| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | OBLIGATELY ANAEROBIC ACETIC ACID-PRODUCING MICROORGANISM, AND RECOMBINANT MICROORGANISM | US16335377 | 2017-09-05 | US20190233854A1 | 2019-08-01 | Kana MATSUSHIMA; Masahiro FURUTANI; Kazufumi KAWABATA |
| Provided is a modified obligately anaerobic acetogen in which activity of at least one enzyme selected from the group consisting of a restriction enzyme, a modification enzyme, and a recognition enzyme constituting a type I restriction modification system enzyme is deleted or suppressed. Preferably, the activity of at least the restriction enzyme is deleted or suppressed. The obligately anaerobic acetogen is preferably a Clostridium bacterium or a Moorella bacterium, and particularly preferably Clostridium ljungdahlii. | ||||||
| 2 | RECOMBINANT CELL, AND METHOD FOR PRODUCING ISOPRENE | US14437034 | 2013-10-22 | US20150284742A1 | 2015-10-08 | Masahiro Furutani; Akihiro Uenishi; Koichiro Iwasa; Stefan Jennewein; Rainer Fischer |
| To provide a series of techniques capable of producing isoprene from syngas or the like.Provided is a recombinant cell prepared by introducing a nucleic acid encoding isoprene synthase into a host cell having an isopentenyl diphosphate synthesis ability by a non-mevalonate pathway, wherein the nucleic acid is expressed in the host cell, and the recombinant cell is capable of producing isoprene from at least one C1 compound selected from the group consisting of carbon monoxide, carbon dioxide, formic acid, and methanol. As the host cell, a Clostridium bacterium or a Moorella bacterium is exemplified. Also provided is a method for producing isoprene using the recombinant cell. | ||||||
| 3 | Method of thermostabilization of a protein and/or stabilization towards organic solvents | US13604094 | 2012-09-05 | US20130102763A1 | 2013-04-25 | Jiri DAMBORSKY; Zbynek PROKOP; Tana KOUDELAKOVA; Veronika STEPANKOVA; Radka CHALOUPKOVA; Eva CHOVANCOVA; Artur Wiktor GORA; Jan BREZOVSKY |
| Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function. | ||||||
| 4 | 組換え細胞、並びに、イソプレンの生産方法 | JP2014543301 | 2013-10-22 | JP6375227B2 | 2018-08-15 | 古谷 昌弘; 上西 章太; 岩佐 航一郎; ステファン ジュナヴァイン; ライナー フィッシャー |
| 5 | 組換え細胞、並びに、イソプレンの生産方法 | JP2014543301 | 2013-10-22 | JPWO2014065271A1 | 2016-09-08 | 古谷 昌弘; 昌弘 古谷; 章太 上西; 航一郎 岩佐; ジュナヴァイン ステファン; フィッシャー ライナー |
| 合成ガス等からイソプレンを生産することができる一連の技術を提供することを目的とする。非メバロン酸経路によるイソペンテニル二リン酸合成能を有する宿主細胞に、イソプレン合成酵素をコードする核酸が導入されてなり、当該核酸が前記宿主細胞内で発現し、一酸化炭素、二酸化炭素、ギ酸、及びメタノールからなる群より選ばれた少なくとも1つのC1化合物からイソプレンを生産可能である組換え細胞が提供される。宿主細胞としてClostridium属細菌又はMoorella属細菌が例示される。当該組換え細胞を用いたイソプレンの生産方法も提供される。 | ||||||
| 6 | CO HYDRATASE AND METHOD FOR PREPARING FORMIC ACID BY USING SAME | EP17722365 | 2017-01-05 | EP3216862A4 | 2018-07-04 | KIM YONG HWAN; MIN KYOUNGSEON; YEON YOUNG JOO; CHO DAE HAENG; JANG MIN GEE; CHOI EUN-GYU; HWANG HO WON |
| Provided are CO hydratase and a method for producing formate using the same, and more specifically, to CO hydratase which is a novel enzyme which is produced by linking CO dehydrogenase (CODH) and CO 2 reductase and can directly convert CO into formate, and use thereof. | ||||||
| 7 | RECOMBINANT CELL AND PRODUCTION METHOD FOR ISOPRENE | EP13848830 | 2013-10-22 | EP2913392A4 | 2016-06-22 | FURUTANI MASAHIRO; UENISHI AKIHIRO; IWASA KOICHIRO; JENNEWEIN STEFAN; FISCHER RAINER |
| To provide a series of techniques capable of producing isoprene from syngas or the like. Provided is a recombinant cell prepared by introducing a nucleic acid encoding isoprene synthase into a host cell having an isopentenyl diphosphate synthesis ability by a non-mevalonate pathway, wherein the nucleic acid is expressed in the host cell, and the recombinant cell is capable of producing isoprene from at least one C1 compound selected from the group consisting of carbon monoxide, carbon dioxide, formic acid, and methanol. As the host cell, a Clostridium bacterium or a Moorella bacterium is exemplified. Also provided is a method for producing isoprene using the recombinant cell. | ||||||
| 8 | CO HYDRATASE AND METHOD FOR PRODUCING FORMATE USING THE SAME | US15526303 | 2017-01-05 | US20180073042A1 | 2018-03-15 | Yong Hwan Kim; Kyoungseon Min; Young Joo Yeon; Dae Haeng Cho; Min Gee Jang; Eun-Gyu Choi; Ho Won Hwang |
