| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | SUBSTRATE, STRUCTURE, STRUCTURE-MANUFACTURING METHOD, CELL-SORTING METHOD, CELL-MANUFACTURING METHOD, AND SECRETION-PRODUCING METHOD | US15764225 | 2016-09-26 | US20180282677A1 | 2018-10-04 | Takashi OHSAKA; Yasuo SUZUKI; Toshiyuki OGATA; Takuya NOGUCHI; Noriyuki TAKAHASHI; Takeshi BABA; Hiroyuki TSUNODA |
| In an aspect, the present invention provides a structure, a structure-manufacturing method, a cell-sorting method, or the like. In an aspect, a structure (1) of the present invention is a structure including a first substrate (10) and a second substrate (20) disposed to face one side of the first substrate (10), in which the first substrate (10) has a plurality of depressions (11) which are open to the other side of the first substrate and each of which has a size that enables each of the depressions to capture one unit of a cell, at least some of the depressions (11) have communication holes (12) which communicate with one side and the other side of the first substrate and each of which has a size that enables secretions secreted from the cell to move through the communication holes, the second substrate (20) can include accumulation portions (13) in which the secretions moving through the communication holes (12) are accumulated, and the accumulation portions (13) can correspond to the depressions (11). | ||||||
| 22 | MICRO-CHANNEL DEVICE AND METHOD FOR MANUFACTURING MICRO-CHANNEL DEVICE | US15761167 | 2016-07-13 | US20180257072A1 | 2018-09-13 | YUICHI AKI; MASARU FUJII; TOSHIHIRO NAKAJIMA; MASANORI OKAZAKI; TOMOMI YUKUMOTO |
| To provide a high-quality and high-performance micro-channel device which can be manufactured by a simple method. Provided is a micro-channel device used in analyzing a sample. The micro-channel device includes at least two substrates and an elastic film interposed between the two substrates. The substrates are thermally fused to the elastic film in at least a part thereof. Also provided is a method for manufacturing a micro-channel device used in analyzing a sample. The method includes a surface activation step of activating a joining surface of a substrate and/or an elastic film, a lamination step of laminating the elastic film between at least two of the substrates, and a thermal fusion step of thermally fusing the substrates to the elastic film in at least a part thereof. | ||||||
| 23 | CHANNEL STRUCTURE, MEASUREMENT UNIT, METHOD OF MEASURING LIQUID TO BE MEASURED, AND MEASUREMENT DEVICE FOR LIQUID TO BE MEASURED | US15884499 | 2018-01-31 | US20180149582A1 | 2018-05-31 | Yoshihiro TAGUCHI; Minaguchi HIROYOSHI; Ken HOSOYA |
| A channel structure includes a liquid storage having a liquid container portion and an outlet portion, a separation-element housing having arranged therein a separation element between two open ends thereof, a supply channel causing the liquid storage and the separation-element housing to communicate with one another, and a discharge channel connected to the separation-element housing. The supply channel includes a liquid-storage-side channel connected to the outlet portion of the liquid storage, a separation-element-side channel connected to the separation-element housing, and an injection portion located between the liquid-storage-side channel and the separation-element-side channel. The liquid storage includes a pressure transmission portion capable of transmitting an external force applied to the channel structure, and is capable of causing liquid to flow out from the outlet portion to the supply channel on the basis of the variation in the pressure in the liquid storage. | ||||||
| 24 | LIQUID-SEALED CARTRIDGE, SPECIMEN ANALYZER, AND SPECIMEN ANALYSIS METHOD | US15796224 | 2017-10-27 | US20180120338A1 | 2018-05-03 | Kazuyoshi HORII; Takao FUJIWARA; Noriyuki OGAI; Kenpei ONOZUKA; Yasuhiro TODA |
| This liquid-sealed cartridge includes: a cartridge body including a plurality of liquid storage portions; a seal body configured to seal an opening of each of the plurality of liquid storage portions; and an elastic body disposed so as to be opposed to the plurality of liquid storage portions, the elastic body being configured to form a passage adjacent to the plurality of liquid storage portions. Each of the plurality of liquid storage portions and the passage are configured to be communicated with each other by the corresponding seal body being pushed to be opened through the elastic body. | ||||||
| 25 | CHECK-VALVE AND MICROCHEMICAL CHIP USING THE SAME | US15568143 | 2016-04-27 | US20180066769A1 | 2018-03-08 | Tsutomu TAKANO |
