| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 包含磷酸酮醇酶的重组宿主细胞 | CN201180039718.6 | 2011-06-16 | CN103140584A | 2013-06-05 | M.道纳; L.A.马吉奥-霍尔; J-F.汤布 |
| 本发明涉及重组宿主细胞，其包含：（i）编码多肽的内源性基因中的至少一个缺失、突变或替换，所述多肽将丙酮酸转化为乙醛、乙酰-磷酸或乙酰-CoA；和（ii）编码具有磷酸酮醇酶活性的多肽的异源性多核苷酸。本发明也涉及重组宿主细胞，其还包含（iii）编码具有磷酸转乙酰酶活性的多肽的异源性多核苷酸。 | ||||||
| 2 | Recombinant host cells comprising phosphoketolases | US13161168 | 2011-06-15 | US08871488B2 | 2014-10-28 | Michael Dauner; Lori Ann Maggio-Hall; Jean-Francois Tomb |
| The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | ||||||
| 3 | RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES | US13161168 | 2011-06-15 | US20120156735A1 | 2012-06-21 | Michael Dauner; Lori Ann Maggio-Hall; Jean-Francois Tomb |
| The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | ||||||
| 4 | Recombinant Host Cells Comprising Phosphoketalase | US15375858 | 2016-12-12 | US20170088863A1 | 2017-03-30 | Michael Dauner; Lori Ann Maggio-Hall; Jean-Francois Tomb |
| The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | ||||||
| 5 | Recombinant host cells comprising phosphoketolases | US14335734 | 2014-07-18 | US09550999B2 | 2017-01-24 | Michael Dauner; Lori Ann Maggio-Hall; Jean-Francois Tomb |
| The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate, or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | ||||||
| 6 | Process for the Bioconversion of Butane to 1-Butanol | US14908656 | 2014-07-21 | US20160168597A1 | 2016-06-16 | Michael Breuer; Boris Breitscheidel; Hans-Günter Wagner; Detlef Kratz; Bernhard Hauer; Daniel Scheps; Bernd Nebel |
| A process for preparing 1-butanol from butane by incubating a host organism having a functional P153 enzyme under elevated butane pressure in the presence of oxygen. | ||||||
| 7 | RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES | US14335734 | 2014-07-18 | US20140349349A1 | 2014-11-27 | MICHAEL DAUNER; Lori Ann Maggio-Hall; Jean-Francois Tomb |
| The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate, or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | ||||||
| 8 | Recombinant host cells comprising phosphoketalase | US15375858 | 2016-12-12 | US10006058B2 | 2018-06-26 | Michael Dauner; Lori Ann Maggio-Hall; Jean-Francois Tomb |
| The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | ||||||
| 9 | Process for the Bioconversion of C3-C13 Alkanes to C3-C13 Primary Alcohols | US14908293 | 2014-07-21 | US20160201093A1 | 2016-07-14 | Michael Breuer; Boris Breitscheidel; Hans-Günter Wagner; Detlef Kratz; Bernhard Hauer; Daniel Scheps; Bernd Nebel |
| A process for preparing linear or branched primary alcohols with 3 to 13 carbon atoms from linear or branched alkanes with 3 to 13 carbon atoms by incubating a host organism having a functional P153 enzyme under elevated pressure in the presence of oxygen. | ||||||
| 10 | PROCESS FOR THE BIOCONVERSION OF C3-C13 ALKANES TO C3-C 13 PRIMARY ALCOHOLS | EP14744296.6 | 2014-07-21 | EP3027760A1 | 2016-06-08 | BREUER, Michael; BREITSCHEIDEL, Boris; WAGNER, Hans-Günter; KRATZ, Detlef; HAUER, Bernhard; SCHEPS, Daniel; NEBEL, Bernd |
| A process for preparing linear or branched primary alcohols with 3 to 13 carbon atoms from linear or branched alkanes with 3 to 13 carbon atoms by incubating a host organism having a functional P153 enzyme under elevated pressure in the presence of oxygen. | ||||||
| 11 | RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES | EP11727094.2 | 2011-06-16 | EP2593552B1 | 2017-02-15 | DAUNER, Michael; MAGGIO-HALL, Lori, Ann; TOMB, Jean-Francois |
| The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | ||||||
| 12 | PROCESS FOR THE BIOCONVERSION OF BUTANE TO 1-BUTANOL | EP14741872.7 | 2014-07-21 | EP3027759A1 | 2016-06-08 | BREUER, Michael; BREITSCHEIDEL, Boris; WAGNER, Hans-Günter; KRATZ, Detlef; HAUER, Bernhard; SCHEPS, Daniel; NEBEL, Bernd |
| A process for preparing 1-butanol from butane by incubating a host organism having a functional P153 enzyme under elevated butane pressure in the presence of oxygen. | ||||||
| 13 | RECOMBINANT HOST CELLS COMPRISING PHOSPHOKETOLASES | EP11727094.2 | 2011-06-16 | EP2593552A1 | 2013-05-22 | DAUNER, Michael; MAGGIO-HALL, Lori, Ann; TOMB, Jean-Francois |
| The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate to acetaldehyde, acetyl-phosphate or acetyl-CoA; and (ii) a heterologous polynucleotide encoding a polypeptide having phosphoketolase activity. The present invention is also related to recombinant host cells further comprising (iii) a heterologous polynucleotide encoding a polypeptide having phosphotransacetylase activity. | ||||||
| 14 | 포스포케톨라아제를 포함하는 재조합 숙주 세포 | KR1020137001252 | 2011-06-16 | KR1020130117753A | 2013-10-28 | 다우너,마이클; 마지오-할,로리,앤; 툼,장-프랑수와 |
| 본 발명은 (i) 피루베이트를 아세트알데하이드, 아세틸-포스페이트 또는 아세틸-CoA로 전환시키는 폴리펩타이드를 인코딩하는 내인성 유전자에서의 하나 이상의 결실, 돌연변이, 및/또는 치환; 및 (ii) 포스포케톨라아제 활성을 갖는 폴리펩타이드를 인코딩하는 이종성 폴리뉴클레오타이드를 포함하는 재조합 숙주 세포에 관한 것이다. 본 발명은 또한, (iii) 포스포트랜스아세틸라아제 활성을 갖는 폴리펩타이드를 인코딩하는 이종성 폴리뉴클레오타이드를 추가로 포함하는 재조합 숙주 세포에 관한 것이다.
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