| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 221 | Bone repair material | US15476012 | 2017-03-31 | US10098983B2 | 2018-10-16 | Corinna Mauth; Aaldert-Rens Molenberg |
| Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 μm. In addition said scaffold has a total porosity of 80 to 95%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores. | ||||||
| 222 | METHOD FOR PREPARING SUPERABSORBENT POLYMER | US15506828 | 2015-12-14 | US20180257059A1 | 2018-09-13 | Seong Beom HEO; Tae Hwan JANG; Mi Young KIM; Jiyoon JEONG; Bhom Ri KIM |
| The preparation method of superabsorbent polymer according to the present invention can increase suction power without degradation of other properties of superabsorbent polymer, and thus, the prepared superabsorbent polymer may be usefully used as material of hygienic goods such as a diaper. | ||||||
| 223 | Method for producing hydrogel, method for enveloping envelopment target, and method for releasing envelopment target | US15304675 | 2015-04-16 | US10016506B2 | 2018-07-10 | Noriho Kamiya; Kosuke Moriyama; Kosuke Minamihata |
| Provided is a method for producing a hydrogel, which enables a hydrogel comprising polyethylene glycol to be produced under low peroxidase concentration conditions and physiological conditions. The method for producing a hydrogel involves crosslinking polyethylene glycol having two or more thiol groups using peroxidase in the presence of a phenol compound. | ||||||
| 224 | Vitamin functionalized gel-forming block copolymers for biomedical applications | US15340795 | 2016-11-01 | US09987369B2 | 2018-06-05 | Wei Cheng; Mareva B. Fevre; James L. Hedrick; Nor Lizawati Ibrahim; Ashlynn L. Z. Lee; Victor W. L. Ng; Robert J. Ono; Chuan Yang; Yi Yan Yang |
| Gel-forming block copolymers were prepared comprising i) a central hydrophilic block consisting essentially of a divalent poly(ethylene oxide) chain and ii) two peripheral monocarbonate or polycarbonate hydrophobic blocks linked to the central block by linking groups bearing one or more hydrogen bond forming *—N(H)—* groups. The hydrophobic blocks comprise one or more vitamin-bearing subunits. The gel-forming block copolymers can be used to prepare various biodegradable and/or biocompatible hydrogel and organogel drug compositions, in particular antimicrobial and/or anti-tumor drug compositions. The hydrogel compositions have utility in depot injections for drug delivery. The hydrogen bonding *—N(H)—* group(s) provide longer in vivo lifetime of the hydrogel before degradation and a more prolonged and controlled release rate of a hydrophobic drug compared to similar hydrogels prepared from poly(ethylene glycol). | ||||||
| 225 | AMPHIPHILIC BRANCHED POLYDIORGANOSILOXANE MACROMERS | US15792807 | 2017-10-25 | US20180113237A1 | 2018-04-26 | Frank Chang; Feng Jing; Fei Cheng; Ying Zheng |
| The invention provides a class of amphiphilic branched polydiorganosiloxane macromers and the uses thereof. Such a macromer comprises a polydiorganosiloxane polymer chain and two terminal groups free of any ethylenically unsaturated group, wherein the polydiorganosiloxane polymer chain comprises (1) at least 5 dimethylsiloxane units in a consecutive sequence, (2) at least two first siloxane units each having methyl as one of the two substituents of each first siloxane unit and one first first organic radical having one sole (meth)acryloyl group as the other substituent, (3) at least one second siloxane unit having methyl as one of the two substituents of the second siloxane unit and one second organic radical, which is free of any ethylenically unsaturated group and comprises one or more hydrophilic groups or polymer chains, as the other substituent. | ||||||
| 226 | POLYCARBONATE BASED PI-PI STABILIZED NANO-OBJECTS AND HYDROGELS | US15332010 | 2016-10-24 | US20180112041A1 | 2018-04-26 | DYLAN J. BODAY; MAREVA B. FEVRE; JEANNETTE M. GARCIA; JAMES L. HEDRICK; NATHANIEL H. PARK; RUDY J. WOJTECKI; MU SAN ZHANG |
| A block copolymer includes a water-soluble block that is bonded to one or more hydrophobic polycarbonate blocks that include pendant fluoroaryl substituents. | ||||||
| 227 | POLYSACCHARIDE-POLYAMINE COPOLYMER AND USE THEREOF IN REDUCING URIC ACID CONCENTRATION IN PLASMA | US15559196 | 2016-03-18 | US20180110801A1 | 2018-04-26 | Dazhi YANG |
