| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 221 | System and method of automatically generating chemical compounds with desired properties | US535822 | 1995-09-28 | US5574656A | 1996-11-12 | Dimitris K. Agrafiotis; Roger F. Bone; Francis R. Salemme; Richard M. Soll |
| A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity chemical library is robotically generated in accordance with robotic synthesis instructions; (2) the compounds in the directed diversity chemical library are analyzed to identify compounds with the desired properties; (3) structure-property data are used to select compounds to be synthesized in the next iteration; and (4) new robotic synthesis instructions are automatically generated to control the synthesis of the directed diversity chemical library for the next iteration. | ||||||
| 222 | System and method of automatically generating chemical compounds with desired properties | US306915 | 1994-09-16 | US5463564A | 1995-10-31 | Dimitris K. Agrafiotis; Roger F. Bone; Francis R. Salemme; Richard M. Soll |
| A computer based, iterative process for generating chemical entities with defined physical, chemical and/or bioactive properties. During each iteration of the process, (1) a directed diversity chemical library is robotically generated in accordance with robotic synthesis instructions; (2) the compounds in the directed diversity chemical library are analyzed to identify compounds with the desired properties; (3) structure-property data are used to select compounds to be synthesized in the next iteration; and (4) new robotic synthesis instructions are automatically generated to control the synthesis of the directed diversity chemical library for the next iteration. | ||||||
| 223 | METHOD FOR PREPARING NOVEL ANTIBODY LIBRARY AND LIBRARY PREPARED THEREBY | EP16737531.0 | 2016-01-13 | EP3246434A1 | 2017-11-22 | SHIM, Hyun Bo; KIM, Ji Hye; BAI, Xuelian |
The present invention relates to a method for preparing a novel antibody library and a library prepared thereby. The antibody library prepared according to the present invention contains antibodies having excellent physical properties against a plurality of antigens, thereby having functional diversity and containing a plurality of unique sequences, and thus can be favorably used as an antibody library. |
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| 224 | EPITOPE FOCUSING BY VARIABLE EFFECTIVE ANTIGEN SURFACE CONCENTRATION | EP13793347.9 | 2013-05-21 | EP2852608A2 | 2015-04-01 | GLANVILLE, Jacob, E. |
| The present disclosure provides compositions and methods for the generation of an antibody or immunogenic composition, such as a vaccine, through epitope focusing by variable effective antigen surface concentration. Generally, the composition and methods of the disclosure comprise three steps: a “design process” comprising one or more in silico bioinformatics steps to select and generate a library of potential antigens for use in the immunogenic composition; a “formulation process”, comprising in vitro testing of potential antigens, using various biochemical assays, and further combining two or more antigens to generate one or more immunogenic compositions; and an “administering” step, whereby the immunogenic composition is administered to a host animal, immune cell, subject or patient. Further steps may also be included, such as the isolation and production of antibodies raised by host immune response to the immunogenic composition. | ||||||
| 225 | Methods, systems, and software for identifying functional biomolecules | EP10181000.0 | 2003-03-03 | EP2278509B1 | 2014-11-19 | Gustafsson, Claes; Govindarajan, Sridar; Emig, Robin; Fox, Richard John; Roy, Ajoy; Minshull, Jeremy; Davis, S., Christopher; Cox, Anthony; Patten, Phil; Castle, Linda A.; Siehl, Daniel L.; Gorton, Rebecca Lynne; Chen, Teddy |
| 226 | SCREENING METHOD | EP11845394 | 2011-11-29 | EP2646824A4 | 2014-08-13 | HÄMÄLÄINEN MARKKU; ROOS HÅKAN |
| 227 | METHODS, SYSTEMS, AND SOFTWARE FOR IDENTIFYING FUNTIONAL BIOMOLECULES | EP05779687.2 | 2005-06-21 | EP1761879B1 | 2013-08-14 | FOX, Richard, John |
| The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods. | ||||||
