| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | Preparation of aqueous nicotinaldehyde | JP5514294 | 1994-03-01 | JPH06316562A | 1994-11-15 | UURU SHIIGURISUTO; HENRII SUZUSHIEPANSUKII |
| PURPOSE: To economically obtain an aqueous nicotinaldehyde in high yield and high selectivity by catalytically reducing a 3-cyanopyridine under hydrogen in the presence of Raney-nickel under specified conditions. CONSTITUTION: An aqueous nicotinaldehyde is obtained by catalytically reducing a 3-cyanopyridine under hydrogen in the presence of Raney-nickel catalyst in a solvent (e.g. aqueous acetatic acid) at 10 to 30°C at a hydrogen pressure of 0.2 to 5 bar at pH3.5 to 7. The Raney-nickel catalyst used is 2 to 10 wt.% of cyanopyridine, the amount of the hydrogen used is to 110% of cyanopyridine and the amount of water existed is used excessively for cyanopyridine. A catalyst carrying an expensive rhodium is not required and the reaction is carried out under moderate conditions. The nicotinaldehyde is useful as a reagent for the synthesis of agricultural chemicals. COPYRIGHT: (C)1994,JPO | ||||||
| 22 | JPH06506955A - | JP51309793 | 1993-02-01 | JPH06506955A | 1994-08-04 | |
| 23 | N-heterocyclosulfonyl-n'-pyrimidyl urea, n-heterocyclosulfonyl-n'-triazolyl urea and n-heterocyclosulfonyl-n'-triazinyl urea | JP14247286 | 1986-06-18 | JPS61291586A | 1986-12-22 | UERUNAA FUERII; UIRII MEIYAA |
| 24 | Antitumor agent | JP3501985 | 1985-02-22 | JPS61194021A | 1986-08-28 | HARA YOICHI; HARA NOBUYUKI; KIRINO OSAMU |
| PURPOSE: An antitumor agent having an inhibitory action on secretion of neutral acid in the stomach which has never existed, containing 3-(2'-pyridyl)-1,2,4- triazin-5-one well-known as an agricultural fungicide or a herbicide as an active ingredient. CONSTITUTION: An antitumor agent containing 3-(2'-pyridyl)-1,2,4-triazin-5-one shown by the formula as an active ingredient. The compound shown by the formula has an inhibitory action on secretion of neutral acid in the stomach, and strong antitumor action. The compound shown by the formula can select various forms of drug preparation (e.g., tablet, capsule, injection, etc.). A dose is preferably 0.6W50mg/kg/day. 10W1,000mg active component is preferably contained in an administration unit form. COPYRIGHT: (C)1986,JPO&Japio | ||||||
| 25 | Triazinone derivative and antitumor agent | JP25711384 | 1984-12-04 | JPS61134389A | 1986-06-21 | HIRAI KENTARO; SUGIMOTO HIROHIKO; MIZUSHIMA TAKAO |
| NEW MATERIAL:A compound shown by the formula I[R<1> is (substituted) phenyl, or (substituted) heterocyclic group; R<2> is (substituted) alkyl, aryl, etc.; R<3> is amino, or alkanoylamino; m is 0-2; n is 1-3; X is O, S, or single bond; Y is S, or NH]. EXAMPLE:4-Amino-6-benzyl-3-[2-(2-guanidnothiazol-4-ylmethylthi-o)ethyl ]amino-1,2,4-triazine-5(4H)-one. USE:An antitumor agent. PREPARATION:For example, a compound [e.g., 2-guanidino-4-(2-aminoethyl) thiomethylthiazole.dihydrochlo-ride, etc.] shown by the formula R<1> CmH2nXCnH2nNH2 is reacted with a compound [e.g., 4-amino-6-benzyl-3- methylthio-1,2,4-triazin-5-(4H)-one, etc.] shown by the formula II in a solvent such as ethanol, etc., in the presence of a base such as triethylamine, etc., to give a compound shown by the formula I(Y is NH). | ||||||
