| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 201 | Modular multiple fluid sample preparation assembly | US396655 | 1989-08-22 | US5003988A | 1991-04-02 | Raouf A. Guirguis |
| An apparatus for collecting and testing multiple biological markers comprising a tubular compartmentalized container holding covalently bound antigen beads and correlating anti-antibody beads contained in separated compartments. The biological fluid, namely urine, is collected in the tubular container and is forced to flow through the separated compartment of the compartmentalized container so that predetermined ligands become attached to the bead ligands to obtain a plurality of biological markers. | ||||||
| 202 | Reagent for reticulocyte counting by flow cytometry | US117026 | 1987-11-04 | US4981803A | 1991-01-01 | Tomoyuki Kuroda |
| A reagent for reticulocyte counting by flow cytometry which comprises two solutions, namely, a stock solution for staining in which a dye is dissolved in a nonaqueous solvent, and a buffer solution which satisfies the optimum staining conditions.By combining these two solutions immediately before measurement, a stable final staining solution for reticulocyte counting can always be obtained. | ||||||
| 203 | Reagent for reticulocyte counting by flow cytometry | US117024 | 1987-11-04 | US4971917A | 1990-11-20 | Tomoyuki Kuroda |
| A reagent for reticulocyte counting by flow cytometry characterized in that it contains a carbonate salt.If a blood sample is left exposed to ordinary air, non-specific staining of erythrocyte can be prevented with the addition of not less than about 1 mM of NaHCO.sub.3. | ||||||
| 204 | A-associated H-antigens, monoclonal antibodies specific thereto and methods for employing the same in blood typing | US343566 | 1989-04-27 | US4942224A | 1990-07-17 | Henrik Clausen |
| The present invention relates to antigens present in blood group A and blood group AB erythrocytes but absent in blood group B and blood group O erythrocytes. More specifically, the present invention relates to A-associated H-antigens having the following structure: ##STR1## wherein X is a sugar residue and n=O or a positive integer and wherein R is a primary amino group containing material selected from the group consisting of a polypeptide, a primary amino group containing lipid and a primary amino group containing support; monoclonal antibodies specific thereto and methods for employing the same in blood typing. | ||||||
| 205 | Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes | US840054 | 1986-03-17 | US4806466A | 1989-02-21 | Demetrios P. Papahadjopoulos; Timothy D. Heath |
| A number of naturally occurring antibodies to human erythrocyte surface antigens are capable of combining with their specific antigens (for example, Rhesus factor), but are not capable of producing visible hemagglutination. Also, the sensitivity of many diagnostic methods, such as in human blood typing, depends upon cell agglutination.The present invention provides liposome-protein conjugates, especially useful for hemagglutination assays, having an enhanced agglutination capacity with respect to antibody from which the conjugates are derived. | ||||||
| 206 | Method and composition for isolating white cell elements | US756393 | 1985-07-17 | US4797475A | 1989-01-10 | Paul I. Terasaki; Jimmy Loon; Steven Hardiwidjaja; Nadim El-Awar |
| A composition of matter and method for using the composition of matter to isolate various cell elements from a heterogeneous cell suspension in a simple one step procedure. The composition is a monoclonal antibody mixture including complement and a non-toxic density gradient media. The composition provides a negative selection technique in which undesired subpopulation cells are lysed and separated from the desired cell subpopulation. The invention has particular application to isolation of white cell elements. | ||||||
| 207 | Viable cell labelling | US925192 | 1986-10-31 | US4783401A | 1988-11-08 | Paul K. Horan; Bruce D. Jensen; Sue E. Slezak |
| Methods for reproducibly labelling viable cells with cyanine dyes that do not significantly affect cell viability. Applications for labelled cells include using labelled red blood cells to distinguish post-transfusional bleeding from immunologic reaction and using dilution to measure growth rate of cultured cells. | ||||||
| 208 | Method for increasing agglutination of groups of cells to produce improved cell layer interface in centrifuged blood sample using antibodies | US794127 | 1985-11-01 | US4695553A | 1987-09-22 | Stephen C. Wardlaw; Robert A. Levine; Rodolfo R. Rodriguez; Michael R. Loken |
| In order to produce a more well defined interface between adjacent cell layers in a centrifuged sample of anticoagulated whole blood, a material which will bond one group of cells together is added to the blood sample prior to centrifugation. The bonding material must produce a high strength bond between one group of cells, but not effect the other cell types. The material is added prior to centrifugation of the blood sample. An example of a bonding agent is a monoclonal antibody. | ||||||
| 209 | Synthetic, plasma-free, transfusible platelet storage medium | US841435 | 1986-03-19 | US4695460A | 1987-09-22 | Stein Holme |