| 228 | UNIVERSAL FIBRONECTIN TYPE III BOTTOM-SIDE BINDING DOMAIN LIBRARIES | EP10771435.4 | 2010-10-27 | EP2494046A1 | 2012-09-05 | LOEW, Andreas; VASH, Brian, Edward |
| The invention pertains to a natural-variant combinatorial library of fibronectin Type 3 domain (Fn3) polypeptides useful in screening for the presence of one or more polypeptides having a selected binding or enzymatic activity. The library polypeptides include (a) regions A, AB, B, C, CD, D, E, EF, F, and G having wildtype amino acid sequences of a selected native fibronectin Type 3 polypeptide or polypeptides, and (b) loop regions AB, CD, and EF having selected lengths (Bottom Loops). The Fn3 may also have loop regions BC, DE, and FG having wildtype amino acid sequences, having selected lengths, or mutagenized amino acid sequences (Top Loops). | ||||||
| 229 | PROBES, LIBRARIES AND KITS FOR ANALYSIS OF MIXTURES OF NUCLEIC ACIDS AND METHODS FOR CONSTRUCTING THE SAME | EP04738926.7 | 2004-06-18 | EP1639130B1 | 2012-04-11 | RAMSING, Niels, B.; MOURITZEN, Peter; ECHWALD, Sören, Morgenthaler; TOLSTRUP, Niels |
| The invention relates to nucleic acid probes, nucleic acid probe libraries, and kits for detecting, classifying, or quantitating components in a complex mixture of nucleic acids, such as a transcriptome, and methods of using the same. The invention also relates to methods of identifying nucleic acid probes useful in the probe libraries and to methods of identifying a means for detection of a given nucleic acid. | ||||||
| 230 | METHOD OF GENERATING AN OPTIMIZED DIVERSE POPULATION OF VARIANTS | EP09710859.1 | 2009-02-12 | EP2250595A1 | 2010-11-17 | FOX, Richard |
| The present disclosure relates to methods of rapidly and efficiently searching biologically-related data space to identify a population set maximally diverse and optimized for sets of desired properties. More specifically, the disclosure provides methods of identifying a diverse, evolutionary separated bio-molecules with desired properties from complex bio-molecule libraries. The disclosure additionally provides digital systems and software for performing these methods. | ||||||
| 231 | PROGRAMMABLE ITERATED ELONGATION: A METHOD FOR MANUFACTURING SYNTHETIC GENES AND COMBINATORIAL DNA AND PROTEIN LIBRARIES | EP07736483 | 2007-06-19 | EP2035984A4 | 2010-03-31 | SHAPIRO EHUD Y; LINSHIZ GREGORY; BEN-YEHEZKEL TUVAL; KAPLAN SHAI; ADAR RIVKA; GRONAU ILAN; RAVID SIVAN |
| 232 | SINGLE-TUBE, READY-TO-USE ASSAY KITS AND METHODS USING SAME | EP03707531 | 2003-01-27 | EP1468103A4 | 2008-12-31 | GILBERT DENNIS A; LIVAK KENNETH J; STEVENS JUNKO; HUNKAPILLER MICHAEL W; LUCERO MICHAEL; EDDINS SUSAN K |
| Methods and systems for ordering assays which detect SNPs or gene expression are provided. The methods use PCR and RT-PCR procedures. Collections of stock assays are assembled using pre- and post-manufacturing quality control procedures and made available to consumers via the Internet. In addition, custom assays are prepared upon order from the consumer and these assays are also prepared using pre- and post-manufacturing quality control procedures. The assays are then delivered to the consumer. | ||||||
| 233 | PHARMACOKINETIC-BASED DRUG DESIGN TOOL AND METHOD | EP99949642 | 1999-09-14 | EP1144675A4 | 2007-05-02 | GRASS GEORGE M; LEESMAN GLEN D; NORRIS DANIEL A; SINKO PATRICK J; WEHRLI JOHN E |
| The present invention relates to a pharmacokinetic-based design and selection tool (PK tool) and methods for predicting absorption of an administered compound of interest. The methods utilize the tool, and optionally a separately operable component or subsystem thereof. The PK tool includes as computer-readable components: (1) input/output system; (2) physiologic-based simulation model of one or more segments of a mammalian system of interest having one or more physiological barriers to absorption that is based on the selected route of administration; and (3) simulation engine having a differential equation solver. The invention also provides methods for optimizing as well as enabling minimal input requirements a physiologic-based simulation model for predicting in vivo absorption, and optionally one or more additional properties, from either in vitro or in vivo data. The PK tool of the invention may be provided as a computer system, as an article of manufacture in