPSILON-CAPROLACTAM | US15523120 | 2015-10-27 | US20170320819A1 | 2017-11-09 | Masateru ITO; Daijiro TSUKAMOTO; Kenji KAWAMURA; Kohei YAMASHITA; Masato AKAHIRA; Katsushige YAMADA; Koji YAMAUCHI |
| A method for selective production of ε-caprolactam, wherein a substance inducible from a biomass resource is used as a material; the reaction process is short; ammonium sulfate is not produced as a by-product; and production of by-products is suppressed; is disclosed. The method for producing ε-caprolactam comprises the step of reacting a particular compound inducible from a biomass resource, such as α-hydromuconic acid, 3-hydroxyadipic acid, or 3-hydroxyadipic acid-3,6-lactone, or a salt thereof with hydrogen or ammonia. | ||||||
| 128 | PHOTOCHEMICAL REACTION DEVICE, PHOTOCHEMICAL REACTION METHOD USING SAME, AND LACTAM PRODUCTION METHOD USING SAID METHOD | US15517424 | 2015-09-17 | US20170298015A1 | 2017-10-19 | Takenori Sugimoto; Toru Takahashi; Kazuki Sugawara |
| Provided is a photochemical reaction device wherein two partitions formed from an optically transparent material are arranged apart from each other between a light source and a reaction liquid, and an optically transparent fluid introduction/discharge means for introducing an optically transparent fluid between the partitions and discharging the fluid and a state change detection means for detecting a change in the state of the optically transparent fluid at the discharge side of the optically transparent fluid introduction/discharge means are provided. Also provided are a photochemical reaction method that uses the photochemical reaction device and a lactam production method that uses the photochemical reaction method. The present invention prevents decreases in the performance of the light source even when the optically transparent material in the photochemical reaction device is damaged, and makes it possible to reliably prevent ignition even if the reaction liquid is a flammable liquid. | ||||||
| 129 | METHOD FOR PRODUCING OLEFIN | US15633336 | 2017-06-26 | US20170291862A1 | 2017-10-12 | Yusuke TAKAHIRA |
| A method for producing at least one olefin compound selected from the group consisting of a compound of formula (51), a compound of formula (52), a compound of formula (53), and a compound of formula (54), the method including reacting an olefin compound of formula (21) with a olefin compound of formula (31) in the presence of at least one metal catalyst selected from the group consisting of a compound of formula (11), a compound of formula (12), a compound of formula (13), a compound of formula (14), and a compound of formula (15). | ||||||
| 130 | HYDROSILYLATION IRON CATALYST | US15504736 | 2015-08-19 | US20170260216A1 | 2017-09-14 | Hideo NAGASHIMA; Yusuke SUNADA; Daisuke NODA; Hiroe SOEJIMA; Koji SAKUTA |
| A hydrosilylation iron catalyst prepared from a two-electron ligand (L) and a mononuclear, binuclear, or trinuclear complex of iron indicated by formula (1), Fe having bonds with carbon atoms included in X and the total number of Fe-carbon bonds being 2-10. As a result of using iron, the hydrosilylation iron catalyst is advantageous from a cost perspective as well as being easily synthesized. Hydrosilylation reactions can be promoted under mild conditions by using this catalyst. Fe(X)a (1) (in the formula, each X independently indicates a C2-30 ligand that may include an unsaturated group excluding carbonyl groups (CO groups) and cyclopentadienyl groups, however at least one X includes an unsaturated group, a indicates an integer of 2-4 per Fe atom.) | ||||||
| 131 | METHOD FOR RECOVERING INERT MATERIAL AND METHOD FOR PRODUCING ACRYLIC ACID USING INERT MATERIAL RECOVERED BY SAID METHOD | US15500238 | 2015-07-30 | US20170260118A1 | 2017-09-14 | Yasuhiro MIMURA; Fumio MUNECHIKA; Hisao KAKUTA; Motoki HISANAGA; Seiichi HARA |
