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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	生产邻氨基苯甲酸和/或盐的重组菌株和经2-氨基苯甲酸从可再生资源发酵生产苯胺	CN201580019598.1	2015-02-19	CN106414714A	2017-02-15	G.耶格; J.马格努斯; A.S.穆萨; G.奥尔夫; G.洛利; S.贝恩肯; J-W.尹; M.雅尔法尼; G.施普伦格
本发明提供了能够将包含可发酵碳底物的原料生物转化为邻氨基苯甲酸和/或盐的重组微生物宿主细胞。本发明还提供了生产苯胺的方法，其包括步骤：a）使用能够将包含至少一种可发酵的碳底物的原料生物转化为邻氨基苯甲酸和/或盐的重组微生物宿主细胞，通过发酵所述包含至少一种可发酵的碳底物的原料来生产邻氨基苯甲酸和/或盐，其中所述邻氨基苯甲酸和/或盐包含邻氨基苯甲酸阴离子，b）通过酸质子化将所述邻氨基苯甲酸和/或盐从所述邻氨基苯甲酸阴离子转化为邻氨基苯甲酸，c）通过沉淀或通过溶解于有机溶剂回收所述邻氨基苯甲酸，和d）通过在有机溶剂中的热脱羧反应将所述邻氨基苯甲酸转化为苯胺。
2	MICROORGANISMS HAVING L-TRYPTOPHAN PRODUCTIVITY AND A METHOD FOR PRODUCTION OF L-TRYPTOPHAN USING SAME (AS AMENDED)	US14784621	2014-04-16	US20160153014A1	2016-06-02	Hyung Joon Kim; Ju No Jang; Kyung Rim Kim; Keun Cheol Lee; Young Bin Hwang; Hyeong Pyo Hong
The present invention relates to a microorganism of the genus Escherichia having enhanced L-tryptophan productivity, which has been modified to express yeast anthranilate phosphoribosyltransferase in order to be able to produce L-tryptophan at high concentration, and to a method for producing L-tryptophan, comprising a step of culturing the microorganism. The microorganism of the genus Escherichia can produce L-tryptophan, and thus can be advantageously used in the pharmaceutical industry and the feed industry, particularly for animal feed.
3	Production of tryptophan by microorganisms	US627696	1996-03-29	US5939295A	1999-08-17	Mark S. Dunkak; Richard D. Dancey; Thomas W. McMullin; Paul D. Hanke
An improved recombinant DNA plasmid composed of a DNA vector and other DNA fragments containing the tryptophan operon from E. coli, the aroG gene from E. coli and the serA gene from E. coli is shown. The plasmid is transformed into a microorganism belonging to Escherichia coli, and the microorganisms are cultured in a medium and the L-tryptophan accumulated in the culture is recovered.
4	RECOMBINANT STRAIN PRODUCING O-AMINOBENZOATE AND FERMENTATIVE PRODUCTION OF ANILINE FROM RENEWABLE RESOURCES VIA 2-AMINOBENZOIC ACID	US15119825	2015-02-19	US20170152535A1	2017-06-01	Gernot Jaeger; Jorgen Magnus; Amgad Salah Moussa; Guenter Olf; Giulio Lolli; Swantje Behnken; Jung-Won Youn; Mohammad Yalfani; Georg Sprenger
The invention provides a recombinant microbial host cell capable of converting a raw material comprising a fermentable carbon substrate to o-aminobenzoate biologically. The invention further provides a method for producing aniline, comprising the steps of: a) producing o-aminobenzoate by fermentation of a raw material comprising at least one fermentable carbon substrate using the recombinant microbial host cell of the capable of converting said raw material comprising at least one fermentable carbon substrate to o-aminobenzoate biologically, wherein said o-aminobenzoate comprises anthranilate anion, b) converting said o-aminobenzoate from said anthranilate anion to anthranilic acid by acid protonation, c) recovering said anthranilic acid by precipitation or by dissolving in an organic solvent, and d) converting said anthranilic acid to aniline by thermal decarboxylation in an organic solvent.
