| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | PROSTATE CARCINOMA DETERMINATION METHOD | US16043994 | 2018-07-24 | US20180328930A1 | 2018-11-15 | Chikara OYAMA; Tohru YONEYAMA; Yuki TOBISAWA; Tomokazu ISHIKAWA; Tatsuo KUROSAWA; Kenji NAKAMURA |
| An object of the present invention is to provide a novel Pca determination method and a Pca malignancy determination method. The present invention is an invention relating to a “prostate carcinoma determination method, including determining the ratio of the amount of free prostate specific antigen, which has a glycan in which the terminal sialic acid residue of the glycan is α(2,3)-linked to a second galactose residue from the terminal of the glycan, to the amount of free PSA in a biological sample, and then determining that prostate carcinoma is developed or the probability of developing prostate carcinoma is high in the case where the ratio is 40% or higher.” | ||||||
| 42 | COATING AGENT FOR FLOW PASSAGE | US15768427 | 2016-10-14 | US20180305652A1 | 2018-10-25 | Junko KATAYAMA; Yoshiomi HIROI; Ayako AIHARA; Natsuki ABE; Taito NISHINO |
| The invention provides a coating agent for a flow passage which comprises a copolymer containing a recurring unit which contains an organic group of the formula (a) wherein Ua1 and Ua2 are defined herein, and a recurring unit which contains an organic group of the formula (b) wherein Ub1, Ub2, Ub3, and An− are defined herein. The invention also provides a flow passage device having the coating agent for a flow passage on at least part of an inner surface of a flow passage, a platelet-producing flow passage device and a method for manufacturing the same. | ||||||
| 43 | LIQUID DELIVERY METHOD, LIQUID DELIVERY APPARATUS AND ANALYZER | US15762074 | 2016-10-26 | US20180292428A1 | 2018-10-11 | Takanori MURAYAMA; Youichi AOKI |
| A liquid delivery method according to the present invention performs a procedure including supplying a first liquid into a microchannel and collecting the first liquid from within the microchannel, and then, dispensing a first amount of a second liquid without hermetically sealing a pipette tip insertion hole, then, dispensing a second amount of the second liquid in a state where the pipette tip insertion hole is hermetically closed to supply the second liquid into the microchannel. | ||||||
| 44 | NANO-FLUIDIC DEVICE AND CHEMICAL ANALYSIS APPARATUS | US15764529 | 2016-10-21 | US20180280974A1 | 2018-10-04 | Yutaka KAZOE; Yuriy PIHOSH; Takehiko KITAMORI |
| A nano-fluidic device includes: a first substrate that has a nanoscale groove on one surface; and a second substrate that is integrally provided with the first substrate by bonding one surface of the second substrate to the one surface of the first substrate and forms a nanochannel with the groove of the first substrate, in which either the first substrate or the second substrate includes at least a thin portion in a part of a position overlapping the nanochannel in plan view, and the thin portion is deformed by pressing to open and close the nanochannel. | ||||||
| 45 | PCR REACTION VESSEL, PCR DEVICE, AND PCR METHOD | US15993814 | 2018-05-31 | US20180274019A1 | 2018-09-27 | Takashi FUKUZAWA; Hidenori NAGAI; Naofumi NISHIZAWA |
| A PCR reaction vessel includes: a substrate; a channel formed on the substrate; a pair of filters, a first filter and a second filter, provided at respective ends of the channel; a pair of air communication ports, a first air communication port and a second air communication port, that communicate with the channel through the first filter and the second filter; a thermal cycle region formed between the first filter and the second filter in the channel; a branch point formed between the first filter and the second filter in the channel; a branched channel whose one end is connected to the branch point; and a sample introduction port formed at the other end of the branched channel. | ||||||
| 46 | SPECIMEN TREATMENT CHIP, SPECIMEN TREATMENT APPARATUS, AND SPECIMEN TREATMENT METHOD | US15947218 | 2018-04-06 | US20180221881A1 | 2018-08-09 | Ayato TAGAWA; Tsuyoshi NAKANO; Yasuko KAWAMOTO; Koya YAMAWAKI; Hiroaki TOBIMATSU |
| The present specimen treatment chip includes: a first flow channel for forming a droplet containing a mixed liquid of a nucleic acid, a reagent for an amplification reaction of the nucleic acid, and a carrier to which a primer for binding to the nucleic acid is added, in a dispersion medium; a second flow channel for amplifying the nucleic acid in the droplet; and a third flow channel for mixing the droplet containing the carrier with the primer having bound to an amplification product of the nucleic acid, and a reagent for breaking down the droplet, to break down the droplet. | ||||||
