| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | METHOD OF PRODUCING (-)-ROTUNDONE | US15609260 | 2017-05-31 | US20170356059A1 | 2017-12-14 | Kuniki KINO; Toshiki FURUYA |
| The present invention provides a method of producing (−)-rotundone from α-guaiene. The method includes the steps of: (1) allowing a cytochrome P450 protein to act on α-guaiene, which cytochrome P450 belongs to the CYP152 family and is capable of oxidizing the methylene group at position 3 of α-guaiene to the carbonyl group; and/or (2) allowing a cytochrome P450 protein to act on α-guaiene in the presence of an electron transfer protein capable of transferring electrons to the cytochrome P450 protein, which cytochrome P450 belongs to the CYP152, CYP106, or CYP107 family and is capable of oxidizing the methylene group at position 3 of α-guaiene to the carbonyl group. | ||||||
| 2 | METHOD OF PRODUCING (-)-ROTUNDONE | EP17174027.7 | 2017-06-01 | EP3255151A2 | 2017-12-13 | Kino, Kuniki; Furuya, Toshiki |
The present invention provides a method of producing (-)-rotundone from α-guaiene. The method includes the steps of: (1) allowing a cytochrome P450 protein to act on α-guaiene, which cytochrome P450 belongs to the CYP152 family and is capable of oxidizing the methylene group at position 3 of α-guaiene to the carbonyl group; and/or (2) allowing a cytochrome P450 protein to act on α-guaiene in the presence of an electron transfer protein capable of transferring electrons to the cytochrome P450 protein, which cytochrome P450 belongs to the CYP152, CYP106, or CYP107 family and is capable of oxidizing the methylene group at position 3 of α-guaiene to the carbonyl group. |
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| 3 | METHOD OF PRODUCING (-)-ROTUNDONE | EP17174027.7 | 2017-06-01 | EP3255151A3 | 2018-02-21 | Kino, Kuniki; Furuya, Toshiki |
The present invention provides a method of producing (-)-rotundone from α-guaiene. The method includes the steps of: (1) allowing a cytochrome P450 protein to act on α-guaiene, which cytochrome P450 belongs to the CYP152 family and is capable of oxidizing the methylene group at position 3 of α-guaiene to the carbonyl group; and/or (2) allowing a cytochrome P450 protein to act on α-guaiene in the presence of an electron transfer protein capable of transferring electrons to the cytochrome P450 protein, which cytochrome P450 belongs to the CYP152, CYP106, or CYP107 family and is capable of oxidizing the methylene group at position 3 of α-guaiene to the carbonyl group. |
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| 4 | (−)−ロタンドンの製造方法 | JP2016116213 | 2016-06-10 | JP2017216974A | 2017-12-14 | 木野 邦器; 古屋 俊樹 |
| 【課題】 (−)−ロタンドンを高効率かつ高純度で製造する方法を提供する。 【解決手段】 シトクロムP450をα−グアイエンに作用させる工程、またはシトクロムP450を、該シトクロムP450に電子を伝達する活性を有する電子伝達タンパク質の共存下でα−グアイエンに作用させる工程を含む、(−)−ロタンドンを製造する方法とする。 【選択図】 なし |
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