5	Microorganisms having L-tryptophan productivity and a method for production of L-tryptophan using same	US14784621	2014-04-16	US09562246B2	2017-02-07	Hyung Joon Kim; Ju No Jang; Kyung Rim Kim; Keun Cheol Lee; Young Bin Hwang; Hyeong Pyo Hong
The present invention relates to a microorganism of the genus Escherichia having enhanced L-tryptophan productivity, which has been modified to express yeast anthranilate phosphoribosyltransferase in order to be able to produce L-tryptophan at high concentration, and to a method for producing L-tryptophan, comprising a step of culturing the microorganism. The microorganism of the genus Escherichia can produce L-tryptophan, and thus can be advantageously used in the pharmaceutical industry and the feed industry, particularly for animal feed.
6	L−トリプトファン産生能を有する微生物およびこれを用いてL−トリプトファンを産生する方法	JP2016508868	2014-04-16	JP6177995B2	2017-08-09	キム,ヒュンジュン; チャン,ジュノ; キム,ギョンリム; イ,グンチョル; ファン,ヨンビン; ホン,ヒョンピョ

7	Ｌ−トリプトファン産生能を有する微生物およびこれを用いてＬ−トリプトファンを産生する方法	JP2016508868	2014-04-16	JP2016515400A	2016-05-30	ジュンキム，ヒュン; ノチャン，ジュ; リムキム，ギョン; チョルイ，グン; ビンファン，ヨン; ピョホン，ヒョン
本発明は、高濃度にてL−トリプトファンを産生するために、酵母由来のアントラニル酸ホスホリボシル転移酵素を発現するように変形された、L−トリプトファン産生能が向上したエシェリキア属微生物および前記微生物を培養するステップを含むL−トリプトファンの産生方法に関する。前記遺伝子組み換え大腸菌は、L−トリプトファンを高い歩留まりにて産生することができて医薬および薬学産業、飼料産業において、特に、動物飼料のために有効に使用可能である。
8	MICROORGANISM HAVING L-TRYPTOPHAN PRODUCTIVITY AND METHOD FOR PRODUCTION OF L-TRYPTOPHAN USING SAME	EP14785937	2014-04-16	EP2987854A4	2016-12-14	KIM HYUNG JOON; JANG JU NO; KIM KYUNG RIM; LEE KEUN CHEOL; HWANG YOUNG BIN; HONG HYEONG PYO

9	MICROORGANISM HAVING L-TRYPTOPHAN PRODUCTIVITY AND METHOD FOR PRODUCTION OF L-TRYPTOPHAN USING SAME	EP14785937.5	2014-04-16	EP2987854A1	2016-02-24	KIM, Hyung Joon; JANG, Ju No; KIM, Kyung Rim; LEE, Keun Cheol; HWANG, Young Bin; HONG, Hyeong Pyo
The present invention relates to a microorganism of the genus Escherichia having enhanced L-tryptophan productivity, which has been modified to express yeast anthranilate phosphoribosyltransferase in order to be able to produce L-tryptophan at high concentration, and to a method for producing L-tryptophan, comprising a step of culturing the microorganism. The microorganism of the genus Escherichia can produce L-tryptophan, and thus can be advantageously used in the pharmaceutical industry and the feed industry, particularly for animal feed.