the form of a computer-readable medium, or a computer program product and the like. Subsystems and individual components of the PK tool also can be utilized and adapted in a variety of disparate applications for predicting the fate of an administered compound. The PK tool and methods of the invention can be used to screen and design compound libraries, select and design drugs, as well as predict drug efficacy in mammals from in vitro and/or in vivo data of one or more compounds of interest. The PK tool and methods of the invention also finds use in selecting, designing, and preparing drug compounds, and multi-compound drugs and drug formulations (i.e., drug delivery system) for preparation of medicaments for use in treating mammalian disorders. | ||||||
| 234 | COMMON PROTEIN SURFACE SHAPES AND USES THEREFOR | EP03700720 | 2003-02-10 | EP1483291A4 | 2007-03-14 | SMYTHE MARK LESLIE; TRAN TRAN TRUNG; BRYANT DARRYN; LONG STEPHEN; ADAMS PETER |
| A method of determining common three-dimensional structural features of protein surfaces is provided, as is use of representations of these common structures in molecular database searching and in designing focussed molecular libraries. The method is particularly concerned with the analysis and representation of protein surfaces such as b-turns, loops and contact surfaces. In one form, the method identifies common locations and orientations of amino acid side-chains, simplified as Calpha-Cbeta vectors. In another form, the method identifies common regions of surface charge represented by grid points in three-dimensional space. Further provided are common three dimensional structural features of proteins that can be used to search molecular databases for the purposes of identifying molecules that match these common three dimensional structural features. The common three dimensional structural features can also be used to focus de novo molecular generation to produce libraries containing molecules that have these common three dimensional structural features. Libraries of these structurally-related molecules may then be produced for the purposes of drug discovery. | ||||||
| 235 | OPTIMIZATION OF CROSSOVER POINTS FOR DIRECTED EVOLUTION | EP03711540 | 2003-03-10 | EP1488335A4 | 2006-11-15 | GOVINDARAJAN SRIDHAR; GUSTAFSSON CLAES; MINSHULL JEREMY S |
| Methods and devices for more efficiently engineering diversity into recombinant polypeptides and/or nucleic acids are provided herein. For example, a variety of methods of selecting and/or assessing potential crossover sites in an amino acid sequence or a nucleotide sequence are provided, as well as the resulting chimeric product sequences. These methods include, e.g., consideration of structural, functional and/or statistical data in the selection and assessment of sequences and crossover sites for use in recombination. | ||||||
| 236 | PROBES, LIBRARIES AND KITS FOR ANALYSIS OF MIXTURES OF NUCLEIC ACIDS AND METHODS FOR CONSTRUCTING THE SAME | EP04738926.7 | 2004-06-18 | EP1639130A2 | 2006-03-29 | RAMSING, Niels, B.; MOURITZEN, Peter; ECHWALD, Sören, Morgenthaler; TOLSTRUP, Niels |
| The invention relates to nucleic acid probes, nucleic acid probe libraries, and kits for detecting, classifying, or quantitating components in a complex mixture of nucleic acids, such as a transcriptome, and methods of using the same. The invention also relates to methods of identifying nucleic acid probes useful in the probe libraries and to methods of identifying a means for detection of a given nucleic acid. | ||||||
| 237 | CELL-BASED ANALYSIS OF HIGH THROUGHPUT SCREENING DATA FOR DRUG DISCOVERY | EP01962014.5 | 2001-08-09 | EP1573072A2 | 2005-09-14 | WELCH, William J.; LAM, Raymond L.H.; YOUNG, Sidney Stanley |
| A method of drug discovery in finding compounds with some desired activity for a chosen biological target that reduces reliance on searches of relatively large numbers of compounds. Rules are derived from a relatively small screening data set linking structural features to biological activity, which rules can be used to guide the selection of additional compounds for screening so that screening costs can be reduced as the total number of compounds screened is reduced. Properties of compounds are described numerically and said compounds are placed into small mathematical bins that comprise narrow ranges of the numerical descriptors. Through statistical analysis, it is then determined which combinations of bins describe regions of chemical space that are most likely to contain active compounds. Untested compounds that fall into these regions are then seen as good candidates for screening. | ||||||
