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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
141	WELL INSERTS WITH BRITTLE MEMBRANES	US15573708	2016-05-10	US20180127694A1	2018-05-10	Silvia ANGELONI SUTER; Kaspar SUTER; Eric MARGUET; Sylvain BERGERAT; Charlotte VOUTAT
Disclosed is a well insert for cell culture, including: a membrane support having an upper end and a lower end, the upper end being adapted to engage a well of a microplate so as to suspend the well insert therein; and a permeable membrane for supporting a tissue culture, the permeable membrane being attached at the lower end of the membrane support and sealed thereto, the permeable membrane being of brittle material. The membrane support is overmolded or fastened on to the permeable membrane so as be sealed thereto.
142	RETROFIT DEVICES FOR BIOREACTORS	US15571313	2016-05-05	US20180112174A1	2018-04-26	William HOLMES; Kenneth LEE; Marcel KUIPER
Disclosed herein are a retrofit device adapted to upgrade bioreactor systems that require at least partially manual addition of liquids, and a method for using the retrofit device with the bioreactor systems. The retrofit device automatically adds the liquids by weight to the bioreactor vessels according to a protocol or procedure. The retrofit device also includes a valve that in the event of power cut-off automatically closes to prevent unintentional addition of liquids.
143	CASSETTE FOR STERILITY TESTING	US15687857	2017-08-28	US20180072975A1	2018-03-15	Robert C. AVILES; Devin T. MICHAUD; Douglas J. BROWNE
The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.
144	Biomanufacturing suite and methods for large-scale production of cells, viruses, and biomolecules	US14424944	2013-08-28	US09902928B2	2018-02-27	Mark Hirschel; Robert J. Wojciechowski; Kim Arneson
The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.
145	Devices, systems, and methods for targeted plating of materials in high-throughput culture plates	US14533373	2014-11-05	US09885012B2	2018-02-06	Robert Dixon Grier, Jr.; Anthony Michael Nicolini; Colin Michael Arrowood; Swaminathan Rajaraman
Devices, systems, and methods for facilitating placement of cells and materials in culture plates configured for high-throughput applications are provided. A culture system is provided with a culture plate having a lid for guiding placement of cells and materials in each individual culture well of a culture plate. The lid may provide for coupling to an electrophysiology culture plate comprising a biosensor plate and a biologic culture plate, where the biosensor plate underlies and is coupled to the culture well plate such that each biosensor is operatively coupled to one culture well of the plurality of culture wells. A containment device that physically influences the positioning of fluid received in the culture plate is also provided herein.
146	Aseptically Connectable Sensor Patch	US15545378	2016-01-29	US20180002653A1	2018-01-04	Christian Kaisermayer
The invention discloses a first connection unit having a plurality of sensor surfaces and which is adapted to be asepetically connected to a second connection unit mounted e.g. on a flexible bioreactor bag.
147	LUNG MODEL DEVICE FOR INHALATION TOXICITY TESTING	US15322894	2015-06-04	US20170160268A1	2017-06-08	Kyu Hong LEE; Hyo Seon YANG
A lung model device for inhalation toxicity testing is provided. The device has a plurality of mesh tissue panels having lung cells attached thereto arranged inside a case so as to have a similar structure to a human lung, and air and nanoparticles are supplied into the case through a separate respiratory operating unit, thereby enabling inhalation toxicity testing on nanoparticles to be simply and conveniently performed in an indirect way by determining changes in the state of the lung cells without using real laboratory animals. The mesh tissue panels having a smaller lattice spacing size are sequentially positioned according to the nanoparticle inflow direction, thereby providing a structure similar to the structure of a real lung.
