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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
261	Sewage treating apparatus	US19878D		USRE19878E	1936-03-03

262	Sewage treating apparatus	US54313131	1931-06-09	US1892688A	1933-01-03	KEEFER CLARENCE E; WACHTER FRANK C

263	MODULAR TUBULAR BIOREACTOR	US16038492	2018-07-18	US20180320121A1	2018-11-08	Alexander Sitek; Cameron Wyatt; Richard Mazur; James Riley; Jason Licamele; Thomas Kulaga; Timonthy Sullivan
Embodiments of a modular tubular bioreactor system for culturing an aqueous culture of microorganisms are described herein. The tubular bioreactor may comprise culture tubes configured in a vertically spaced and horizontally staggered arrangement to optimize the application of light to the culture in phototrophic and mixotrophic cultivation.
264	Feeding/Discharging Device and Method	US15768555	2016-10-12	US20180291321A1	2018-10-11	Jing Xiang
A feeding and discharging device (1) and a method of feeding and discharging with said feeding and discharging device (1), which hermetically convey the upstream object (3) from the upstream space (6) to the downstream space (7) which is separated from the upstream space (6), a loaded transition space (8) is formed after a sequence of the operations of opening the upstream opening (4), moving the upstream object (3) out of the upstream space (6) through the upstream opening (4), closing the upstream opening (4), an unloaded transition space (9) is formed after a sequence of the operations of opening the downstream opening (4″), moving the upstream object (3) into the downstream space (7) through the downstream opening (4′), closing the downstream opening (4′), the scheme improves the air tightness of the feeding and discharging process, increases the flow of feeding and discharging, prolongs the service life of the device.
265	METHODS AND APPARATUS FOR GAS STREAM MASS TRANSFER WITH A LIQUID	US15916635	2018-03-09	US20180195034A1	2018-07-12	Christopher D. Brau; Nephi D. Jones; Benjamin R. Madsen; Michael E. Goodwin
A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A tube has a first end and an opposing second end, the first end of the tube being disposed within the compartment of the container. A nozzle is disposed within the compartment of the container and has at least one outlet, the nozzle being coupled with the tube so that a gas can be passed through the tube and out the at least one outlet of the nozzle. The nozzle is sufficiently buoyant so that when a fluid is disposed within the compartment of the container, the nozzle floats on the fluid.
266	BIOMANUFACTURING SUITE AND METHODS FOR LARGE-SCALE PRODUCTION OF CELLS, VIRUSES, AND BIOMOLECULES	US15885186	2018-01-31	US20180155668A1	2018-06-07	MARK HIRSCHEL; ROBERT J. WOJCIECHOWSKI; KIM ARNESON
The present invention provides a production module for large-scale production of cells and/or cell-derived products such as antibodies or virus; a production suite comprising a plurality of functionally connected production modules of the invention; and a method for large-scale production of cells and/or cell-derived products using the production modules and/or production suites of the invention.
267	Methods and apparatus for gas stream mass transfer with a liquid	US15187258	2016-06-20	US09932553B2	2018-04-03	Christopher D. Brau; Nephi D. Jones; Benjamin R. Madsen; Michael E. Goodwin
A system for performing a gas-liquid mass transfer includes a container bounding a compartment and having a top wall, a bottom wall, and an encircling sidewall extending therebetween. A first opening is formed on the container so as to communicate with the compartment. A liquid is disposed within the compartment and having a top surface disposed below the first opening. A gas is blown through the first opening so that the gas passes over at least a portion of the top surface of the liquid, the gas producing turbulence on the top surface of the liquid that is sufficient to produce a mass transfer between the gas and the liquid. A mixing element is disposed within the compartment.
268	STERILE SENSOR INSERTION	US15500623	2015-07-30	US20170218320A1	2017-08-03	Vincent Francis PIZZI; Jeffrey CARTER; Ralph STANKOWSKI
The present invention provides a system for the insertion of a pre-sterilized sensor probe into a sterile vessel. The system of the invention provides a reliable and straightforward way to insert one or more sterile probes into a sterile vessel. The present invention also provides a sterile vessel that includes one or more of the systems of the invention. The sterile vessel can be a flexible or semi-rigid bag or tubing of the type typically used for carrying out biochemical and/or biological processes and/or manipulating liquids and other products of such processes. Furthermore, the present invention provides a method for aseptically inserting a probe into a sterile vessel where the method makes use of the system of the invention.