| 238 | GENERATION AND SELECTION OF PROTEIN LIBRARY IN SILICO | EP03755415.1 | 2003-05-20 | EP1514216A2 | 2005-03-16 | LUO, Peizhi; HSIEH, Mark; ZHONG, Pingyu; WANG, Caili; CAO, Yicheng; LIU, Shengjiang |
| The present invention provides a methodology for efficiently generating and screening protein libraries for optimized proteins with desirable biological functions, such as improved binding affinity towards biologically and/or therapeutically important target molecules. The process is carried out computationally in a high throughput manner by mining the ever-expanding databases of protein sequences of all organisms, especially human. In one embodiment, a method for constructing a library of designed proteins, comprising the steps of: providing an amino acid sequence derived from a lead protein, the amino acid sequence being designated as a lead sequence; comparing the lead sequence with a plurality of tester protein sequences; and selecting from the plurality of tester protein sequences at least two peptide segments that have at least 15% sequence identity with the lead sequence, the selected peptide segments forming a hit library; and forming a library of designed proteins by substituting the lead sequence with the hit library. The library of designed proteins can be expressed in vitro or in vivo to produce a library of recombinant proteins that can be screened for novel or improved function(s) over the lead protein, such as an antibody against therapeutically important target. | ||||||
| 239 | A COMPUTER BASED METHOD FOR IDENTIFYING CONSERVED INVARIANT PEPTIDE MOTIFS | EP00993858.0 | 2000-08-31 | EP1268512B1 | 2005-01-12 | BRAHMACHARI, Kumar, Samir, Central Biochem. Tech.; DASH, Debasis, Central for Biochem. Technology, |
| The present invention relates to a novel computer based method for performing genomewise comparison of several organisms, the said computational method involves creation of peptide libraries from protein sequences of several organisms and subsequent comparison leading to identification of conserved invariant peptide motifs, and to this end several invariant peptide motifs have been identified by direct sequence comparison between various bacterial organisms and host genomes without any a <i>priori</i> assumptions, and the present method is useful for identification of potential drug targets and can serve as drug screen for broad-spectrum antibacterial as well as for specific diagnosis of infections, and in addition, for assignment of function to proteins of yet unknown functions with the help of such invariant peptide motif signatures. | ||||||
| 240 | VERFAHREN UND VORRICHTUNG ZUM AUFFINDEN VON STOFFGEMISCHEN FÜR SUBSTANZBIBLIOTHEKEN | EP02754874.2 | 2002-07-11 | EP1412079A2 | 2004-04-28 | JAKUPOVIC, Jasmin; BINKELE, Heidrun; WOLF, Dietmar; SIEMS, Karsten |
| Method of discovering mixtures of substances to build up a substance library, comprises: (A) separating mixtures by chromatographic or electrophoretic means; and (B) identifying low molecule organic substances in each mixture by the physical parameters of retention time and the molecular mass registered by mass spectrometry. Method of discovering mixtures of substances to build up a substance library, comprises: (a) separating mixtures by chromatographic or electrophoretic means; and (b) identifying low molecule organic substances in each mixture by the physical parameters of retention time and the molecular mass registered by mass spectrometry. The high performance liquid chromatograph (HPLC) diagram (10) of a standard solution under standard conditions gives two peaks (12,14) for retention times of reference measurements. In a subsequent diagram (16) under laboratory conditions, the corresponding peaks (18,20) of the same substances are shifted (22,24) against the previous peaks. | ||||||
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