| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | SUBSTRATE FOR SAMPLE ANALYSIS, SAMPLE ANALYSIS DEVICE, SAMPLE ANALYSIS SYSTEM, AND PROGRAM FOR SAMPLE ANALYSIS SYSTEM | EP15866519 | 2015-12-11 | EP3232203A4 | 2018-07-18 | OKAMOTO FUSATOSHI; JOHNO MASAHIRO |
| Provided is a substrate for sample analysis, which involves transportation of a liquid through rotational motion, the substrate for sample analysis including: a substrate including a rotation axis; a first chamber (101), which is positioned in the substrate and includes a first space configured to retain the liquid; a second chamber (102), which is positioned in the substrate and includes a second space configured to retain the liquid discharged from the first chamber; and a first flow passage (111), which is positioned in the substrate, includes a path configured to connect the first chamber and the second chamber to each other, and is capable of being filled with the liquid retained in the first space through a capillary phenomenon, in which the first flow passage (111) has a first opening (111c) and a second opening (111d), the first opening (111c) and the second opening (111d) are connected to the first chamber (101) and the second chamber (102), respectively, and the first opening is positioned on a side closer to the rotation axis (110) than the second opening, in which the first space includes a first region, which is connected to the first opening (111c) and includes a portion extending from the first opening toward a side farther from the rotation axis, and in which the first space of the first chamber (101) has a capacity larger than a capacity of the first flow passage (111). | ||||||
| 162 | MICRO-CHANNEL DEVICE AND METHOD FOR MANUFACTURING MICRO-CHANNEL DEVICE | EP16850815.8 | 2016-07-13 | EP3339867A1 | 2018-06-27 | AKI Yuichi; FUJII Masaru; NAKAJIMA Toshihiro; OKAZAKI Masanori; YUKUMOTO Tomomi |
To provide a high-quality and high-performance micro-channel device which can be manufactured by a simple method. Provided is a micro-channel device used in analyzing a sample. The micro-channel device includes at least two substrates and an elastic film interposed between the two substrates. The substrates are thermally fused to the elastic film in at least a part thereof. Also provided is a method for manufacturing a micro-channel device used in analyzing a sample. The method includes a surface activation step of activating a joining surface of a substrate and/or an elastic film, a lamination step of laminating the elastic film between at least two of the substrates, and a thermal fusion step of thermally fusing the substrates to the elastic film in at least a part thereof. |
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| 163 | KIT OR DEVICE FOR DETECTING LUNG CANCER, AND LUNG CANCER DETECTION METHOD | EP15809623 | 2015-06-18 | EP3159416A4 | 2018-04-18 | SUDO HIROKO; NOBUMASA HITOSHI; KOZONO SATOKO; KONDOU SATOSHI; KAWAUCHI JUNPEI; OCHIAI ATSUSHI; KOJIMA MOTOHIRO |
| It is intended to provide a kit or a device for the detection of lung cancer and a method for detecting lung cancer. The present invention provides a kit or a device for the detection of lung cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample from a subject, and a method for detecting lung cancer, comprising measuring the miRNA in vitro. | ||||||
| 164 | LIQUID HANDLING DEVICE | EP15858997 | 2015-10-29 | EP3220150A4 | 2018-04-11 | KITAMOTO KEN; ONO KOICHI |
| A liquid handling device has an accommodation part for accommodating a liquid, two or more flow paths each opening to a lower part of a side wall surface of the accommodation part, and a liquid movement suppression part that is disposed in the lower part of the side wall between the openings of two of the flow paths that are adjacent to each other and slows or stops the movement of the liquid along the corner formed by the lower surface of the accommodation part and the side wall surface. | ||||||
| 165 | MICROCHIP, MICROCHIP CONTROL DEVICE AND MICROCHIP CONTROL SYSTEM | EP15834976 | 2015-08-26 | EP3187577A4 | 2018-04-11 | ASOGAWA MINORU; IIMURA YASUO; MISHINA YOSHINORI |