| The invention is a sterile, plasma-free platelet storage medium. The platelet storage medium includes a physiologically compatible, aqueous electrolyte solution. In one liter of this electrolyte solution there is between about 3.0 grams and about 7.5 grams of dextrose, between about 3.0 grams and about 6.0 grams of sodium citrate, and between about 2.0 grams and about 4.2 grams of sodium bicarbonate. The platelet storage medium is isotonic and has a pH in a range of between about 6.8 and about 7.4. The platelet storage medium is capable of storing and preserving platelets for at least 10 days. | ||||||
| 210 | Beta-d-galactose derivatives and their use | US498732 | 1983-05-27 | US4686193A | 1987-08-11 | Cenek Kolar |
| New compounds of the general formula I ##STR1## in which R.sup.1 and R.sup.2 each denote a hydrogen atom or an acyl or benzyl protective group,R.sup.1 and R.sup.2 together denote an alkylidene or benzylidene protective group,R.sup.4 denotes a hydrogen atom, an acyl or benzyl protective group or a 2,3,4-tri-O-benzyl-.alpha.-L-fucopyranosyl or .alpha.-L-fucopyranosyl radical,R.sup.5 denotes H, OH, NH.sub.2, NHNH.sub.2, N.sub.3, O-alkyl, O-aryl, NH--(CH.sub.2).sub.m NH.sub.2, where m=2-5, lysine, polylysine or a carrier,n denotes a number from 1 to 10 andR.sup.3 denotes a hydrogen atom, an acyl or benzyl protective group or an .alpha.-D-glycopyranosyl radical of the general formula II ##STR2## in which R.sup.6 denotes a hydrogen atom or an acyl or benzyl protective group,R.sup.7 denotes a hydrogen atom or halogen andR.sup.8 denotes a hydrogen atom, an acyloxy or benzyloxy group or an azido, amino, acetamido or hydroxyl group,a process for their preparation and their use, when bonded to a carrier, as synthetic antigens, glycolipids or immuno-adsorbents, are described. | ||||||
| 211 | Biological fluid assay system | US660721 | 1984-10-18 | US4683120A | 1987-07-28 | Peter M. Meserol; Jesse L. Acker |
| A biological fluid assay system and method for the determination of immunoreactive characteristics of biological specimen and more particularly for the qualitative determination of immunological reactions. The apparatus includes a centrifuge rotor, a disposable belt mountable on the centrifuge rotor, and a plurality of light transmissive chambers as components of the removable belt, each of the chambers having a vertical apex and a horizontal radial apex for accepting a sample comprising a specimen and an appropriate reagent. An illumination system projects an image of the sample while a linear photosensitive array detects the image of the sample for measuring the vertical dimension of the sample and a microprocessor analyzes the vertical dimension of the sample. A sample is radially accelerated to compress the particulate portion of the sample or reagent into a compact mass in the extreme radial portion of the transparent chamber. The centrifugal force on the sample is balanced with the gravitational force acting on the compact mass by decelerating the rotor. The vertical dimension of the compact mass is measured while the sample is rotating. The vertical dimension of the compact mass is again measured after a delay to determine the presence of vertical streaming. The difference between the vertical dimension of the compact mass before streaming and the vertical dimension of the mass after streaming is completed, due to gravitational attraction, is determined. | ||||||
| 212 | Method for B cell typing of total human lymphocyte sample | US616574 | 1984-06-04 | US4657852A | 1987-04-14 | Frank C. Grumet; Edgar G. Engleman |
| An HLA-DR typing test based on lymphocytotoxicity in which a vital dye-labeled total human lymphocyte sample, such as a sample of peripheral blood lymphocytes, is incubated with HLA-DR antisera, a monoclonal antibody against T cells, and complement and the DR type is determined based upon the resultant cytotoxicity as measured by the fluorescence of B cells surviving the incubation. | ||||||
| 213 | Fluorescent multiparameter particle analysis | US482124 | 1983-04-05 | US4584277A | 1986-04-22 | Edwin F. Ullman |
| Methods are provided for rapidly determining a number of parameters in a few determinations. Particularly, the method is applicable to blood typing, determining the blood type as to the ABO and Rh type, as well as the determination of isoantibodies to the antigens. The method employs fluorescent particles having a plurality of fluorescers, where the presence or absence of light emission of a particular wavelength can be determined. | ||||||
| 214 | Antibody/antigen determination method | US575237 | 1984-01-30 | US4560647A | 1985-12-24 | John Stocker |
| A method for the determination of antigens or antibodies in a fluid by incubation of particles, which have antigens on the surface, and antibodies, whereby either the antigens or the antibodies are of known specificity is described. This method comprises introducing the antigen/antibody complex into a container having a conical-shaped or keel-shaped bottom recess, whereby at least the recess of the container is coated with an immunoglobulin-building component which is directed against the antibodies. After centrifugation the amount of the sediment is determined, which indicates whether the antigen or antibody to be determined is present or not. | ||||||