148	METHOD AND APPARATUS TO PREPARE CARDIAC ORGANOIDS IN A BIOREACTOR SYSTEM	US15314870	2015-05-29	US20170107469A1	2017-04-20	Kevin David Costa; Timothy James Cashman; Peter Constantine Backeris
A bioreactor system for preparing a cardiac organoid chamber and for subsequent testing thereof is described herein and shown in the exemplary drawing figures. The bioreactor system includes a first vessel having a hollow interior and an open top. A first cover is mated with the open top of the first vessel. The first cover has a first opening formed therein. The system further includes a cannula having a lumen that extends from an open first end to an open second end. The cannula is disposed within the first opening of the first cover such that a portion of the cannula lies below the first cover and for insertion into the hollow interior of the first vessel. A porous ring is coupled to the cannula at or proximate the open second end thereof. The system also includes a balloon catheter having an inflatable balloon at a distal end of a catheter shaft. The balloon catheter is adapted to pass through the lumen of the cannula when the balloon is in a deflated state. The balloon catheter is axially adjustable within the lumen to allow the balloon in an inflated state to be disposed adjacent: (1) the open second end of the cannula; and (2) the porous ring for preparing the cardiac organoid chamber about the inflated balloon and porous ring. The cannula and porous ring construction and combination allows for the balloon to be deflated and removed from the lumen of the cannula while the engineered cardiac organoid chamber remains attached to the porous ring. This permits the testing of organoid pump function, such as organoid pressure and volume characteristics, without having to transfer the engineered cardiac organoid from one tool (e.g., an incubation tool) to another tool (e.g., a functional testing apparatus).
149	AGITATING DEVICE FOR A DIGESTER OF A BIOGAS PLANT AND METHOD FOR MANUFACTURING AN AGITATING DEVICE	US15035133	2014-11-07	US20160289622A1	2016-10-06	Andreas CZWALUK
Digester (1) having an agitating device (10) and an agitating device (10) and a method for manufacturing an agitating device (10), the agitating device (10) comprising multiple agitator blades (21-29) which agitator blades (11-13) comprise a plurality of blade sections (21-29) angled relative to one another. The blade sections (21-29) of the agitator blade (11-13) are angled relative to one another such that the agitator blade gradient (11-13) decreases with the distance (30) from a central rotational axis (19) increasing to configure the agitator blade in a flow-optimized three-dimensional shape.
150	Clamping insert for cell culture	US13554370	2012-07-20	US09371508B2	2016-06-21	Silvia Angeloni Suter; Martha Liley
A clamping insert for cell culture having a lower support with a hollow member engagable in a well of a microplate, the hollow member being open at both ends and including a support surface at one end, and first tightening elements. The clamping insert further having an inner holder sized to be fitted inside the hollow member, and second tightening elements arranged to cooperate with the first tightening elements of the hollow member to tighten reversibly between the inner holder and the support surface of the lower support a porous substrate. The inner holder further including an open channel keeping free the porous substrate. Retaining elements intended to cooperate with the well of the microplate are provided to allow the clamping insert to be suspended in the well, and sealing elements are provided to hermetically seal the contact area between the clamping insert and the porous substrate.
151	COMPOSITE SENSOR ASSEMBLIES FOR SINGLE USE BIOREACTORS	US14997324	2016-01-15	US20160130548A1	2016-05-12	Mark Selker; Timothy Johnston; Barbara Paldus
A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises:i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate portion being fusibly sealable to the bioreactor vessel at a hole in the wall thereof;ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly tits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
152	Aseptic connectors for bio-processing containers	US14724659	2015-05-28	US09335000B2	2016-05-10	Mark Selker; Barbara Paldus; Timothy Johnston
Disclosed herein are apparatuses and methods for installing a sterilized peripheral in a bio-processing vessel or component. One aspect is an aseptic peripheral connection assembly for installing a sterilized peripheral in a bio-processing vessel or component via an aseptic connector affixed to the vessel or component. The aseptic peripheral connection assembly may include a carrier, an applicator, and a removable hermetic sealing tab.
153	GLYCOCONJUGATE VACCINES	US14655210	2014-01-21	US20150328301A1	2015-11-19	Brendan Wren; Jon Cuccui; Madeleine Moule
The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.
154	Apparatus for production of biogas by digestion of organic material	US13984686	2012-02-08	US09133430B2	2015-09-15	Soren J. Hojsgaard; Bente E. Nielsen; Per Koefoed-Hansen
An apparatus for production of a biogas by anaerobic digestion of organic material, the apparatus comprising: a digester chamber defining: a gas generating zone and a gas collecting zone. A biogas outlet is defined in the gas collecting zone, and one or more nozzles is/are arranged to spray a gas cooling liquid into the gas accommodated in the gas collecting zone so as to cool the gas. A collecting member is arranged in the gas collecting zone to collect the gas cooling liquid when sprayed from the one or more nozzles towards the collecting member so as to prevent the gas cooling liquid from entering the organic material. The collecting member is arranged to cause the collected gas cooling liquid to flow into a liquid based safety valve.
