| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 编码磷酸烯醇丙酮酸:糖类磷酸转移酶系统蛋白质的谷氨酸棒杆菌基因 | CN00812165.6 | 2000-06-27 | CN1371420A | 2002-09-25 | M·波姆佩朱斯; B·克雷格尔; H·施雷德尔; O·策尔德; G·哈贝豪尔 |
| 本发明描述了分离的编码新的谷氨酸棒杆菌PTS蛋白的核酸分子,该分子被称为PTS核酸分子。本发明也提供了反义核酸分子,含有PTS核酸分子的重组表达载体,以及已导入表达载体的宿主细胞。本发明也进一步提供了分离的PTS蛋白,PTS突变蛋白,融合蛋白质,抗原肽,以及基于谷氨酸棒杆菌PTS基因遗传工程提高由该生物体进行的所需化合物生产的方法。 | ||||||
| 2 | 一种产L-色氨酸基因工程菌及其构建方法与用途 | CN201610021610.9 | 2016-01-13 | CN105543154A | 2016-05-04 | 吴涛; 毛贤军; 赵津津; 王小霞 |
| 本发明涉及微生物领域，公开了一种产L-色氨酸基因工程菌及其构建方法以及用途。本发明通过基因工程的方法改造大肠杆菌的中央碳代谢途径的共有途径，敲除大肠杆菌自身的以磷酸烯醇式丙酮酸为底物的磷酸烯醇式丙酮酸-糖磷酸转移酶系统，并增强以非PEP为底物的葡萄糖转运系统，改变葡萄糖转运入胞的路径，获得一种产L-色氨酸基因工程菌，避免了L-色氨酸合成前体物磷酸烯醇式丙酮酸在葡萄糖转运过程中的消耗，从而提高胞内PEP的水平，进而提高菌株发酵产L-色氨酸的能力。实验表明本发明构建的产L-色氨酸基因工程菌为大肠杆菌L-色氨酸高产菌株，能有效积累L-色氨酸，提高L-色氨酸的产量，为L-色氨酸的工业化生产奠定了基础。 | ||||||
| 3 | 编码磷酸烯醇丙酮酸:糖类磷酸转移酶系统蛋白质的谷氨酸棒杆菌基因 | CN200510067207.1 | 2000-06-27 | CN1680559A | 2005-10-12 | M·波姆佩朱斯; B·克雷格尔; H·施雷德尔; O·策尔德; G·哈贝豪尔 |
| 本发明描述了分离的编码新的谷氨酸棒杆菌PTS蛋白的核酸分子，该分子被称为PTS核酸分子。本发明也提供了反义核酸分子，含有PTS核酸分子的重组表达载体，以及已导入表达载体的宿主细胞。本发明也进一步提供了分离的PTS蛋白，PTS突变蛋白，融合蛋白质，抗原肽，以及基于谷氨酸棒杆菌PTS基因遗传工程提高由该生物体进行的所需化合物生产的方法。 | ||||||
| 4 | Process for producing target substance by fermentation | US13983917 | 2012-02-09 | US09567616B2 | 2017-02-14 | Tetsuro Ujihara; Tetsuya Abe; Makoto Yagasaki |
| A target substance can be efficiently produced by culturing, in a medium, a coryneform bacterium in which the activity of a PTS protein relating to fructose uptake is reduced or lost as compared with a parent strain and the bacterium can produce the target substance, allowing the target substance to form and accumulate in a culture; and collecting the target substance from the culture. | ||||||
| 5 | Methods for production of xylitol in microorganisms | US11133045 | 2005-05-19 | US07960152B2 | 2011-06-14 | Paul Taylor; Ian Fotheringham; Nathan Wymer; Badal Saha; David Demirjian; Yoshikiyo Sakaibara; Francis Michael Racine |
| The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates. | ||||||
| 6 | Animal models for demyelination disorders | US12799670 | 2010-04-28 | US20100281548A1 | 2010-11-04 | Brian Popko; Wensheng Lin |
| This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders. | ||||||
| 7 | Methods for production of xylitol in microorganisms | US11133045 | 2005-05-19 | US20060110809A1 | 2006-05-25 | Paul Taylor; Ian Fotheringham; Nathan Wymer; Badal Saha; David Demirjian; Yoshikiyo Sakaibara; Francis Racine |
| The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates. | ||||||
| 8 | CELLS AND METHOD FOR PRODUCING RHAMNOLIPIDS USING ALTERNATIVE GLUCOSE TRANSPORTERS | US16334781 | 2017-10-18 | US20190233856A1 | 2019-08-01 | Oliver Thum; Steffen Schaffer; Christoph Schorsch; Mirja Wessel |
| The invention relates to cells which make rhamnolipids and are genetically modified such that they have a decreased activity, compared to the wild type thereof, of an ABC glucose transporter and, compared to the wild type thereof, an increased activity of at least one non-ABC glucose transporter and to a method for producing rhamnolipids using the cells according to the invention. | ||||||
| 9 | METABOLIC EVOLUTION OF ESCHERICHIA COLI STRAINS THAT PRODUCE ORGANIC ACIDS | US14491073 | 2014-09-19 | US20160083753A1 | 2016-03-24 | Tammy Grabar; Wei Gong; R. Rogers Yocum |
| This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids. | ||||||
| 10 | Animal models for demyelination disorders | US12799670 | 2010-04-28 | US08309790B2 | 2012-11-13 | Brian Popko; Wensheng Lin |
| This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders. | ||||||
| 11 | Animal models for demyelination disorders | US11729242 | 2007-03-27 | US07754941B2 | 2010-07-13 | Brian Popko; Wensheng Lin |
| This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders. | ||||||
| 12 | Animal models for demyelination disorders | US11431372 | 2006-05-09 | US20060282905A1 | 2006-12-14 | Brian Popko; Wensheng Lin |
| This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders. | ||||||
| 13 | Metabolic evolution of Escherichia coli strains that produce organic acids | US14491073 | 2014-09-19 | US10017793B2 | 2018-07-10 | Tammy Grabar; Wei Gong; R. Rogers Yocum |