| 47 | SPECIMEN TREATMENT CHIP, SPECIMEN TREATMENT APPARATUS, AND SPECIMEN TREATMENT METHOD | US15947006 | 2018-04-06 | US20180221878A1 | 2018-08-09 | Ayato TAGAWA; Tsuyoshi NAKANO; Yasuko KAWAMOTO; Koya YAMAWAKI; Hiroaki TOBIMATSU |
| This specimen treatment chip includes: a first fluid module having a first flow channel for performing a first treatment step on an object component in a specimen; a second fluid module having a second flow channel for performing a second treatment step on the object component subjected to the first treatment step; a substrate; and a connection flow channel for connecting the first fluid module and the second fluid module disposed on the substrate. | ||||||
| 48 | ANALYSIS CONTAINER | US15759374 | 2016-08-10 | US20180207635A1 | 2018-07-26 | Masahiro KOUGE; Fumiya MATSUBARA |
| An analysis container comprises a main body; a first chamber that is provided inside the main body and holds a liquid sample; a second chamber; a liquid passage; and an air passage. The liquid passage connects the first chamber and the second chamber, and moves the liquid sample from the first chamber to the second chamber. The air flow chamber connects the first chamber and the second chamber, and moves air from the second chamber to the first chamber. | ||||||
| 49 | Method and system for overlay control | US14733300 | 2015-06-08 | US10031426B2 | 2018-07-24 | Yang-Hung Chang; Chih-Ming Ke; Kai-Hsiung Chen |
| A method for overlay monitoring and control is introduced in the present disclosure. The method includes selecting a group of patterned wafers from a lot using a wafer selection model; selecting a group of fields for each of the selected group of patterned wafers using a field selection model; selecting at least one point in each of the selected group of fields using a point selection model; measuring overlay errors of the selected at least one point on a selected wafer; forming an overlay correction map using the measured overlay errors on the selected wafer; and generating a combined overlay correction map using the overlay correction map of each selected wafer in the lot. | ||||||
| 50 | ANALYSIS CHIP | US15561573 | 2016-03-31 | US20180087100A1 | 2018-03-29 | Hiroki Otsuka; Yoji Ueda |
| An analysis chip includes a substrate main body having a plurality of reaction portions in which a selective binding substance selectively binding to a substance to be examined is immobilized; a corner portion in which different straight lines or curved lines intersect with each other in a cross section in which a plane passing through a surface of the substrate main body on which the reaction portions are provided is a cut surface; a partition portion formed by applying water repellent treatment to the surface of the substrate main body on which the reaction portions are provided, the partition portion being configured to partition the reaction portions inside an outer edge formed by the surface, and a connection portion having water repellency, the connection portion being configured to connect between a part of the partition potion and the corner portion. | ||||||
| 51 | ANALYTICAL DEVICE | US15560921 | 2016-03-17 | US20180080929A1 | 2018-03-22 | Toshihiro KASAMA; Yoshinobu BABA; Manabu TOKESHI; Nanako NISHIWAKI |
| The present invention provides a device capable of detecting a plurality of items in a specimen using a single optical system. Microstructures holding specific binding reagents in a photocured hydrophilic resin are arranged in a channel, whereby the reagents do not mix during manufacture of the device, and a device capable of multiplex detection can be manufactured. | ||||||
| 52 | Target Analysis Chip and Target Analysis Method | US15545496 | 2016-01-22 | US20180008981A1 | 2018-01-11 | Akira Murakami; Akio Kobori; Asako Yamayoshi; Yuichiro Noda; Masayuki Kondo |
| The present invention provides a novel target analysis chip and analysis method for directly detecting a target such as a microRNA without performing PCR. | ||||||
| 53 | CIRCUITS AND METHODS FOR ARTIFACT ELIMINATION | US15623687 | 2017-06-15 | US20170285058A1 | 2017-10-05 | Edgar A. Brown; James D. Ross; Richard A. Blum; Stephen P. DeWeerth |
| Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants. | ||||||
| 54 | METHOD AND DEVICE FOR COMPARATIVE ANALYSIS OF miRNA EXPRESSION LEVEL | US15511877 | 2015-09-15 | US20170262581A1 | 2017-09-14 | Satoko KOZONO; Satoshi KONDOU |
