| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 2,3-二芳香基噻唑啉酮类化合物及其在制备治疗肿瘤药物中的用途 | CN201210139633.1 | 2012-05-08 | CN102653526A | 2012-09-05 | 陈益华; 吴婧; 郁林羲; 翟东; 易正芳; 罗剑; 刘明耀 |
| 本发明公开了一种由结构式(I)表示的一种2，3-二芳香基噻唑啉酮类化合物或其水合物或药学上可接受的盐，以及含有此类化合物的药物组合物，及其用于制备治疗各种恶性肿瘤以及肿瘤转移的相关疾病的药物的应用。 | ||||||
| 2 | 有机电致发光器件和含稠环的芳胺类化合物 | CN202080060064.4 | 2020-10-22 | CN114514220A | 2022-05-17 | 李涛; 曾洁坤; 宋晶尧; 谭甲辉 |
| 一种有机电致发光器件和含稠环的芳胺类化合物。所述有机电致发光器件，包含两个电极，设置在所述两个电极之间的一个或多个有机功能层和设置于一电极表面且远离所述有机功能层一侧的光取出层，其特征在于：所述光取出层的材料包含具有如通式(1)所示结构的化合物。所述光取出层的材料在紫外区域具有较高的消光系数，在可见光区域拥有较高的折射率，它能降低外部高能量光对有机电致发光显示设备内部材料的损害，用于有机电致发光器件中，提高器件光取出效率，提高器件的发光效率。 | ||||||
| 3 | 一种含苯基和氟碳链的疏水单体及基于该单体的聚合物 | CN201510420236.5 | 2015-07-16 | CN106349181A | 2017-01-25 | 褚奇; 赵素丽; 高书阳; 王海波; 钱晓琳; 李涛; 宋兆辉; 薛玉志 |
| 本发明提供了一种含苯基和氟碳链的疏水单体，所述单体的结构式如式I所示，以及所述单体的制备方法。并以烯基酰胺、烯基羧酸、所述含苯基和氟碳链的疏水单体、乳化剂和引发剂为反应原料，制备得到疏水缔合型聚合物。所述聚合物溶液粘度随浓度升高而急剧增大，抗温抗盐性好。本发明将含苯基和氟碳链的疏水单元同时引入分子中，增强了分子链的疏水作用，提高了聚合物的增粘能力，可用于钻井液、完井液、压裂液和三次采油等油田开发领域。 | ||||||
| 4 | 作为大麻素CB1受体拮抗剂的杂芳基-吡唑衍生物 | CN200780036330.4 | 2007-09-28 | CN101528740A | 2009-09-09 | 李镇华; 金政民; 张宗焕; 李硕镐; 徐希静; 姜锡炼; 宋光燮; 金钟烨; 金旼姝; 李晟汉; 安光羽; 郑明恩 |
| 式(I)的杂芳基－吡唑化合物或其药物学可接受的盐可有效地用作大麻素CB1受体的反相激动剂或拮抗剂，其可用于预防或治疗肥胖和与肥胖相关的代谢障碍。本发明还提供了用于制备本发明杂芳基－吡唑化合物或其药物学可接受的盐的方法、包含它们的药物组合物和用于预防或治疗肥胖和与肥胖相关的代谢障碍的方法。 | ||||||
| 5 | 提纯N－羧基酸酐的方法 | CN200310104429.7 | 2003-10-29 | CN1498887A | 2004-05-26 | A·帕里斯; M·勒邦 |
| 本发明涉及提纯氨基酸的N－羧基酸酐的方法，其特征是N－羧基酸酐在非极性溶剂介质的溶液或悬浮液中和二氧化硅接触。而且通过使用无机酸或有机酸水溶液处理N－羧基酸酐可以进一步改进提纯方法，处理后的N－羧基酸酐不再有颜色。 | ||||||
| 6 | 一种含苯基和氟碳链的疏水单体及基于该单体的聚合物 | CN201510420236.5 | 2015-07-16 | CN106349181B | 2018-08-17 | 褚奇; 赵素丽; 高书阳; 王海波; 钱晓琳; 李涛; 宋兆辉; 薛玉志 |
| 本发明提供了一种含苯基和氟碳链的疏水单体，所述单体的结构式如式I所示，以及所述单体的制备方法。并以烯基酰胺、烯基羧酸、所述含苯基和氟碳链的疏水单体、乳化剂和引发剂为反应原料，制备得到疏水缔合型聚合物。所述聚合物溶液粘度随浓度升高而急剧增大，抗温抗盐性好。本发明将含苯基和氟碳链的疏水单元同时引入分子中，增强了分子链的疏水作用，提高了聚合物的增粘能力，可用于钻井液、完井液、压裂液和三次采油等油田开发领域。 | ||||||
| 7 | 2,3-二芳香基噻唑啉酮类化合物及其在制备治疗肿瘤药物中的用途 | CN201210139633.1 | 2012-05-08 | CN102653526B | 2015-04-08 | 陈益华; 吴婧; 郁林羲; 翟东; 易正芳; 罗剑; 刘明耀 |
| 本发明公开了一种由结构式(I)表示的一种2，3-二芳香基噻唑啉酮类化合物或其水合物或药学上可接受的盐，以及含有此类化合物的药物组合物，及其用于制备治疗各种恶性肿瘤以及肿瘤转移的相关疾病的药物的应用。 | ||||||
| 8 | 杂环胺及其用途 | CN201180064392.2 | 2011-11-18 | CN103298792A | 2013-09-11 | 胡可堪; 大卫·迪勒; 杰弗里·J·莱托尼奥; 布赖恩·F·迈克圭尼斯; 安德鲁·G·科尔; 大卫·罗森; 科尼利斯·A·万厄费伦; 詹森·C·皮肯斯; 智林; 沈宜兴; 比基安·派德拉姆 |
| 在此披露了化学和医学领域中的化合物和方法。所披露的实施例中的一些包括使用杂环胺的化合物、组合物以及方法。所披露的实施例中的一些包括用于治疗炎症性病症的杂环胺。 | ||||||
| 9 | 作为大麻素CB1受体拮抗剂的杂芳基-吡唑衍生物 | CN200780036330.4 | 2007-09-28 | CN101528740B | 2012-09-19 | 李镇华; 金政民; 张宗焕; 李硕镐; 徐希静; 姜锡炼; 宋光燮; 金钟烨; 金旼姝; 李晟汉; 安光羽; 郑明恩 |
| 式(I)的杂芳基-吡唑化合物或其药物学可接受的盐可有效地用作大麻素CB1受体的反相激动剂或拮抗剂，其可用于预防或治疗肥胖和与肥胖相关的代谢障碍。本发明还提供了用于制备本发明杂芳基-吡唑化合物或其药物学可接受的盐的方法、包含它们的药物组合物和用于预防或治疗肥胖和与肥胖相关的代谢障碍的方法。 | ||||||
