专利检索_杂环化合物含五元环有两个氧原子作为仅有的杂环原子专利检索_杂环化合物含五元环有两个氧原子作为仅有的杂环原子专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
121	PROCESS FOR THE PREPARATION OF Z-5-CARBOXYMETHYLENE-1,3-DIOXOLAN-4-ONES	EP05792648.7	2005-08-25	EP1784395A1	2007-05-16	NUGENT, William A.; ZHU, Keming; SIMPSON, James H.; DELANEY, Edward J.
A process for preparing Z-5-carboxymethylene-1,3-dioxolan-4-ones is provided which includes the steps of reacting a bis-ketal or bis-acetal of tartaric acid with a potassium containing base to form the carboxymethylene-1,3-dioxolan-4-one. A process for preparing HIV integrase inhibitors employing the carboxymethylene-1,3-dioxolan-4-one inhibitor is also provided.
122	EXTRACTION OF ALKALOIDS FROM OPIUM	EP05758039.1	2005-05-06	EP1758908A1	2007-03-07	TOMAZI, Keith, G.
A method for extracting at least one alkaloid from opium that includes dissolving opium in a solvent, heating the dissolved opium solution, cooling the dissolved opium solution, adjusting the pH of the dissolved opium solution with at least one first weak acid, filtering the dissolved opium solution to recover a filtrate; and then separating and purifying at least one alkaloid in the filtrate. Preferably, this includes an additional step of chilling the opium solution after adjusting the pH of the dissolved opium solution with at least one first acid. The preferred method for separating and purifying at least one alkaloid in the filtrate includes utilizing preparative liquid chromatography, however, solvent extraction and filtration can also be utilized.
123	ANTICONVULSANT PSEUDOFRUCTOPYRANOSE SULFAMATES	EP95904333.2	1994-12-15	EP0736029B1	2006-03-08	COSTANZO, Michael, J.; MARYANOFF, Bruce, E.; McCOMSEY, David, F.; NORTEY, Samuel, O.
A compound of general formula (I) is disclosed as a potent anticonvulsant drug. Pharmaceutical compositions and methods of treatment are also disclosed.
124	SUBSTITUIERTE INDOLINONE ALS TYROSINKINASE INHIBITOREN	EP00958481.4	2000-08-22	EP1212318B1	2006-01-25	ROTH, Gerald, Jürgen; HECKEL, Armin; WALTER, Rainer; TONTSCH-GRUNT, Ulrike; SPEVAK, Walter; VAN MEEL, Jacobus, C., A.
The invention relates to substituted indolinones of the general formula (I), in which R1 to R6 and X are defined as per claim 1, to their isomers and salts, in particular, their physiologically compatible salts which exhibit valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases, cyclin/CDK complexes and also on the proliferation of endothelial cells and different tumour cells. The invention also relates to medicaments containing these compounds, to their use and to a method for their production.
125	COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF i FLAVIVIRUS /i INFECTIONS	EP03767343.1	2003-12-09	EP1569929A1	2005-09-07	CHAN CHUN KONG, Laval; DAS, Sanjoy, Kumar; NGUYEN-BA, Nghe; HALAB, Liliane; HAMELIN, Bettina; PEREIRA, Oswy, Z.; POISSON, Carl; PROULX, Mélanie; REDDY, Thumkunta, Jagadeeswar; ZHANG, Ming-Qiang
The present invention provides novel compounds represented by formula (I) or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.
126	Alkyl substituted nitrotoluene derivatives	EP93302852.4	1993-04-13	EP0569139A3	1993-12-08	Milner, David John
A compound of Formula (1): wherein: R is -H or alkyl; R¹, R² and R³ each independently is -H or alkyl; X is halogen, -SO₂alkyl, -CN, -CO₂alkyl, -CO₂alkylaryl, -CO₂aryl, -CO₂H or aryl; and Y is H, alkyl, alkoxy, aryl or halogen, and a process for their preparation are disclosed. The compounds of Formula (1) are useful as intermediates in the preparation of dyestuffs, pharmaceuticals and agrochemicals.
127	Polymerisierbare Verbindungen und Verfahren zu ihrer Herstellung	EP86110847.0	1986-08-05	EP0213440B1	1990-09-19	Sander, Jürgen, Dr. Dipl.-Chem.; Schneller, Arnold, Dr. Dipl.-Chem.