| The present invention provides a method for allowing a used inert material that has been subjected to a reaction once, which is disposed of in the background art, to be used again as well as a brand-new one. A method of recovering an inert material of the present invention is characterized by in the fixed-bed reactor, the inert material is loaded in an inert material layer provided between a first-stage catalyst layer and a second-stage catalyst layer, the first-stage catalyst layer is loaded with a first-stage catalyst for producing acrolein from propylene, and the second-stage catalyst layer is loaded with a second-stage catalyst for producing acrylic acid from acrolein, the method comprising the steps of: extracting the inert material from the fixed-bed reactor; washing the extracted inert material; and screening the washed inert material. | ||||||
| 132 | SOLID ACID CATALYST AND METHOD FOR PRODUCING OXIDE | US15507000 | 2015-07-31 | US20170253575A1 | 2017-09-07 | Takamasa SUZUKI; Ichiro TAKASE |
| Provided is a solid acid catalyst for use in oxidation of a substrate in the coexistence of oxygen and ozone (solid acid catalyst for oxygen-ozone-coexisting oxidation). The solid acid catalyst enables oxidation of the substrate with a high conversion. This solid acid catalyst for oxygen-ozone-coexisting oxidation is a solid acid catalyst for use in an oxidation reaction to oxidize a substrate (A) in the coexistence of oxygen and ozone. The solid acid catalyst includes a transition metal in the form of an elementary substance, a compound, or an ion, and a support supporting the transition metal. The support includes, at least in its surface, a strong acid or super strong acid having a Hammett acidity function (H0) of −9 or less. The support is preferably a pellet or particle made of a fluorinated sulfonic acid resin, or a support including a solid and a layer of a fluorinated sulfonic acid resin disposed on the solid. | ||||||
| 133 | HYDROSILYLATION REACTION CATALYST | US15503209 | 2015-08-12 | US20170233417A1 | 2017-08-17 | Hideo NAGASHIMA; Yusuke SUNADA; Atsushi TAHARA; Daisuke NODA; Hiroe SOEJIMA; Koji SAKUTA |
| A hydrosilylation reaction catalyst prepared from: a catalyst precursor comprising a transition metal compound, excluding platinum, belonging to group 8-10 of the periodic table, e.g., iron acetate, cobalt acetate, nickel acetate, etc.; and a ligand comprising an isocyanide compound such as t-butyl isocyanide. The hydrosilylation reaction catalyst has excellent handling and storage properties. As a result of using this catalyst, a hydrosilylation reaction can be promoted under gentle conditions. | ||||||
| 134 | APPARATUS AND METHOD FOR PRODUCING CYCLIC CARBONATE | US15314804 | 2015-05-29 | US20170197931A1 | 2017-07-13 | Kouzo OSAKI; Takashi NANIKI; Yasunori HAYASHI; Takeshi HARUNA |
| Disclosed herein are an apparatus and method for continuously producing a cyclic carbonate. The apparatus includes an adiabatic reactor to be filled with a heterogeneous catalyst for reacting an epoxide with carbon dioxide, a circulation path for returning at least a portion of a fluid mixture in a liquid form flowed out through a reactor outlet into the reactor, a carbon dioxide supply means for continuously supplying carbon dioxide in a liquid form or a supercritical state into the circulation path, and an epoxide supply means for continuously supplying an epoxide in a liquid or solution form into the circulation path. | ||||||
| 135 | Method for producing 1,1-dichloro-3,3,3-trifluoropropane | US15370352 | 2016-12-06 | US09676688B2 | 2017-06-13 | Yu Takeuchi; Shoji Furuta |
| To provide a method for obtaining 1,1-dichloro-3,3,3-trifluoropropane by reacting 1,1-difluoroethylene with dichlorofluoromethane, which suppresses the production of chloroform as a by-product and achieves a product having a high R-243fa concentration. This method is characterized by obtaining 1,1-dichloro-3,3,3-trifluoropropane by reacting 1,1-difluoroethylene with dichlorofluoromethane in the presence of trifluoromethane. | ||||||
| 136 | CATALYST FOR SYNTHESIZING THEAFLAVINS AND METHOD FOR SYNTHESIZING THEAFLAVINS | US15320347 | 2015-06-29 | US20170158660A1 | 2017-06-08 | Yoshie FUJIMORI; Tsuruo NAKAYAMA; Tomokazu NAGAO |
