| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)- 1,3-dioxoran-2-yl)-methyl)-1h-imidazole and 1h-1,2,4-triazole | JP3276884 | 1984-02-24 | JPS59172486A | 1984-09-29 | JIYAN HEERESU; REIMONDO EI SUTOTSUKUBURETSUKU; REO JIEI JIEI BATSUKUSU |
| 182 | Novel chromanes and chromenes, manufacture and medicinal composition | JP19511283 | 1983-10-18 | JPS5993076A | 1984-05-29 | JIYON MORISU EBANSU; BARERII AN ATSUSHIYUUTSUDO |
| 183 | Novel 2,3-dihydro-1,4-benzodioxine derivative and its preparation | JP15230181 | 1981-09-26 | JPS5855482A | 1983-04-01 | TERANISHI MASAYUKI; OBASE HIROYUKI; TAKAI HARUKI; NOMOTO YUUJI; SHIYUTOU SHIYOUICHI; KARASAWA HIROSHI; KASUYA YUTAKA |
| NEW MATERIAL:The compound of formulaI[Q is CO or CH(OR); R is H or acyl; X is heterocyclic group of formula II, formula III, etc.; R 1 is H or acyl], and its pharmacologically permissible acid addition salt. EXAMPLE: 2-{2-[4-(2-Oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)piperidin-1-yl]-oxoethyl}-2,3-dihydro-1,4-benzodioxine. USE: An antihypertension and antiphlogistic agent. It exhibits excellent pharmacological activity, and is useful as a medicine. PROCESS: The compound of e.g. formula VI can be prepared by reacting the compound of formula IV with an optically active novel compound of formula V (Z is halogen or eliminable group) in an inert solvent such as acetone, chloroform, DMF, etc. COPYRIGHT: (C)1983,JPO&Japio | ||||||
| 184 | Substituted or unsubstituted fatty acid amide derivative and its salt | JP15103981 | 1981-09-24 | JPS5852256A | 1983-03-28 | YOSHIDA MASANORI; HIRAGA KUNIKAZU; SHIBAYAMA SHIYOUICHI; IKEDA KENICHI; MIYAGI YUKIO |
| NEW MATERIAL:The compound of formulaI[X is halogen, group of formula IV (R 4 is H, lower alkyl or halogen), etc.; R 1 is 1W10C alkyl or phenoxy substituted with phenyl, etc.; R 2 is H, 1W5C alkyl, allyl, etc.; R 3 is 1W8C alkyl, allyl, cycloalkyl, pentylidine, phenyl, etc.]. EXAMPLE: N-2'-Methyl-4'-chlorophenyl-2-( 3-chloro-1,2,4-triazol-1-yl )-2-n-octanamide. USE: Nonmedical bactericide, herbicide or fungicide. PROCESS: The objective compound of e.g. formulaI' can be prepared by reacting the compound of formula III with the compound of formula II in an inert solvent such as benzene, toluene, THF, etc. in the presence of a proper base (e.g. Na 2CO 3, NaOH, etc.) at -20W+30°C, preferably -10W+10°C. COPYRIGHT: (C)1983,JPO&Japio | ||||||
| 185 | JPS5813540B2 - | JP511575 | 1975-01-08 | JPS5813540B2 | 1983-03-14 | KISHIMOTO TEIJI; KAWACHI HIROMU; KANEDA YOSHUKI |
| 186 | JPS5653555B2 - | JP4163674 | 1974-04-10 | JPS5653555B2 | 1981-12-19 | |
| 187 | 22aryll2hhbenzotriazole* its manufacture and stabilizing organic material containing it | JP18117380 | 1980-12-20 | JPS5699463A | 1981-08-10 | JIIN RODEI; MARIO SURONGO |
| 188 | JPS549047B1 - | JP2520671 | 1971-04-19 | JPS549047B1 | 1979-04-20 | |
| 189 | JPS547800B1 - | JP3970071 | 1971-06-05 | JPS547800B1 | 1979-04-10 | |
| 190 | 2-hydroxy-thiazolo(b3,2,-b)-s-triazoles and preparation or the same | JP2987976 | 1976-03-22 | JPS52113989A | 1977-09-24 | KATOU KINPEI; MORISHIMA YASUSHI; OZAWA KAZUO; SAKATANI MINORU; HATANO MASAMI |
| PURPOSE: Title compounds of formula I(R is 3-4C alkyl, phenyl which may have substituent groups of Cl of methyl); for example, 2-hydroxy-thiazole [3,2-b]-S-triazole. COPYRIGHT: (C)1977,JPO&Japio | ||||||
| 191 | Novel pyrid 2,3-d -s-trazoro 4,3-c pirimidine derivatives | JP131676 | 1976-01-05 | JPS5285194A | 1977-07-15 | NODA KANJI; NAKAGAWA AKIRA; NAKAJIMA YOUICHI; IDE HIROYUKI |
| PURPOSE: Pyrido[2,3-d]-S-triazoro[4,3-c]pyrimidine derivatives I(R 1 is phenyl or substituted phenyl; R 2 is H, trihalogenomethyl, lower alkyl or substituted lower alkyl; X is methylene or carbonyl), e.g. 6-(p-fluorophenyl)-1,2dihydropyrido-[2,3-d]S-triazoro[4,3-c] pyrimidine. COPYRIGHT: (C)1977,JPO&Japio | ||||||