| Provided are CO hydratase and a method for producing formate using the same, and more specifically, to CO hydratase which is a novel enzyme which is produced by linking CO dehydrogenase (CODH) and CO2 reductase and can directly convert CO into formate, and use thereof. | ||||||
| 9 | Recombinant cell, and method for producing isoprene | US14437034 | 2013-10-22 | US09783828B2 | 2017-10-10 | Masahiro Furutani; Akihiro Uenishi; Koichiro Iwasa; Stefan Jennewein; Rainer Fischer |
| To provide a series of techniques capable of producing isoprene from syngas or the like.Provided is a recombinant cell prepared by introducing a nucleic acid encoding isoprene synthase into a host cell having an isopentenyl diphosphate synthesis ability by a non-mevalonate pathway, wherein the nucleic acid is expressed in the host cell, and the recombinant cell is capable of producing isoprene from at least one C1 compound selected from the group consisting of carbon monoxide, carbon dioxide, formic acid, and methanol. As the host cell, a Clostridium bacterium or a Moorella bacterium is exemplified. Also provided is a method for producing isoprene using the recombinant cell. | ||||||
| 10 | Method of thermostabilization of a protein and/or stabilization towards organic solvents | US13604094 | 2012-09-05 | US08580932B2 | 2013-11-12 | Jiri Damborsky; Zbynek Prokop; Tana Koudelakova; Veronika Stepankova; Radka Chaloupkova; Eva Chovancova; Artur Wiktor Gora; Jan Brezovsky |
| Thermostabilization of a protein where the protein contains access routes and wherein at least one amino acid in the bottleneck of the access route is mutated, includes identifying the amino acids of the bottleneck and the amino acids control exchange of the solvent between a buried protein core and surrounding environment and/or in the packing of the amino acids inside the access route. Modification of the amino acids are determined so that the packing of the amino acids inside the tunnel is improved and the access route prevents access of undesired solvent molecules to the protein core, while allowing passage of the compounds necessary at the protein core to enable the protein to perform its biological function. | ||||||
| 11 | Methods to Enhance Carbon Monoxide Dehydrogenase Activity and Uses Thereof | US11884522 | 2006-02-16 | US20090155875A1 | 2009-06-18 | David A. Berry; Robert S. Langer; Richard J. Resnick |
| This invention relates, in part, to methods and compositions for modulating the water-gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water-gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention. | ||||||
| 12 | Compositions and methods for the prevention, treatment and detection of tuberculosis and other diseases | US10265190 | 2002-10-07 | US20030108927A1 | 2003-06-12 | Kathryn Leishman |
| Methods and compositions are provided for the prevention and treatment of infectious diseases such as syphilis, tuberculosis, pneumonia, other bacterial infections, AIDS, and other viral infections. Many of the compositions are active against carbon monoxide dehydrogenase (nullCODHnull), and include substances such as antigens, antibodies specific for CODH, and other inhibitors of CODH such as nickel and molybdenum metal chelators. The methods and compositions are particularly suited for treatment of diseases from previously under recognized anaerobic or facultative anaerobic pathogens such as Mycobacterium tuberculosis and Mycobacterium pneumonia. | ||||||
| 13 | CO HYDRATASE AND METHOD FOR PREPARING FORMIC ACID BY USING SAME | EP17722365.8 | 2017-01-05 | EP3216862A1 | 2017-09-13 | KIM, Yong Hwan; MIN, Kyoungseon; YEON, Young Joo; CHO, Dae Haeng; JANG, Min Gee; CHOI, Eun-Gyu; HWANG, Ho Won |
Provided are CO hydratase and a method for producing formate using the same, and more specifically, to CO hydratase which is a novel enzyme which is produced by linking CO dehydrogenase (CODH) and CO2 reductase and can directly convert CO into formate, and use thereof. |
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| 14 | RECOMBINANT CELL AND PRODUCTION METHOD FOR ISOPRENE | EP13848830.9 | 2013-10-22 | EP2913392A1 | 2015-09-02 | FURUTANI, Masahiro; UENISHI, Akihiro; IWASA, Koichiro; JENNEWEIN, Stefan; FISCHER, Rainer |