| The objective/problem addressed by the present invention is to provide a novel technique pertaining to theaflavins synthesis. The present invention pertains to: a theaflavins synthesis catalyst characterized in having a base comprising an inorganic material, and metal nanoparticles anchored to the base, said particles measuring 0.5-100 nm in diameter; and a theaflavins synthesis method in which the catalyst is used. | ||||||
| 137 | PROCESS FOR PRODUCING HYDROFLUOROOLEFIN | US15434882 | 2017-02-16 | US20170158587A1 | 2017-06-08 | Shinji TERAZONO; Xu WANG; Masahiro KANDA; Satoshi KAWAGUCHI; Mitsuga KASAGAWA |
| To provide a method for producing a hydrofluoroolefin, wherein formation of an over-reduced product having hydrogen added to a material chlorofluoroolefin and an over-reduced product having not only chlorine atoms but also fluorine atoms in the chlorofluoroolefin replaced with hydrogen atoms, as by-products, is suppressed.A method for producing a hydrofluoroolefin, which comprises reacting a specific chlorofluoroolefin with hydrogen in the presence of a catalyst supported on a carrier, to obtain a specific hydrofluoroolefin, wherein the catalyst is a catalyst composed of an alloy containing at least one platinum group element selected from the group consisting of palladium and platinum, and at least one second element selected from the group consisting of manganese, copper, aluminum, gold, lithium, sodium, potassium, magnesium, silver, zinc, cadmium, indium, silicon, germanium, tin, lead, arsenic, antimony and bismuth. | ||||||
| 138 | METHOD FOR PRODUCING HYDROFLUOROOLEFIN | US15425283 | 2017-02-06 | US20170144949A1 | 2017-05-25 | Xu WANG; Shinji TERAZONO; Masahiro KANDA; Satoshi KAWAGUCHI; Mitsugu KASAGAWA |
| A method for producing a hydrofluoroolefin, which comprises reacting a chlorofluoroolefin represented by the following formula (1) with hydrogen in the presence of a platinum group metal catalyst supported on a carbon carrier, to obtain a hydrofluoroolefin represented by the following formula (2), wherein the carbon carrier has acidic functional groups, and the total acidic functional group amount in the carbon carrier is at most 50 μmol/g: CZX═CClY (1) wherein X is F or Cl, Y is F, Cl or H, and Z is F or CF3; CZX′═CHY′ (2) wherein X′ is F when X is F, or X′ is H when X is Cl, Y′ is F when Y is F, or Y′ is H when Y is Cl or H, and Z is the same as Z in the formula (1). | ||||||
| 139 | Apparatus and methods for the automated synthesis of small molecules | US13811527 | 2011-07-22 | US09238597B2 | 2016-01-19 | Martin D. Burke; Eric P. Gillis; Steven G. Ballmer |
| Provided are methods for purifying N-methyliminodiacetic acid (MIDA) boronates from solution. Also provided are methods for deprotection of boronic acids from their MIDA ligands. The purification and deprotection methods can be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chemical compounds of interest. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated synthesis of small molecules using iterative cycles of deprotection, coupling, and purification in accordance with methods of the invention. Coupling and other reactions embraced by the invention include, without limitation, Suzuki-Miyaura coupling, oxidation, Swern oxidation, “Jones reagents” oxidation, reduction, Evans' aldol reaction, HWE olefination, Takai olefination, alcohol silylation, desilylation, p-methoxybenzylation, iodination, Negishi cross-coupling, Heck coupling, Miyaura borylation, Stille coupling, and Sonogashira coupling. | ||||||
| 140 | LOW-VISCOSITY CONCENTRATED SOLUTIONS OF ALKALINE EARTH METAL ALKOXIDES IN APROTIC SOLVENTS AND PROCESSES FOR PREPARATION THEREOF | US14436710 | 2013-10-25 | US20150291708A1 | 2015-10-15 | Ulrich Wietelmann; Armin Stoll; Florian Kiefer; Ute Emmel |
| A solution of a mixed alkaline earth alkoxide compound with an aluminum compound in an aprotic solvent, and methods of making and using them. | ||||||
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