| This invention relates to the metabolic evolution of a microbial organism previously optimized for producing an organic acid in commercially significant quantities under fermentative conditions using a hexose sugar as sole source of carbon in a minimal mineral medium. As a result of this metabolic evolution, the microbial organism acquires the ability to use pentose sugars derived from cellulosic materials for its growth while retaining the original growth kinetics, the rate of organic acid production and the ability to use hexose sugars as a source of carbon. This invention also discloses the genetic change in the microorganism that confers the ability to use both the hexose and pentose sugars simultaneously in the production of commercially significant quantities of organic acids. | ||||||
| 14 | PROCESS FOR PRODUCING TARGET SUBSTANCE BY FERMENTATION PROCESS | US13983917 | 2012-02-09 | US20130323784A1 | 2013-12-05 | Tetsuro Ujihara; Tetsuya Abe; Makoto Yagasaki |
| A target substance can be efficiently produced by culturing, in a medium, a coryneform bacterium in which the activity of a PTS protein relating to fructose uptake is reduced or lost as compared with a parent strain and the bacterium can produce the target substance, allowing the target substance to form and accumulate in a culture; and collecting the target substance from the culture | ||||||
| 15 | Methods for production of xylitol in microorganisms | US13105027 | 2011-05-11 | US08367346B2 | 2013-02-05 | Paul Taylor; Nathan Wymer; Francis Michael Racine |
| The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates. | ||||||
| 16 | Methods for Production of Xylitol in Microorganisms | US13105027 | 2011-05-11 | US20110212458A1 | 2011-09-01 | Paul Taylor; Ian Fotheringham; Nathan Wymer; Badal Saha; David Demirjian; Yoshikiyo Sakaibara; Francis Michael Racine |
| The invention provides biosynthetic routes to xylitol production that do not require pure D-xylose for synthesis and that can utilize inexpensive substrates such as hemicellulose hydrolysates. | ||||||
| 17 | Animal models for demyelination disorders | US11431372 | 2006-05-09 | US07423194B2 | 2008-09-09 | Brian Popko; Wensheng Lin |
| This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders. | ||||||
| 18 | Animal models for demyelination disorders | US11729242 | 2007-03-27 | US20080096202A1 | 2008-04-24 | Brian Popko; Wensheng Lin |
| This invention is in the field of neurology. Specifically, the invention relates to the discovery and characterization of molecular components that play a role in neuronal demyelination or remyelination. In addition, the invention relates to the generation of an animal model that exhibits hypomyelination. The compositions and methods embodied in the present invention are particularly useful for drug screening and/or treatment of demyelination disorders. | ||||||
| 19 | 発酵法による目的物質の製造法 | JP2012556925 | 2012-02-09 | JPWO2012108493A1 | 2014-07-03 | 哲朗 氏原; 阿部 哲也; 哲也 阿部; 誠 矢ケ崎 |
| 親株に比べフラクトースの取り込みに係るPTS系蛋白質の活性が低下、または喪失しており、かつ目的物質を生産することができるコリネ型細菌を培地に培養し、培養物中に該目的物質を生成蓄積させ、該培養物中から該目的物質を採取することにより、該目的物質を効率よく製造することができる。 | ||||||
| 20 | Corynebacterium glutamicum gene encoding phosphoenolpyruvate: sugar phosphotransferase system protein | JP2007115460 | 2007-04-25 | JP2007267744A | 2007-10-18 | POMPEJUS MARKUS; KROEGER BURKHARD; SCHROEDER HARTWIG; ZELDER OSKAR; HABERHAUER GREGOR |
| <P>PROBLEM TO BE SOLVED: To provide a Corynebacterium glutamicum gene encoding phosphoenolpyruvate: sugar phosphotransferase system (PTS) protein. <P>SOLUTION: The isolated nucleic acid encoding a novel PTS protein from Corynebacterium glutamicum is isolated. The antisense nucleic acid molecule, the recombinant expression vector containing a PTS nucleic acid molecule, and the host cell into which the expression vector has been introduced are also prepared. The isolated PTS protein, the mutated PTS protein, the fusion protein, the antigenic peptide and the method for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of the PTS gene are also provided. <P>COPYRIGHT: (C)2008,JPO&INPIT | ||||||
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