| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | The method for manufacturing a precursor of vitamin b1 | JP2007552562 | 2006-01-24 | JP2008528529A | 2008-07-31 | レインハルド カルゲ，; リサ ジラウディ，; ジョセリン フィシュケッサー，; ワーナー ボンラス， |
| 本発明は、式（ＩＩ）（式中、Ｒは、水素または直鎖もしくは分枝鎖Ｃ
１〜４アルキルである）の化合物を水酸化アルカリまたはアルカリ土類金属水溶液で加水分解する工程を含む、グルー−ジアミン（Ｇｒｅｗｅ−ｄｉａｍｉｎｅ）の新規の製造方法であって、加水分解は、有機溶媒の存在下で行われることを特徴とする方法に関する。
【選択図】なし |
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| 82 | Drink composition | JP2003102908 | 2003-04-07 | JP2004305087A | 2004-11-04 | HONMA YOSHIKO |
| <P>PROBLEM TO BE SOLVED: To provide a drink composition formulated with thiamine or a salt thereof and diminished in the unpleasant odor with time inherent in thiamines. <P>SOLUTION: The drink composition is such as to be formulated with thiamine or a salt thereof along with a polyhydric phenolic compound and a sparingly digestible dextrin. Thereby, the unpleasant odor with time inherent in thiamines can be diminished. <P>COPYRIGHT: (C)2005,JPO&NCIPI | ||||||
| 83 | Pharmaceutical for treatment of nerve disorder | JP2003062489 | 2003-01-31 | JP2003292438A | 2003-10-15 | HAYASHI YOSHIMITSU; UNO TAKASHI; SHIROISHI AKIRA; MATSUNAGA MANABU; SHIMIZU HIROKI; ONOKI TATSUHIRO; ARAKI SEIICHI |
| <P>PROBLEM TO BE SOLVED: To provide a safe and effective agent for the prevention and treatment of peripheral neuropathy. <P>SOLUTION: A pharmaceutical composition composed of B complex vitamin, vitamin E, folic acid, etc., has high effectiveness for the prevention and treatment of peripheral neuropathy. <P>COPYRIGHT: (C)2004,JPO | ||||||
| 84 | Method of manufacturing pyrimidine derivatives and thiamine | JP11883689 | 1989-05-15 | JP2755368B2 | 1998-05-20 | URUSU HENGARUTONAA; JERAARU MOWANU |
| 85 | Athlete's foot, etc. bacterial skin disease of the therapeutic agent | JP22031785 | 1985-10-04 | JPH0751506B2 | 1995-06-05 | 孝男 岩崎 |
| 86 | Bathing agent | JP26289693 | 1993-09-27 | JPH0710742A | 1995-01-13 | IWASAKI TAKAO |
| PURPOSE:To obtain a bathing agent high in safety for skins, excellent in the antimicrobial action, and having a dermatosis-treating effect. CONSTITUTION:This bathing agent contains an asymmetric thiamine disulfide derivative of formula I (R1 is lower alkyl; R2 is oxygen-containing heterocyclic group), e.g. furfuryl thiamine disulfide, as an active ingredient. The compound of formula I is obtained by reacting a thiamine compound of formula II with a compound of formula III obtained by the reaction of an organic halide having an oxygen-containing heterocyclic group with sodium thiosulfate. The concentration of the compound of formula I in a hot bath is >=0.001g, usually 0.01-0.05g, in 1l of the bathing hot water. | ||||||
| 87 | JPH0567638B2 - | JP11197583 | 1983-06-23 | JPH0567638B2 | 1993-09-27 | JOBANNI GERII; ARESANDORO BARUBON; RUCHIANO KONCHI; RUIJI ORIARI |
| 88 | Production of thiamine hydrochloride crystal | JP22246692 | 1992-08-21 | JPH05202039A | 1993-08-10 | ASOGAWA TATSUO; KAKIGUCHI YOSHITOMI; IZUMIHARA SEIJI |
| PURPOSE:To produce a beta-type thiamine hydrochloride crystal which is more stable and hardly causes agglomeration and its preparation by a simple method. CONSTITUTION:The objective method for producing a beta-type thiamine hydrochloride crystal is characterized in that a alpha-type thiamine hydrochloride crystal is moistened with water and then stirred in the presence of the beta-type thiamine hydrochloride crystal and the objective method for producing a preparation of beta-type thiamine hydrochloride crystal is characterized in that the alpha-type thiamine hydrochloride crystal is moistened with water together with a binder and then stirred in the presence of the preparation of beta-type thiamine hydrochloride crystal. | ||||||
| 89 | Production of high-melting point thiamine disulfide | JP24087683 | 1983-12-22 | JPS60132965A | 1985-07-16 | AYUKAWA KOUICHI; AZUMA TADASHI; TOYAMA MIYAKO; UEDA FUMIO |
