| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | 制备2－脱氧核糖5－磷酸的方法 | CN02805786.4 | 2002-02-26 | CN1494596A | 2004-05-05 | 清水昌; 小川顺 |
| 本发明披露了在微生物本身或衍生自所述微生物的酶存在下，反应甘油醛3－磷酸和乙醛来制备2－脱氧核糖5－磷酸的方法；所述微生物包含2－脱氧核糖5－磷酸醛缩酶但基本上不含磷酸酶。本发明也披露了在微生物本身或衍生自所述微生物的酶存在下，反应二羟丙酮磷酸和乙醛来制备2－脱氧核糖5－磷酸的方法；所述微生物包含2－脱氧核糖5－磷酸醛缩酶和丙糖磷酸异构酶，但基本上不含磷酸酶。 | ||||||
| 22 | 生产L－谷氨酸的细菌和生产L－谷氨酸的方法 | CN99105593.4 | 1999-03-18 | CN1233661A | 1999-11-03 | 守屋美加; 泉井裕; 小野荣治; 松井和彦; 伊藤久生; 原吉彦 |
| 生产L－谷氨酸的方法,包括在培养基中培养属于克雷伯氏菌属,欧文氏菌属或泛菌属并且具有生产L－谷氨酸能力的微生物,并且从该培养基中收集产生的L－谷氨酸。所使用的微生物菌株优选的是催化L－谷氨酸生物合成途径的分支反应并且产生不是L－谷氨酸的化合物的酶的活性减少或缺乏,或催化L－谷氨酸生物合成反应的酶的活性增加的菌株。 | ||||||
| 23 | Compositions and methods for the treatment of microbial infections | JP2003567189 | 2003-02-13 | JP2005516631A | 2005-06-09 | ジョン バルケアック、; ジリ ピリッチ、 |
| The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an effective amount of bacterial lysate compositions for the treatment of pathological conditions of microbial infections. The present invention can also be used to enhance the immune system to prevent infections by the administration of an effective amount of the compositions. | ||||||
| 24 | 工業的生産に有用な微生物 | JP2003502196 | 2002-05-29 | JPWO2002099086A1 | 2004-09-16 | 英郎 森; 達郎 藤尾; 雅夫 西原 |
| 本発明は、通性嫌気性を示す微生物において、嫌気的な生育のみに必要な1以上の遺伝子を欠失または不活性化させた微生物、該微生物を用いた、タンパク質、アミノ酸、核酸、ビタミン、糖、有機酸、脂質あるいはそれらの類縁体等の有用物質の好気的な製造法に関する。 | ||||||
| 25 | Production method of N- acetylmannosamine by biotechnology | JP2000602750 | 2000-03-03 | JP2002537797A | 2002-11-12 | ハインツマン・クラウス; ピーターセン・ミヒャエル |
| (57)【要約】 本発明はＮ−アセチルマンノサミンの存在下にＮ−アセチルグルコサミンを急速に代謝することができる性質を有する微生物、及びこの微生物の使用下にＮＡＭ及びＮＡＧからなる混合物から出発してＮＡＭをバイオテクノロジーにより製造する方法を開示する。 | ||||||
| 26 | Biotechnological preparation of cyclic s-alpha-aminocarboxylic acid and r-alpha-aminocarboxamide | JP14068495 | 1995-06-07 | JPH0856652A | 1996-03-05 | ANDOREASU KIINAA; JIYANNPOORU RODEYUI; IERUKU KOORU; NIKORASU SHIYOU |
| PURPOSE: To prepare a new microorganism having the ability to convert an (RS)-α-aminocarboxamide into an S-α-aminocarboxylic acid and capable of separating the product in a high enantiomeric purity. CONSTITUTION: This microorganism is capable of utilizing an α- aminocarboxamide in the form of a racemate or its optically active isomer represented by formula I [A together with NH and CH forms a (substituted)5- to 6-membered saturated heterocyclic ring] as a sole nitrogen source and converting the (RS)-α-aminocarboxamide represented by formula I into an S-α- aminocarboxylic acid represented by formula II and preferably belongs to the genus Klebsiella or Pseudomonas. COPYRIGHT: (C)1996,JPO | ||||||
| 27 | Preparation of bioactive fraction and ittcontaining medicine | JP15765376 | 1976-12-28 | JPS5282713A | 1977-07-11 | JIIN SHIYOEI; MIREIYU SAKOUI NEE KUUZAN |
| A biologically active fraction of reduced toxicity or substantially free of it formed of components having molecular weights not exceeding 10,000-12,000, capable of stimulating in vivo the resistance to bacterial infections, is obtained from bacteria, more particularly Gram-negative bacteria. | ||||||
| 28 | Compositions and methods for the treatment of microbial infections | JP2003567189 | 2003-02-13 | JP4304077B2 | 2009-07-29 | ジョン バルケアック、; ジリ ピリッチ、 |
| The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an effective amount of bacterial lysate compositions for the treatment of pathological conditions of microbial infections. The present invention can also be used to enhance the immune system to prevent infections by the administration of an effective amount of the compositions. | ||||||
| 29 | Biotechnological production method of a cyclic S-α- amino acids and R-α- aminocarboxamides | JP14068495 | 1995-06-07 | JP3694065B2 | 2005-09-14 | キーナー アンドレアス; コール イェルク; ロデュイ ジャン−ポール; ショウ ニコラス |
| Microorganisms capable of (a) utilising racemic or optically active cyclic alpha -amino acid amides of formula (I) as their sole N source and (b) converting (RS)- alpha -amino acid amides of formula (I) to (S)- alpha -amino acids of formula (II) are new. A = an opt. substd. 5- or 6-membered satd. ring. Also claimed is a process for preparing (S)- alpha -amino acids of formula (II) and/or (R)- alpha -amino acid amides of formula (III) from (RS)- alpha -amino acid amides of formula (I), in which the (S)-amide component of (I) is converted to the (S)-acid using a microorganism as above or a cell-free enzyme extract of such a microorganism and the (S)-acid is isolated and the unconverted (R)-amide is opt. isolated. | ||||||