| A check-valve comprises: a thin sheet and a thick sheet; flow paths for flowing fluid which are formed by penetrating the thin sheet and the thick sheet; a flow-in chamber and a flow-out chamber which are connected to the flow paths; a partition sheet which is bonded to the thin sheet and the thick sheet while being sandwiched therebetween, and has a flexible inner flange which projects in cavities of the flow-in chamber and the flow-out chamber and does not close the flow-out valve chamber by flexing toward the flow-out valve chamber in a normal flow, and closes the flow-in valve chamber by flexing toward the flow-in valve chamber in a reverse flow; and a through-pass hole which is opened at the partition sheet and connects the both valve chambers. | ||||||
| 26 | MICROFLUIDIC DEVICE | US15504552 | 2016-02-26 | US20180056298A1 | 2018-03-01 | Narimasa IWAMOTO; Takao MIYAI; Nobuyuki MIYAGAWA; Tsutomu ICHIHARA; Masashi ISHIMARU; Toshihiko SATO; Hiroaki TACHIBANA |
| A microfluidic device includes a flow path through which a reaction solution flows, and an introducing portion for introducing the reaction solution into the flow path, wherein the flow path passes alternately and repeatedly several times through a first temperature region and a second temperature region having different predetermined temperatures, and the flow path includes the repeating unit portions passing through the first temperature region and the second temperature region, the repeating unit portions having decreasing lengths as the repeating unit portions are located farther away from the introducing portion. | ||||||
| 27 | MICROCHIP, MICROCHIP CONTROLLING APPARATUS AND MICROCHIP CONTROLLING SYSTEM TECHNICAL FIELD | US15506015 | 2015-08-26 | US20170260494A1 | 2017-09-14 | Minoru ASOGAWA; Yasuo IIMURA; Yoshinori MISHINA |
| A microchip includes a cell accepting section, a lysis solution chamber and a lysis reaction chamber. The cell accepting section accepts cells obtained from a subject. The lysis solution chamber stores lysis solution for lysis of the cells. The lysis reaction of the cells is executed in the lysis reaction chamber. | ||||||
| 28 | MICRO LIQUID TRANSFER STRUCTURE AND ANALYSIS DEVICE | US15606014 | 2017-05-26 | US20170259259A1 | 2017-09-14 | Ryuuji Oonuki; Masahiro Kuninori; Tsutomu Iwasaki |
| A micro liquid transfer structure includes a plurality of micro projections arranged at intervals causing a capillary action, wherein the plurality of micro projections form periodically arranged unit rows, wherein each of the unit rows comprises the micro projections arranged in one row; and liquid transfer paths that are gaps between the micro projections, wherein at least one of the liquid transfer paths is a low flow resistance liquid transfer path having a flow resistance lower than flow resistances of the other liquid transfer paths, and wherein the low flow resistance liquid transfer path is disposed along a predetermined liquid transfer direction. | ||||||
| 29 | ANALYSIS DEVICE, ANALYSIS CHIP, ANALYSIS KIT, AND ANALYSIS METHOD USING SAME | US15314373 | 2016-01-28 | US20170197216A1 | 2017-07-13 | Koichiro TSUJIMARU |
| The present invention provides a tool that can analyze a target in a sample by a simple operation and can be downsized and an analysis method using the tool. By inserting an analysis chip into an analysis device, a reaction of a sample and a reagent is analyzed. The analysis chip includes a parallel flow channel in which plural reaction flow channels are connected in parallel, and the axial direction of the parallel flow channel is a direction of inserting the analysis chip into the analysis device. The analysis device includes a main body case being a housing, including an insertion opening into which the analysis chip is to be inserted; and a void; a heating unit that causes a sample to thermally react with a reagent, the heating unit being disposed in the void at at least one of inner surfaces so as to face a parallel surface of the parallel flow channel of the analysis chip; a light source unit that emits light to the analysis chip, the light source unit being disposed in the void at least above or below a reaction flow channel located at at least one end of the parallel flow channel of the analysis chip and extended along the axial direction of the parallel flow channel; and a plurality of detection units that detect the thermal reactions, each detection unit being disposed in the void at a downstream side end in the insertion direction of the analysis chip so as to correspond to each reaction flow channel of the analysis chip. | ||||||
| 30 | SUBSTANCE SEALING METHOD AND TARGET MOLECULE DETECTING METHOD | US15321312 | 2015-07-01 | US20170176430A1 | 2017-06-22 | Hiroyuki NOJI; Lisa YAMAUCHI |