| In order to carry out DNA analysis etc. with a microchip, it was required to prepare sample solution in advance with an apparatus different from a controlling apparatus for the microchip. Herein, there is provided a microchip contributing to reduce operator' operation. The microchip comprises a cell accepting section, a lysis solution chamber and a lysis reaction chamber. The cell accepting section accepts cells obtained from a subject. The lysis solution chamber stores lysis solution for lysis of the cells. The lysis reaction of the cells is executed in the lysis reaction chamber. | ||||||
| 166 | DETECTION KIT OR DEVICE AND DETECTION METHOD FOR BILIARY TRACT CANCER | EP15806290 | 2015-06-11 | EP3156500A4 | 2018-04-04 | KAWAUCHI JUNPEI; NOBUMASA HITOSHI; KOZONO SATOKO; KONDOU SATOSHI; SUDO HIROKO; OCHIAI ATSUSHI; KOJIMA MOTOHIRO |
| The present invention provides a kit or device for the detection of biliary tract cancer, and a method for detecting biliary tract cancer. The present invention relates to a kit or device for the detection of biliary tract cancer, comprising a nucleic acid capable of specifically binding to miRNA in a sample of a subject, and a method for detecting biliary tract cancer, comprising measuring the miRNA in vitro. | ||||||
| 167 | RISK-MANAGED, SINGLE-USE, PRE-CALIBRATED, PRE-STERILIZED SENSORS FOR USE IN BIO-PROCESSING APPLICATIONS | EP13765569.2 | 2013-09-05 | EP2893476B1 | 2018-03-07 | SCHICK, Karl, G.; UHEN, David |
| Single-use, pre-sterilized, and pre-calibrated, pre-validated sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor or in a barcode printed on the sensor. These sensors may be utilized with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances. The sensors exhibit both their primary sensing function such as conductivity, pH level, dissolved oxygen, pressure or temperature, as well as at least one secondary sensing function of risk management or risk mitigation. | ||||||
| 168 | METHOD FOR PREPARING SINGLE-STRANDED DNA PRODUCT | EP16743510.6 | 2016-01-29 | EP3252159A1 | 2017-12-06 | YAMASHITA, Hiroki |
The purpose of the invention is to provide the technique of a method for preparing highly precise single-stranded DNA that makes it possible to obtain accurate results even by a simple test in a clinical setting or the like. The invention provides a highly precise single-stranded DNA product that can be utilized even in simpler, more rapid genetic analyses by taking as the detection sample a single-stranded nucleotide product amplified by ligation, preferably by cycling ligation, without PCR or LCR amplification. |
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| 169 | TARGET ANALYSIS CHIP AND TARGET ANALYSIS METHOD | EP16740307.0 | 2016-01-22 | EP3249038A1 | 2017-11-29 | MURAKAMI, Akira; KOBORI, Akio; YAMAYOSHI, Asako; NODA, Yuichiro; KONDO, Masayuki |
The present invention provides a novel target analysis chip and analysis method for directly detecting a target such as a microRNA without performing PCR. The target analysis chip according to the invention includes a substrate, and the substrate includes a reaction section at which a sample containing a target is made to react with a reagent, a detection section at which label detection is performed, and a flow channel that communicates the reaction section with the detection section, in which the reagent includes a carrier; the carrier has a labeled probe immobilized thereon, the labeled probe being configured to bind to the target, and the carrier being configured to form a conjugate with the target; the flow channel includes a movement controller configured to control movement of the carrier from the reaction section to the detection section; the movement controller includes a hydrophobic inner wall in the flow channel; and, due to the movement controller, the conjugate is made to move to the detection section through the flow channel when a centrifugal force (C2), that is larger than a resistance force (R) caused by the hydrophobicity of the flow channel, is applied,. |
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| 170 | MICROCHIP, MICROCHIP CONTROL DEVICE AND MICROCHIP CONTROL SYSTEM | EP15834976.1 | 2015-08-26 | EP3187577A1 | 2017-07-05 | ASOGAWA, Minoru; IIMURA, Yasuo; MISHINA, Yoshinori |
