| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | IMMUNOGENS FOR MENINGITIDIS-A VACCINES | EP06765581.1 | 2006-05-08 | EP1885734B1 | 2015-01-14 | OSCARSON, Stefan, Stockholm University; TEODOROVIC, Peter, Stockholm University; COSTANTINO, Paolo, Novartis Vaccines |
| 122 | ANTIVIRAL COMPOUNDS | EP08708068.5 | 2008-01-22 | EP2125848B1 | 2014-09-10 | VERONESI, Paolo Alberto; RODRIGUEZ, Pablo Eduardo Andres; PESCHECHERA, Emanuela; VERONESI, Susanna Lucia |
| 123 | SYNTHETIC C-GLYCOLIPID AND ITS USE FOR TREATING CANCER INFECTIOUS DISEASES AND AUTOIMMUNE DISEASES | EP03760354.5 | 2003-06-13 | EP1551228B1 | 2012-10-03 | TSUJI, Moriya; FRANCK, Richard, W.; YANG, Guangli; CHEN, Guangwu |
| 124 | IMPROVED EXPRESSION SYSTEMS WITH SEC-SYSTEM SECRETION | EP04817876.8 | 2004-11-22 | EP1687324B1 | 2012-08-22 | RETALLACK, Diane, M.; SCHNEIDER, Jane, C.; RAMSEIER, Thomas, Martin |
| Improved methods and prokaryotic expression systems for producing recombinant proteins using Sec-system secretion signal peptides are described using Pseudomonas fluorescens Sec secretion systems. Specific novel Sec-system secretion signal peptides are described, as are fusion proteins and coding sequences for improved secretion of recombinant proteins and peptides. | ||||||
| 125 | C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE | EP07762288 | 2007-05-22 | EP2035011A4 | 2009-08-19 | TSUJI MORIYA; CHEN GUANGWU; FRANCK RICHARD; YANG GUANGLI |
| 126 | GLYCOSOLATED ENKEPHALIN AGENTS | EP04714123 | 2004-02-24 | EP1597265A4 | 2007-04-18 | POLT ROBIN L; BILSKY EDWARD J |
| 127 | ELECTRODIALYSIS METHODS FOR PURIFICATION AND RECOVERY OF GLUCONIC ACID DERIVATIVES | EP99953361 | 1999-05-26 | EP1084264A4 | 2005-11-23 | GENDERS J DAVID; GOPAL RAM; HARTSOUGH DAN M; KENDALL PETER M; LONG WILLIAM J; MAZUR DUANE J; ZAPPI GUILLERMO D |
| A process for purifying and concentrating a gluconic acid derivative, such as 2-keto-L-gulonic acid, comprising introducing a non-viable and/or acidified fermentation medium or an in-vitro reactor medium comprising at least the gluconic acid derivative and/or salt thereof to electrodialysis thereby purifying and concentrating the gluconic acid derivative. | ||||||
| 128 | AGGREGATE-FORMING AGENT | EP01967701 | 2001-09-17 | EP1338638A4 | 2005-03-23 | OKU KAZUYUKI; KUBOTA MICHIO; FUKUDA SHIGEHARU; MIYAKE TOSHIO |
| The present invention is to provide means of inhibiting chemical changes in unsaturated compounds by radical reactions through inhibition of radical formation in such an unsaturated compound: The present invention attains such an objective by providing an agent which comprises trehalose as an effective ingredient to form an association product between trehalose and an unsaturated compound. | ||||||
| 129 | Utilisation cosmétique de nouveaux agents desquamants | EP04290756.8 | 2004-03-22 | EP1466590A1 | 2004-10-13 | Dalko, Maria; Cavezza, Alexandre; Bernard, Dominique |
L'invention se rapporte à une composition adaptée à une application topique sur la peau ou le cuir chevelu contenant, dans un milieu physiologiquement acceptable, au moins un composé de formule (I)
Elle concerne également un procédé de traitement cosmétique comprenant l'application topique sur la peau de cette composition, en particulier en vue de prévenir ou estomper les signes cutanés du vieillissement et/ou d'améliorer l'éclat du teint et/ou de lutter contre la peau sèche. L'invention concerne encore de nouveaux dérivés C-glycoside (III) :
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| 130 | ABSORBANCE MULTIPLEX TECHNOLOGY | EP01992259.0 | 2001-12-21 | EP1352241A1 | 2003-10-15 | DAMAJ, Bassam; AL-ASSAAD, Ali-Samer |
| A method of simultaneously detecting and quantitating multiple target molecules in a single reaction well of a reaction surface. Antibodies to different target molecules are bound to a reaction surface. A sample solution believed to contain the target molecules in added to the reaction surface and incubated. During incubation, the target molecules from complexes with the bound antibodies. After a washing step, an enzyme-bound antibody mixture is added to the reaction surface. The enzyme-bound antibodies have an affinity for the target molecule/bound antibody complexes. The sequential addition of specific enzyme substrates permits the detection of multiple target molecules without poisoning any of the enzymes. A kit for the simultaneous detection of multiple target molecules is also disclosed. | ||||||