To provide a series of techniques capable of producing isoprene from syngas or the like. Provided is a recombinant cell prepared by introducing a nucleic acid encoding isoprene synthase into a host cell having an isopentenyl diphosphate synthesis ability by a non-mevalonate pathway, wherein the nucleic acid is expressed in the host cell, and the recombinant cell is capable of producing isoprene from at least one C1 compound selected from the group consisting of carbon monoxide, carbon dioxide, formic acid, and methanol. As the host cell, a Clostridium bacterium or a Moorella bacterium is exemplified. Also provided is a method for producing isoprene using the recombinant cell. |
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| 15 | 재조합 세포, 및 이소프렌의 생산 방법 | KR1020157010718 | 2013-10-22 | KR1020150072410A | 2015-06-29 | 후루따니,마사히로; 우에니시,아끼히로; 이와사,고이찌로; 옌네바인,스테판; 피셔,라이너 |
| 본발명은합성가스등으로부터이소프렌을생산할수 있는일련의기술을제공하는것을목적으로한다. 비메발론산경로에의한이소펜테닐이인산합성능을갖는숙주세포에, 이소프렌합성효소를코딩하는핵산이도입되어이루어지고, 당해핵산이상기숙주세포내에서발현하며, 일산화탄소, 이산화탄소, 포름산및 메탄올로이루어지는군에서선택된적어도하나의 C1 화합물로부터이소프렌을생산가능한재조합세포가제공된다. 숙주세포로서클로스트리디움속세균또는무렐라속세균이예시된다. 당해재조합세포를사용한이소프렌의생산방법도제공된다. | ||||||
| 16 | 대장균 내 과발현 가능한 Pantoea species YR343 유래 호기성 일산화탄소-탈수소효소(carbon monoxide dehydrogenase, PsCODH)를 코딩하는 재조합 벡터, 재조합 PsCODH의 과발현 방법 및 PsCODH를 이용하여 철강 제조 공정에서 발생한 CO(carbon monoxide) 포함 폐가스를 전환하는 방법 | KR1020160148877 | 2016-11-09 | KR101826207B1 | 2018-02-06 | 김용환; 민경선; 최은실; 권인찬 |
| 본발명에따른재조합벡터는서열번호 1의아미노산서열을가지는폴리펩티드를코딩하는유전자; 서열번호 2의아미노산서열을가지는폴리펩티드를코딩하는유전자; 및서열번호 3의아미노산서열을가지는폴리펩티드를코딩하는유전자; 를포함하고, 상기및폴리펩티드는서로결합하여호기성일산화탄소-탈수소효소(aerobic carbon monoxide dehydrogenase; CODH)를만든다. | ||||||
| 17 | 합성가스를 이용하는 다탄소 화합물 생산용 균주 및 다탄소 화합물의 생산방법 | KR1020130110905 | 2013-09-16 | KR1020150031562A | 2015-03-25 | 장인섭; 박신영 |
| The present invention relates to a strain, which uses a synthesis gas as a carbon source and produces an organic acid as a by-product. According to the present invention, an oscillibactersp._whose accession number is KCTC 12249BP uses a synthesis gas as a matrix and accordingly produces C5 of isovaleric acid, compared with an existing acetogen for producing C2 or C4 of carbon compounds, thereby expanding the range of producing biochemical compounds. | ||||||
| 18 | METHODS TO ENHANCE CARBON MONOXIDE DEHYDROGENASE ACTIVITY AND USES THEREOF | PCT/US2006005797 | 2006-02-16 | WO2006089206A3 | 2007-02-22 | BERRY DAVID A; LANGER ROBERT S; RESNICK RICHARD J |
| This invention relates, in part, to methods and compositions for modulating the water- gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water- gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention. | ||||||
| 19 | METHODS TO ENHANCE CARBON MONOXIDE DEHYDROGENASE ACTIVITY AND USES THEREOF | PCT/US2006005797 | 2006-02-16 | WO2006089206A9 | 2006-12-14 | BERRY DAVID A; LANGER ROBERT S; RESNICK RICHARD J |
| This invention relates, in part, to methods and compositions for modulating the water- gas shift reaction (e.g., promoting the water-gas shift forward reaction) or in which the water- gas shift reaction has been modulated. The methods and compositions, therefore, also relate, in part, to increasing the oxidation rate of carbon monoxide (CO), for increasing the availability of CO (e.g., to the carbon monoxide dehydrogenase (CODH) enzyme complex), for removing and/or promoting the release of hydrogen and/or carbon dioxide (CO2), for regulating the redox potential of cells, for preventing free radical damage and/or promoting cell survivability, etc. The invention also relates, in part, to methods and compositions for modulating CODH activity, such as increasing CODH activity. Methods and compositions are also provided for modulating the PSII reaction (e.g., promoting the PSII forward reaction) or in which the PSII reaction has been modulated. The modulation of the PSII reaction can be in conjunction with the modulation of the water-gas shift reaction. The invention also relates, in part, to methods and compositions for modulating PSII activity, such as increasing PSII activity. The invention further relates to uses of the aforementioned methods and compositions. For example, methods and compositions are provided for the production of hydrogen and/or for the elimination of CO. The methods and compositions provided can be used for a variety of industrial and medical applications, and such applications are also provided as part of the invention. | ||||||
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