| Disclosed is a pharmaceutical composition for treating hyperuricemia (HUA). The pharmaceutical composition includes a polysaccharide-polyamine copolymer and a pharmaceutically acceptable salt thereof as active ingredients. The polysaccharide-polyamine copolymer is formed by copolymerization of the following two parts: a selectively oxidized polysaccharide with 2,3-dialdehydo, and a polyamine with an amino functional group; the polyamine with an amino functional group and the selectively oxidized polysaccharide with 2,3-dialdehydo can form a net structure by means of covalent crosslinking, resulting in a hydrogel with an amino functional group or a granular polysaccharide-polyamine copolymer, wherein the amino functional group in the hydrogel with an amino functional group or the granular polysaccharide-polyamine copolymer can be protonated so as to form a cationic copolymer of a three-dimensional network structure having a protonated site, and the nitrogen content of the cationic copolymer and the nitrogen content of the polysaccharide-polyamine copolymer are above 12.3 wt %, and both the cationic copolymer and the polysaccharide-polyamine copolymer are water-insoluble. | ||||||
| 228 | HYDROGEL CAPABLE OF BEING USED FOR SEAWATER DESALINATION AND PREPARATION METHOD THEREFOR | US15562585 | 2015-12-31 | US20180105617A1 | 2018-04-19 | Shuanshi Fan; Chi Yu; Xuemei Lang; Yanhong Wang |
| A hydrogel capable of desalinating seawater and a preparation method thereof. The hydrogel is a polymer polymerized by a monomer containing a hydrophilic group and a carbon-carbon double bond via carbon-carbon double bonds. A degree of crosslinking of the polymer is 0.01 to 0.2. The monomer accounts for 5 wt % to 50 wt % of a mass of the hydrogel. The preparation method includes: mixing a monomer with a pore-forming agent, a cross-linking agent, a initiator and a catalyst evenly, obtaining a mixed material, then transferring the mixed material into a die; conducting a polymerization for 2 to 3 hours at a temperature of 20° C. to 30° C. first, followed by increasing the temperature to continue the polymerization until the polymerization is completed; and obtaining the hydrogel capable of desalinating seawater. The method according is convenient and efficient, and has advantages of being used under special conditions such as earthquake relief work, maritime rescue and wild adventure. | ||||||
| 229 | BOTTLEBRUSH COPOLYMERS AND USES THEREOF | US15725036 | 2017-10-04 | US20180094099A1 | 2018-04-05 | Jeremiah A. Johnson; Qixian Chen; Farrukh Vohidov |
| Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. In certain embodiments, the triblock bottlebrush copolymers, particles, and hydrogels described herein are thermally-responsive and gel at physiological temperature (e.g., upon administration to a subject), providing injectable and/or implantable gels which can be used for extended release drug delivery. The present invention also provides methods for extended release drug delivery, and methods of treating and/or preventing a disease or conditions in a subject, using the inventive copolymers, particles, and hydrogels. In addition, the present invention provides methods of preparing the triblock bottlebrush copolymers described herein. | ||||||
| 230 | Organo-modified silicone polymers and hydrogels comprising the same | US14492646 | 2014-09-22 | US09890234B2 | 2018-02-13 | Anubhav Saxena; Sandeep Shashikant Naik; Monjit Phukan; Shreedhar Bhat |
| A hydrophilic silicone polymer composition suitable for use in producing hydrogel polymer films disclosed. In one aspect, a hydrophilic silicone monomer is of the Formula 1: wAmBnw (1) where A is a divalent block comprising a silicone-containing pendant group. In one embodiment, the silicone-containing pendant group comprises polyalkylene oxide groups. The structure of the polymer can be controlled and tuned to provide a material with excellent wettability and oxygen permeability. The polymers are suitable for use in a variety of applications including in providing a film for forming contact lenses. | ||||||
| 231 | PROCESS FOR PRODUCING LOW-CONCENTRATION GEL USING GEL-PRECURSOR CLUSTERS, AND GEL OBTAINED BY SAID PRODUCTION PROCESS | US15551442 | 2016-03-03 | US20180030205A1 | 2018-02-01 | Takamasa SAKAI; Yuichi TEI |
| [Problem] To provide a gel which can be produced in a short time, has controlled properties such as modulus and expansion pressure, and has a low polymer concentration.[Solution] A process for producing a polymer gel in which gel-precursor clusters have been crosslinked with one another to form a three-dimensional network structure, characterized by comprising a) a step in which monomer or polymer units that are present in a concentration less than a critical gelation concentration are crosslinked to form the gel-precursor clusters, the gel-precursor clusters having a storage modulus G′ and a loss modulus G″ which satisfy the relationship G′ | ||||||
| 232 | CONDUCTIVE SELF-HEALING NETWORK | US15484597 | 2017-04-11 | US20170292008A1 | 2017-10-12 | Guihua Yu; Ye Shi; Xiaopeng Li |
| Disclosed herein are self-healing conductive network compositions. The networks can contain one or more conductive polymers and one or more supramolecular complexes. The supramolecular complex can be introduced into conductive polymer matrix, resulting in a network of the two components. In this network, the nanostructured conductive polymer gel constructs a 3D network to promote the transport of electrons and mechanically reinforce the network while the supramolecular complex contributes to self-healing property and also conductivity. The networks disclosed herein are useful for various applications such as self-healing electronics, artificial skins, soft robotics and biomimetic prostheses. | ||||||
