| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | β1,2-xylosyltransferase-gene from arabidopsis | US10220467 | 2001-03-02 | US07205137B2 | 2007-04-17 | Josef Glössl; Richard Strasser; Jan Mucha; Lukas Mach; Friedrich Altmann; Iain B. Wilson; Herta Steinkellner |
| A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50% homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having β1,2-xylosyltransferase activity or being complementary thereto. | ||||||
| 2 | Beta 1,2-xylosyltransferase-gene from arabidopsis | US10220467 | 2003-03-07 | US20040121325A1 | 2004-06-24 | Josef Glossl; Richard Strasser; Jan Mucha; Lukas Mach; Friedrich Altmann; Iain B Wilson; Herta Steinkellner |
| A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50% homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having null1,2-xylosyltransferase activity or being complementary thereto. | ||||||
| 3 | Method for Producing Recombinant Glycoproteins Having Beta1,2-Bound Xylose Residues | US13428777 | 2012-03-23 | US20120331578A1 | 2012-12-27 | Josef Glössl; Richard Strasser; Jan Mucha; Lukas Mach; Friedrich Altmann; Iain B. Wilson; Herta Steinkellner |
| A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50% homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having β1,2-xylosyltransferase activity or being complementary thereto. | ||||||
| 4 | BETA 1,2-xylosyltransferase-gene from arabidopsis | US11684898 | 2007-03-12 | US20070186311A1 | 2007-08-09 | Josef Glossl; Richard Strasser; Jan Mucha; Lukas Mach; Friedrich Altmann; Iain Wilson; Herta Steinkellner |
| A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50% homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having β1,2-xylosyltransferase activity or being complementary thereto. | ||||||
| 5 | Arabidopsis from β1,2- xylosyltransferase gene | JP2001563590 | 2001-03-02 | JP5279976B2 | 2013-09-04 | ヨーゼフ・グレッスル; リヒャルト・シュトラッサー; ヤン・ムハ; ルーカス・マッハ; フリードリッヒ・アルトマン; イアン・ビー・ウィルソン; ヘルタ・シュタインケルナー |
| Recombinant glycoproteins, obtainable by a method wherein the recombinant glycoproteins are expressed in plants or in cells, wherein the expression of ²1, 2-xylosyltranferase is suppressed or completely blocked so that the peptide sequence of the glycoprotein has less than 50%, particulary less than 20%, particularly 0% of ²1, 2-bound xylose residues present in proteins expressed in non-xylosyl-transferase reduced plant systems. Preferably, said recombinant glycoprotein is characterized in that it is a human protein, especially a human protein for medical use. | ||||||
| 6 | Arabidopsis from β1,2- xylosyltransferase gene | JP2001563590 | 2001-03-02 | JP2004500096A | 2004-01-08 | イアン・ビー・ウィルソン; フリードリッヒ・アルトマン; ヘルタ・シュタインケルナー; ヤン・ムハ; ヨーゼフ・グレッスル; リヒャルト・シュトラッサー; ルーカス・マッハ |
| 塩基対２２７〜塩基対１８３１のオープンリーディングフレームを有する配列番号：８で示される配列、または上記配列と少なくとも５０％の相同性を有するかもしくはストリンジェント条件下で上記配列とハイブリダイズする配列、または遺伝子コードのため上記ＤＮＡ配列と縮重した配列を含む、β１，２−キシロシルトランスフェラーゼ活性を有する植物タンパク質をコードする配列またはそれと相補的な配列を含むＤＮＡ分子を提供する。 | ||||||
| 7 | β1,2-XYLOSYLTRANSFERASE-GENE FROM ARABIDOPSIS | JP2013005404 | 2013-01-16 | JP2013116113A | 2013-06-13 | GLOESSL JOSEF; STRASSER RICHARD; MUCHA JAN; MACH LUKAS; ALTMANN FRIEDRICH; WILSON IAIN B; STEINKELLNER HERTA |