| 192 | Heterocyclic compounds | JP128676 | 1976-01-01 | JPS5283892A | 1977-07-13 | KUWATA YUTAKA; MEGURO KANJI; NATSUKARI HIDEAKI |
| PURPOSE: Heterocyclic compounds of formula I (R 1, R 2 are H, alkyl which may be substituted by alkylamino, OH, or alkoxy, or in combination may form a heterocyclic ring together with the adjacent N atom; R 3 is H, lower alkyl; Y is O,S,NH; B is lower alkylene; ring A may be substituted by halogen, nitro, etc.); for example, 1-2-(2-pyridinecarbonyl)phenyl-5-chloromethyl-1H-1,2,4-triazole3-carboxamide. COPYRIGHT: (C)1977,JPO&Japio | ||||||
| 193 | Hetero cyclic compounds | JP125176 | 1976-01-01 | JPS5283886A | 1977-07-13 | KUWATA YUTAKA; MEGURO KANJI; TAWADA KOUSHI; NATSUKARI HIDEAKI |
| PURPOSE: Heterocyclic compounds of formula I (R 1, R 2 are H, alkylamino, alkyl which may be substituted by OH or alkoxy, etc.; R 3 is H, lower alkyl; Py is pyridyl; ring A may be substituted by halogen, nitro, lower alkyl, etc.); for example, 6-(2-pyridyl)-4H-5-triazolo [1,5-a] [1,4] benzodiazepin2-carboxamide. COPYRIGHT: (C)1977,JPO&Japio | ||||||
| 194 | Heterocyclic compounds | JP128276 | 1976-01-01 | JPS5283850A | 1977-07-13 | KUWATA YUTAKA; MEGURO KANJI; SATOU YOSHIHARU; TAWADA KOUSHI; NATSUKARI HIDEAKI |
| PURPOSE: Heterocyclic compounds I(R 1 and R 2 are alkyl, aralkyl, either R 1 or R 2 may be H, or R 1 and R 2 together with the adjacent N may form a heterocyclic ring; R 3 is H or hydrocarbon residue; R 4 is H or lower alkyl; Py is pyridyl; the ring A may be substituted by halogen, nitro, alkyl, trifluoromethyl, alkoxy), e.g. 4-[4-bromo-2-(2-pyridinecarbonyl)phynyl]-3-dimethylaminomethyl4H-1,2,4-triazole. COPYRIGHT: (C)1977,JPO&Japio | ||||||
| 195 | Production of novel thienoo *2*33e**triazoloo*3*44c* 4*11oxezepines | JP12486175 | 1975-10-16 | JPS5214800A | 1977-02-03 | KAARU HAINTSU BEEBAA; ADORUFU BAUAA; ADORUFU RANKUBAIN |
| 196 | 1 2 3 44 tetorahidoroisokinorinruioseizosuruhoho | JP10452074 | 1974-09-10 | JPS5132569A | 1976-03-19 | KISHIMOTO TEIJI; KAWAUCHI KOMU; KANEDA YOSHUKI |
| 197 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | US17584155 | 2022-01-25 | USRE49893E1 | 2024-04-02 | Alaric J. Dyckman; Dharmpal S. Dodd; Tasir Shamsul Hague; Louis J. Lombardo; John E. Macor; Christopher P. Mussari; Laxman Pasunoori; Sreekantha Ratna Kumar; Trevor C. Sherwood; Shoshana L. Posy; Ramesh Kumar Sistla; Subramanya Hegde; Anupama Kandhi Ramachandra Reddy |
| Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. | ||||||
| 198 | [1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS | US18307119 | 2023-04-26 | US20230255941A1 | 2023-08-17 | Alaric J. DYCKMAN; Dharmpal S. Dodd; Tasir Shamsul Haque; Louis J. Lombardo; John E. Macor; Christopher P. Mussari; Laxman Pasunoori; Sreekantha Ratna Kumar; Trevor C. Sherwood; Shoshana L. Posy; Ramesh Kumar Sistla; Subramanya Hegde; Anupama Kandhi Ramachandra Reddy |
| Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. | ||||||
| 199 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | US17113495 | 2020-12-07 | US11672780B2 | 2023-06-13 | Alaric J. Dyckman; Dharmpal S. Dodd; Tasir Shamsul Haque; Louis J. Lombardo; John E. Macor; Christopher P. Mussari; Laxman Pasunoori; Sreekantha Ratna Kumar; Trevor C. Sherwood; Shoshana L. Posy; Ramesh Kumar Sistla; Subramanya Hegde; Anupama Kandhi Ramachandra Reddy |
| Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. | ||||||
| 200 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | US15635055 | 2017-06-27 | US10071079B2 | 2018-09-11 | Alaric J. Dyckman; Dharmpal S. Dodd; John E. Macor; Christopher P. Mussari; Laxman Pasunoori; Sreekantha Ratna Kumar; Trevor C. Sherwood; Ramesh Kumar Sistla |
| Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases. | ||||||
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