| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 碳青霉烯(CARBAPENEM)的无细胞制备 | CN201280054408.6 | 2012-09-07 | CN104093848A | 2014-10-08 | 威廉·杰瑞米·布雷克; 丹尼尔·克莱恩-马库斯查梅尔 |
| 本文提供用于生成碳青霉烯、例如式(I)化合物或其盐的无细胞系统；其中(II)、R1、R2、R3、R4、R5和R6如本文所定义。还提供包含通过本发明无细胞系统生成的化合物的医药组合物，以及这些化合物和组合物用于治疗细菌感染的用途。 | ||||||
| 2 | CELL-FREE PREPARATION OF CARBAPENEMS | US13606911 | 2012-09-07 | US20130065878A1 | 2013-03-14 | William Jeremy Blake; Daniel Klein-Marcuschamer |
| Provided herein are cell-free systems for generating carbapenems, e.g., a compound of the Formula (I): or salts thereof; wherein , R1, R2, R3, R4, R5, and R6 are defined herein. Also provided are pharmaceutical compositions comprising a compound generated by the inventive cell-free system, and use of these compounds and compositions for the treatment of bacterial infections. | ||||||
| 3 | Cell-free preparation of carbapenems | US13606911 | 2012-09-07 | US09469861B2 | 2016-10-18 | William Jeremy Blake; Daniel Klein-Marcuschamer |
| Provided herein are cell-free systems for generating carbapenems, e.g., a compound of the Formula (I): or salts thereof; wherein , R1, R2, R3, R4, R5, and R6 are defined herein. Also provided are pharmaceutical compositions comprising a compound generated by the inventive cell-free system, and use of these compounds and compositions for the treatment of bacterial infections. | ||||||
| 4 | CELL-FREE PREPARATION OF CARBAPENEMS | US15291943 | 2016-10-12 | US20170096692A1 | 2017-04-06 | William Jeremy Blake; Daniel Klein-Marcuschamer |
| Provided herein are cell-free systems for generating carbapenems, e.g., a compound of the Formula (I): or salts thereof; wherein , R1, R2, R3, R4, R5 and R6 are defined herein. Also provided are pharmaceutical compositions comprising a compound generated by the inventive cell-free system, and use of these compounds and compositions for the treatment of bacterial infections. | ||||||
| 5 | Cell-free preparation of carbapenem | JP2014529904 | 2012-09-07 | JP2014526250A | 2014-10-06 | ブレーク，ウィリアム，ジェレミー; クライン−マルクスチェイマー，ダニエル |
| 本明細書において提供されるのは、カルバペネム、例えば、式（Ｉ）：の化合物またはその塩；式中、（ＩＩ）、Ｒ １ 、Ｒ ２ 、Ｒ ３ 、Ｒ ４ 、Ｒ ５ 、およびＲ ６は、本明細書において定義されるとおりである、を生成するための無細胞系である。 また提供されるのは、本発明の無細胞系により生成された化合物を含む医薬組成物、ならびに細菌感染の処置のためのこれらの化合物および組成物の使用である。 | ||||||
| 6 | 카바페넴의 무세포 제조법 | KR1020147009054 | 2012-09-07 | KR1020150010932A | 2015-01-29 | 블레이크,윌리엄,제러미; 클레인-마커스차머,다니엘 |
| 본 발명에서 제공되는 것은 카바페넴, 예를 들면 식(I)의 화합물 또는 그의 염을 발생시키는 무세포 시스템이고, 여기서, R 1 , R 2 , R 3 , R 4 , R 5 , 및 R 6 는 본원에서 정의된 바와 같다. 또한, 본 발명에서 제공되는 것은 본 발명의 무세포 시스템에 의해 발생된 화합물을 포함한 제약학적 조성물이고, 이들 화합물 및 조성물을 박테리아 감염의 치료제로 사용하는 용도이다. | ||||||
| 7 | CELL-FREE PREPARATION OF CARBAPENEMS | PCT/US2012054195 | 2012-09-07 | WO2013036787A3 | 2013-06-13 | BLAKE WILLIAM JEREMY; KLEIN-MARCUSCHAMER DANIEL |
| Provided herein are cell-free systems for generating carbapenems, e.g., a compound of the Formula (I): or salts thereof; wherein (II), R1, R2, R3, R4, R5, and R6 are defined herein. Also provided are pharmaceutical compositions comprising a compound generated by the inventive cell- free system, and use of these compounds and compositions for the treatment of bacterial infections. | ||||||
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