摘要 |
Steroids of formula (I) are new: In (I), R1 is H or halo (F, Cl), alkyl (m)ethyl, (cyclo) propyl, butyl or aryl, or a OH group or its ehter or ester(acetate, propionate, trichloroacetate, valerate, oenanthate, undecanoate); R2 is H, allene, mono, di- or tri-substd. halo allene, or lower alkane, alkene, or alkyne groups which may be substd.; R3 is H or CH3; R4 is aliphatic gp. (e.g. (m)ethyl or propyl); R5 is H, allene, mono, di or tri halo allene, substd. allene, lower alkane, alkene or alkyne which may be substd.; R6 is H, ether or ester group (acetate, propionate, trichloroacetate, valerate, oenanthate, undecanoate) and n = 0-3. (I) are anti ovulation agents, and some are anti-androgens, useful as contraceptives and in the treatment of some dermatoses such as acne. |