| 26 | Manufacture of tetrahydro-1,3,5-triazi-2,6-diones | JP9198984 | 1984-05-10 | JPS6034953A | 1985-02-22 | HANSU GEORUKU SHIYUREE; KURAUSU ZATSUSE; RUUTOBUITSUHI OIE |
| 27 | N-substituted amidine derivative and production thereof | JP8785083 | 1983-05-19 | JPS59212460A | 1984-12-01 | OKADA YASUSHI; HASHIMOTO MITSUNORI; YOSHIHARA HISAYOSHI; TAKEBAYASHI TOYONORI; EDA YUTAKA; OSANAI YASUTOMO |
| NEW MATERIAL:A compound of formula I [R 1 is H, (halogen-substituted) lower alkyl or phenyl which may have a substituent group (a lower alkoxyl, halogen or nitro, etc.) etc.; R 2 is aralkyloxycarbonyl, allyloxycarbonyl or aralkyl, etc.]. EXAMPLE: N-(p-Nitrobenzyloxycarbonyl)formamidine. USE: Useful as a synthetic intermediate for penem and carbapenem derivatives having improved antimicrobial activity. PREPARATION: A compound of formula II or a salt thereof is reacted with a compound of the formula R 2-X 1(X 1 is azido) in an organic solvent at room temperatureW-70°C, preferably room temperature W-15°C to give the compound of formula I . The reaction is carried out using equimolar amounts of the compound of formula II and the compound of the formula R 2-X 1. Alternatively, the compound of formula II is reacted with a compound of the formula R 2 -X 2(X 2 is halogen) in the presence of a base to afford the compound of formula I . COPYRIGHT: (C)1984,JPO&Japio | ||||||
| 28 | 유기 전계 발광 소자 | KR1020117016126 | 2010-02-12 | KR101700975B1 | 2017-01-31 | 카이저,요아힘; 베스트베버,호르스트; 로이,지모네 |
| 본발명은컬러포인트의발광성에대한의존성이구체적으로조정될수 있는백색발광성유기전계발광소자에관한것이다. | ||||||
| 29 | 살충제및 진드기 구충제로서 N-아릴히드라진 유도체 | KR1019930030416 | 1993-12-28 | KR100314220B1 | 2002-02-19 | 조오지프아우구스투스퍼어치; 데이빗조오지쿠운; 데이빗앨런헌트; 앨버트치예류우; 신씨아엠마그로노스타예스키 |
| 일반식 I의 N-아릴히드라진 유도체 곤충 및 진드기 페스트의 방제를 위한 이들의 사용 및 상기 페스트로 인한 손해 및 손실로부터 작물을 보호하기 위한 방법 및 조성물이 제공된다. | ||||||
| 30 | 치환된 6-할로게노-3급 부틸-2,4-트리아신-5-온의 제조 방법 | KR1019810003748 | 1981-10-02 | KR1019830007587A | 1983-11-04 | 엑카르트쿠란즈외3인 |
| 내용없음 | ||||||
| 31 | Retroviral protease inhibitor compound | JP2012245536 | 2012-11-07 | JP5597689B2 | 2014-10-01 | ヒン・リユウン・シヤム; ダニエル・ダブリユ・ノーベツク; シヤオキ・チエン; デイビツド・エイ・ベテベンナー; デール・ジエイ・ケンプ; トーマス・アール・ヘリン; ゴンデイ・エヌ・クマー; ステイーブン・エル・コンドン; アーサー・ジエイ・クーパー; ダニエル・エイ・デイツクマン; ステイーブン・エム・ハンニツク; ローレンス・コラツエコウスキイ; パトリシア・エイ・オリバー; ダニエル・ジエイ・プラタ; ピーター・ジエイ・ステンゲル; エリツク・ジエイ・ストーナー; ジー−ハー・ジエイ・テイエン; ジー−ホワ・リウ; ケタン・エム・パテル |
| 32 | Retroviral protease inhibiting compound | JP2007327351 | 2007-12-19 | JP2008115189A | 2008-05-22 | SHAM HING LEUNG; NORBECK DANIEL W; CHEN XIAOQI; BETEBENNER DAVID A; DALE J KEMP; THOMAS R HERIN; GONDEI N KUMAA; STEVEN L CONDON; ARTHUR J COOPER; DANIEL A DICKMAN; STEVEN M HANNIKKU; LAWRENCE KORATSUEKOUSUKII; PATRICIA A OLIVER; DANIEL J PRATA; PETER J STENGEL; ERIK J SUTOONAA; JII-HAA J TEIEN; JII-HOWA RIU; KETAN M PATEL |
| <P>PROBLEM TO BE SOLVED: To provide a new compound as an HIV protease inhibiting compound, and to provide a production intermediate thereof. <P>SOLUTION: A compound represented by formula (1) is provided. Wherein, R1 and R2 are independently selected from the group consisting of an alkyl, a cycloalkyl and an arylalkyl; R3 is a lower alkyl, a hydroxyalkyl, or a cycloalkylalkyl; R4 is an aryl or a heterocycle; R5 is a 5-7 membered ring containing nitrogen atom and having a hetero atom directly bonded with the heterocycle; and L1 is a bivalent bonding group such as -O- or -S-. <P>COPYRIGHT: (C)2008,JPO&INPIT | ||||||
