序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
1 PEPTIDE REGULATORS OF MITOCHONDRIAL FUSION AND METHODS OF USE US15710696 2017-09-20 US20180080926A1 2018-03-22 Daria Mochly-Rosen; Gerald W. Dorn, II
Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (Mfn1) and/or mitofusin 2 (Mfn2) and mitochondrial dysfunction. Methods of treatment, pharmaceutical formulations and methods of identifying compounds that mimic the activity of the peptides for use in screening assays are also described.
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