| As a technique for efficiently sealing many substances, such as beads, nucleic acid, protein, virus, cells, and lipid membrane complex, into an array, the present invention provides a method for sealing a substance, including: (i) a step of introducing a first solvent containing a substance on a substrate on which a plurality of receptacles capable of storing the substance are formed separated from each other by a side wall; and (ii) a step of introducing a second solvent having a greater specific gravity than that of the first solvent onto the first solvent, the step (ii) being carried out after the step (i). | ||||||
| 31 | Risk-managed, single-use, pre-calibrated, pre-sterilized sensors for use in bio-processing applications | US13964833 | 2013-08-12 | US09575087B2 | 2017-02-21 | Karl G. Schick; David Uhen |
| Single-use, pre-sterilized, and pre-calibrated, pre-validated sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor or in a barcode printed on the sensor. These sensors may be utilized with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances. The sensors exhibit both their primary sensing function such as conductivity, pH level, dissolved oxygen, pressure or temperature, as well as at least one secondary sensing function of risk management or risk mitigation. | ||||||
| 32 | Checking unit and method for calibrating a checking unit | US14130053 | 2012-07-03 | US09310231B2 | 2016-04-12 | Michael Bloss; Wolfgang Deckenbach; Werner Heimann; Hans-Peter Ehrl; Erich Kerst |
| The invention relates to a checking unit for checking a material web and to a calibrating method for the checking unit. The checking unit is equipped with drive means for transporting the calibration medium past the checking unit in order to detect a multiplicity of measurement values of the calibration medium. The drive means are arranged in the housing of the checking unit in order for the drive means to be protected from moisture or contaminants from the environment. To obtain a transporting of the calibration medium past the checking unit in spite of the arrangement of the drive means in the housing, drive means are employed that are configured for a contactless interaction with the calibration medium and can transport the calibration medium past the checking unit contactlessly. For this purpose there is preferably used a magnetic interaction between the drive means and the calibration medium. | ||||||
| 33 | BIOMOLECULE DETECTION METHOD, BIOMOLECULE DETECTION DEVICE AND ANALYSIS DEVICE | US14418480 | 2013-06-28 | US20150308977A1 | 2015-10-29 | Toshiro Saito; Kenta Imai; Kyoko Imai; Kazumichi Imai; Itaru Yanagi; Yoshimitsu Yanagawa; Masahiko Ando; Naoshi Itabashi |
| The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors. | ||||||
| 34 | POWER DELIVERY SYSTEM FOR PROVIDING POWER TO SENSOR HEAD OF PAPER MACHINE OR OTHER SYSTEM | US13900190 | 2013-05-22 | US20140345376A1 | 2014-11-27 | Cristian Andronic; Michael J. Wardas; Jeffrey D. Austin; Ronald E. Beselt; Stuart James Heath; Bradley Humble |
| An apparatus includes a chassis configured to move back and forth along multiple rails. The apparatus also includes electrical contacts configured to form electrical connections to the rails. The apparatus further includes a power converter/conditioner configured to receive power from the rails via the electrical contacts and to convert the power into a different form and/or condition the power. In addition, the apparatus includes one or more sensors configured to measure at least one characteristic of a material, where the one or more sensors are configured to operate using the power from the power converter/conditioner. The electrical contacts could touch the rails and receive the power directly from the rails. The electrical contacts could also touch rail contacts and receive the power indirectly from the rails via the rail contacts. | ||||||
| 35 | Exercise equipment usage monitoring method and apparatus | US12844221 | 2010-07-27 | US08622873B2 | 2014-01-07 | Rhoderick Euan McGown |
| A method of monitoring the use of exercise equipment at an exercise facility having a plurality of items of exercise equipment, the method comprising the steps of: providing a plurality of usage monitors, each associated with an item of exercise equipment, monitoring the usage of the plurality of items of exercise equipment concurrently using the usage monitors, and thereby calculating, for at least some of the items of exercise equipment, a measure of the proportion of the period of time during which respective items of exercise equipment are used. In some embodiments, the usage monitors can detect when an item of exercise equipment is occupied, even if it is not being operated, for example using a heat sensor. A graphical representation may be prepared of the usage of items of exercise equipment at each of a plurality of locations within the exercise facility. | ||||||