269	SINGLE-USE BIOREACTOR SENSOR INTERFACE	US15278766	2016-09-28	US20170166852A1	2017-06-15	Chang-Dong Feng
A bioreactor sensing system is presented. The bioreactor sensing system comprises a bioreaction vessel. The bioreaction vessel comprises an aperture configured to provide an interface for monitoring contents within the bioreaction vessel. The bioreaction vessel also comprises a port coupled to the bioreaction vessel proximate the aperture. The bioreactor sensing system also comprises a sensing device disposed at least partially within the port such that a sensing element is exposed to the contents. The bioreactor sensing system also comprises an external seal configured to be applied over a portion of the sensing device and a portion of the port.
270	Systems and methods for aseptic sampling	US14529203	2014-10-31	US09677975B2	2017-06-13	Chengkun Zhang; Kenneth Roger Conway; Donald Joseph Buckley; Eugene Pauling Boden; Weston Blaine Griffin; Anshika Bajaj; Reginald Donovan Smith
A sampling assembly configured to be coupled to a sample source and facilitate aseptic sampling at one or more instances in time is provided. Further, the sampling assembly includes a first conduit having first and second ports, where the first port is configured to be coupled to the sample source. The sampling assembly also includes a plurality of sub-conduits having corresponding sub-ports, where each of the plurality of sub-conduits is operatively coupled to the first conduit at respective connector junctions. Also, each of the sub-ports is in fluidic communication with the first conduit. The sampling assembly also includes a plurality of sampling kits and one or more pumping devices. Further, each sampling kit is operatively coupled to a respective sub-port of a corresponding sub-conduit. Moreover, the one or more pumping devices are operatively and aseptically coupled to the second port of the first conduit.
271	Systems, methods, and devices relating to a biomimetic cellularized nephron unit	US13524981	2012-06-15	US09657261B2	2017-05-23	Joseph L. Charest; Else Frohlich; Jeffrey T. Borenstein
Disclosed herein are systems and devices for culturing cells in a biomimetic environment of a cellularized nephron unit, and methods for fabricating and using the cellularized nephron unit.
272	STIRRED TANK REACTOR SYSTEMS AND METHODS OF USE	US15376362	2016-12-12	US20170088806A1	2017-03-30	Kurt T. Kunas; Robert V. Oakley; Fauad F. Hasan; Michael E. Goodwin; Jeremy K. Larsen; Nephi D. Jones
A reactor system includes a support housing having an interior surface bounding a chamber, the chamber having a vertically extending central longitudinal axis. A flexible bag is disposed within the chamber of the support housing and has an interior surface bounding a compartment. A mixing element is disposed within the compartment of the flexible bag. A drive element, such as a drive shaft, is secured the mixing element, wherein the mixing element is laterally offset from and/or is angled relative to the vertically extending central longitudinal axis of the support housing.
273	Anaerobic digester service device with a separation curtain	US14358574	2012-11-16	US09512394B2	2016-12-06	Michael David Theodoulou; Warren Bruce Lee; Juan Carlos Josse
A digester tank has a servicing device that allows access to the interior of the digester tank. The sealing device may have a movable retention wall adapted to resist the pressure of the gas inside the digester by one or more of a) increasing the bending resistance of the retention wall, for example by inflating pockets in the wall, b) forcing the lower edge of the retention wall downwards, for example by weight, a mechanical arm or inflating pockets, and c) providing a mechanical structure within the retention wall, for example a non-moving cage-like structure. A sealing device with a fixed wall has a pipe with an isolation valve between the headspace of the tank and the inside of the sealing device. In operation, a seal may be formed across the separation curtain by raising the level of the liquid contents and closing the isolation valve.