155	SYSTEM AND METHOD FOR ANALYTE SENSING AND MONITORING	US14321904	2014-07-02	US20150093775A1	2015-04-02	Govind RAO; Xudong GE; Yordan KOSTOV; Madhubanti CHATTERJEE; Leah TOLOSA; Shaunak Dilip UPLEKAR; Manohar PILLI
An analyte sensing and monitoring system and method is provided that is particularly applicable to monitoring of analytes in cell cultures. The system and method relies on the initial diffusion rates of the analytes from the medium that contains the analytes being measured (e.g., cell culture) into a diffusion chamber that is inserted into the medium, and remote sensing of the analytes using an analyte sensing system that is coupled to the diffusion chamber.
156	Polymeric Thin-Film Tube Connectors, Bioreactors, Systems and Methods	US14361973	2012-11-29	US20140329297A1	2014-11-06	John E. Longan
Polymeric thin-film tube connectors, bioreactors, systems and methods are described, the connectors allowing connection of a polymeric thin-film tube of a bioreactor chamber with a complementary part, typically, rigid port of flange of the bioreactor or bioreactor system. Further, bioreactors having a thin-film reactor chamber and one or more connectors are described. The thin-film reactor chamber can have a thin-film wall for enclosing culture medium and microorganisms. The connector can include a flexible boot. An opening of the thin-film wall couples to the flexible boot. The thin-film wall can extend through a reactor end of the flexible boot and can rest against an interior surface of the flexible boot. The connectors are particularly advantageous for connecting standard utilities in a bioreactor system to thin-film bioreactor chambers or capsules having a thin-film tubular opening.
157	CONTAINER FOR CELL CHIP	US13770986	2013-02-19	US20140102939A1	2014-04-17	Dong Woo Lee; Bo Sung Ku
There is provided a container for a cell chip including: a lower body including an installation space allowing a cell chip to be installed therein and one or more holes connected to the installation space; and an upper body coupled to the lower body.
158	NON-ADHERENT CELL SUPPORT AND MANUFACTURING METHOD	US14043442	2013-10-01	US20140093953A1	2014-04-03	Patrick Neal Ingram; Euisik Yoon
A non-adherent cell support for use as a substrate in fluidic chambers used for cell culturing and assays. The non-adherent cell support allows for the formation of sphere cultures from single cells, which can better mimic primary tumor-like behavior in the study of cancer stem cells. The non-adherent cell support can allow for adhesive culturing and may include a hydrophobic substrate having a lower body and a raised support structure extending upwardly from an upper surface of the body. The support structure comprises one or more vertically extending support members that extend from a proximal portion at the upper surface of the body to a distal end spaced from the upper surface of the body. The support structure may be formed from a biocompatible material such as poly-2-hydroxyethyl methacrylate, polydimethylsiloxane, polymethyl methacrylate, polystyrene, or a polyethylene glycol diacrylate-based hydrogel.
159	Polymeric Film for Use in Bioprocessing Applications	US13874536	2013-05-01	US20130302894A1	2013-11-14	Solomon Bekele; Patrick Wayne Thompson
The presently disclosed subject matter is directed to a polymeric films suitable for use in a wide variety of applications, including (but not limited to) the formation of bioprocessing containers. Particularly, the disclosed films comprise a first barrier layer comprising polyglycolic acid, polyamide, EVOH, and/or an EVOH blend and a second barrier layer comprising EVOH. The dual barrier layers of the film maintain a high gas barrier under a variety of relative humidity conditions. In addition, the disclosed film is biologically inert and free from film surface-modifying additives such that the film does not inhibit the growth of biological cell cultures.
160	Bioreactor probe connection system	US12664398	2008-06-11	US08568657B2	2013-10-29	Christophe Braet; Tom Claes; Steven Vanhamel; Nicolas Havelange
A system providing a sterile connection between a sensor probe and a fluid processing apparatus (e.g., a bioreactor) includes a first probe receiving element mountable to the fluid processing apparatus and a second probe receiving element having a gas-permeable contaminant barrier material and coupleable to the first probe receiving element. A sensor probe may be mounted to the second probe receiving element, with the combination being sterilized with a sterilant gas such as steam. Following such sterilization, connection between the first and second probe receiving elements is made through matable sterile couplings, and the probe is insertable through the coupled receiving elements to a position in fluid contact with the interior of the fluid processing apparatus.

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