| 131 | CHEMILUMINESCENT SUBSTRATES FOR NEURAMINIDASE, ASSAYS FOR DETECTION OF NEURAMINIDASE AND KITS THEREFOR | EP99964958 | 1999-11-17 | EP1131330A4 | 2002-06-12 | BRONSTEIN IRENA; EDWARDS BROOKS; JUO ROUH-RONG |
| The present invention discloses chemiluminescent 1,2-dioxetane substrates capable of reacting with a neuraminidase to release optically detectable energy. These 1,2-dioxetanes have general formula (I), wherein Z is formula (II) and the variables are selected so as to induce decomposition of said dioxetane accompanied by chemiluminescence where Z is cleaved by neuraminidase present. | ||||||
| 132 | CYCLIC PEPTIDE ANTIFUNGAL AGENTS | EP99966324.8 | 1999-12-15 | EP1140991A1 | 2001-10-10 | RODRIGUEZ, John, Michael; JAMISON, James, Andrew |
| A compound represented by structure (I) is described where R<4> and/or R<8> represent a sugar moiety. The compounds are shown to be useful as an antifungal and antiparatic agent or as an intermediate to such an agent. Methods of treatment and pharmaceutical formulations containing compounds represented by structure (I) are also described. | ||||||
| 133 | Décarboxylation au cuivre | EP98402918.1 | 1998-11-24 | EP0926153A1 | 1999-06-30 | Tamion, Rodolphe |
La présente invention a pour objet un procédé de fabrication d'un aldose ou d'un dérivé d'aldose comportant sur la chaîne hydrocarbonée n atomes de carbone, caractérisé par le fait que l'on met en contact une solution aqueuse d'un dérivé acide d'ose à n+1 atomes de carbone, comportant au moins un motif α-hydroxyacide, ou un de ses sels, avec du peroxyde d'hydrogène en présence d'un sel de cuivre, que l'on sépare ensuite le cuivre qui précipite du milieu, puis que l'on régénère un sel de cuivre à l'aide de l'acide correspondant et que l'on recycle ensuite le sel de cuivre ainsi régénéré en tête du procédé. |
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| 134 | Deacetylcolchicine derivatives | EP91311942.6 | 1991-12-23 | EP0493064B1 | 1995-02-15 | Akiyama, Kiyoshi |
| 135 | N-Methyldeacetylcolchiceinamide derivatives | EP93303191.6 | 1993-04-23 | EP0607647A1 | 1994-07-27 | Akiyama, Kiyoshi |
N-methyldeacetylcolchiceinamide derivatives represented by the formula
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| 136 | CELL-PERMEABLE PROBES FOR IDENTIFICATION AND IMAGING OF SIALIDASES | EP13831440.6 | 2013-08-16 | EP2885311A1 | 2015-06-24 | WONG, Chi-Huey; FANG, Jim-Min; CHENG, Yih-Shyun, E.; TSAI, Charng-Sheng |
| Provided herein are novel irreversible sialidase inhibitors. These compounds can be conjugated with a detectable tagging moiety such as azide-annexed biotin via CuAAC for isolation and identification of sialidases. The provided compounds and the corresponding detectable conjugates are useful for detecting sialidase-containing pathogens and imaging in situ sialidase activities under physiological conditions. | ||||||
| 137 | MIMES STABLES DE SUCRES DE TYPE C-GLYCOSIDES ET C- GLYCOCONJUGUES, LEUR PROCEDE DE PREPARATION ET LEURS APPLICATIONS NOTAMMENT DANS LE DOMAINE DE LA COSMETIQUE ET DU MEDICAMENT. | EP07731342.7 | 2007-04-23 | EP2027138B1 | 2012-12-05 | CASTELOT-DELIENCOURT-GODEFROY, Géraldine; QUIRION, Jean-Charles; JUBAULT, Philippe; ZOUTE, Ludivine |
| 138 | AMPHIPHILIC COMPOUNDS AND VESICLES/LIPOSOMES FOR ORGAN-SPECIFIC DRUG TARGETING | EP02788510 | 2002-12-04 | EP1461014A4 | 2010-11-10 | HELDMAN ELIAHU; LINDER CHARLES; GRINBERG SARINA; KOLOT VICTORIA; SHAUBI ELEONORA |
| An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine derivative, and at least one hydrogen-bonding group located either within said headgroup and/or in close proximity thereto. The cleavable group or moiety is cleaved under selective conditions including change of chemical, physical or biological environment and is preferably cleaved enzymatically in a biological environment such as the brain or the blood. Vesicles or liposomes made from said amphiphilic compounds are suitable for delivery of a therapeutic substance or a diagnostic agent specifically to a target organ or tissue, or for delivery of a nucleic acid for gene therapy. | ||||||
| 139 | NOUVEAUX COMPOSES C-GLYCOSIDES GEM-DIFLUORES DERIVES DE LA PODOPHYLLOTOXINE, LEUR PREPARATION ET LEURS APPLICATIONS | EP07731356.7 | 2007-04-24 | EP2024379B1 | 2010-09-22 | QUIRION, Jean-Charles; CASTELOT DELIENCOURT-GODEFROY, Géraldine; AUDOUARD, Christophe |
| 140 | METHOD OF DRUG DESIGN | EP06790302 | 2006-10-03 | EP1934388A4 | 2010-07-21 | TOMETZKI GERALD B; MEUTERMANS WIM; ZUEGG JOHANNES |
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