| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 染发组合物 | CN200780004834.8 | 2007-02-02 | CN101379145A | 2009-03-04 | 罗克萨娜·伯尔别鲁; 维尔纳·鲁斯; 多米尼克·普拉特; 哈特穆特·默林 |
| 本发明涉及包括一或多种通式(I)染料的染发组合物，其中R、X、Y及Z如权利要求1所定义，以及使头发着色的方法。 | ||||||
| 2 | 特殊的萘二甲酰亚胺类染料，包含至少一种这类染料的染料组合物及其使用方法和应用 | CN200780000127.1 | 2007-03-23 | CN101374911A | 2009-02-25 | 蒂莫·卢卡斯; 安德鲁·格里夫斯; 赫维·戴维 |
| 本发明涉及可以用作直接染料的新型阳离子萘二甲酰亚胺化合物和用于将角蛋白纤维，特别是人的角蛋白纤维如头发染色的染料组合物，所述染料组合物在适合的染色介质中包含至少一种这样的化合物。本发明还涉及使用这种组合物的染色方法及其应用。 | ||||||
| 3 | 染料及染发组合物 | CN200780004824.4 | 2007-02-02 | CN101379144B | 2012-08-22 | 罗克萨娜·伯尔别鲁; 维尔纳·鲁斯; 多米尼克·普拉特; 哈特穆特·默林 |
| 本发明涉及通式(I)的染料其中R、X、Y及Z如权利要求中所定义，含有该染料的染料混合物及染发组合物，及染发的方法。 | ||||||
| 4 | 三价阳离子染料 | CN200780022263.0 | 2007-06-04 | CN101466797A | 2009-06-24 | 克里斯琴·克里默; 奥洛夫·沃尔奎斯特; 维克托·P·埃利厄; 基肖尔·R·尼瓦尔卡 |
| 本发明披露了式(1)的化合物，其中D是芳族基团或阳离子杂芳族基团，所述基团任选被以下基团取代：C1－C14烷基、C1－C14烷氧基、羟基－C1－C14烷基、C3－C8环烷基、－CN，NO2、－NR3R4、卤素、任选被C1－C14烷基取代的C6－C10芳基，或一个或多个基团Z；E1和E2各自独立地为＝CH；或＝N－；K为芳族基团或杂芳族基团，所述基团任选被以下基团取代：C1－C14烷基、C1－C14烷氧基、C3－C8环烷基、C6－C10芳基、卤素、羟基、NO2、－NR3R4、－N(R3)(CO)R4、－SO2NR1R2、－SONR1R2或一个或多个Z；或式－NR1R2的基团；R1和R2各自独立地为氢；C1－C14烷基；C1－C14环烷基；C6－C10芳基；芳族基团或杂芳族基团，所述基团任选被以下基团取代：C1－C14烷基、C1－C14烷氧基、C3－C8环烷基、C6－C10芳基、卤素、羟基、－NR5R6、－N(R5)－(CO)R5或Z；Z是式(1a)*－X1－Y1－W1的基团，其中X1是直接键；－NR7－；－O－；－NR7(C＝O)－；－(CO)NR7－；－O(C＝O)－；－(CO)O－；或－(C＝O)－；Y1是直接键；C1－C12亚烷基，所述C1－C12亚烷基可任选被－O－、－NR8、－S－、－(C＝O)－、－O(C＝O)－、(C＝O)O－、－NR7(C＝O)－、－(C＝O)NR7－隔断，并且其可被C1－C14烷基、羟基－C1－C14烷基、羟基、－NR9R10或卤素取代；或C6－C10亚芳基，所述C6－C10亚芳基可被C1－C14烷基、羟基－C1－C14烷基、羟基、氨基或卤素取代；W1是阳离子基团；和R3、R4、R5、R6、R7、R8、R9和R10各自独立地为氢；C1－C14烷基；或Z；和An1－、An2－和An3－各自独立地为阴离子。所述化合物可用于对有机物质进行染色，所述有机物质例如是角蛋白纤维、羊毛、皮革、丝、纤维素或聚酰胺，特别是含角蛋白的纤维、棉或尼龙、优选为毛发，更优选为人类毛发。 | ||||||
| 5 | 染料及染发组合物 | CN200780004824.4 | 2007-02-02 | CN101379144A | 2009-03-04 | 罗克萨娜·伯尔别鲁; 维尔纳·鲁斯; 多米尼克·普拉特; 哈特穆特·默林 |
| 本发明涉及通式(I)的染料，其中R、X、Y及Z如权利要求中所定义，含有该染料的染料混合物及染发组合物，及染发的方法。 | ||||||
| 6 | 线粒体靶向的抗氧剂 | CN98812314.2 | 1998-11-25 | CN1318434C | 2007-05-30 | M·P·墨菲; R·A·J·史密斯 |
| 本发明提供了线粒体靶向的抗氧剂化合物。本发明的化合物含有与抗氧剂部分共价偶联的亲脂性阳离子。在优选的实施方案中，亲脂性阳离子是三苯基阳离子，所述化合物是式P(Ph3)+XRZ-的化合物，其中X是连接基团，Z是阴离子，R是抗氧剂部分。本发明还提供含有所述线粒体靶向的抗氧剂化合物的药物组合物，以及对可以从减少氧化性应激反应中受益的患者进行治疗或预防的方法，该方法包括施用本发明化合物的步骤。 | ||||||
| 7 | 线粒体靶向的抗氧剂 | CN98812314.2 | 1998-11-25 | CN1282334A | 2001-01-31 | M·P·墨菲; R·A·J·史密斯 |
| 本发明提供了线粒体靶向的抗氧剂化合物。本发明的化合物含有与抗氧剂部分共价偶联的亲脂性阳离子。在优选的实施方案中,亲脂性阳离子是三苯基鏻阳离子,所述化合物是式P(Ph3)+XRZ－的化合物,其中X是连接基团,Z是阴离子,R是抗氧剂部分。本发明还提供含有所述线粒体靶向的抗氧剂化合物的药物组合物,以及对可以从减少氧化性应激反应中受益的患者进行治疗或预防的方法,该方法包括施用本发明化合物的步骤。 | ||||||
| 8 | Compound for labeling mitochondria and method of producing the same | US15479150 | 2017-04-04 | US10100065B2 | 2018-10-16 | Jun-Seok Lee; Dhiraj P. Murale; Seong-Cheol Hong; Seok Lee |
| This invention relates to a compound for labeling mitochondria and a method of producing the same, wherein the compound is represented by Chemical Formula 1 or Chemical Formula 2 below, and is useful in labeling mitochondria. In Chemical Formulas 1 and 2, n is 4 or 10. | ||||||
| 9 | CONTACT LENSES CARRYING MITOCHONRIALLY-TARGETED ANTIOXIDANTS | US15561784 | 2016-03-25 | US20180185276A1 | 2018-07-05 | Anton Dmitrievich Petrov; Maxim Vladimirovich Skulachev; Vadim Neronovich Tashlitsky; Elena Mirovna Karger; Lawrence T Friedhoff |