| 233 | Epimorphic Regeneration and Related Hydrogel Delivery Systems | US15618715 | 2017-06-09 | US20170273971A1 | 2017-09-28 | Phillip B. Messersmith; lossif A. Strehin; Ellen Heber-Katz |
| Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel. | ||||||
| 234 | LOW-SWELLING BIOCOMPATIBLE HYDROGELS | US15483172 | 2017-04-10 | US20170216487A1 | 2017-08-03 | Amarpreet S. Sawhney; Steven L. Bennett |
| Some aspects of the present disclosure relate to a surgical treatment for treating a tissue inside a vertebral column by forming a low-swelling biodegradable hydrogel in situ adherent to a tissue inside the vertebral column and substantially exterior to a theca in the vertebral column. | ||||||
| 235 | BONE REPAIR MATERIAL | US15476012 | 2017-03-31 | US20170203000A1 | 2017-07-20 | Corinna MAUTH; Aaldert-Rens MOLENBERG |
| Sliceable bone repair material is a porous block-shaped scaffold containing a hydrogel, wherein the hydrogel is formed by Michael type addition of at least two precursor molecules. Said scaffold is made of a synthetic ceramic material and has interconnected macropores having a diameter above 100 μm. In addition said scaffold has a total porosity of 80 to 95%. The total volume of the hydrogel is smaller than the total volume of the interconnected macropores. | ||||||
| 236 | DEGRADABLE HYDROGEL WITH PREDICTABLE TUNING OF PROPERTIES, AND COMPOSITIONS AND METHODS THEREOF | US15119892 | 2015-02-26 | US20170182220A1 | 2017-06-29 | Jie Song; Jianwen Xu |
| The invention provides a novel approach to hydrogels with predictable degradation/gelling kinetics, which is useful for many biomedical applications where appropriate gelling kinetics and the timely disintegration of the hydrogel (e.g., drug delivery, guided tissue regeneration) is required. Precisely controlling hydrogel degradation over a broad range in a predictable manner is achieved via a simple but versatile hydrogel platform that allows formulation of hydrogels with predictable disintegration time from within 2 days to >250 days yet comparable macroscopic physical properties. | ||||||
| 237 | Negative-swelling and exceptionally robust adhesive hydrogels | US14056281 | 2013-10-17 | US09687582B2 | 2017-06-27 | Phillip B. Messersmith; Devin G. Barrett |
| The present invention provides adhesive hydrogels that negatively swell at physiological temperature. By combining mussel-mimetic chemistry and the thermosensitive nature of poly(ethylene oxide)-poly(propylene oxide) copolymers, novel materials were designed that are suitable as medical sealants and adhesives. | ||||||
| 238 | Method for the treatment of nanohydrogels | US14896974 | 2014-06-11 | US09655972B2 | 2017-05-23 | Giorgia D'Arrigo; Claudia Cencetti; Chiara Di Meo; Pietro Matricardi |
| A method for treating nanohydrogels comprising—a dispersion step, in which a nanohydrogel obtained from a polysaccharide functionalized with hydrophobic molecules is dispersed in an aqueous solution, and a sterilization and homogenization step, in which the aqueous dispersion of nanohydrogels is added with a compound designed to be charged in the nanohydrogel particles by being englobed or adsorbed thereby and is subjected to a temperature of between 70° C. and 150° C. and a pressure of between 1 and 5 bar; in said sterilization and homogenization step, the conditions of temperature and pressure must be such that boiling of the aqueous dispersion of nanohydrogels does not occur. | ||||||
| 239 | Silicone hydrogels having a structure formed via controlled reaction kinetics | US14495264 | 2014-09-24 | US09562161B2 | 2017-02-07 | Azaam Alli; Douglas G. Vanderlaan; James D. Ford; Scott L. Joslin |
| The present invention relates to a process comprising the steps of reacting a reactive mixture comprising at least one silicone-containing component, at least one hydrophilic component, and at least one diluent to form an ophthalmic device having an advancing contact angle of less than about 80°; and contacting the ophthalmic device with an aqueous extraction solution at an elevated extraction temperature, wherein said at least one diluent has a boiling point at least about 10° higher than said extraction temperature. | ||||||
| 240 | Class of Anti-Adhesion Hydrogels With Healing Aspects | US15283374 | 2016-10-01 | US20170021053A1 | 2017-01-26 | Lukas Bluecher; Michael Milbocker |
| Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the biofunctional aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies. | ||||||
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