274	Sensor probe seal	US13949953	2013-07-24	US09410626B2	2016-08-09	Nigel David Feltham
A sealing system is provided for preventing leakage of a fluid from a fluid-containing chamber when a sensor probe for measuring fluid conditions within the chamber is inserted into the chamber. The sealing system has at least one port in fluid communication with the fluid-containing chamber. The port has a stem projecting outwardly from the chamber, a tapered flange, and a stem passageway in fluid communication with the chamber interior. A probe seal which is adapted to attach to the stem forms a seal between the port and the sensor probe and prevents fluid in the processing chamber from leaking past the probe seal. The probe seal has spaced-apart inner and outer skirts. The inner skirt forms a seal passageway which is in fluid communication with the chamber, and an inner end disposed to enter the stem passageway when the probe seal is attached to the stem. The inner skirt has a seal member disposed near the inner end for sealably compressing against the probe sensor and the stem passageway to form a leak-tight seal in response to insertion of the sensor probe into the seal passageway. The inner and outer skirt also form a skirt channel adapted to receive the tapered flange of the stem when the inner skirt is inserted into the stem passageway.
275	PHOTOBIOREACTOR SYSTEM FOR AIR PURIFICATION BY USING MICROALGAE	US14968931	2015-12-15	US20160166985A1	2016-06-16	YEUK TIN LAU; Lok Hang Roger KEUNG; Sik Chun Johnny LO; Jonathan Christianto
The present invention relates to air purification. The present invention provides a system for reducing carbon dioxide concentration in air in locations with sub-tropical to temperate climates and method of reducing carbon dioxide concentration using the system.
276	Aseptic connectors for bio-processing containers	US14292637	2014-05-30	US09346578B2	2016-05-24	Mark Selker; Barbara Paldus; Timothy Johnston
Disclosed herein are apparatuses and methods for installing a sterilized peripheral in a bio-processing vessel. One aspect is an aseptic peripheral connection assembly for installing a sterilized peripheral in a bio-processing vessel via an aseptic connector affixed to the vessel. The aseptic peripheral connection assembly may include a carrier, an applicator, a plunger, and a removable hermetic sealing tab.
277	ASEPTIC CONNECTORS FOR BIO-PROCESSING CONTAINERS	US14292637	2014-05-30	US20150344161A1	2015-12-03	Mark Selker; Barbara Paldus; Timothy Johnston
Disclosed herein are apparatuses and methods for installing a sterilized peripheral in a bio-processing vessel. One aspect is an aseptic peripheral connection assembly for installing a sterilized peripheral in a bio-processing vessel via an aseptic connector affixed to the vessel. The aseptic peripheral connection assembly may include a carrier, an applicator, a plunger, and a removable hermetic sealing tab.
278	MODULAR TUBULAR BIOREACTOR	US14812713	2015-07-29	US20150329810A1	2015-11-19	Cameron Wyatt; Richard Mazur; James Riley; Thomas Kulaga; Alexander Sitek; Jason Licamele; Timothy Sullivan
Embodiments of a modular tubular bioreactor system for culturing an aqueous culture of microorganisms are described herein. The tubular bioreactor may comprise culture tubes configured in a vertically spaced and horizontally staggered arrangement to optimize the application of light to the culture in phototrophic and mixotrophic cultivation.
279	Enzymatic modifications of a cellular monolithic carbon and uses thereof	US13521835	2011-01-19	US09121002B2	2015-09-01	Nicolas Mano; Victoria Flexer; Nicolas Brun; Rénal Backov
A porous electrochemical electrode is made up of a solid cellular material provided in the form of a semi-graphitized carbon monolith comprising a hierarchized porous network free of mesopores and including macropores with a mean dimension dA of 1 μm to 100 μm, and micropores with a mean dimension dI of 0.5 nm to 2 nm, said macropores and micropores being interconnected. In said electrode, the macropores contain at least one electroactive species in direct contact with the semi-graphitized carbon that makes up the surface of the macropores. The invention also relates to a method for preparing such an electrode as well as to the use thereof as a biosensor or for manufacturing a biopile.
280	FLUIDIC DEVICE FOR STUDYING OF SURFACE-DWELLING MULTICELLULAR LAYERS AND MICROBIAL BIOFILMS	US14426177	2013-09-06	US20150218502A1	2015-08-06	Thomas Vanzieleghem; Jacques Mahillon; Hervé Jeanmart; Simon Degand; Christine Dupont; Sandy Ladeuze
The present invention relates to a fluidic device that can be used for the analysis of surface-dwelling multicellular layers, some of which comprise biofilm and can be referred to as biofilms, and their formation under controlled dynamic conditions. More particularly, the surface in the fluidic chamber on which the multicellular layer is grown is detachable and/or removable from the fluidic chamber, thereby providing a highly versatile device.

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