10	MICROORGANISM HAVING L-TRYPTOPHAN PRODUCTIVITY AND METHOD FOR PRODUCTION OF L-TRYPTOPHAN USING SAME	EP14785937.5	2014-04-16	EP2987854B1	2017-09-27	KIM, Hyung Joon; JANG, Ju No; KIM, Kyung Rim; LEE, Keun Cheol; HWANG, Young Bin; HONG, Hyeong Pyo

11	RECOMBINANT STRAIN PRODUCING O-AMINOBENZOATE AND FERMENTATIVE PRODUCTION OF ANILINE FROM RENEWABLE RESOURCES VIA 2-AMINOBENZOIC ACID	EP15705036.0	2015-02-19	EP3108015A1	2016-12-28	JAEGER, Gernot; MAGNUS, Jorgen; MOUSSA, Amgad Salah; OLF, Günter; LOLLI, Giulio; BEHNKEN, Swantje; YOUN, Jung-Won; YALFANI, Mohammad; SPRENGER, Georg
The invention provides a recombinant microbial host cell capable of converting a raw material comprising a fermentable carbon substrate to o-aminobenzoate biologically. The invention further provides a method for producing aniline, comprising the steps of: a) producing o-aminobenzoate by fermentation of a raw material comprising at least one fermentable carbon substrate using the recombinant microbial host cell of the capable of converting said raw material comprising at least one fermentable carbon substrate to o-aminobenzoate biologically, wherein said o-aminobenzoate comprises anthranilate anion, b) converting said o-aminobenzoate from said anthranilate anion to anthranilic acid by acid protonation, c) recovering said anthranilic acid by precipitation or by dissolving in an organic solvent, and d) converting said anthranilic acid to aniline by thermal decarboxylation in an organic solvent.
12	L-트립토판 생산능을 갖는 미생물 및 이를 이용하여 L-트립토판을 생산하는 방법	KR1020140045650	2014-04-16	KR101530817B1	2015-06-25	김형준; 장준호; 김경림; 이근철; 황영빈; 홍형표
본발명은고농도로 L-트립토판을생산할수 있도록하기위해서, 효모유래의안트라닐산포스포리보실전이효소를발현하도록변형된 L-트립토판생산능이향상된에스케리키아속 미생물및 상기미생물을배양하는단계를포함하는 L-트립토판생산방법에관한것이다. 상기유전자재조합대장균은 L-트립토판을고수율로생산할수 있어의약및 약학산업, 사료산업에서, 특히동물사료를위해유용하게사용될수 있다.
13	o-아미노벤조에이트를 생산하는 재조합 균주, 및 2-아미노벤조산을 통한 재생 가능 자원으로부터의 아닐린의 발효적 생산	KR1020167025310	2015-02-19	KR1020160123351A	2016-10-25	자에거,게르노트; 마그누스,요르겐; 모우사,암가트사라; 올프,귄터; 롤리,기울리오; 벤켄,스반트예; 연,정-원; 얄파니,모함마트; 스프렌거,게오르크
본발명은발효성탄소기질을포함하는원료를생물학적으로 o-아미노벤조에이트로전환시킬수 있는재조합미생물숙주세포를제공한다. 본발명은추가로, a) 적어도하나의발효성탄소기질을포함하는원료를생물학적으로 o-아미노벤조에이트로전환시킬수 있는재조합미생물숙주세포를이용하여적어도하나의발효성탄소기질을포함하는원료를발효시킴으로써 o-아미노벤조에이트를생산하는단계 (여기서, 상기 o-아미노벤조에이트는안트라닐레이트음이온을포함한다); b) 산양성자부가에의해상기 o-아미노벤조에이트를상기안트라닐레이트음이온에서안트라닐산으로전환시키는단계, c) 상기안트라닐산을유기용매에용해시키거나또는침전시킴으로써회수하는단계, 및 d) 유기용매에서열 탈카르복실화함으로써상기안트라닐산을아닐린으로전환시키는단계를포함하는, 아닐린의생산방법을제공한다.
14	L-트립토판 생산능을 갖는 미생물 및 이를 이용하여 L-트립토판을 생산하는 방법	KR1020140045650	2014-04-16	KR1020140125314A	2014-10-28	김형준; 장준호; 김경림; 이근철; 황영빈; 홍형표
본발명은고농도로 L-트립토판을생산할수 있도록하기위해서, 효모유래의안트라닐산포스포리보실전이효소를발현하도록변형된 L-트립토판생산능이향상된에스케리키아속 미생물및 상기미생물을배양하는단계를포함하는 L-트립토판생산방법에관한것이다. 상기유전자재조합대장균은 L-트립토판을고수율로생산할수 있어의약및 약학산업, 사료산업에서, 특히동물사료를위해유용하게사용될수 있다.

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