| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Benzylisoquinoline alkaloids (BIA) producing microbes, and methods of making and using the same | US14211611 | 2014-03-14 | US09534241B2 | 2017-01-03 | Christina D. Smolke; Catherine Thodey; Isis Trenchard; Stephanie Galanie |
| Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention. | ||||||
| 2 | BENZYLISOQUINOLINE ALKALOIDS (BIA) PRODUCING MICROBES, AND METHODS OF MAKING AND USING THE SAME | US14211611 | 2014-03-14 | US20140273109A1 | 2014-09-18 | Christina D. Smolke; Catherine Thodey; Isis Trenchard; Stephanie Galanie |
| Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention. | ||||||
| 3 | Benzylisoquinoline alkaloids (BIA) producing microbes, and methods of making and using the same | US15360763 | 2016-11-23 | US10017799B2 | 2018-07-10 | Christina D. Smolke; Catherine Thodey; Isis Trenchard; Stephanie Galanie |
| Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention. | ||||||
| 4 | Polypeptides Having Berberine Bridge Enzyme Like Activity and Polynucleotides Encoding Same | US14375402 | 2013-01-29 | US20150152455A1 | 2015-06-04 | Kirk Matthew Schnorr; Junxin Duan; Lars Kiemer; Hong Zhi Huang |
| Provided are isolated polypeptides having Berberine Bridge Enzyme Like activity, catalytic domains, FAD binding domains and polynucleotides encoding the polypeptides, catalytic domains or FAD binding domains. The nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or FAD binding domains are also provided. | ||||||
| 5 | BENZYLISOQUINOLINE ALKALOIDS (BIA) PRODUCING MICROBES, AND METHODS OF MAKING AND USING THE SAME | US15978005 | 2018-05-11 | US20180334695A1 | 2018-11-22 | Christina D. Smolke; Catherine Thodey; Isis Trenchard; Stephanie Galanie |
| Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention. | ||||||
| 6 | BENZYLISOQUINOLINE ALKALOIDS (BIA) PRODUCING MICROBES, AND METHODS OF MAKING AND USING THE SAME | US15360763 | 2016-11-23 | US20170145454A1 | 2017-05-25 | Christina D. Smolke; Catherine Thodey; Isis Trenchard; Stephanie Galanie |
| Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention. | ||||||
| 7 | ベンジルイソキノリンアルカロイド（ＢＩＡ）産生微生物、ならびにそれらを作製および使用する方法 | JP2016502637 | 2014-03-14 | JP2016512046A | 2016-04-25 | クリスティーナ ディー． スモルク; キャサリーン ソーデイ; イシス トレンチャード; ステファニー ギャラニー |
| 本発明の局面は、ベンジルイソキノリンアルカロイド(BIA)を産生するように操作された宿主細胞を含む。宿主細胞は、出発化合物からBIAへの宿主細胞の合成経路に関与する様々な酵素の異種コード配列を含む。また、宿主細胞の異種コード配列によってコードされる酵素の発現を促進する培養条件下で宿主細胞を培養することによって、関心対象のBIAを産生する方法も提供される。本発明の局面は、本発明の方法に使用される構成物、例えば宿主細胞、出発化合物、およびキット等をさらに含む。 | ||||||
| 8 | POLYPEPTIDES HAVING BERBERINE BRIDGE ENZYME LIKE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME | EP13743709 | 2013-01-29 | EP2809778A4 | 2015-08-05 | SCHNORR KIRK MATTHEW; DUAN JUNXIN; KIEMER LARS |
| 9 | BENZYLISOQUINOLINE ALKALOIDS (BIA) PRODUCING MICROBES, AND METHODS OF MAKING AND USING THE SAME | EP14729501.8 | 2014-03-14 | EP2970999A2 | 2016-01-20 | SMOLKE, Christina D.; THODEY, Catherine; TRENCHARD, Isis; GALANIE, Stephanie |
| Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention. | ||||||
| 10 | POLYPEPTIDES HAVING BERBERINE BRIDGE ENZYME LIKE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME | EP13743709.1 | 2013-01-29 | EP2809778A1 | 2014-12-10 | SCHNORR, Kirk Matthew; DUAN, Junxin; KIEMER, Lars |
| Provided are isolated polypeptides having Berberine Bridge Enzyme Like activity, catalytic domains, FAD binding domains and polynucleotides encoding the polypeptides, catalytic domains or FAD binding domains. The nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains or FAD binding domains are also provided. | ||||||
| 11 | BENZYLISOQUINOLINE ALKALOIDS (BIA) PRODUCING MICROBES, AND METHODS OF MAKING AND USING THE SAME | PCT/US2014027833 | 2014-03-14 | WO2014143744A2 | 2014-09-18 | SMOLKE CHRISTINA D; THODEY CATHERINE; TRENCHARD ISIS; GALANIE STEPHANIE |
| Aspects of the invention include host cells that are engineered to produce benzylisoquinoline alkaloids (BIAs). The host cells include heterologous coding sequences for a variety of enzymes involved in synthetic pathways from starting compounds to BIAs of the host cell. Also provided are methods of producing the BIAs of interest by culturing the host cells under culture conditions that promote expression of enzymes encoded by the heterologous coding sequences of the host cells. Aspects of the invention further include compositions, e.g., host cells, starting compounds and kits, etc., that find use in methods of the invention. | ||||||
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