| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 241 | Vitamin functionalized gel-forming block copolymers for biomedical applications | US14697878 | 2015-04-28 | US09511146B2 | 2016-12-06 | James L. Hedrick; Ashlynn L. Z. Lee; Victor W. L. Ng; Yi Yan Yang |
| Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The vitamin-bearing subunits comprise a carbonate backbone portion and a side chain comprising a covalently bound form of a vitamin. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions can be suitable for depot injections. Synergistic enhancement of toxicity to microbes was observed with compositions comprising an antimicrobial cationic polymer and an antimicrobial compound. | ||||||
| 242 | POLYESTER HYDROGELS | US15105348 | 2014-12-17 | US20160326307A1 | 2016-11-10 | Motonori YAMAMOTO; Alexander WISSEMEIER; Wolfgang WEIGELT; Harald KELLER; Michael SEUFERT; Gimmy Alex FERNANDEZ RAMIREZ; Jorge SANZ-GOMEZ; Alexandra WIEDEMANN |
| The present invention relates to a polyester comprising units derived from monomers A, B and C, wherein the group of monomers A consists of (a1) monomers A1, or (a2) monomers A1 and monomers A2, with monomers A1 and monomers A2 being present in a molar ratio of at least 31:69, preferably at least 4:1, wherein the monomers A1 are selected from the group consisting of aromatic sulfonated dicarboxylic acid based monomers of general formulae (I), (II), (III) and (IV), and wherein the monomers A2 are selected from the group consisting of non-sulfonated aromatic dicarboxylic acid based monomers of general formulae (V), (VI) and (VII); and wherein the group of monomers B consists of (b1) monomers B1, or (b2) monomers B1 and monomers B2, with monomers B1 and monomers B2 being present in a molar ratio of at least 1:9, preferably at least 4:1, wherein the monomers B1 are selected from the group consisting of unsaturated dicarboxylic acid based monomers of general formula (VIII), and wherein the monomers B2 are selected from the group consisting of saturated dicarboxylic acid based monomers of general formula (IX); and wherein the group of monomers C consists of (c1) monomers C1, (c2) monomers C2, or (c3) monomers C1 and C2, wherein the monomers C1 are selected from the group consisting of ethylene glycol based monomers of general formula (X), and wherein the monomers C2 are selected from the group consisting of propylene glycol based monomers of general formula (XI), and wherein the molar ratio of the units derived from the group of monomers A to the units derived from the group of monomers B is from 9:1 to 1:2.4, and wherein the molar ratio of the units derived from the groups of monomers A and B to the units derived from the group of monomers C is from 1.3:1 to 1:1.3. The polyester of the invention is preferably cross-linked. | ||||||
| 243 | NOVEL POLYMER PLATFORM TO PREPARE NANOHYDROGEL | US15036191 | 2014-11-14 | US20160289394A1 | 2016-10-06 | Pietro MATRICARDI; Chiara DI MEO; Claudio VILLANI |
| Methods to prepare nanohydrogels are disclosed that include functionalizing a polysaccharide with a hydrophobic compound to form a functionalized polysaccharide, and subjecting the functionalized polysaccharide to a self-assembling process in a water environment for the formation of the nanohydrogel. The hydrophobic compound is riboflavin, or a derivative thereof, to which an alkyl group having a functional group suited to form a covalent bond with the polysaccharide has been bonded. | ||||||
| 244 | Self-assembling biomimetic hydrogels having bioadhesive properties | US15041170 | 2016-02-11 | US09446167B2 | 2016-09-20 | Andrea Jennifer Vernengo; Jennifer Kadlowec; Pamela Kubinski; Thomas N. Tulenko; Cristina Iftode; Bryan Johnson; Craig Wiltsey |