| PROBLEM TO BE SOLVED: To prepare vectors comprising the gene or an altered DNA or a DNA derived therefrom after cloning and sequencing the whole gene which codes for a plant β1,2-xylosyltransferase, and to transfect plants as well as cells thereof with one of these vectors for producing glycoproteins without containing the normally occurring β1,2-xylose, as well as providing corresponding methods therefor.SOLUTION: There is provided a DNA molecule which comprises a specified base sequence having an open reading frame or having at least 50% homology to the sequence, or hybridizing with the sequence under stringent conditions, or comprising a sequence which has degenerated to the DNA sequence because of the genetic code, the sequence coding for a plant protein having β1,2-xylosyltransferase activity or being complementary thereto. There are provided transgenic plants or methods for producing plant cells. | ||||||
| 8 | Glycoproteins produced in plants with suppressed expression of beta 1, 2-xylosyltransferase | EP05108014.1 | 2001-03-02 | EP1621633B1 | 2014-04-16 | Glössl, Josef, Universität für Bodenkultur Wien; Steinkellner, Herta, Univ. für Bodenkultur Wien; Wilson, Iain B., Universität für Bodenkultur Wien; Altmann, Friedrich, Universität für Bodenkultur Wien; Mach, Lukas, Universität für Bodenkultur Wien; Mucha, Jan, Universität für Bodenkultur Wien; Strasser, Richard, Univ. für Bodenkultur Wien |
| 9 | Glycoproteins produced in plants with suppressed expression of beta 1, 2-xylosyltransferase | EP05108014.1 | 2001-03-02 | EP1621633A3 | 2006-02-08 | Glössl, Josef, Universität für Bodenkultur Wien; Steinkellner, Herta, Univ. für Bodenkultur Wien; Wilson, Iain B., Universität für Bodenkultur Wien; Altmann, Friedric Universität für Bodenkultur Wien; Mach, Lukas, Universität für Bodenkultur Wien; Mucha, Jan, Universität für Bodenkultur Wien; Strasser, Richard, Univ. für Bodenkultur Wien |
Recombinant glycoproteins, obtainable by a method wherein the recombinant glycoproteins are expressed in plants or in cells, wherein the expression of β1, 2-xylosyltranferase is suppressed or completely blocked so that the peptide sequence of the glycoprotein has less than 50%, particulary less than 20%, particularly 0% of β1, 2-bound xylose residues present in proteins expressed in non-xylosyl-transferase reduced plant systems. |
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| 10 | BETA 1, 2-XYLOSYLTRANSFERASE-GENE FROM ARABIDOPSIS | EP01919367.1 | 2001-03-02 | EP1263968B2 | 2014-09-10 | GLÖSSL, Josef, c/o Zentrum für Angewandte; STRASSER, Richard, c/o Zentrum für Angewandte; MUCHA, Jan, c/o Zentrum für Angewandte; MACH, Lukas, c/o Zentrum für Angewandte; ALTMANN, Friedrich, c/o Institut für Chemie; WILSON, Iain, B., c/o Institut für Chemie; STEINKELLNER, Herta, c/o Zentrum für Angewandte |
| 11 | Glycoproteins produced in plants with suppressed expression of beta 1, 2-xylosyltransferase | EP05108014.1 | 2001-03-02 | EP1621633A2 | 2006-02-01 | Glössl, Josef, Universität für Bodenkultur Wien; Steinkellner, Herta, Univ. für Bodenkultur Wien; Wilson, Iain B., Universität für Bodenkultur Wien; Altmann, Friedric Universität für Bodenkultur Wien; Mach, Lukas, Universität für Bodenkultur Wien; Mucha, Jan, Universität für Bodenkultur Wien; Strasser, Richard, Univ. für Bodenkultur Wien |
