| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Acid-tolerant yeast cell, method of producing organic acid using the same, and method of producing the yeast cell | US15222646 | 2016-07-28 | US10053714B2 | 2018-08-21 | Hunsu Chu; Hwayoung Cho; Jinhwan Park; Dongsik Yang; Hongsoon Rhee; Kwangmyung Cho |
| Provided is an acid-tolerant yeast cell, a method of producing an organic acid by using the yeast cell, and a method of producing the yeast cell resistant to acid. | ||||||
| 2 | ACID-TOLERANT YEAST CELL, METHOD OF PRODUCING ORGANIC ACID USING THE SAME, AND METHOD OF PRODUCING THE YEAST CELL | US15222646 | 2016-07-28 | US20170029853A1 | 2017-02-02 | Hunsu Chu; Hwayoung Cho; Jinhwan Park; Dongsik Yang; Hongsoon Rhee; Kwangmyung Cho |
| Provided is an acid-tolerant yeast cell, a method of producing an organic acid by using the yeast cell, and a method of producing the yeast cell resistant to acid. | ||||||
| 3 | VARIANTS OF YEAST NDI1 GENE, AND USES THEREOF IN THE TREATMENT OF DISEASE ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION | US14367004 | 2012-12-21 | US20150099798A1 | 2015-04-09 | Gwyneth Jane Farrar; Sophia Millington-Ward; Naomi Chadderton; Mathew Alan Carrigan; Paul Kenna |
| An isolated nucleic acid sequence encoding the yeast NDI1 protein of SEQ ID NO: 542 or a functional variant thereof is described. The nucleic acid sequence comprises at least 50 codons which are codon optimised compared with the sequence of yeast NDI1 gene of SEQ ID NO: 1. | ||||||
| 4 | ACID-TOLERANT YEAST CELL, METHOD OF PRODUCING ORGANIC ACID USING THE SAME, AND METHOD OF PRODUCING THE YEAST CELL | EP16180739.1 | 2016-07-22 | EP3124604A3 | 2017-04-05 | CHU, Hunsu; CHO, Hwayoung; PARK, Jinhwan; YANG, Dongsik; RHEE, Hongsoon; CHO, Kwangmyung |
Provided are an acid-tolerant yeast cell, a method of producing an organic acid by using the yeast cell, and a method of producing the yeast cell resistant to acid.
|
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| 5 | 내산성을 갖는 효모 세포, 그를 이용하여 유기산을 생산하는 방법 및 상기 내산성 효모 세포를 생산하는 방법 | KR1020150106771 | 2015-07-28 | KR1020170013711A | 2017-02-07 | 추헌수; 조화영; 박진환; 양동식; 이홍순; 조광명 |
| 내산성을갖는효모세포, 그를이용하여유기산을생산하는방법및 상기내산성효모세포를생산하는방법을제공한다. | ||||||
| 6 | HOST CELLS FOR DICARBOXYLIC ACID PRODUCTION | EP16825761.6 | 2016-12-22 | EP3394251A1 | 2018-10-31 | LOS, Alrik Pieter; ZHAO, Zheng; VERWAAL, René; PRONK, Jacobus Thomas; POLDERMANS, Rolf |
| The present invention relates to a host cell which is capable of producing a dicarboxylic acid and which comprises at least one genetic modification in its genome resulting in the deficiency of at least one enzymatic step catalysing the oxidation of a cofactor. The invention also relates to a process for producing a dicarboxylic acid, which method comprises fermenting such a host cell in a suitable fermentation medium and producing the dicarboxylic acid. | ||||||
| 7 | VARIANTS OF YEAST NDI1 GENE, AND USES THEREOF IN THE TREATMENT OF DISEASE ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION | EP12818508.9 | 2012-12-21 | EP2794642B1 | 2018-07-04 | FARRAR, Gwyneth Jane; MILLINGTON-WARD, Sophia; CHADDERTON, Naomi; CARRIGAN, Mathew Alan; KENNA, Paul |
| A nucleic acid sequence encoding the yeast NDI1 protein of SEQ ID NO: 542 or a functional variant thereof having at least 90% sequence identity with SEQ ID NO: 2 is described. The nucleic acid sequence comprises at least 50 codons which are codon optimised compared with the sequence of yeast NDI1 gene of SEQ ID NO: 1. An immune optimised functional variant of the yeast NDI1 protein of SEQ ID NO: 542 having at least 90% sequence identity with SEQ ID NO: 542 is also described, and includes at least one amino acid change selected from the group consisting of L194F, K283E, K9R, S142N, L501M, L402I, A386S, S85K, F89H, L93M, K195E, L18M, K213E, K372E, L258F, K510E, L158M, R478Q, L482M. | ||||||
| 8 | ACID-TOLERANT YEAST CELL, METHOD OF PRODUCING ORGANIC ACID USING THE SAME, AND METHOD OF PRODUCING THE YEAST CELL | EP16180739.1 | 2016-07-22 | EP3124604A2 | 2017-02-01 | CHU, Hunsu; CHO, Hwayoung; PARK, Jinhwan; YANG, Dongsik; RHEE, Hongsoon; CHO, Kwangmyung |
Provided are an acid-tolerant yeast cell, a method of producing an organic acid by using the yeast cell, and a method of producing the yeast cell resistant to acid.