| The present inventor has discovered how to adsorb a mitochondrially targeted compound (MTC) of general formula I on contact lenses and other matrices prior the application of lenses or other matrix on the eye surface. After such matrix is positioned on eye, MTC is translocated from lens into cornea cells of the eye providing cornea protective effect and thus reducing side effects of contact lens application. | ||||||
| 10 | COMPOSITION, METHOD OF MANUFACTURING COMPOSITION, CURABLE COMPOSITION, CURED FILM, NEAR-INFRARED CUT FILTER, SOLID-STATE IMAGING DEVICE, INFRARED SENSOR, AND CAMERA MODULE | US15447335 | 2017-03-02 | US20170174869A1 | 2017-06-22 | Kyohei ARAYAMA; Takuya TSURUTA; Kazutaka TAKAHASHI; Tetsuya KAMIMURA; Masahiro MORI |
| Provided are a composition of which dispersibility of particles including a pyrrolopyrrole coloring agent is satisfactory, a method of manufacturing a composition, a curable composition, a cured film using a curable composition, a near-infrared cut filter, a solid-state imaging device, an infrared sensor, and a camera module. The composition includes particles including a coloring agent represented by Formula (1), in which an average secondary particle diameter of the particles is 500 nm or less. R1a and R1b each independently represent an alkyl group, an aryl group, or a heteroaryl group, R2 and R3 each independently represent a hydrogen atom or a substituent, R2 and R3 may be bonded to each other to form a ring, R4's each independently represent a hydrogen atom, an alkyl group, an aryl group, a heteroaryl group, —BR4AR4B, or a metal atom, R4's may form a covalent bond or a coordinate bond with at least one selected form R1a, R1b, or R3, and R4A and R4B each independently represent a hydrogen atom or a substituent. | ||||||
| 11 | HIGHLY FLUOROGENIC PROTEIN LABELLING AGENTS | US15378400 | 2016-12-14 | US20170168064A1 | 2017-06-15 | Jeffrey KEILLOR; Yingche CHEN |
| There are provided fluorogenic labelling agents comprising a dimaleimide core connected to a BODIPY-based fluorophore, processes for preparation thereof, and uses thereof for labelling and/or detection of specific protein targets. Fluorogenic labelling agents having an excitation wavelength that can be visualized in the green or red channels of fluorescence microscopes are provided. In some embodiments, fluorogenic labelling agents comprising a compound having the structure of Formula I or II, and salts thereof, are described. | ||||||
| 12 | DYE COMPOSITION COMPRISING A CATIONIC PARA-AMINOPHENOL OXIDATION BASE | US15054634 | 2016-02-26 | US20160374913A1 | 2016-12-29 | Aziz FADLI |
| The present invention relates to a para-aminophenol compound of formula (I), the addition salts thereof with an acid and the solvates thereof: in which: R represents a hydrogen or halogen atom; a C1-C4 alkyl radical; a carboxyl radical or a (C1-C4)alkoxycarbonyl radical; Z1 is an oxygen atom or a group NR2; R2 is a hydrogen atom or a linear or branched C1-C4 alkyl radical, a benzyl radical or an acetyl radical; R1 is a saturated, linear or branched C1-C10 alkyl radical, which is substituted with or interrupted by a cationic radical, optionally interrupted by one or more oxygen atoms and/or by one or more groups NR2, optionally substituted with one or more radicals chosen from hydroxyl, alkoxy or C1-C4 hydroxyalkyl radicals; or R1 is a