| The disclosure relates to a composition that is liquid at a temperature below the body temperature of a mammal and that solidifies at or above the body temperature of the mammal. The composition includes a thermally-desolubilizable polymer interspersed with a polymeric component of extracellular matrix and an encapsulated form of an amine compound (preferably an aminated component of extracellular matrix) that is de-encapsulated in the body of the mammal. The polymeric component is able to form covalent bonds with amine moieties in the aminated component, in one or more tissues in the body of the mammal, or both. Upon injection of a liquid suspension of these components into the body of the mammal, the thermally-desolubilizable polymer condenses, entrapping the polymeric component. The polymeric component binds covalently with a tissue in the body, and the aminated component end-caps the remaining reactive moieties of the polymeric component, forming a matrix at the site of injection. The disclosure also relates to uses of such compositions for forming a matrix on or within the body of a mammal. The compositions have a variety of uses, such as bioadhesives, as sealants for ruptured tissues, as drug or imaging agent depots, or as mechanical cushions. | ||||||
| 245 | Polyamine-dihydroxybenzoic acid conjugate hydrogels as iron chelators | US13603125 | 2012-09-04 | US09402861B2 | 2016-08-02 | Cory Berkland; Zahra Mohammadi |
| Compositions and methods for making a composition comprising a polymer and one or more chelators covalently coupled to polymer, wherein the one or more chelators has a benzene ring with more than one hydroxyl group at any position that is free, or a derivative of the chelator, or a salt of the chelator and methods of use. | ||||||
| 246 | METHOD FOR THE TREATMENT OF NANOHYDROGELS | US14896974 | 2014-06-11 | US20160151500A1 | 2016-06-02 | Giorgia D'Arrigo; Claudia Cencetti; Chiara Di Meo; Pietro Matricardi |
| A method for treating nanohydrogels comprising—a dispersion step, in which a nanohydrogel obtained from a polysaccharide functionalized with hydrophobic molecules is dispersed in an aqueous solution, and a sterilization and homogenization step, in which the aqueous dispersion of nanohydrogels is added with a compound designed to be charged in the nanohydrogel particles by being englobed or adsorbed thereby and is subjected to a temperature of between 70° C. and 150° C. and a pressure of between 1 and 5 bar; in said sterilization and homogenization step, the conditions of temperature and pressure must be such that boiling of the aqueous dispersion of nanohydrogels does not occur. | ||||||
| 247 | POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS | US14859486 | 2015-09-21 | US20160090432A1 | 2016-03-31 | Frank Chang; Jinyu Huang; Venkat Shankar |
| The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention. | ||||||
| 248 | Oxirane (ethylene oxide) polyurethane coatings | US13834988 | 2013-03-15 | US09255173B2 | 2016-02-09 | Peter Anthony Edwards |
| The present invention relates to hydrophilic, i.e., water loving coatings (hereafter referred to as “WLC”). Polyurethane epoxy alkylene oxide coatings usable as coatings on for example, medical devices are a preferred WLC. | ||||||
| 249 | Polymer composite actuator and generator driven by water gradients | US14071482 | 2013-11-04 | US09236556B2 | 2016-01-12 | Mingming Ma; Liang Guo; Daniel G. Anderson; Omid C. Farokhzad; Robert S. Langer |
| Water-responsive composite materials are provided containing a polymeric matrix and a water-responsive gel integrated into the polymeric matrix. The water-responsive gel can include a polyol or an alkoxylated polyol crosslinked by reversibly hydrolysable bonds, such as borate ester bonds. The polymeric matrix can include conjugated polymers such as poly(pyrrole) containing polymers. The composite material is capable of rapid actuation in the presence of a water gradient and can exhibit power densities greater than 1 W/kg. Methods of making water-responsive composite materials are provided, including by electropolymerization. Devices containing water-responsive composite materials are provided for sensing, locomotion, and power generation. | ||||||
| 250 | Hydrogel Prodrugs | US14434585 | 2013-10-08 | US20150258205A1 | 2015-09-17 | Harald Rau; Tobias Voigt; Burkhardt Laufer; Nicola Bisek; Franziska Hahn; Thomas Knappe |
| The present invention relates to a process for the preparation of a hydrogel and to a hydrogel obtainable by said process. The present invention further relates to a process for the preparation of a hydrogel-spacer conjugate, to a hydrogel-spacer conjugate obtainable by said process, to a process for the preparation of a carrier-linked prodrug and to carrier-linked prodrugs obtainable by said process, in particular to carrier-linked prodrugs that provide for a controlled or sustained release of a drug from a carrier. In addition, the invention relates to the use of the hydrogel for the preparation of a carrier-linked prodrug. | ||||||
