| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 半合成抗生素生产中的类MbtH蛋白 | CN201380007614.6 | 2013-01-28 | CN104093831A | 2014-10-08 | 乌尔里克·玛丽亚·穆勒尔; 瑞蒙·鲍尔; 鲁洛夫·阿利·兰斯·伯韦比格 |
| 本发明涉及制备β-内酰胺抗生素的方法，其中所述方法包括以下步骤：在类MbtH蛋白存在时，将4-羟苯基甘氨酸或苯基甘氨酸、半胱氨酸和缬氨酸与非核糖体肽合成酶接触，随后使用异青霉素N合成酶环化。本发明还涉及能够完成所述制备的宿主细胞。 | ||||||
| 2 | MBTH-LIKE PROTEINS IN THE PRODUCTION OF SEMI SYNTHETIC ANTIBIOTICS | US15252636 | 2016-08-31 | US20160362715A1 | 2016-12-15 | Ulrike Maria MUELLER; Rémon BOER; Roelof Ary Lans BOVENBERG |
| The present invention relates to the preparation of β-lactam antibodies comprising contacting 4-hydroxyphenylglycine of phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation. | ||||||
| 3 | MBTH-LIKE PROTEINS IN THE PRODUCTION OF SEMI SYNTHETIC ANTIBIOTICS | US14374137 | 2013-01-28 | US20140349340A1 | 2014-11-27 | Ulrike Maria Mueller; Rémon Boer; Roelof Ary Lans Bovenberg |
| The present invention relates to the preparation of β-lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation. | ||||||
| 4 | MBTH-LIKE PROTEINS IN THE PRODUCTION OF SEMI SYNTHETIC ANTIBIOTICS | EP13702014.5 | 2013-01-28 | EP2809777A1 | 2014-12-10 | MUELLER, Ulrike Maria; BOER, Rémon; BOVENBERG, Roelof, Ary, Lans |
| The present invention relates to the preparation of &bgr;-lactam antibiotics comprising contacting 4-hydroxyphenylglycine or phenylglycine, cysteine and valine with a non-ribosomal peptide synthetase and subsequent cyclization using an isopenicillin N synthase in the presence of an MbtH-like protein and to a host cell equipped to perform such preparation. | ||||||
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