| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 甘草酸三钾的生产工艺和用途 | CN00119121.7 | 2000-06-17 | CN1110502C | 2003-06-04 | 刘钢; 匡军 |
| 本发明涉及一种甘草酸三钾的生产工艺和用途，解决了甘草酸三钾不易制备的缺点，并开创性地用于卷烟的添加剂中，使其功效得以全面发挥。它采用粗甘草酸作原料，与乙醇反应，然后用氢氧化钾乙醇液中和，过滤、干燥即得。工艺简单，操作容易，产品质量稳定。 | ||||||
| 2 | 甘草酸三钾的生产工艺和用途 | CN00119121.7 | 2000-06-17 | CN1277969A | 2000-12-27 | 刘钢; 匡军 |
| 本发明涉及一种甘草酸三钾的生产工艺和用途,解决了甘草酸三钾不易制备的缺点,并开创性地用于卷烟的添加剂中,使其功效得以全面发挥。它采用粗甘草酸作原料,与乙醇反应,然后用氢氧化钾乙醇液中和,过滤、干燥即得。工艺简单,操作容易,产品质量稳定。 | ||||||
| 3 | METHOD OF MAKING THE (+) 3A, 7A-TRANS-4-/7,7-/ETHYLENEDIOXY /-OXOOKTYL/-7A BETA-METHYLPERHYDROINDANE-1,5-DION | CS443080 | 1979-06-14 | CS212221B2 | 1982-03-26 | COOPER GARY F; VAN HORN ALBERT R |
| 4 | A-nor oestrane(s), androstane(s) and gonane(s) - having contraceptive and anti-dermatosis activity | FR7636906 | 1976-12-02 | FR2398756A1 | 1979-02-23 | |
| Steroids of formula (I) are new: In (I), R1 is H or halo (F, Cl), alkyl (m)ethyl, (cyclo) propyl, butyl or aryl, or a OH group or its ehter or ester(acetate, propionate, trichloroacetate, valerate, oenanthate, undecanoate); R2 is H, allene, mono, di- or tri-substd. halo allene, or lower alkane, alkene, or alkyne groups which may be substd.; R3 is H or CH3; R4 is aliphatic gp. (e.g. (m)ethyl or propyl); R5 is H, allene, mono, di or tri halo allene, substd. allene, lower alkane, alkene or alkyne which may be substd.; R6 is H, ether or ester group (acetate, propionate, trichloroacetate, valerate, oenanthate, undecanoate) and n = 0-3. (I) are anti ovulation agents, and some are anti-androgens, useful as contraceptives and in the treatment of some dermatoses such as acne. | ||||||
| 5 | Methods for stereoselective reduction | US14268952 | 2014-05-02 | US09238672B2 | 2016-01-19 | Brian C. Austad; Andre Lescarbeau; Lin-Chen Yu |
| The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution or suspension of the steroidal compound in a solvent with hydrogen gas in the presence of a catalyst and a substituted pyridine. | ||||||
| 6 | Dehydro-17alpha-carboxyethyl-17beta-hydroxyandrost-4-en-3-one lactones | US70349157 | 1957-12-18 | US2900383A | 1959-08-18 | CELLA JOHN A |
| 7 | Métodos para reducción estereoselectiva de derivados de 4-en-3-ona de ciclopamina | ES16197797 | 2008-12-24 | ES2717797T3 | 2019-06-25 | AUSTAD BRIAN C; LESCARBEAU ANDRE; YU LIN-CHEN |
| 8 | UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS 2-SUBSTITUIDOS DE ESTRONA Y ESTRADIOL. | ARP050103233 | 2005-08-04 | AR050195A1 | 2006-10-04 | STOELWINDER JOHANNES; MOERS NICOLAAS ELISABETH CORNE |
| La presente brinda un procedimiento para preparar derivados 2-substituidos de estrona y estradiol, que comprende: i) la preparacion de un compuesto de formula general (2) por reaccion de un compuesto de formula general (1) en una o más etapas en un compuesto de formula general (2) en la cual R1 es un grupo alquilo C1-10, alquenilo o arilo; -Cl, -Br, -I, -F; -CN, -OH; o un grupo -OR2, -O(CO)R2 o -R2-OH, donde R2 es un grupo alquilo o alquileno que tiene entre 1 y 6 átomos de C; y la union entre los átomos 9 y 10 es un enlace simple o doble; ii) aromaticion del compuesto de formula general (2) en un compuesto de formula general (3) en la cual R1 y R2 tinen los significados anteriormente definidos; y iii) opcionalmente, reduccion del compuesto de formula general (3) en un compuesto de formula general (4) en la cual R1 y R2 tienen los significados anteriormente descriptos. Además, la presente reivindica varios compuestos que pueden ser intermediarios en el procedimiento anterior, y procedimientos para preparar estps compuestos. La presente también reivindica 2-alcoxi-estrona o 2-alcoxi-estradiol, o mezclas de ellos, esencialmente libres de otros intermediarios estrogénicos. | ||||||
| 9 | New spiro(cyclopentano-perhydronaphthalene)-3,1'-alkanes useful as steroid mimetics potentially having steroidal activity and triterpenoid properties | DE10303668 | 2003-01-28 | DE10303668A1 | 2004-07-29 | KASCH HELMUT; LIEDTKE BEATRICE |
| Spiro(cyclopentano-perhydronaphthalene)-3,1'-alkanes (I) are new. Spiro(cyclopentano-perhydronaphthalene)-3,1'-alkanes of formula (I) and their amine salts and esters are new: R1 = H, OH, oxo, 1-12C alkoxy, 2-13C alkanoyloxy, (1-3C alkoxy)methoxy, aryl(2-5C)alkanoyloxy, 2-5C hydroxyalkoxy, SCH2CH2S, OCH2CH2S, 17-spiro-2'-oxirane or (OY,CH2X); Y = H, 1-6C alkyl or 2-13C alkanoyl; X = H, halo, pseudohalogen, CN, 1-6C alkoxy, 2-13C alkanoyloxy or OSO2NR6R7; R6, R7 = H, 1-6C alkyl, 3-7C cycloalkyl or 2-9C alkanoyl; R2 = H, Me or Et; R3 = Me or H if ring A is not aromatic and there is no double bond between C5 and C10 or C10 and C9; R4 = H, OH, oxo, 2-5C hydroxyalkoxy, 1-12C alkoxy, 2-13C alkanoyloxy, (1-3C alkoxy)methoxy, aryl(1-3C)alkoxy aryl(2-5C)alkanoyloxy or OSO2NR6R7; R5 = H, OH, oxo, 1-12C alkoxy, 2-13C alkanoyloxy, (1-3C alkoxy)methoxy, aryl(1-3C)alkoxy aryl(2-5C)alkanoyloxy or OSO2NR6R7; A = an aromatic, partially hydrogenated or saturated ring; n = 1 or 2. An Independent claim is also included for a process for preparing (I). | ||||||
| 10 | METHODS FOR STEREOSELECTIVE REDUCTION OF CYCLOPAMINE 4-EN-3-ONE DERIVATIVE | EP16197797.0 | 2008-12-24 | EP3190121B1 | 2019-02-20 | Austad, Brian C.; Lescarbeau, Andre; Yu, Lin-Chen |
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