Recombinant glycoproteins, obtainable by a method wherein the recombinant glycoproteins are expressed in plants or in cells, wherein the expression of β1, 2-xylosyltranferase is suppressed or completely blocked so that the peptide sequence of the glycoprotein has less than 50%, particulary less than 20%, particularly 0% of β1, 2-bound xylose residues present in proteins expressed in non-xylosyl-transferase reduced plant systems. |
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| 12 | BETA 1, 2-XYLOSYLTRANSFERASE-GENE FROM ARABIDOPSIS | EP01919367.1 | 2001-03-02 | EP1263968B1 | 2005-12-14 | GLÖSSL, Josef, c/o Zentrum für Angewandte; STRASSER, Richard, c/o Zentrum für Angewandte; MUCHA, Jan, c/o Zentrum für Angewandte; MACH, Lukas, c/o Zentrum für Angewandte; ALTMANN, Friedrich, c/o Institut für Chemie; WILSON, Iain, B., c/o Institut für Chemie; STEINKELLNER, Herta, c/o Zentrum für Angewandte |
| A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50 % homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having β1,2-xylosyltransferase activity or being complementary thereto. | ||||||
| 13 | BETA 1, 2-XYLOSYLTRANSFERASE-GENE FROM ARABIDOPSIS | EP01919367.1 | 2001-03-02 | EP1263968A1 | 2002-12-11 | GLÖSSL, Josef,c/o Zentrum für Angewandte; STRASSER, Richard,c/o Zentrum für Angewandte; MUCHA, Jan,c/o Zentrum für Angewandte; MACH, Lukas,c/o Zentrum für Angewandte; ALTMANN, Friedrich,c/o Institut für Chemie; WILSON, Iain, B.,c/o Institut für Chemie; STEINKELLNER, Herta,c/o Zentrum für Angewandte |
| A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50 % homology to the above-indicated sequence, or hybridizing with the above-indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having β1,2-xylosyltransferase activity or being complementary thereto. | ||||||
| 14 | 인간화 저-만노스형 엔-당질 합성 식물 및 이의 용도 | KR1020140100010 | 2014-08-04 | KR1020160016276A | 2016-02-15 | 이균오; 유재용; 고기성; 이상열 |
| 본발명은인간화된저-만노스형엔-당질을포함하는단백질을생산하는식물체및 이를이용한인간화된맞춤형저-만노스형엔-당질을포함하는단백질의생산방법에관한것이다. 본발명에따른식물체는알파1,3-퓨코실트랜스퍼레이즈 I(), 알파1,3-퓨코실트랜스퍼레이즈 II(), 베타1,2-자일로실트랜스퍼레이즈() 및 N-아세틸글루코사미닐트랜스퍼레이즈 II() 유전자에 T-DNA가삽입되어상기효소의기능을상실하고, 인간유래알파1,6-퓨코실트랜스퍼레이즈() 유전자를도입하여상기효소의기능을가짐으로써, 인간화된맞춤형저-만노스형엔-당질을포함하는단백질을생산할수 있다. 따라서본 발명에따른저-만노스형엔-당질을포함하는단백질은대식세포표적화/리소좀축적질환의단백질치료제로서, 만노스말단을가지는당단백질의약품등에이용될수 있으므로단백질의약품분야에서유용하게이용될수 있다. | ||||||
| 15 | 아라비돕시스로부터의 베타1,2-크실로실트랜스퍼라제-유전자 | KR1020087019207 | 2001-03-02 | KR1020080077296A | 2008-08-21 | 그뢰슬,요세프; 스트라세르,리차드; 무카,잔; 마크,루카스; 알트만,프리드리히; 윌슨,아인,비.; 스타인켈너,헤르타 |
| A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50 % homology to the above-indicated sequence, or hybridizing with the above- indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having beta1,2- xylosyltransferase activity or being complementary thereto. | ||||||
| 16 | 아라비돕시스로부터의 베타 1,2-크실로실트랜스퍼라제-유전자 | KR1020107023909 | 2001-03-02 | KR101185123B1 | 2012-09-21 | 그뢰슬,요세프; 스트라세르,리차드; 무카,잔; 마크,루카스; 알트만,프리드리히; 윌슨,아인,비.; 스타인켈너,헤르타 |
| 염기쌍 227로부터 염기쌍 1831까지 개방 판독 프레임을 갖거나, 상기 서열에 50% 이상의 상동성을 갖거나, 엄격한 조건하에 상기 서열과 잡종을 형성하거나, 유전 코드 때문에 상기 지시된 DNA 서열에 따라 변성된 서열을 포함하는 SEQ ID NO:8에 따른 서열을 포함하는 DNA 분자가 제공되며, 서열 코딩은 β1,2-크실로실트랜스퍼라제 활성을 갖거나 그것에 상보적인 식물 단백질을 위한 것이다.