In order to carry out DNA analysis etc. with a microchip, it was required to prepare sample solution in advance with an apparatus different from a controlling apparatus for the microchip. Herein, there is provided a microchip contributing to reduce operator' operation. The microchip comprises a cell accepting section, a lysis solution chamber and a lysis reaction chamber. The cell accepting section accepts cells obtained from a subject. The lysis solution chamber stores lysis solution for lysis of the cells. The lysis reaction of the cells is executed in the lysis reaction chamber. |
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| 171 | METHOD FOR PRODUCING MICROCHANNEL AND MICROCHANNEL | EP13867007 | 2013-12-18 | EP2939976A4 | 2016-10-12 | KATO SEIKO; IDE MASAFUMI; NOZAKI TAKAAKI; TAKEISHI TAKAAKI; ISHIGURE TAKAAKI; SOMA KAZUTOMO |
| 172 | BIOMOLECULE DETECTION METHOD, BIOMOLECULE DETECTION DEVICE AND ANALYSIS DEVICE | EP13828561 | 2013-06-28 | EP2884270A4 | 2016-03-23 | SAITO TOSHIRO; IMAI KENTA; IMAI KYOKO; IMAI KAZUMICHI; YANAGI ITARU; YANAGAWA YOSHIMITSU; ANDO MASAHIKO; ITABASHI NAOSHI |
| The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors. | ||||||
| 173 | RISK-MANAGED, SINGLE-USE, PRE-CALIBRATED, PRE-STERILIZED SENSORS FOR USE IN BIO-PROCESSING APPLICATIONS | EP13765569.2 | 2013-09-05 | EP2893476A2 | 2015-07-15 | SCHICK, Karl, G.; UHEN, David |
| Single-use, pre-sterilized, and pre-calibrated, pre-validated sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor or in a barcode printed on the sensor. These sensors may be utilized with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances. The sensors exhibit both their primary sensing function such as conductivity, pH level, dissolved oxygen, pressure or temperature, as well as at least one secondary sensing function of risk management or risk mitigation. | ||||||
| 174 | UNINHABITED TEST CITY | EP13767495.8 | 2013-04-01 | EP2845183A1 | 2015-03-11 | BRUMLEY, Robert H.; REEDY, Michael, J.; BRUMLEY, Fletcher, W.; WARNER, Charles |
| A full scale uninhabited test facility is configured for building modular man made structures, evaluating modular man made structures, evaluating use of modular man made structures, and/or for other purposes. The structures may be located in a user configurable simulated environment. One or more structures may be configured to simulate use by inhabitants in a simulated environment. After testing, the constructed structure(s) may remain where built in the simulated environment(s) until such time as another user may reconfigure the environments or structures. As additional structures are built and/or modified, new and old structures may operate side by side, generating opportunity, for example, to test new and/or different technology on the same structures. | ||||||
| 175 | METHOD FOR FABRICATING MICROARRAYS OF SOFT MATERIALS | EP12763427 | 2012-03-27 | EP2594941A4 | 2014-08-13 | HIYAMA SATOSHI; KURIBAYASHI KAORI; ONOE HIROAKI; TAKEUCHI SHOJI |
| 176 | PRÜFGERÄT UND VERFAHREN ZUR KALIBRIERUNG EINES PRÜFGERÄTS | EP12740480.4 | 2012-07-03 | EP2729797A1 | 2014-05-14 | BLOSS, Michael; DECKENBACH, Wolfgang; HEIMANN, Werner; EHRL, Hans-Peter; KERST, Erich |
| The invention relates to a test instrument for testing a material web and to a calibration method for the test instrument. The test instrument is equipped with drive means for transporting the calibration medium past the test instrument in order to detect a multiplicity of measured values of the calibration medium. The drive means are arranged in the housing of the test instrument, such that the drive means are protected against humidity or contaminants from the surroundings. In order to enable the transportation of the calibration medium past the test instrument despite the arrangement of the drive means in the housing, drive means are used that are designed for non-contact interaction with the calibration medium and are able to transport the calibration medium past the test instrument without contact. For this purpose, a magnetic interaction between the drive means and the calibration medium is used preferably. | ||||||
