| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | サンプル調製装置 | JP2015518882 | 2013-06-14 | JP6227638B2 | 2017-11-08 | オリヴィア,ステファン; グェドン,ピエール; アラルド,フロリアン |
| 102 | 内蔵型生物学的インジケータ | JP2017035967 | 2017-02-28 | JP2017153476A | 2017-09-07 | ベーナム・アミン |
| 【課題】生物学的滅菌インジケータの提供。 【解決手段】(a)第1のエンクロージャ136と第2のエンクロージャ138とを有するハウジング102と、(b)液体増殖培地を含有するアンプル142で、アンプル142の少なくとも一部が第1のエンクロージャ136内部に配置され、アンプル142と、(c)第1のエンクロージャ136に部分的に配置された挿入部材146で、挿入部材146が、(i)上面、当接面、及び側面を含むプラットフォームと、(ii)プラットフォームに配置され、液体増殖培地の第1の量が第2のエンクロージャ138内へと通過する様に構成された第1の空洞と、(iii)側面の一部を通じて配置され、液体増殖培地の第2の量が第2のエンクロージャ138内へと通過する様に構成された第2の空洞と、を含む、挿入部材146と、を含む、生物学的滅菌インジケータ100。 【選択図】図1 |
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| 103 | 生物学的滅菌インジケーター | JP2013537727 | 2011-10-28 | JP5934231B2 | 2016-06-15 | サイラジャ チャンドラパティ; ヘザー エム.ウェブ; ジェフリー シー.ペダーソン; ジェフリー ディー.スミス; ルーサン アール.デューダ; ブライアン ジェイ.エンジェル |
| 104 | 低温滅菌処理モニタリング用の生物学的インジケータ | JP2015560214 | 2014-02-20 | JP2016508418A | 2016-03-22 | アイム フランソワ; ベンナールス−エイデン アスンプタ; イー．フォルツ ウィリアム; スワミナサン スワーナラサ |
| 滅菌処理の有効性を評価するための物品及び方法が、提供されている。本物品は、内部体積を有する外装容器と、内部体積内に配されている測定可能な生物活性の乾性供給源と、減菌剤化合物を中和するための有効量の乾性薬剤と、を具備し、測定可能な生物活性の供給源及び薬剤の両方が、外装容器の外側にある環境と蒸気連通している。本方法は、物品を第1の減菌剤に曝露させ、任意選択的に第2の減菌剤にしばらくの間曝露させる工程と、測定可能な生物活性を検出する工程と、を含む。 | ||||||
| 105 | Detection method of biological activity | JP2013536855 | 2011-10-28 | JP2013545451A | 2013-12-26 | チャンドラパティ サイラジャ; エム．ウェブ ヘザー; シー．ペダーソン ジェフェリー; ジェイ．ハルバーソン カート; ジェイ．エンジェル ブライアン |
| 本発明は、既定の生物活性を検出する方法を提供する。 本方法は、第１の吸収スペクトルを有する第１の指示試薬と、第２の指示試薬とを含む、水性混合物を使用する工程を含む。 この第２の指示試薬は、既定の生物活性によって、第２の発光スペクトルを有する第２の生物学的誘導体に変換される。 第１の吸光度スペクトルは、第２の発光スペクトル内に存在する波長の少なくとも一部分内に、検出可能な吸光度を含む。 第１の指示試薬は、水性液体から、基材によって受容及び濃縮され、第２の生物学的誘導体の検出を促進する。 | ||||||
| 106 | Removal evaluation method and microbial removal evaluation apparatus of microorganisms | JP2003102054 | 2003-04-04 | JP4142974B2 | 2008-09-03 | 久晴 八木; 哲幸 大谷; 善弘 清水; 和男 西川; 秀雄 野島; 正人 青木 |
| 107 | Method for detecting contamination of bacteria or the like in cell culture tank, and apparatus thereof | JP2006288741 | 2006-10-24 | JP2008104379A | 2008-05-08 | FUKUNAGA SAKAE; WATANABE MASAMI; ISHII KOSUKE; YAMAMURA HAYASHI; NAKAYAMA MAMORU |
| PROBLEM TO BE SOLVED: To provide a method for detecting the contamination of bacteria or the like in a cell culture tank, by which the contamination of the bacteria or the like can be readily detected at low cost, in the initial period in the cell culture tank, and to provide an apparatus thereof. SOLUTION: This method for detecting the contamination of bacteria or the like in the cell culture tank comprises injecting a tracer gas 22, capable of metabolizing only prokaryotes, such as bacteria, into the cell culture tank 10 for animal or plant cells 13 and monitoring the tracer gas 22 evacuated from the cell culture tank 10 with a tracer gas analyzer 23, to detect the contamination of the prokaryotes. COPYRIGHT: (C)2008,JPO&INPIT | ||||||
| 108 | Biological display system | JP7536690 | 1990-03-23 | JP2562221B2 | 1996-12-11 | REIMONDO SHII KURAROBITSUKU |
| 109 | Culture apparatus | JP33836492 | 1992-12-18 | JPH06181737A | 1994-07-05 | YAMAGUCHI SHUJI; MURAKAMI SEI; NAKANO TAKAMORI |
| PURPOSE: To determine the sterilization effect at various parts of a culture apparatus by filling a suspension of indicator microorganism in the apparatus, sterilizing with high-pressure steam, recovering the proliferation medium of the indicator microorganism from each part and determining the growth of bacteria after cultivation. CONSTITUTION: A bacterial strain having strong resistance to high-pressure steam sterilization treatment and free from pathogenicity (e.g. thermostable sporangium) is used as an indicator microorganism and filled together with a culture liquid into a culture apparatus through indicator microorganism filling pipes 14-17. The indicator microorganism is distributed throughout the apparatus by extracting the culture liquid through indicator microorganism recovery pipes 18-21 connected to drain exhaustion ports 10-13. High-pressure steam is blown into the apparatus through steam inlet pipes 6-9 to sterilize the apparatus. The culture liquid is filled into the apparatus through the pipes 14-17, the system is maintained to the state for a prescribed period, the culture liquid is recovered from the system through the pipes 18-21 and the growth of bacteria (or clouding of the medium) is determined by culturing the liquid. COPYRIGHT: (C)1994,JPO&Japio | ||||||
| 110 | Biological indicator system | JP7536690 | 1990-03-23 | JPH02286073A | 1990-11-26 | REIMONDO SHII KURAROBITSUKU |