|
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| 9 | VARIANTS OF YEAST NDI1 GENE, AND USES THEREOF IN THE TREATMENT OF DISEASE ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION | EP12818508.9 | 2012-12-21 | EP2794642A2 | 2014-10-29 | FARRAR, Gwyneth Jane; MILLINGTON-WARD, Sophia; CHADDERTON, Naomi; CARRIGAN, Mathew Alan; KENNA, Paul |
| A nucleic acid sequence encoding the yeast NDI1 protein of SEQ ID NO: 542 or a functional variant thereof having at least 90% sequence identity with SEQ ID NO: 2 is described. The nucleic acid sequence comprises at least 50 codons which are codon optimised compared with the sequence of yeast NDI1 gene of SEQ ID NO: 1. An immune optimised functional variant of the yeast NDI1 protein of SEQ ID NO: 542 having at least 90% sequence identity with SEQ ID NO: 542 is also described, and includes at least one amino acid change selected from the group consisting of L194F, K283E, K9R, S142N, L501M, L402I, A386S, S85K, F89H, L93M, K195E, L18M, K213E, K372E, L258F, K510E, L158M, R478Q, L482M. | ||||||
| 10 | Variants of yeast NDI1 gene, and uses thereof in the treatment of disease associated with mitochondrial dysfunction. | EP11194796.6 | 2011-12-21 | EP2607375A1 | 2013-06-26 | Farrar, Gwyneth Jane; Millington-Ward, Sophia; Chadderton, Naomi |
A nucleic acid sequence encoding the yeast NDI1 protein of SEQ ID NO: 542 or a functional variant thereof having at least 90% sequence identity with SEQ ID NO: 2 is described. The nucleic acid sequence comprises at least 50 codons which are codon optimised compared with the sequence of yeast NDI1 gene of SEQ ID NO: 1. An immune optimised functional variant of the yeast NDI1 protein of SEQ ID NO: 542 having at least 90% sequence identity with SEQ ID NO: 542 is also described, and includes at least one amino acid change selected from the group consisting of L194F, K283E, K9R, S142N, L501M, L402I, A386S, S85K, F89H, L93M, K195E, L18M, K213E, K372E, L258F, K510E, L158M, R478Q, L482M. |
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| 11 | VARIANTS OF YEAST NDI1 GENE, AND USES THEREOF IN THE TREATMENT OF DISEASE ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION | PCT/EP2012076697 | 2012-12-21 | WO2013093029A2 | 2013-06-27 | FARRAR GWYNETH JANE; MILLINGTON-WARD SOPHIA; CHADDERTON NAOMI; CARRIGAN MATHEW ALAN; KENNA PAUL |
| An isolated nucleic acid sequence encoding the yeast NDI1 protein of SEQ ID NO: 542 or a functional variant thereof is described. The nucleic acid sequence comprises at least 50 codons which are codon optimised compared with the sequence of yeast NDI1 gene of SEQ ID NO: 1. | ||||||
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