| 177 | MAGNETO-OPTICAL BIO-DISCS AND SYSTEMS INCLUDING RELATED METHODS | EP02795687.9 | 2002-11-27 | EP1585957A2 | 2005-10-19 | COOMBS, James, Howard; PHAN, Brigitte, Chau; VALENCIA, Ramoncito, Magpantay |
| The present invention relates in general to molecular and cellular biomagnetic assays and, in particular, to molecular and cellular biomagnetic assays conducted on magneto-optical bio-discs. The invention further relates to magneto-optical bio-disc systems including the magneto-optical bio-discs and MO drives. More specifically, but without restriction to the particular embodiments hereinafter described in accordance with the best mode of practice, this invention relates to biomagnetic methods, including immunomagnetic methods, for detection and selective manipulation of specific target cells in cell populations and solutions of cell populations, using magnetic particles or beads, and to magnetically guided neurite growth, nerve regeneration, and magnetically formed neural networks using the MOBDS. | ||||||
| 178 | DETECTION OF CHROMOSOME COPY NUMBER CHANGES TO DISTINGUISH MELANOCYTIC NEVI FROM MALIGNANT MELANOMA | EP00925923 | 2000-04-10 | EP1181392A4 | 2005-03-16 | BASTIAN BORIS; PINKEL DANIEL |
| The present invention provides for methods of distinguishing melanocytic nevi, such as Spitz nevi, from malignant melanoma. The methods comprise contacting a nucleic acid sample from a patient with a probe which binds selectively to a target polynucleotide sequence on a chromosomal region such as 11p, which is usually amplified in Spitz nevi. The nucleic acid sample is typically from skin tumor cells located within a tumor lesion on the skin of the patient. Using another probe which binds selectively to a chromosomal region such as 1q, 6p, 7p, 9p, or 10q, which usually show altered copy number in melanoma, the method can determine that those tumor cells with no changes in copy number of 1q, 6p, 7p, 9p, or 10q, are not melanoma cells but rather Spitz nevus cells. The finding of amplifications of chromosome 11p, particularly the presence of an 11p isochromosome would be an additional indication of Spitz nevus. An increase in copy number of chromosome 11p can also be determined by detecting the presence of an amplification of the H-RAS gene. The amplified gene can be normal or can be a mutated H-RAS gene. | ||||||
| 179 | FUNCTIONAL UNIT ENABLING CONTROLLED FLOW IN A MICROFLUIDIC DEVICE | EP02773081.1 | 2002-09-17 | EP1427530A1 | 2004-06-16 | KYLBERG, Gunnar; ANDERSSON, Per; THORS N, Gunnar |
| A micro fluidic device which comprises two or more micro channel structures (201.301) (set 1), each of which comprises a structural unit which comprises (i) one or more inlet microconduits (102,103,202,203, 302,303), and (ii) an outlet microconduit (105,205,305) downstream said one or more inlet microconduits, and (iii) a flow path for a liquid passing through either of said inlet microconduits and said outlet microconduit. The device is characterized in that each outlet microconduit (105,305) in said two or more microchannel structures (201,301) is a restriction microconduit (105,205,305). There may also be a microcavity between the inlet microconduit(s) and the restriction micro conduit in each microchanel structure. Typically common flow control is used for driving a liquid flow within the device. The innovative design is useful for creating flow with low inter-channel variation with respect 15 to the microchannel structures of the device. | ||||||
| 180 | LINKING GENE SEQUENCE TO GENE FUNCTION BY THREE DIMENSIONAL (3D) PROTEIN STRUCTURE DETERMINATION | EP99935746.0 | 1999-07-21 | EP1104488A1 | 2001-06-06 | ANDERSON, Stephen; MONTELIONE, Gaetano; HUANG, Yuanpeng |
| The present invention provides a structure-functional analysis engine for the high-throughput determination of the biochemical function of protein domains of unknown function, as exemplified in the flowchart of the figure. The present invention uses bioinformatics, molecular biology and nuclear magnetic resonance tools for the rapid and automated determination of the three-dimensional structures of proteins and protein domains. | ||||||
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