Diphenyl compound

申请号 JP16743090 申请日 1990-06-25 公开(公告)号 JPH0356431A 公开(公告)日 1991-03-12
申请人 Fujisawa Pharmaceut Co Ltd; 发明人 MATSUO MASAAKI; OGINO TAKASHI; IKARI NORIHIRO; TAKATANI TAKAO; SENOO HACHIRO; SHIMOMURA KYOICHI;
摘要 NEW MATERIAL:A compound expressed by formula I [R
1 is halogen, (protected amino, hydrazino, aminophenoxy, (protected) OH, etc.; R
2 is halogen, alkylamino, (protected) amino, (protected) hydrazino, etc.; R
3 is H, alkyl, halogen, CN, carboxy, etc.; R
3a is H or alkyl; R
4 and R
4a are H, alkyl or halogen; A is CH(OH), CH
2 , CO, O, S, SO
2 , C(=NOR
a ) (R
a is H, alkyl, alkenyl, etc.), SO
2 N(RC) (RC is H or alkyl), etc.] and salts thereof.
EXAMPLE: 1,1-Bis(4-aminophenyl)-1-methoxyiminomethane.
USE: A remedy for pains, inflammatory diseases, rheumatism, nephritis and thrombocytophenia.
PREPARATION: For example, a compound expressed by formula II, its reactive derivative or salt thereof is reacted with a compound expressed by formula III or salt thereof to afford the compound expressed by formula I (A is SO
2 NH).
COPYRIGHT: (C)1991,JPO&Japio
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