| PURPOSE: To obtain a high-melting point thiamine disulfide in the form of fine crystals, by dissolving a low-melting point thiamine disulfide in molten higher fatty acid, cooling and solidifying the mixture, and treating with a solvent to dissolve only the higher fatty acid. CONSTITUTION: 1pt.wt. of a low-melting thiamine disulfide is dissolved in ≥3 pts.wt. of molten 10W18C higher fatty acid (e.g. stearic acid, palmitic acid, etc.), and the mixture is solidified by leaving to stand at room temperature or by quenching with a cooling device. The solidified product is treated with a solvent (e.g. petroleum benzine, hexane, isooctane, etc.) which does not dissolve thiamine disulfide but dissolves the higher fatty acid, and the solution is treated by filtration, centrifugal separation, etc. to obtain a high-melting point thiamine disulfide in the form of fine crystals having a long axis of ≤10μ. USE: A raw material of vitamin B 1 preparation. COPYRIGHT: (C)1985,JPO&Japio | ||||||
| 90 | Adduct for mutually stabilizing menadione and thiamine | JP11197583 | 1983-06-23 | JPS5925324A | 1984-02-09 | JIYOBANNI GERII; ARESANDORO BARUBON; RUCHIANO KONCHI; RUIJI ORIARI |
| 91 | Method and apparatus for production of vitamin b1 and intermediate thereof | JP14941978 | 1978-12-01 | JPS5576084A | 1980-06-07 | NIINOBE TAKAO; YOSHIDA KOUKICHI; YOKOYAMA MASAO |
| PURPOSE: To obtain the captioned product by performing electrolytic oxidation and reduction efficiently, by electrochemically oxidizing the thiothiazolone compound under specified conditions on the anode side separated by cation exchange membrane, and simultaneously reducing cyanopyrimidine on the cathode side. CONSTITUTION: On the anode side of an electrolytic cell 18 equipped with cathode and anode 1, 2 and two cation exchange membranes 3, while keeping the potential on the surface of the anode 2 below the oxygen generation potential, N-[2'-methyl- 4'-amino-pyrimidyl-5'-]methyl-4-methy-5-β-hydroxy ethyl-thiothiazolone (2) is electrochemically oxidized to produce vitamin B 1, which is then taken out from a discharge route 12. On the other hand, on the cathode side, 2-methyl-4-amino-5- cyanopyrimidine is electrochemically reduced to produce 2-methyl-4-amino-5-amino methyl pyrimidine, which is then taken out from a discharge route 17. COPYRIGHT: (C)1980,JPO&Japio | ||||||
| 92 | Thiamine derivative and its preparation | JP10694377 | 1977-09-05 | JPS5441883A | 1979-04-03 | OKA YOSHIKAZU; NISHIKAWA KOUHEI; AONO TETSUYA |
| NEW MATERIAL:Thiamine derivatives of formulaI(R is H, lower alkyl, aralkyl) and their salts. EXAMPLE:3-[2-N-(4-amino-2-methyl-5-pyrimidnyl)methylformamide-1-(2-hyd roxyethyl)-1-propenyldithio]-2-methylpropionyl-L-proline benzyl ester. USE:It has vitamin B1 activity as well as activities inhibiting the enzyme transforming angiotensin and the enzyme hydrolyzing bradykinin (kininase) and is used as preventive agents or remedy for hyperpiesia. PREPARATION:A compound of formula II is reacted with a compound of formula III[either X or Y is MSO3-(M is alkali metal) and the other is H or alkali metal] to form the compound of formulaI. | ||||||
| 93 | Karubosuchirirujudotaino seizoho | JP14033974 | 1974-12-04 | JPS5165770A | 1976-06-07 | NAKAGAWA KAZUYUKI; YOSHIZAKI SHIRO; TANIMURA KAORU; TAMADA SHIGEHARU |
| 94 | JPS5095284A - | JP24674 | 1973-12-27 | JPS5095284A | 1975-07-29 | |
| 95 | JPS506534B1 - | JP1531372 | 1972-02-15 | JPS506534B1 | 1975-03-14 | |
| 96 | JPS502005B1 - | JP2358171 | 1971-04-13 | JPS502005B1 | 1975-01-23 | |
| 97 | JPS4948498B1 - | JP1410369 | 1969-02-25 | JPS4948498B1 | 1974-12-21 | |
| 98 | JPS4946046B1 - | JP6536964 | 1964-11-18 | JPS4946046B1 | 1974-12-07 | |
| 99 | JPS4993379A - | JP763773 | 1973-01-16 | JPS4993379A | 1974-09-05 | |
| 100 | JPS4975588A - | JP11878572 | 1972-11-27 | JPS4975588A | 1974-07-20 | |
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