| 251 | REVERSELY THERMO-REVERSIBLE HYDROGEL COMPOSITIONS | US14492288 | 2014-09-22 | US20150071864A1 | 2015-03-12 | Shao Xiang LU; Jeffrey LU; Letian LIU |
| A reversely thermo-reversible hydrogel composition comprising a water soluble block copolymer comprising at least two blocks of polyethylene oxide and at least one block of polypropylene oxide, and at least one associative gelling adjuvant having water solubility less than 0.5 g/100 ml, preferably less than 0.3 g/100 ml at 20° C., and being capable of forming water soluble inter-molecular complexes with the water soluble block copolymer in water. The hydrogel composition exhibits improved gelling efficiency, enhanced solubility and/or stability for water sparely soluble and insoluble pharmaceutical agents. The hydrogel compositions are useful in a variety of pharmaceutical and cosmetic products and applications, such as esophageal, otic, vaginal, rectal, ophthalmic, treatments of disorders and imperfections of the skin, and treating and/or preventing alopecia and restoring and/or promoting hair growth. | ||||||
| 252 | Silicone hydrogels having a structure formed via controlled reaction kinetics | US13720218 | 2012-12-19 | US08937110B2 | 2015-01-20 | Azaam Alli; Douglas G. Vanderlaan; James D. Ford; Scott L. Joslin |
| The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature. | ||||||
| 253 | ORGANO-MODIFIED SILICONE POLYMERS | US14492378 | 2014-09-22 | US20150011788A1 | 2015-01-08 | Anubhav Saxena; Sandeep Shashikant Naik; Monjit Phukan; Shreedhar Bhat |
| A linear silicone polymer suitable for use in producing homopolymers, copolymers, polymerized emulsions, latex compositions, and hydrogel polymer films. In one aspect, a hydrophilic silicone monomer is of the Formula 1: WAmBnW (1) Where, A is a divalent block comprising a silicone-containing pendant group. In one embodiment, the silicone-containing pendant group comprises polyalkylene oxide groups. The structure of the polymer can be controlled and tuned to provide a material with excellent wettability and oxygen permeability. The polymers are suitable for use in a variety of applications including in providing a film for forming contact lenses. | ||||||
| 254 | ORGANO-MODIFIED SILICONE POLYMERS AND HYDROGELS COMPRISING THE SAME | US14492646 | 2014-09-22 | US20150011671A1 | 2015-01-08 | Anubhav Saxena; Sandeep Shashikant Naik; Monjit Phukan; Shreedhar Bhat |
| A hydrophilic silicone polymer composition suitable for use in producing hydrogel polymer films disclosed. In one aspect, a hydrophilic silicone monomer is of the Formula 1: wAmBnw (1) where A is a divalent block comprising a silicone-containing pendant group. In one embodiment, the silicone-containing pendant group comprises polyalkylene oxide groups. The structure of the polymer can be controlled and tuned to provide a material with excellent wettability and oxygen permeability. The polymers are suitable for use in a variety of applications including in providing a film for forming contact lenses. | ||||||
| 255 | METHOD FOR REHYDRATING POLYSACCHARIDE PARTICLES | US14324889 | 2014-07-07 | US20140323433A1 | 2014-10-30 | Matthew F. Myntti; Dana A. Oliver; Brian J. Vaccaro |
| Tissue and other body structures may be protected using a hydrated composition made from free-flowing substantially collagen-free rehydratable polysaccharide particles and rehydratable polysaccharide sponges. Rehydration of the particles without clumping may be carried out be dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated composition may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function. | ||||||
| 256 | Reversely thermo-reversible hydrogel compositions | US13425923 | 2012-03-21 | US08865143B2 | 2014-10-21 | Shao Xiang Lu; Jeffrey Lu; Letian Liu |