| 36 | Uninhabited Test City | US13436531 | 2012-03-30 | US20130255405A1 | 2013-10-03 | Robert H. Brumley; Robert H. Brumley, III; Michael J. Reedy; Fletcher W. Brumley; Charles Warner |
| A full scale uninhabited test facility is configured for building modular man made structures, evaluating modular man made structures, evaluating use of modular man made structures, and/or for other purposes. The structures may be located in a user configurable simulated environment. One or more structures may be configured to simulate use by inhabitants in a simulated environment. After testing, the constructed structure(s) may remain where built in the simulated environment(s) until such time as another user may reconfigure the environments or structures. As additional structures are built and/or modified, new and old structures may operate side by side, generating opportunity, for example, to test new and/or different technology on the same structures. | ||||||
| 37 | Nucleotide analogs with six-membered rings | US10816298 | 2004-04-01 | US07276592B2 | 2007-10-02 | Frank Bergmann; Horst Donner; Herbert Von Der Eltz; Dieter Heindl; Piet Herdewijn |
| The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane, cyclohexene, tetrahydropyran, tetrahydrothiopyran or piperidine. These compounds may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are provided wherein the oligomeric compounds are used. | ||||||
| 38 | Circuits and methods for artifact elimination | US11511794 | 2006-08-29 | US20070178579A1 | 2007-08-02 | James Ross; Edgar Brown; Richard Blum; Stephen DeWeerth |
| Disclosed are apparatus and methods that provide the ability to electrical stimulate a physical system, and actively eliminate interference with signal acquisition (artifacts) that arises from the stimulation. The technique implemented in the circuits and methods for eliminating interference connects a discharge path to a physical interface to the system to remove charge that is built-up during stimulation. By placing the discharge path in a feedback loop that includes a recording preamplifier and AC-coupling circuitry, the physical interface is brought back to its pre-stimulation offset voltage. The disclosed apparatus and methods may be used with piezoelectric transducers, ultrasound devices, optical diodes, and polarizable and non-polarizable electrodes. The disclosed apparatus can be employed in implantable devices, in vitro or in vivo setups with vertebrate and invertebrate neural tissue, muscle fibers, pancreatic islet cells, osteoblasts, osteoclasts, bacteria, algae, fungi, protists, and plants. | ||||||
| 39 | Gas-measuring probe for determining the physical characteristic of a measuring gas | US11404234 | 2006-04-13 | US20070033986A1 | 2007-02-15 | Bernhard Wild; Rainer Maier; Gregor Jaehnig; Peter Dettling; Stefan Heinzelmann; Bernd Rattay; Bastian Buchholz; Juergen Moratz |
| A gas-measuring probe for determining a physical characteristic of a measuring gas, in particular the concentration of a gas component or the temperature or pressure of the measuring gas, which includes a sensor element accommodated in a housing, at least one connection cable for the sensor element having an electrical conductor, which is enclosed by an insulation sheath and contacts the sensor element, and a cable channel sealing the housing end, which has at least one axial cable feedthrough through which the connection cable is guided out of the housing. To achieve long-lasting sealing at the cable-exit end of the housing even at higher temperatures, the insulation sheath of the connection cable is at least regionally welded to the cable wall of the cable feedthrough. To this end, a tube made of a material that fuses with the insulation sheath and the cable channel when heated is slipped over the cable section of the connection cable lying inside the cable channel. | ||||||
| 40 | Nucleotide analogs with six-membered rings | US10816298 | 2004-04-01 | US20050004078A1 | 2005-01-06 | Frank Bergmann; Horst Donner; Herbert Von Der Eltz; Dieter Heindl; Piet Herdewijn |
| The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane, cyclohexene, tetrahydropyran, tetrahydrothiopyran or piperidine. These compounds may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are provided wherein the oligomeric compounds are used. | ||||||
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