| 215 | Blood typing apparatus | US489660 | 1983-04-28 | US4533638A | 1985-08-06 | Istvan Muranyi; Laszlone Balazs; Jozsef Molnar; Ferencne Burda; Maria Metzler; Lajos Szerdahelyi |
| Apparatus for blood-typing comprises a sampler, a reagent recipient, peristaltic pumps serving for the delivery of the reagents and the materials to be examined, a mixer, reactors, a sample-placing device, elements for the control of volume and means for washing.The mixer is formed as a flattened tube led in a helical line. Before such tube there is a connection for introduction of enzyme.Means for removal of agglutinate test result are provided. The elements serving for the control of volume are formed by telescopic tubes of variable length.The device is much simpler than heretofore known devices. It enables achievement of high operational safety and reduction of production and operation cost. | ||||||
| 216 | Blood bank cuvette cassette and label therefor | US322639 | 1981-11-18 | US4472357A | 1984-09-18 | Didya D. Levy; Richard E. Scordato |
| A plurality of cuvettes joined together by breakable links between each cuvette for use in testing blood for its ABO classification and the presence of a typical antibodies, and for crossmatching blood for compatibility, together with label means for indicating the reagents used in each cuvette and the identity of the person whose blood is being tested. The cuvettes may be adapted to accept a closure means which permits the cuvettes to be pre-packaged with reagents required to carry out blood tests. The cuvettes have a hydrophilic polymer coating thereon that is non-destructive of red blood cells. | ||||||
| 217 | Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein | US356539 | 1982-03-09 | US4447547A | 1984-05-08 | Robert H. Allen; Paul A. Seligman |
| The reticulocyte content present in a specimen of red blood cells is quantitatively measured based upon the selective immunoreactivity of the reticulocyte portion of the specimen with a reticulocyte-specific antibody which is immunoreactive with proteinaceous material associated with reticulocytes but not associated with mature red blood cells. Such immunoreactive proteinaceous material may be transferrin, transferrin receptor, transcobalamin II, or transcobalamin II receptor. Various procedures are described for quantitating such selective immunoreactivity, including fluorescent and radioactive detection techniques employing direct or indirect fluorescent or radioactive labeling of the reticulocyte-specific antibody. | ||||||
| 218 | Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein | US138785 | 1980-04-09 | US4332785A | 1982-06-01 | Robert H. Allen; Paul A. Seligman |
| The reticulocyte content present in a specimen of red blood cells is quantitatively measured based upon the selective immunoreactivity of the reticulocyte portion of the specimen with a reticulocyte-specific antibody which is immunoreactive with proteinaceous material associated with reticulocytes but not associated with mature red blood cells. Such immunoreactive proteinaceous material may be transferrin, transferrin receptor, transcobalamin II, or transcobalamin II receptor. Various procedures are described for quantitating such selective immunoreactivity, including fluorescent and radioactive detection techniques employing direct or indirect fluorescent or radioactive labeling of the reticulocyte-specific antibody. | ||||||
| 219 | Apparatus and analysis for agglutination reaction | US658204 | 1976-02-17 | US4148607A | 1979-04-10 | Domenico Bernoco; Andre Mottu; Lothar Waltz |
| Analysis of and apparatus for studying simple or complex agglutination reactions, such as for blood analysis and in particular blood groupings in which the specimen is mixed with at least one reagent in a vessel of predetermined shape and this mixture is incubated and thereafter centrifuged in this vessel. The nature of the reaction, the operations performed on the mixture and the shape of the vessel are such as to provide at cessation of the centrifuging the accumulation of the agglutinated particles at a particular location in the vessel. Following a waiting period in which the mixture is given the opportunity to partly or substantially entirely move under the influence of gravity away from said location, the path of said movement is observed by an optical arrangement which enables determination of the nature of the reaction, i.e. the presence or absence of agglutinated or non-agglutinated elements is observed after a time interval sufficient to permit their separation. | ||||||
| 220 | Diagnostic test card | US646830 | 1976-01-06 | US3990850A | 1976-11-09 | Stephen B. Friedman; Mel J. Riley |
| A novel test card adapted for the performance of an immunochemical, diagnostic or serological test upon its surface, and which is provided with an end flap which may be folded over to enclose and preserve the test results. The flap portion is provided with circular openings which when folded over, are in registry with circular test areas on the surface of the card, permitting visual observation of the test results. The card may be used, for example, for blood group typing. | ||||||
QQ群二维码
意见反馈
意见反馈