首页 / 专利分类库 / 有机化学 / 甾族化合物 / 甾族化合物,其中环戊烷并[a]氢化菲骨架以两个环各减少1个原子予以改变 / A-nor oestrane(s), androstane(s) and gonane(s) - having contraceptive and anti-dermatosis activity

A-nor oestrane(s), androstane(s) and gonane(s) - having contraceptive and anti-dermatosis activity

申请号 FR7636906 申请日 1976-12-02 公开(公告)号 FR2398756A1 公开(公告)日 1979-02-23
申请人 CRABBE PIERRE; 发明人
摘要 Steroids of formula (I) are new: In (I), R1 is H or halo (F, Cl), alkyl (m)ethyl, (cyclo) propyl, butyl or aryl, or a OH group or its ehter or ester(acetate, propionate, trichloroacetate, valerate, oenanthate, undecanoate); R2 is H, allene, mono, di- or tri-substd. halo allene, or lower alkane, alkene, or alkyne groups which may be substd.; R3 is H or CH3; R4 is aliphatic gp. (e.g. (m)ethyl or propyl); R5 is H, allene, mono, di or tri halo allene, substd. allene, lower alkane, alkene or alkyne which may be substd.; R6 is H, ether or ester group (acetate, propionate, trichloroacetate, valerate, oenanthate, undecanoate) and n = 0-3. (I) are anti ovulation agents, and some are anti-androgens, useful as contraceptives and in the treatment of some dermatoses such as acne.
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