| 33 | The use of alkyl metal reagents for orientation metal of azaaromatic compound | JP2006510079 | 2004-04-07 | JP2006524694A | 2006-11-02 | ウォルターマン，クリストファー・ジェイ; サットン，ダグラス・イー |
| （トリメチルシリルメチル）リチウムなどの置換アルキル金属試薬にアザ芳香族化合物および／または窒素複素環化合物を反応させて、官能基化アザ芳香族化合物および官能基化窒素複素環化合物を生成する。 | ||||||
| 34 | Antibacterial agent | JP2004550496 | 2003-11-04 | JP2006505603A | 2006-02-16 | ウィリアム・ヘンリー・ミラー; ジェフリー・マイケル・アクステン; ティモシー・フランシス・ギャラガー; マーク・アントニー・シーフェルド |
| 本発明は、哺乳類、特にヒトにおける細菌感染症の治療に有用なキノリンおよびナフチリジン誘導体に関する。 | ||||||
| 35 | Pyrrolotriazine compounds useful as a treatment method and a kinase inhibitor of p38 kinase-related diseases | JP2002543494 | 2001-11-07 | JP2004522713A | 2004-07-29 | カテリナ・レフセリス; ジョエル・バーリッシュ; ジョン・ハインズ; スティーブン・ティ・ローブルスキー |
| 本発明は、ｐ３８キナーゼ活性に関連する疾患の１つ以上の処置方法であって、該処置の必要な患者に式（Ｉ）：
【化９０】 ［式中、 Ｒ ３は、水素、メチル、ペルフルオロメチル、メトキシ、ハロゲン、シアノまたはＮＨ ２であって、メチルであることが好ましい。 Ｘ、Ｒ １ 〜Ｒ ６およびＺは本明細書中に記載する通りである。 ＺＲ ４ Ｒ ５基は一緒になってＮＨ−置換アリールを含むことが有利である］ を有する化合物、またはその医薬的に許容し得る塩、プロドラッグもしくは溶媒和物の少なくとも１つを投与することを含む方法に関する。 |
||||||
| 36 | The liquid crystal compounds having a perfluoroether terminal portion | JP51944993 | 1993-04-26 | JP3515109B2 | 2004-04-05 | エム． サブ，パトリシア; ピー． ジャナリス，ユージン; シー． ジョンソン，ギルバート; ディー． スパウン，テレンス |
| 37 | Compound of retrovirus protease inhibitor | JP2000190510 | 2000-06-26 | JP2001058979A | 2001-03-06 | SHAM HING LEUNG; NORBECK DANIEL W; CHEN XIAOQI; BETEBENNER DAVID A; DALE J KEMP; THOMAS R HERIN; GONDEI N KUMAA; STEVEN L CONDON; ARTHUR J COOPER; DANIEL A DICKMAN; STEVEN M HANNIKKU; LAWRENCE KORATSUEKOUSUKII; PATRICIA A OLIVER; DANIEL J PRATA; PETER J STENGEL; ERIK J SUTOONAA; JII-HAA J TEIEN; JII-HOWA RIU; KETAN M PATEL |
| PROBLEM TO BE SOLVED: To obtain a new compound having retrovirus protease inhibiting activities, and useful for treatment of disease caused by retrovirus. e.g. Acquired Immune Deficiency Syndrome(AIDS) and human acute cellular leukemia. SOLUTION: This new compound is represented by formula I [R1 and R2 are each a lower alkyl, a cycloalkyl or an arylalkyl; R3 is a lower alkyl, a hydroxyalkyl or the like; R4 is an aryl or the like; R5 is a group of formula II (n is 1-3; X is O, S or the like; Y is CH2 or the like) or the like; L1 is O, S or the like], and exemplified by (2S,3S,5S)-2-(2,6-dimethylphenoxyacetyl) amino-3-hydroxy-5-[2S-(1-tetrahydropyrimid-2-onyl)-3-methylbutanoyl]am ino-1,6- diphenylhexane. The compound of formula I is obtained by reacting a compound of formula III with a compound of formula IV in the presence of a diimide to provide a compound of formula V, deprotecting the N, and reacting the deprotected N with a carboxylic acid. | ||||||
| 38 | Nitro compound having a vasodilating activity | JP50913993 | 1992-11-02 | JP3082243B2 | 2000-08-28 | 真行 加藤; 満津子 濱野; 重孝 西野; 寿 高杉 |
| 39 | JPH07501329A - | JP50913993 | 1992-11-02 | JPH07501329A | 1995-02-09 | |
| 40 | JPH0576468B2 - | JP5020785 | 1985-03-12 | JPH0576468B2 | 1993-10-22 | NOHARA FUJIO; FUJINAWA TOMOAKI |
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