| PURPOSE: To obtain an indicator system suitable for the use in a liquid sterilizer system by providing a specific sealing means to allow the passage of steam into a capsule containing a culture base and placing a member inoculated with microorganism at a part near the capsule. CONSTITUTION: A capsule 10 is heat-sealed with a breakable sealing means 20, a vent tube 28 is extended from an annular member 24 to a vent hole 30 and the upper surface of a liquid culture base 12 is positioned below the vent hole 30. The vent tube 28 is sealed with a sealing means 32 which is broken at a temperature below the boiling point of the culture base to discharge the vapor from the capsule. A member 24 inoculated with microorganism is provided, a cap 40 is placed in such a manner as to move between a connecting position and a sealed position of the opening 42 and a means 44 far separating the inoculated member 34 is provided. COPYRIGHT: (C)1990,JPO | ||||||
| 111 | Biological indicator for sterilization process | JP918087 | 1987-01-20 | JPS62228147A | 1987-10-07 | PATORITSUKU JIYOSEFU MAKOOMITS; JIYON ROBAATO SUKOBIRU JIYUNIA |
| 112 | BIOLOGICAL INDICATOR | US16001266 | 2018-06-06 | US20180273958A1 | 2018-09-27 | Phillip P. Franciskovich; Tricia A. Cregger; William A. Yirava; Peter A. Burke |
| This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed. | ||||||
| 113 | RECOVERY MEDIUM FOR DETECTION OF MICROORGANISMS BY FLUORESCENCE | US15903212 | 2018-02-23 | US20180245122A1 | 2018-08-30 | Kelly SOTO; Nicholas WHITE; Jennifer AUFMUTH; Sarah SMITH; Kathleen A. FIX; William A. YIRAVA |
| A recovery medium that is particularly suited for following enzymatic reactions where the fluorescent product is excited at a wavelength of 320 to 370 nm and emits at a wavelength of 420 to 460 nm is provided. The recovery medium is clear in color and does not contain the combination of compounds that participate in the Maillard reaction. The recovery medium is suitable for self-contained biological indicator systems. | ||||||
| 114 | Biological sterilization indicator | US15064918 | 2016-03-09 | US10047334B2 | 2018-08-14 | Sailaja Chandrapati; Heather M. Webb; Jeffrey C. Pederson; Jeffrey D. Smith; RuthAnn R. Duda; Brian J. Engel |
| A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity. | ||||||
| 115 | Biological indicator | US15618158 | 2017-06-09 | US10017772B2 | 2018-07-10 | Phillip P. Franciskovich; Tricia A. Cregger; William A. Yirava; Peter A. Burke |
| This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed. | ||||||
| 116 | Biological indicator | US15618156 | 2017-06-09 | US10011843B2 | 2018-07-03 | Phillip P. Franciskovich; Tricia A. Cregger; William A. Yirava; Peter A. Burke |
| This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed. | ||||||
| 117 | Reactor Surface Finish Remediation | US15285656 | 2016-10-05 | US20180094231A1 | 2018-04-05 | Michael Mietzner; Jim Heimbach; Andrew Harris |
| Improved biopharmaceutical processing equipment such as reactor vessels and stainless steel surfaces, and methods of determining the same are disclosed herein. In some embodiments, a biopharmaceutical processing equipment can include a vessel having a surface that is configured to contact proteinaceous processing material, wherein the surface has a pre-commissioning surface roughness of greater than about 20 Ra Max (μin). | ||||||
| 118 | BIOLOGICAL INDICATOR | US15618156 | 2017-06-09 | US20170275631A1 | 2017-09-28 | Phillip P. Franciskovich; Tricia A. Cregger; William A. Yirava; Peter A. Burke |
| This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed. | ||||||
| 119 | BIOLOGICAL INDICATOR FOR MONITORING A LOW-TEMPERATURE STERILIZATION PROCESS | US15601571 | 2017-05-22 | US20170252475A1 | 2017-09-07 | Francois Ahimou; Assumpta Bennaars-Eiden; William E. Foltz; Swarnalatha Swaminathan |
| An article and method are provided for assessing the efficacy of a sterilization process. The article comprises an outer container having an interior volume; a dry source of measurable biological activity disposed in the interior volume; and an effective amount of a dry agent for neutralizing a sterilant compound; wherein both the source of measurable biological activity and the agent are in vapor communication with an environment outside the outer container. The method comprises exposing the article to a first sterilant and, optionally, a second sterilant for a period of time and detecting the measurable biological activity. | ||||||
| 120 | Biological indicator | US15204079 | 2016-07-07 | US09695428B2 | 2017-07-04 | Phillip P. Franciskovich; Tricia A. Cregger; William A. Yirava; Peter A. Burke |
| This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed. | ||||||
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