| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 一种诱导制备胸苷磷酸化酶的方法及应用 | CN201510096101.8 | 2015-03-04 | CN104630173A | 2015-05-20 | 邱蔚然; 杜卫群; 邱志云; 马志娟; 冯璐; 周长林; 易凤炎; 王欢 |
| 本发明涉及生物工程领域，具体涉及一种诱导制备胸苷磷酸化酶的方法及应用。其特征是：将作为TPase酶源的微生物在加入了诱导物的固体培养基上培养，然后再接入液体培养基摇瓶培养，即得，所述的诱导物胸苷类的嘧啶核苷，胸苷类嘧啶核苷能使TPase的酶活性得到显著提高。 | ||||||
| 2 | 合成膜−レシーバー複合体 | JP2016533105 | 2014-11-12 | JP2017504568A | 2017-02-09 | アバク カーベジアン，; ジョルディ マタ−フィンク，; ジョン ラウンド，; デイビッド エー． ベリー，; ノーバー ビー． アフェヤン， |
| 合成膜−レシーバー複合体を含む組成物、合成膜−レシーバー複合体の作成方法、及びそれによって疾患、障害又は病態を治療又は予防する方法。一部の態様において、本明細書には、標的自己抗体の循環濃度を低減する方法が開示される。本方法は、自己抗体媒介性疾患、障害又は病態に罹患しているか又はそれを発症するリスクがあるヒト対象に、合成膜−レシーバーポリペプチド複合体を含む医薬組成物を投与するステップを含み、ここで医薬組成物は、標的自己抗体の循環濃度を実質的に低減するのに有効な量で投与される。 | ||||||
| 3 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | EP14824599.6 | 2014-11-12 | EP3071515A2 | 2016-09-28 | KAHVEJIAN, Avak; MATA-FINK, Jordi; ROUND, John; BERRY, David A.; AFEYAN, Noubar B. |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 4 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US15900029 | 2018-02-20 | US20180187154A1 | 2018-07-05 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 5 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US15899895 | 2018-02-20 | US20180187153A1 | 2018-07-05 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 6 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US14738414 | 2015-06-12 | US20150306212A1 | 2015-10-29 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 7 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US15940215 | 2018-03-29 | US20180216067A1 | 2018-08-02 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 8 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US15925212 | 2018-03-19 | US20180208897A1 | 2018-07-26 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 9 | Synthetic membrane-receiver complexes | US14738414 | 2015-06-12 | US09644180B2 | 2017-05-09 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 10 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US15940069 | 2018-03-29 | US20180265847A1 | 2018-09-20 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 11 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US15824877 | 2017-11-28 | US20180119101A1 | 2018-05-03 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 12 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US15783921 | 2017-10-13 | US20180030411A1 | 2018-02-01 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 13 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US15473421 | 2017-03-29 | US20170369843A1 | 2017-12-28 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 14 | GENETICALLY ENGINEERED ENUCLEATED ERYTHROID CELLS COMPRISING A PHENYLALANINE AMMONIA LYASE RECEIVER POLYPEPTIDE | US15157006 | 2016-05-17 | US20160257932A1 | 2016-09-08 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| A genetically engineered enucleated erythroid cell comprises a phenylalanine ammonia lyase receiver polypeptide that is not associated with the membrane of the erythroid cell, produced by genetically engineering the cell by viral transduction, RNA transfection, or RNA electroporation. | ||||||
| 15 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | US14581486 | 2014-12-23 | US20150182588A1 | 2015-07-02 | Avak Kahvejian; Jordi Mata-Fink; John Round; David Arthur Berry; Noubar B. Afeyan |
| Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
| 16 | TP expression-inhibiting compound and siRNA sequence thereof | US12484858 | 2009-06-15 | US08110675B2 | 2012-02-07 | Lih-Chyang Chen; Yu-Sun Chang |
| The present invention discloses a TP expression-inhibiting compound and a TP expression-inhibiting siRNA sequence, wherein a siRNA sequence partially or completely complementary to the sequence of TP is used to inhibit TP expression, whereby is effectively reduced the survival rate of cancer cells in an anoxic environment. | ||||||
| 17 | TP EXPRESSION-INHIBITING COMPOUND AND SIRNA SEQUENCE THEREOF | US12484858 | 2009-06-15 | US20100317839A1 | 2010-12-16 | Lih-Chyang CHEN; Yu-Sun Chang |
| The present invention discloses a TP expression-inhibiting compound and a TP expression-inhibiting siRNA sequence, wherein a siRNA sequence partially or completely complementary to the sequence of TP is used to inhibit TP expression, whereby is effectively reduced the survival rate of cancer cells in an anoxic environment. | ||||||
| 18 | SYNTHETIC MEMBRANE-RECEIVER COMPLEXES | PCT/US2014065304 | 2014-11-12 | WO2015073587A3 | 2015-08-06 | KAHVEJIAN AVAK; MATA-FINK JORDI; ROUND JOHN; BERRY DAVID A; AFEYAN NOUBAR B |
| Compositions comprising synthetic membrane -receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith. | ||||||
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