| A reversely thermo-reversible hydrogel composition comprising a water soluble block copolymer comprising at least two blocks of polyethylene oxide and at least one block of polypropylene oxide, and at least one associative gelling adjuvant having water solubility less than 0.5 g/100 ml, preferably less than 0.3 g/100 ml at 20° C., and being capable of forming water soluble inter-molecular complexes with the water soluble block copolymer in water. The hydrogel composition exhibits improved gelling efficiency, enhanced solubility and/or stability for water sparely soluble and insoluble pharmaceutical agents. The hydrogel compositions are useful in a variety of pharmaceutical and cosmetic products and applications, such as esophageal, otic, vaginal, rectal, ophthalmic, treatments of disorders and imperfections of the skin, and treating and/or preventing alopecia and restoring and/or promoting hair growth. | ||||||
| 257 | Polyurethane-grafted hydrogels | US13905028 | 2013-05-29 | US08853294B2 | 2014-10-07 | David Myung; Lampros Kourtis; Robert Ward; Michael J. Jaasma; Keith McCrea |
| An article comprising two chemically grafted polymer layers comprising a hydrogel layer and an end-functionalized polyurethane layer. The invention also includes methods of making and using the article. | ||||||
| 258 | Multifunctional stellate prepolymer mixtures, production and use and coatings made thereof | US12709559 | 2010-02-22 | US08816000B2 | 2014-08-26 | Haitao Rong; Peter Greiwe; Jürgen Groll; Christine Mohr; Marina Glesius; Martin Möller |
| The invention relates to coatings having a contact angle hysteresis with water measured by the sessile drop method of at most 20°. The coatings can be produced from a mixture of at least two different stellate prepolymers and/or stellate prepolymer/nanoparticle complexes which may cross-link to each other and to the surface of the substrate coated, wherein the stellate prepolymers and/or stellate prepolymer/nanoparticle complex have at least three hydrophilic polymer branches before cross-linking which are themselves soluble in water with on all or a part of the free ends thereof, silyl end groups R1 of general formula (I): R1=—CRa2—Si(ORb)r(Rc)3−r, where Ra=H or straight or branched chain 1-6C alkyl, ORb=a hydrolysable group, Rc=linear or branched chain 1-6C alkyl and r=a number from 1 to 3 and the optionally non silyl end group carrying ends have reactive end groups which a reactive with each other, with the substrate to be coated optional entities included in the coating and/or with the silyl end groups with the proviso the mixture (a) has at least one stellate prepolymer with 3-5 hydrophilic polymer branches and (b) at least one stellate prepolymer and/or a stellate prepolymer/nanoparticle complex with a least 6 hydrophilic polymer branches. The invention further relates to a method for production for said coatings and stellate prepolymers as used in the coatings. The invention furthermore relates to the use of the stellate prepolymers as additives in various materials for temporary or permanent anti-soiling treatment of surfaces. | ||||||
| 259 | Polymer Composite Actuator and Generator Driven by Water Gradients | US14071482 | 2013-11-04 | US20140125196A1 | 2014-05-08 | Mingming Ma; Liang Guo; Daniel G. Anderson; Omid C. Farokhzad; Robert S. Langer |
| Water-responsive composite materials are provided containing a polymeric matrix and a water-responsive gel integrated into the polymeric matrix. The water-responsive gel can include a polyol or an alkoxylated polyol crosslinked by reversibly hydrolysable bonds, such as borate ester bonds. The polymeric matrix can include conjugated polymers such as poly(pyrrole) containing polymers. The composite material is capable of rapid actuation in the presence of a water gradient and can exhibit power densities greater than 1 W/kg. Methods of making water-responsive composite materials are provided, including by electropolymerization. Devices containing water-responsive composite materials are provided for sensing, locomotion, and power generation. | ||||||
| 260 | WATER-SWELLABLE POLYMERS | US14099663 | 2013-12-06 | US20140107195A1 | 2014-04-17 | Janet Anne Halliday; Jukka Tuominen; Mark Alexander Livingstone; Frank Koppenhagen; Lilias Morton Currie; Sarah Stewart |
| A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc. | ||||||
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