| 30 | Method for producing 2-deoxyribose 5-phosphate | JP2001058902 | 2001-03-02 | JP2002253291A | 2002-09-10 | SHIMIZU AKIRA; OGAWA JUN |
| PROBLEM TO BE SOLVED: To provide an efficient and stable method for producing 2-deoxyribose 5-phosphate. SOLUTION: This method for producing the 2-deoxyribose 5-phosphate comprises reacting glyceraldehyde 3-phosphate with acetaldehyde using a microbial cell of a microorganism containing 2-deoxyribose 5-phosphate aldolase without substantially containing a phosphatase or a yeast derived from the microorganism. Furthermore, the method for producing the 2-deoxyribose 5-phosphate comprises reacting dihydroxyacetone phosphate with acetaldehyde using a microbial cell of a microorganism containing the 2-deoxyribose 5-phosphate aldolase and a triose phosphate isomerase without substantially containing the phosphatase or a yeast derived from the microorganism. | ||||||
| 31 | Novel polysaccharides, their production and pharmaceutical composition containing the same as active ingredients | JP22366088 | 1988-09-08 | JPH01104182A | 1989-04-21 | SERUJIYU KARURU; IBEEMARII PAAJIYU; KURISUCHIINU BUANDERUHOBUAN; NOOMAN MIYUREI; MISHIERU MONSHIINII; FURANSHISU DERUMOOTO; ANNUUKUROODO ROSHIE; KUREIRU PUCHI |
| PURPOSE: To produce a polysaccharide of a specific composition by filtering a bacteriophage-solubilized solution of the culture mixture of one or more kinds of bacteria selected from the group of Escherichia coli and pneumobacilli. CONSTITUTION: The filtrate of a bacteriophage solubilized solution of a culture mixture of bacteria selected from the group of Escherichia coli and pneumobacilli is concentrated. Simultaneously, the filtrate is dialyzed through one or more dialyzing membranes to fractionate the molecules. The extracted polysaccharide solution is extracted by the first chromatography to obtain the first fraction, which is dialyzed and concentrated. The first fraction is further subjected to the second chromatography separation and extraction to collect the first faction. Then, the first fraction from the second chromatography is dried to prepare polysaccharides. This polysaccharides contains 65-75wt.% of neutral polysaccharides and 18-27wt.% of uronic acids and the like. COPYRIGHT: (C)1989,JPO | ||||||
| 32 | Novel sugar protein from klebsiella pneumoniae* method of obtaining it* use as drug and composition containing it | JP10378480 | 1980-07-30 | JPS5622793A | 1981-03-03 | BERUNAARU FUURUNE; RUNE ZARISU |
| Water-soluble glycoproteins extracted from Klebsiella pneumoniae, characterised in that they contain from 10% to 20% of proteins, 50% to 70% of neutral oses, 15% to 25% of glucuronic acid and 1% to 2% of osamines and have a molecular weight of from 80,000 to 350,000 daltons, processes for obtaining them and pharmaceutical compositions containing them are described. The glycoproteins have anti-bacterial and immunostimulant properties. | ||||||
| 33 | Biotechnological process for the preparation of cyclic s-alpha-imino carboxylic acids and r-alpha-imino carboxamides | US614345 | 1996-03-12 | US5766893A | 1998-06-16 | Andreas Kiener; Jean-Paul Roduit; Jorg Kohr; Nicholas Shaw |
| Microorganisms of interest are capable of utilizing .alpha.-imino carboxamides, in the form of the racemate or of its optically active isomers, of the general formula ##STR1## wherein A together with --NH-- and --CH-- is an optionally substituted 5- or 6-membered saturated heterocyclic ring, as sole nitrogen source, and converting (RS)-.alpha.-imino carboxamides of Formula I into an S-.alpha.-imino carboxylic acid of the general formula ##STR2## These microorganisms are useful also for biconversion of an (RS)-.alpha.-imino carboxamide of Formula I into an S-.alpha.-imino carboxylic acid. | ||||||
| 34 | Microorganism for degrading toxic waste materials | US245592 | 1988-09-19 | US5100800A | 1992-03-31 | Charles F. Kulpa; Michael G. Johnston |
| A microorganism is disclosed for degrading toxic waste materials into more environmentally acceptable materials. Processes for utilizing the microorganism in a sequencing batch reactor, and for treating industrial and municipal wastes, such as chemical waste landfill leachate and chemical process wastewater, are also disclosed. | ||||||