|
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| 17 | 아라비돕시스로부터의 베타1,2-크실로실트랜스퍼라제-유전자 | KR1020027011341 | 2001-03-02 | KR100861437B1 | 2008-10-02 | 그뢰슬,요세프; 스트라세르,리차드; 무카,잔; 마크,루카스; 알트만,프리드리히; 윌슨,아인,비.; 스타인켈너,헤르타 |
| 염기쌍 227로부터 염기쌍 1831까지 개방 판독 프레임을 갖거나, 상기 서열에 50% 이상의 상동성을 갖거나, 엄격한 조건하에 상기 서열과 잡종을 형성하거나, 유전 코드 때문에 상기 지시된 DNA 서열에 따라 변성된 서열을 포함하는 SEQ ID NO:8에 따른 서열을 포함하는 DNA 분자가 제공되며, 서열 코딩은 β1,2-크실로실트랜스퍼라제 활성을 갖거나 그것에 상보적인 식물 단백질을 위한 것이다. | ||||||
| 18 | 아라비돕시스로부터의 베타1,2-크실로실트랜스퍼라제-유전자 | KR1020077011024 | 2001-03-02 | KR1020070058018A | 2007-06-07 | 그뢰슬,요세프; 스트라세르,리차드; 무카,잔; 마크,루카스; 알트만,프리드리히; 윌슨,아인,비.; 스타인켈너,헤르타 |
| A DNA molecule is provided which comprises a sequence according to SEQ ID NO: 8 having an open reading frame from base pair 227 to base pair 1831 or having at least 50 % homology to the above-indicated sequence, or hybridizing with the above- indicated sequence under stringent conditions, or comprising a sequence which has degenerated to the above-indicated DNA sequence because of the genetic code, the sequence coding for a plant protein having beta1,2- xylosyltransferase activity or being complementary thereto. | ||||||
| 19 | 아라비돕시스로부터의 베타1,2-크실로실트랜스퍼라제-유전자 | KR1020027011341 | 2001-03-02 | KR1020030030987A | 2003-04-18 | 그뢰슬,요세프; 스트라세르,리차드; 무카,잔; 마크,루카스; 알트만,프리드리히; 윌슨,아인,비.; 스타인켈너,헤르타 |
| 염기쌍 227로부터 염기쌍 1831까지 개방 판독 프레임을 갖거나, 상기 서열에 50% 이상의 상동성을 갖거나, 엄격한 조건하에 상기 서열과 잡종을 형성하거나, 유전 코드 때문에 상기 지시된 DNA 서열에 따라 변성된 서열을 포함하는 SEQ ID NO:8에 따른 서열을 포함하는 DNA 분자가 제공되며, 서열 코딩은 β1,2-크실로실트랜스퍼라제 활성을 갖거나 그것에 상보적인 식물 단백질을 위한 것이다. | ||||||
| 20 | 인간화 저-만노스형 엔-당질 합성 식물 및 이의 용도 | KR1020140100010 | 2014-08-04 | KR101606918B1 | 2016-03-28 | 이균오; 유재용; 고기성; 이상열 |
| 본발명은인간화된저-만노스형엔-당질을포함하는단백질을생산하는식물체및 이를이용한인간화된맞춤형저-만노스형엔-당질을포함하는단백질의생산방법에관한것이다. 본발명에따른식물체는알파1,3-퓨코실트랜스퍼레이즈 I(), 알파1,3-퓨코실트랜스퍼레이즈 II(), 베타1,2-자일로실트랜스퍼레이즈() 및 N-아세틸글루코사미닐트랜스퍼레이즈 II() 유전자에 T-DNA가삽입되어상기효소의기능을상실하고, 인간유래알파1,6-퓨코실트랜스퍼레이즈() 유전자를도입하여상기효소의기능을가짐으로써, 인간화된맞춤형저-만노스형엔-당질을포함하는단백질을생산할수 있다. 따라서본 발명에따른저-만노스형엔-당질을포함하는단백질은대식세포표적화/리소좀축적질환의단백질치료제로서, 만노스말단을가지는당단백질의약품등에이용될수 있으므로단백질의약품분야에서유용하게이용될수 있다. | ||||||
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