| 10 | JPH0545595B2 - | JP7417983 | 1983-04-28 | JPH0545595B2 | 1993-07-09 | GURAHAMU ESU HOINDEKUSUTAA; DEIBISU ERU TENPURU JUNIA |
| 11 | JPH02503923A - | JP50315889 | 1989-03-03 | JPH02503923A | 1990-11-15 | |
| 12 | Surface coating and its formation | JP21432794 | 1994-08-17 | JPH0782524A | 1995-03-28 | KURISUCHIAN TSUBUIINAA; MIHIYAERU ZONTAAKU; DEIITAA MARUGOTSUTE; YOOZEFU PEDAIN; HARARUDO BURUMU; FUORUKAA SHIYUNAIDAA |
| PURPOSE: To obtain a coating compsn. reduced in yellowing tendency even after drying at low temp. and showing excellent solvent resistance by using a polyisocyanate component and a specific component having an isocyanate reactive group as a binder. CONSTITUTION: A mixture of a polyisocyanate component (A), a compd. (B) represented by formula I (wherein X is an n-valent group obtained by removing a primary amino group from a (cyclo)aliphatically bonded amino group inert to an isocyanate group and a polyamine with a mol.wt. of 60-6000; R 1 and R 2 are each a 1-18C alkyl; and n is not less than 2), a compd. having at least one structural unit per one molecule represented by formula II (wherein m is 0 or 1) with a number average mol. wt. of 73-10,000 and, if necessary, other compd. having an isocyanate reactive group is used as a binder. Usually, an equivalent ratio of an isocyanate group and an isocyanate reactive group is set to 0.8:1-2:1. COPYRIGHT: (C)1995,JPO | ||||||
| 13 | Dihydropyridyl cyclic imidate ester | JP7417983 | 1983-04-28 | JPS59204189A | 1984-11-19 | GURAHAMU ESU POINDEKUSUTAA; DEIBISU ERU TENPURU JIYUNIA |
| 14 | Novel method of preparing new morpholine derivatives | JP14308075 | 1975-11-29 | JPS5268187A | 1977-06-06 | KOJIMA YOSHIYUKI; KAMENO YOSHITO; SUNAKAWA JIYUN; TAKASHIMA YOSHINORI; KOSABE SUMIKI; YAMAMOTO HISAO |
| PURPOSE: Morpholine derivatives of formula I (R 1 is H, lower alkyl; R 2 is lower alkynyl, lower hydroxyalkyl, lower polyhaloalkyl; A is 2 W 3C alkylene; B is -CH 2CH 2-, -CH=CH-; C 1, C 2 are 1,2-phenylene); for example, 5-[4(2-hydroxyethyl)morpholin-2-yl] methylidene-10,11-dihydro-5H-dibenzo [a, d] cycloheptene. COPYRIGHT: (C)1977,JPO&Japio | ||||||
| 15 | Surface coaching and how to create them | JP21432794 | 1994-08-17 | JP3522847B2 | 2004-04-26 | クリスチアン・ツヴイーナー; デイーター・マルゴツテ; ハラルド・ブルム; フオルカー・シユナイダー; ミヒヤエル・ゾンターク; ヨーゼフ・ペダイン |