| 35 | Microorganism for degrading toxic waste materials | US881767 | 1986-07-03 | US4803166A | 1989-02-07 | Charles F. Kulpa; Michael G. Johnston |
| A microorganism is disclosed for degrading toxic waste materials into more environmentally acceptable materials. Processes for utilizing the microorganism in a sequencing batch reactor, and for treating industrial and municipal wastes, such as chemical waste landfill leachate and chemical process wastewater, are also disclosed. | ||||||
| 36 | Facultatively anaerobic microorganism for degrading toxic waste materials | US881770 | 1986-07-03 | US4761376A | 1988-08-02 | Charles F. Kulpa; Stanley A. Sojka |
| A facultatively anaerobic microorganism of a strain of Klebsiella oxytoca is disclosed for degrading toxic waste materials into more environmentally acceptable materials. Processes for utilizing the microorganism in a sequencing batch reactor, and for treating industrial and municipal wastes, such as chemical waste landfill leachate and chemical process wastewater, are also disclosed. | ||||||
| 37 | Aqueous polysaccharide composition | US864298 | 1977-12-27 | US4186025A | 1980-01-29 | Kenneth S. Kang; George T. Veeder, III; Danny D. Richey |
| A process for producing a heteropolysaccharide by a bacterial fermentation procedure in which a species of bacteria or a mutant thereof is incubated in a fermentation medium which contains a carbon source, preferably a hydrolyxed starch, a source of magnesium ions, a source of phosphorous, a source of nitrogen and water with the incubation taking place at a temperature of about 28.degree. to about 35.degree. C. | ||||||
| 38 | Humectant, antistatic agent, dispersant and film-forming agent having polysaccharide as active principle, preparation process of polysaccharides, and Kliebsiella ocytoca TNM-3 strain | US620285 | 1996-03-22 | US5989874A | 1999-11-23 | Osamu Nakanishi; Yoichi Ooiso; Takeshi Okumiya; Ryosuke Sugihara; Kaoru Kawashima |
| The disclosure describes a humectant, antistatic agent, film-forming agent or dispersant comprising an effective amount of a polysaccharide produced by two strains of Kliebsiella composed of D-glucuronic acid, L-rhamnose, D-galactose and D-glucose in a molar ratio of D-glucuronic acid:L-rhamnose:D-galactose:D-glucose=0.8-1.2:2.4-3.6:0.8-1.2:0.8-1.2. | ||||||
| 39 | Strain of Klebsiella pneumoniae, subsp. pneumoniae, and a process for the production of a polysaccharide containing L-fucose | US875388 | 1997-07-25 | US5876982A | 1999-03-02 | Fran.cedilla.ois Marie Bernard Paul; David Frank Perry; Pierre Frederic Monsan |
| The present invention discloses a new strain of Klebsiella pneumoniae subsp. pneumoniae BEC1000 CNCMI-1507 which produces industrially useful quantities of a polysaccharide containing L-fucose. Also disclosed is a process of producing the polysaccharide using this strain and mutants thereof. The polysaccharide has properties which are particularly useful to the cosmetics industry. | ||||||
| 40 | Biological system for degrading nitroaromatics in water and soils | US545903 | 1995-10-20 | US5616162A | 1997-04-01 | Donald L. Crawford; Todd O. Stevens; Ronald L. Crawford |
| Novel methods for biodegrading nitroaromatic compounds present as contaminants in soil or water using microorganisms are disclosed. Water is treatable directly; dry soil is first converted into a fluid medium by addition of water. The preferred method comprises two stages, each employing microorganisms: a fermentative stage, followed by an anaerobic stage. The fermentative stage is rapid, wherein an inoculum of aerobic and/or facultative microorganisms ferments a carbohydrate added to the fluid medium, exhausting the oxygen in the fluid medium and thereby inhibiting oxidative polymerization of amino by-products of the nitroaromatics. In the subsequent anaerobic stage, an inoculum of a mixed population of anaerobic microorganisms completes the mineralization of the contaminant nitroaromatics, using the remaining carbohydrate as a carbon and energy source. Preferably, the carbohydrate is a starch and the aerobic and/or facultative microorganisms are amylolytic, which cleave the starch at a moderate rate throughout both stages, ensuring a sustained supply of metabolizable carbohydrate. The microorganisms are preferably selected to be resistant to the types and concentrations of nitroaromatics present as contaminants. | ||||||
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