128	Microbicidal 2-(1-triazolyl)1-phenyl-ethanone-(1)-ketalderivatives	EP86810524	1986-11-17	EP0228343A3	1988-11-30	HUBELE, ADOLF, DR.
Neue substituierte 2-(1H-1,2,4-Triazolyl)-1-phenyl-äthanon(1)-ketale der allgemeinen Formel in welcher einer der beiden Phenylsubstituenten in 2-Stellung und der andere in 4-Stellung steht, und worin R _a Halogen, Methyl oder C₁-C₃-Haloalkoxy bedeutet, und U und V unabhängig voneinander für gegebenenfalls durch Halogen oder C₁-C₆-Alkoxy substituiertes C₁-C₁₂-Alkyl darstellen oder zusammen eine der folgenden Alkylenbrücken
129	PROCESS FOR 1,4-DIHYDROPYRIDINE COMPOUNDS	EP87300981	1987-02-04	EP0234776A3	1988-09-07	PITZENBERGER, STEVEN M.; TROST, BARRY M.

130	N-benzothiazolyl amides	EP87112784	1987-09-02	EP0261459A3	1988-05-11	Kume, Toyohiko; Tsuboi, Shinichi; Sasaki, Shoko; Yanagi, Akihiko; Hattori Yumi; Yagi, Shigeki; Sirrenberg, Wilhelm, Dr.; Becker, Benedikt, Dr.
Offenbart werden neue N-Benzothiazolylamide der Formel (I)
131	Dioxolobenzisoxazole derivatives and process for preparing the same	EP86104714	1986-04-07	EP0197533A3	1988-01-13	Koga, Hiroshi; Dan, Takashi; Sato, Haruhiko; Onuma, Eturo
Dioxolobenzisoxazole derivatives of the formula wherein R₁ is a phenyl group which may be substituted with a halogen atom, a lower alkyl group having 1-3 carbon atoms or a lower haloalkyl group, or a thienyl group; R₂ is a hydrogen atom or a lower alkyl group having 1-4 carbon atoms; and X and Y which may be the same or different represent a hydrogen atom or a halogen atom, as well as non-toxic salts thereof wherein R₂ is a hydrogen atom, a process for preparing the same and a pharmaceutical composition containing the same are disclosed. The derivatives have diuretic and uricosuric activities and, therefore, are useful as a drug for treating hyperuricemia or hypertension.
132	Mikrobizide Mittel.	EP86810273	1986-06-16	EP0206999A2	1986-12-30	NYFELER ROBERT; EHRENFREUND JOSEF
Neue 3-Phenyl-4-cyanopyrrol-Derivate der allgemeinen Formel in welcher X folgende Bedeutungen hat: A: Wasserstoff oder CO - R1, wobei R1 unsubstituiertes C1-C6-Alkyl oder durch Halogen oder C1-C3-Alkoxy substituiertes C1-C6-Alkyl; C3-C6-Alkenyl, C3-C6-Alkinyl, unsubstituiertes C1-C6-Alkoxy oder durch Halogen oder C1-C3-Alkoxy substituiertes C1-C6-Alkoxy; C3-C6-Alkenyloxy, C3-C6-Cycloalkyl oder Tetrahydrofur-2-yl darstellt; B: S - R2, worin R2 C1-C3-Haloalkyl bedeutet; C: CH(Y)R3, wobei R3 für Wasserstoff oder C1-C8-Haloalkyl und Y für Hydroxy, Halogen oder OC(O)R4 stehen, worin R4 C1-C8-Alkyl, C1-C8-Haloalkyl, C2-C6-Alkenyl, 2-Tetrahydrofuryl, 2-Tetrahydropyranyl oder C1-C6-Alkoxycarbonyl darstellen; D: CH2 - Z, wobei Z für eine der Gruppen steht, worin R5 und R6 unabhängig voneinander Wasserstoff, unsubstituiertes oder durch Cyano, C1-C6-Alkoxycarbonyl substituiertes C1-C6-Alkyl; C3-C6-Alkenyl, C3-C6-Alkinyl, C3-C7-Cycloalkyl, unsubstituiertes oder durch Halogen, C1-C6-Alkyl, C1-C6-Haloalkyl und/oder C1-C6-Alkoxy substituiertes Phenyl bedeuten, mit der Massgabe, dass nur R5 oder R6 Wasserstoff sein kann; R7 und R8 unabhängig voneinander für Wasserstoff, C1-C6-Alkyl, C1-C6-Alkoxycarbonyl darstellen oder beide zusammen einen ankondensierten aromatischen Ring bilden; R9 und R10 unabhängig voneinander für Wasserstoff, C1-C6-Alkyl oder C1-C6-Alkoxycarbonyl stehen; und X Sauerstoff, Schwefel, oder bedeutet; worin R11 Wasserstoff, C1-C6-Alkyl, Formyl; C1-C6-Alkanoyl oder C1-C6-Alkoxycarbonyl darstellt; und n für eine der Zahlen 0 oder 1 steht. Die neuen Wirkstoffe dienen der Bekämpfung schädlicher Mikroorganismen, vor allem phytopathogener Pilze. Sie können zusammen mit geeigneten Formulierungshilfsstoffen als Mittel eingesetzt werden und eignen sich gleichfalls zur Verhütung des Befalls von Kulturpflanzen durch schädliche Mikroorganismen.
133	3-pyridyl compounds and process for their preparation	EP85110230	1985-08-15	EP0173172A3	1986-12-30	WESS, GUNTHER, DR.; BARTMANN, WILHELM, DR.; BECK, GERHARD, DR.; LAU, HANS-HERMANN, DR.
Die vorliegende Erfindung betrifft neue, in 3-Stellung sub stituierte Pyridine der Formel
134	Piperidine compounds	EP85810148	1985-04-02	EP0158598A3	1986-01-22	Cantatore, Giuseppe, Dr.; Borzatta, Valerio, Dr.