saturated, unsaturated or aromatic cationic 5- to 8-membered heterocycle optionally substituted with one or more radicals chosen from C1-C4 alkyl, hydroxyl, C1-C4 alkoxy, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, thio, (C1-C4)alkylthio, carboxyl, (C1-C4)alkylcarbonyl, sulfonyl, amido or C1-C4 hydroxyalkyl radicals; and when Z1 represents NR2 then R1 and R2 may form, together with the nitrogen atom to which they are attached, a saturated or unsaturated cationic 5- to 8-membered heterocycle optionally substituted with one or more radicals chosen from C1-C10 alkyl radicals and hydroxyl, C1-C4 alkoxy, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, thio, (C1-C4)alkylthio, carboxyl, (C1-C4)alkylcarbonyl, sulfonyl, amido and C1-C4 hydroxyalkyl radicals, it being possible for this heterocycle to contain one or more heteroatoms chosen from N or O, preferably N; or R1 and R2 may form, together with the nitrogen atom to which they are attached, a saturated or unsaturated noncationic 5- to 8-membered heterocycle substituted with a cationic radical and optionally substituted with one or more radicals chosen from C1-C10 alkyl radicals and hydroxyl, C1-C4 alkoxy, amino, (C1-C4)alkylamino, di(C1-C4)alkylamino, thio, (C1-C4)alkylthio, carboxyl, (C1-C4)alkylcarbonyl, sulfonyl, amido and C1-C4 hydroxyalkyl radicals; An− represents an anion or a mixture of anions which are organic or inorganic and are cosmetically acceptable. | ||||||
| 13 | CYCLOSPORIN CONJUGATES | US14193880 | 2014-02-28 | US20140357569A1 | 2014-12-04 | David Selwood; Martin Crompton |
| A conjugate which comprises a cyclosporin moiety of formula (I) linked to one or more mitochondrial targeting groups, or a pharmaceutically acceptable salt thereof: wherein: A represents or, B represents methyl or ethyl, one Of R1 and R1* represents hydrogen and the other represents methyl, R2 represents ethyl or isopropyl, R3 represents hydrogen or methyl, and R4 represents —CH2CH(CH3)CH3, —CH2CH(CH3)CH2CH3, —CH(CH3)CH3 or —CH(CH3)CH2CH3. | ||||||
| 14 | DYE COMPOSITION COMPRISING A CATIONIC PARA-AMINOPHENOL OXIDATION BASE | US14345103 | 2012-09-13 | US20140352081A1 | 2014-12-04 | Aziz Fadli |
| The present invention relates to a para-aminophenol compound of formula (I) the addition salts thereof with an acid and the solvates thereof, dye composition comprising the latter and a dyeing process. | ||||||
| 15 | FLUORESCENT DYE | US13985098 | 2011-02-18 | US20140206872A1 | 2014-07-24 | Shinichiro Isobe; Shuntaro Mataka |
| There is provided a fluorescent dye which can improve the fluorescent intensity at the time of labeling to thereby detect a biomolecule with higher sensitivity. The fluorescent dye of the present invention includes a nitrogen cation-containing group or a nitrogen-containing group. Its high water solubility can improve the rate of labeling for a biomolecule to thereby detect a biomolecule with high sensitivity. | ||||||
| 16 | CYCLOSPORIN CONJUGATES | US13386317 | 2010-07-19 | US20120157385A1 | 2012-06-21 | David Selwood; Martin Crompton |