| In a method for comparative analysis, the expression levels of the target miRNAs in each body fluid sample are corrected using the expression level(s) of a correcting endogenous miRNA(s) that is/are simultaneously measured with the expression levels of the target miRNAs in the sample. As the correcting endogenous miRNA(s), one or more miRNAs selected from specific 10 kinds of correcting endogenous miRNAs is/are used. Comparative analysis of target miRNAs among body fluid samples can be carried out more accurately than by conventional techniques. | ||||||
| 55 | Biomolecule detection method, biomolecule detection device and analysis device | US14418480 | 2013-06-28 | US09759681B2 | 2017-09-12 | Toshiro Saito; Kenta Imai; Kyoko Imai; Kazumichi Imai; Itaru Yanagi; Yoshimitsu Yanagawa; Masahiko Ando; Naoshi Itabashi |
| The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors. | ||||||
| 56 | A SENSOR FOR PARTICLE DETECTION IN A FLUID | US15516369 | 2014-10-01 | US20170248513A1 | 2017-08-31 | Ai Qun LIU; Lei LEI; Wei HUANG; Shahnawaz PUKKEYIL SHAMSUDDIN |
| A sensor is provided for detecting and characterizing particles in a fluid. The sensor has a microfluidic channel for receiving the fluid sample, an acoustic transducer module configured to generate a standing wave for concentrating the particles in a region of the microfluidic channel; an optical detection module configured to detect optical signals scattered by the particles upon illuminating the region of the fluid sample with a light source; and a data processing module configured to characterize the particles of the fluid sample based on the optical signals using a classifier. | ||||||
| 57 | THERMAL CONVECTION GENERATING CHIP AND LIQUID MEASURING DEVICE | US15308645 | 2015-05-08 | US20170189873A1 | 2017-07-06 | Masato SAITO; Yuichiro KIRIYAMA; Eiichi TAMIYA |
| A thermal convection generating chip (1) includes a rotatory body (2), a thermal convection pathway (11) provided in the rotatory body (2), and a supply path (12A to 12C) that supplies a liquid to the thermal convection pathway (11). The supply path (12A to 12C) includes a liquid receiving section (121) that receives the liquid and a suction passage (122) that provides communication between the liquid receiving section (121) and the thermal convection pathway (11). The suction passage (122) has a first region (122a) extending between a midsection of the suction passage (122) and the thermal convection pathway (11), and a second region (122b) extending between the midsection and the liquid receiving section (121). The liquid in the first region (122a) is separated from the liquid in the second region (122b) through rotation of the rotatory body (2) to be supplied to the thermal convection pathway (11). | ||||||
| 58 | Circuits and methods for artifact elimination | US14133834 | 2013-12-19 | US09684008B2 | 2017-06-20 | Edgar A. Brown; James D. Ross; Richard A. Blum; Stephen P. Deweerth |
| Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants. | ||||||
| 59 | STOMACH CANCER DETECTION KIT OR DEVICE, AND DETECTION METHOD | US15319203 | 2015-06-16 | US20170130276A1 | 2017-05-11 | Satoko KOZONO; Hitoshi NOBUMASA; Satoshi KONDOU; Hiroko SUDO; Junpei KAWAUCHI; Atsushi OCHIAI; Motohiro KOJIMA |
| This invention relates to a kit or a device for the detection of stomach cancer and a method for detecting stomach cancer, and provides a kit or a device for the detection of stomach cancer, comprising a nucleic acid(s) capable of specifically binding to a miRNA(s) in a sample from a subject, and a method for detecting stomach cancer, comprising measuring the miRNA(s) in vitro. | ||||||
| 60 | Method and System for Overlay Control | US14017793 | 2013-09-04 | US20150067617A1 | 2015-03-05 | Yang-Hung Chang; Kai-Hsiung Chen; Chih-Ming Ke |
| A method for overlay monitoring and control is introduced in the present disclosure. The method comprises forming resist patterns on one or more wafers in a lot by an exposing tool; selecting a group of patterned wafers in the lot using a wafer selection model; selecting a group of fields for each of the selected group of patterned wafers using a field selection model; selecting at least one point in each of the selected group of fields using a point selection model; measuring overlay errors of the selected at least one point on a selected wafer; forming an overlay correction map using the measured overlay errors on the selected wafer; and generating a combined overlay correction map using the overlay correction map of each selected wafer in the lot. | ||||||
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