135	Colour-photographic recording material	EP83810554	1983-11-28	EP0111447A3	1986-01-02	Leppard, David G., Dr.; Rody, Jean, Dr.

136	5-Cyclopropyl-5,8-dihydro-8-oxo-1,3-dioxolo-(4,5-g) quinoline-7-carboxylic acid, process for its preparation and bactericidal agent containing it	EP84108002	1984-07-09	EP0134485A3	1985-10-30	Grohe, Klaus, Dr.; Zeiler, Hans-Joachim, Dr.; Metzger, Karl Georg, Dr.
Die neue 5-Cyclopropyl-5,8-dihydro-8-oxo-1,3-dioxolo[4, 5-g]-chinolin-7-carbonsäure ist antibakteriell wirksam und soll als Arzneimittel verwendet werden. Sie wird in einer mehrstufigen Synthese hergestellt.
137	Preparation of the alkyl cyclopentane-carboxylates useful as intermediates for preparing prostaglandins	EP84200655	1984-05-08	EP0126506A3	1985-07-31	Bongini, Alessandro; Cainelli, Gianfranco; Giacomini, Daria; Panunzio, Mauro; Martelli, Giorgio; Spunta, Giuseppe
Preparation of new alkyl cyclopentanecarboxylate derivatives useful as intermediates for preparing prostaglandins. Said products are prepared starting from 3,4-di-(alkoxycar- , bonyl)-6-alken-2-ones.
138	Novel 3-(2-(azabicyclo) ethyl)1,2,3,4-tetrahydro-5H(1)benzopyrano(3,4-c)pyridin-5-ones, pharmaceutical compositions containing them and processes for their production	EP83303557	1983-06-21	EP0101162A3	1984-09-05	Connor, David T.; Schwender, Charles F.; Sorenson, Roderick J.; Unangst, Paul C.
Anticholinergic 3-[2-(azabicyclo)ethyl)-1,2,3,4-tetra- hydro-5H-[1]benzopyrano[3,4-c]pyridin-5-ones, useful for treating broncho-spastic diseases in mammals, are disclosed. Also disclosed are methods for preparing such novel compounds, and pharmaceutical compositions containing them. The novel compounds have the formula I: wherein R₁ is a hydrogen atom, an alkyl radical having from 1 to 6 carbon atoms, an alkoxy radical having from 1 to 6 carbon atoms, or a hydroxy, nitro, halo, amino or acylamino radical; R₂ is a hydrogen atom, a hydroxy radical, an alkyl radical having from 1 to 6 carbon atoms, an alkoxy radical having from 1 to 6 carbon atoms or a phenyl radical; R₃ is a hydrogen atom or an alkoxy radical having from 1 to 6 carbon atoms; or R₁ and R₂ taken together are -OCH₂0-; or R₂ and R₃ taken together are -CH=CH-CH=CH-; and or a pharmaceutically acceptable salt thereof, provided that R₁ is not hydroxy when R₂ is -OC₂H₅ and X is
139	Pyrazolooxazines, -thiazines and -quinolines, process for their preparation and their use as medicaments	EP83100611	1983-01-25	EP0085881A3	1984-03-07	Mardin, Mithat, Dr.; Sundermann, Rudolf, Dr.; Hoffmeister, Friedrich, Prof. Dr.; Busse, Wolf-Dieter, Dr.; Horstmann, Harald, Dr.; Raddatz, Siegfried, Dr.
Die vorliegende Erfindung betrifft Pyrazolooxazine, -thia zine, -chinoline, ein Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, insbesondere ihre Verwen dung als Lipoxygenasehemmer, diese enthaltende Arznei mittel und deren Herstellung.
140	N-substituted 2-pyridyl indoles, process for their preparation, pharmaceutical compositions containing them, and their therapeutical use	EP82110582	1982-11-16	EP0080154A3	1983-09-28	Renfroe, Harris Burt, Dr.

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