| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 转氨酶生物催化剂 | CN201480044593.X | 2014-06-12 | CN105452475A | 2016-03-30 | C·斯科特; M·怀尔丁; L·叶尔明; T·皮特; J·纽曼 |
| 本申请涉及分离自假单胞属物种的丙酮酸盐：ω-氨基酸转氨酶。所述转氨酶作用于长链氨基酸并且能够接受包含8-12个碳原子的底物。所述酶适于作为用于制备尼龙的生物催化剂。 | ||||||
| 2 | Production of renewable hydrocarbon compositions | US14428197 | 2013-09-20 | US09840724B2 | 2017-12-12 | Larry Cameron Anthony; Tyler T. Ames; Keith H. Burlew |
| Provided herein are processes and microorganisms which utilize both protein hydrolysates and carbohydrates from biomass feedstocks to produce renewable hydrocarbon compositions. Advantages of the disclosed methods may be recognized in fuel blends comprising such hydrocarbon compositions. | ||||||
| 3 | ENZYMATIC SYNTHESIS OF OPTICALLY ACTIVE CHIRAL AMINES | US15218270 | 2016-07-25 | US20170101654A1 | 2017-04-13 | Arumugam Govind SWAMINATHAN; Sunil Vaman JOSHI |
| The present invention relates to a method of enantioselective enzymatic transamination of (1R)-1-Hydroxy-1-Phenylacetone (R-PAC) to a chiral amine 1R, 2S-Norephedrine in the presence of an isopropylamine catalyzed by enantioselective transaminase. Isopropylamine is converted to acetone in the process. The transaminase used is in completely purified form, partially purified form or as whole cells. The source is microbial cells, which are genetically engineered. In the present invention, the enzyme is expressed in E. coli and used preferentially as a suspension of native cells. Transaminase comprising polypeptide sequence is obtained from Rhodobacter sphaeroides and expressed in E. coli. The nucleotide sequence of transaminase is expressed in an expression vector system pIEP/Kan/IEP AT12, which is incorporated in E. coli. The yield of 1R, 2S-1-norephedrine is greater than 87% and de % is greater than 99%. The enantioselective transamination process is cost-effective and environment-friendly in addition to providing the amine in high yield and enantioselectivity. | ||||||
| 4 | トランスアミナーゼ生体触媒 | JP2016518802 | 2014-06-12 | JP2016521562A | 2016-07-25 | コリン・スコット; マシュー・ワイルディング; ラース・ジャーミン; トーマス・ピート; ジャネット・ニューマン |
| 本発明は、シュードモナス属種から単離されたピルベート:ω-アミノ酸トランスアミナーゼに関する。トランスアミナーゼは、長鎖アミノ酸に作用し、8から12個の炭素原子を含む基質を受け入れることができる。酵素は、ナイロンの製造用の生体触媒として適している。 | ||||||
| 5 | TYPE II FATTY ACID SYSTHESIS ENZYMES IN REVERSE B-OXIDATION | EP15740946 | 2015-01-26 | EP3099763A4 | 2017-08-02 | GONZALEZ RAMON; CLOMBURG JAMES M; VICK JACOB E |
| This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the β-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the β-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their α-, β-, and ω-functionalized derivatives from renewable carbon sources can be achieved. | ||||||
| 6 | Production of Renewable Hydrocarbon Compositions | US15799466 | 2017-10-31 | US20180066290A1 | 2018-03-08 | Larry Cameron ANTHONY; Tyler T. AMES; Keith H. BURLEW |
| Provided herein are processes and microorganisms which utilize both protein hydrolysates and carbohydrates from biomass feedstocks to produce renewable hydrocarbon compositions. Advantages of the disclosed methods may be recognized in fuel blends comprising such hydrocarbon compositions. | ||||||
| 7 | PRODUCTION OF CHIRAL 1,2-AMINO ALCOHOLS AND ALPHA-AMINO ACIDS FROM ALKENES BY CASCADE BIOCATALYSIS | US15257223 | 2016-09-06 | US20170067084A1 | 2017-03-09 | Zhi Li; Shuke Wu |
| Disclosed herein are methods of forming chiral 1,2-aminoalcohols and α-aminoacids from alkene starting materials by way of an enzymatic cascade reaction sequence that may be accomplished in a single reaction vessel without the need to isolate any intermediates. Also disclosed herein are recombinant nucleic acids, vectors and host cells for use in the methods of the invention. | ||||||
| 8 | TYPE II FATTY ACID SYNTHESIS ENZYMES IN REVERSE ß-OXIDATION | US15114502 | 2015-01-26 | US20160340699A1 | 2016-11-24 | Ramon Gonzalez; James M. CLOMBURG; Jacob E. VICK |
| This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the β-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the β-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their α-, β-, and ω-functionalized derivatives from renewable carbon sources can be achieved. | ||||||
| 9 | Transaminase Biocatalysts | US14896252 | 2014-06-12 | US20160208226A1 | 2016-07-21 | Colin Scott; Matthew Wilding; Lars Jermiin; Thomas Peat; Janet Newman |
| The present invention relates to pyruvate: ω-amino acid transaminases isolated from a Pseudomonas species. The transaminases act on long chain amino acids and are capable of accepting substrates comprising 8 to 12 carbon atoms. The enzymes are suitable as biocatalysts for the manufacture of nylon. | ||||||
| 10 | PRODUCTION OF RENEWABLE HYDROCARBON COMPOSITIONS | US14428197 | 2013-09-20 | US20150240267A1 | 2015-08-27 | Larry Cameron Anthony; Tyler T. Ames; Keith H. Burlew |
| Provided herein are processes and microorganisms which utilize both protein hydrolysates and carbohydrates from biomass feedstocks to produce renewable hydrocarbon compositions. Advantages of the disclosed methods may be recognized in fuel blends comprising such hydrocarbon compositions. | ||||||
| 11 | TRANSAMINASE BIOCATALYSTS | EP14810750 | 2014-06-12 | EP3008199A4 | 2017-01-18 | SCOTT COLIN; WILDING MATTHEW; JERMIIN LARS; PEAT THOMAS; NEWMAN JANET |
| 12 | TYPE II FATTY ACID SYSTHESIS ENZYMES IN REVERSE B-OXIDATION | EP15740946.7 | 2015-01-26 | EP3099763A1 | 2016-12-07 | GONZALEZ, Ramon; CLOMBURG, James, M.; VICK, Jacob, E. |
| This disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis ("FAS") pathway that can be used in combination with thiolases to operate a functional reversal of the β-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the β-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their α-, β-, and ω-functionalized derivatives from renewable carbon sources can be achieved. | ||||||
| 13 | TRANSAMINASE BIOCATALYSTS | EP14810750.1 | 2014-06-12 | EP3008199A1 | 2016-04-20 | SCOTT, Colin; WILDING, Matthew; JERMIIN, Lars; PEAT, Thomas; NEWMAN, Janet |
| The present invention relates to pyruvate : ω-amino acid transaminases isolated from a Pseudomonas species. The transaminases act on long chain amino acids and are capable of accepting substrates comprising 8 to 12 carbon atoms. The enzymes are suitable as biocatalysts for the manufacture of nylon. | ||||||
| 14 | 트랜스아미나제 생물촉매 | KR1020167000545 | 2014-06-12 | KR1020160026977A | 2016-03-09 | 스콧,콜린; 와일딩,매튜; 제르민,라스; 피트,토마스; 뉴먼,자넷 |
| 본발명은트랜스아미나제및 트랜스아미나제를생물촉매로서사용하는방법에관한것이다. | ||||||
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