| A conjugate which comprises a cyclosporin moiety of formula (I) linked to one or more mitochondrial targeting groups, or a pharmaceutically acceptable salt thereof: wherein: A represents or, B represents methyl or ethyl, one Of R1 and R1 represents hydrogen and the other represents methyl, R2 represents ethyl or isopropyl, R3 represents hydrogen or methyl, and R4 represents —CH2CH(CH3)CH3, —CH2CH(CH3)CH2CH3, —CH(CH3)CH3 or —CH(CH3)CH2CH3. | ||||||
| 17 | DYESTUFFS AND HAIR DYE COMPOSITIONS | US12279003 | 2007-02-02 | US20090217466A1 | 2009-09-03 | Roxana Barbieru; Werner Russ; Dominic Pratt; Hartmut Moehring |
| The present invention refers to dyestuffs of the general Formula (I) wherein R, X, Y and Z are defined as given in claim 1, dyestuff mixtures and hair dye compositions comprising them, as well as a process for colouring hair. | ||||||
| 18 | PHOTOSENSITIVE COMPOSITION, LITHOGRAPHIC PRINTING PLATE PRECURSOR, LITHOGRAPHIC PRINTING METHOD, AND NOVEL CYANINE DYES | US12026864 | 2008-02-06 | US20080254384A1 | 2008-10-16 | Yu IWAI |
| A photosensitive composition includes a cyanine dye that has, on a methine chain thereof, a substituent which is a cation moiety of an onium salt structure. | ||||||
| 19 | Dye composition comprising at least one polycationic direct dye, dyeing processes, uses, and multi-compartment devices | US10742841 | 2003-12-23 | US20040194229A1 | 2004-10-07 | Alain Lagrange |
| Disclosed herein is a dye composition for dyeing human keratin fibers, such as the hair, comprising a direct polycationic dye of formula (I) below: Col-Z-Col nullnull(I) in which Col, which may be identical or different, is a noncationic dye chosen from azo dyes, methine dyes, azomethine dyes, phenothiazine dyes, triarylmethene dyes, xanthene dyes, phenanthridine dyes, and phthalocyanin dyes; and Z is chosen from linear and branched, saturated and unsaturated C1-C20 hydrocarbon-based groups comprising at least one nitrogen atom and bearing at least two cationic charges, and also to processes for dyeing human keratin fiber using said composition, to the use of the dyes of formula (I) as direct dyes, and to multi-compartment devices. | ||||||
| 20 | Vattable and non-vattable quinoid dyes | US912174 | 1986-09-22 | US5212312A | 1993-05-18 | Jean-Marie Adam; Athanassios Tzikas |
| Dyes of the formula ##STR1## in which F is the radical of an indigoid dye, of a benzothioxanthene or of an aromatic dye which contains at least 4 alicyclic and/or heterocyclic, fused six-membered rings and at least two ring keto groups and is not water-soluble, R.sub.1 is a substituted or unsubstituted C.sub.1-4 -alkyl radical, a substituted or unsubstituted cycloalkyl radical, a substituted or unsubstituted aryl radical or a radical of the formula--A--Qwhere A is a substituted or unsubstituted C.sub.1-4 -alkylene radical and Q is a basic radical, which may be quaternised, and R.sub.2 is hydrogen or a substituted or unsubstituted C.sub.1-4 -alkyl radical, or in which R.sub.1 and R.sub.2 together with the ##STR2## group are a phthalimide radical, and R.sub.3 is hydrogen, a substituted or unsubstituted C.sub.1-4 -alkyl radical, a substituted or unsubstituted aryl radical, a C.sub.1-4 -alkoxycarbonyl radical or a N,N-di-C.sub.1-4 -alkylcarboxamide radical and n is 1, 2, 3 or 4.The novel dyes are suitable as vat dyes for dyeing natural or regenerated cellulose and as cationic dyes for dyeing paper. | ||||||
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