| A process for the preparation of coatings using a coating composition which contains as binder a two-component system comprising a) a polyisocyanate component and b) a reactive component which is reactive towards polyisocyanates and which comprises b1) specific, secondary polyamines which contain ester groups, b2) specific, moisture-activatable, blocked polyamines and, if desired, b3) other compounds which are known per se from polyurethane chemistry and which contain groups which are reactive towards isocyanate groups. | ||||||
| 16 | Urethane protected amino acid -n- carboxy anhydride | JP50315889 | 1989-03-03 | JP2875834B2 | 1999-03-31 | FURAA UIRIAMU DEI; KOOEN MAIKERU FUIRITSUPU; NAIDAA FURETSUDO AARU; MAREI GUTSUDOMAN |
| 17 | Preparation of n' 1-substituted-p-phenylenediamine and intermediate product | JP25203690 | 1990-09-25 | JPH03122169A | 1991-05-24 | MUSUTAFUA AKURAMU; BUINFURIITO ZAIDERU |
| PURPOSE: To obtain the subject high-purity amine by reacting acetylaminonitroaniline with a chloroformic acid alkyl ester to form a carbamate followed by a basic treatment and deacetylation with a strong acid. CONSTITUTION: (A) 4-acetylamino-2-nitroaniline is reacted with an approximately equimolar amount of a chloroformic acid alkyl ester of formula I wherein X represents H or CH 3 and Y represents Cl or CH 2Cl to obtain a carbamate of formula II. Then, this carbamate is subjected to a basic treatment to be converted to a compound of formula III wherein A represents H or CH 3 and B represents OH or CH 2OH, which is deacetylated with a strong acid to obtain the intended phenylenediamine of formula IV wherein R represent 2- hydroxyethyl, 3-hydroxypropyl or 2-hydroxypropyl. COPYRIGHT: (C)1991,JPO | ||||||
| 18 | JPS5817470B2 - | JP14308075 | 1975-11-29 | JPS5817470B2 | 1983-04-07 | KOJIMA YOSHUKI; KAMENO YOSHITO; SUNAKAWA JUN; TAKASHIMA YOSHINORI; KATSUBE SUMIMOTO; YAMAMOTO HISAO |
| 19 | PIPERAZINE DERIVATIVES FOR TREATING DISORDERS | US15609596 | 2017-05-31 | US20170267670A1 | 2017-09-21 | David Bates; Jonathan Morris |
| Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described. | ||||||
| 20 | Surface coatings and a process for their production | US286612 | 1994-08-05 | US5412056A | 1995-05-02 | Christian Zwiener; Michael Sonntag; Dieter Margotte; Pedain; Harald Blum; Volker Schneider |
| A coating composition in which the binding agent is a two-component system containing a) a polyisocyanate component and b) an isocyanate-reactive component and contains b1) specific ester group-containing secondary polyamines, b2) specific moisture-activatable blocked polyamines and b3) optionally other known compounds containing isocyanate-reactive groups, and a process for preparing coated substrates from this coating composition. | ||||||
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