| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 141 | Arylsulfonamides as phospholipase A.sub.2 inhibitors | US766554 | 1996-12-11 | US5994398A | 1999-11-30 | Varghese John; Russell E. Rydel; Eugene D. Thorsett |
| Arylsulfonamides which have the general structure: with the symbols R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and n representing the groups and integers provided in the detailed description are provided herein. These compounds have activity as inhibitors of phospholipase A2, inhibitors of cytokine release and as inhibitors of neurodegeneration. | ||||||
| 142 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production | US913879 | 1997-09-24 | US5952386A | 1999-09-14 | Sanshiro Matsuo; Taro Hirose; Keiichi Izumi; Masaya Suzuki; Noriyasu Sakamoto; Kazunori Tsushima; Shigeru Saito; Hirotaka Takano |
| The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.10 alkyl or the like; L is C(.dbd.O)NH or the like; R.sub.2, R.sub.3 and R.sub.4 are independently halogen or the like; R.sub.5, R.sub.6 and R.sub.7 are independently hydrogen or the like; m is an integer of 0 to 4; n is an integer of 0 to 2; X is chlorine or the like; Y is oxygen or the like; and Z is oxygen or the like, which have excellent insecticidal activity so that they are satisfactorily effective for the control of noxious insects. | ||||||
| 143 | Process for the preparation of diacerein | US376722 | 1995-01-23 | US5670695A | 1997-09-23 | Guido Di Napoli |
| The present invention relates to a process for the preparation of 1,8-diacetoxy-3-carboxyanthraquinone, also known as diacerein, via aloin acetylation, oxidation of the acetylated product, and purification of the raw diacerein obtained by means of crystallization from 2-methoxyethanol or N,N-dimethylacetamide and optionally by dissolution of the corresponding salt with triethylamine in methylene chloride, followed by removal of the insoluble residue. | ||||||
| 144 | Sunscreening compositions | US492180 | 1974-07-26 | US4002733A | 1977-01-11 | Peter John Degen; Anthony James Lucas |
| Sunscreening compositions are disclosed which comprise a pharmaceutical extending medium having incorporated therein a substantive, dermally non-irritating, ultraviolet light absorbing compound which is a polyfunctional organic molecule containing two or more ultraviolet absorbing moieties connected by two or more polar linking groups to one or more aliphatic bridging groups. These sunscreening compositions are resistant to removal by water and mild abrasion but are readily removed by soap and water. | ||||||
| 145 | Method for cross-linking rubber | US20059571 | 1971-11-19 | US3869435A | 1975-03-04 | TRIVETTE JR CHESTER D |
| Rubber is cross-linked by heating with compounds of the formula (Acc-SSx)nR wherein Acc-S- is an accelerating moiety, R is an organic bridging group and n is two or more. If it is postulated that cross-link formation results from direct reaction of accelerator polysulfide intermediates via a concerted mechanism and that there is ultimately formed from reaction of accelerator and sulfur a polysulfide, Acc-SSx-S-Acc, the simplest cross-linking reaction involves formation of rubber intermediate combining the accelerator moiety followed by formation of sulfur cross-linked rubber and regeneration of the accelerator moiety. Consistent with these postulations, crosslinking of rubber is described with a compound containing two Acc-SSx- groups connected through the organic bridging group R which becomes part of the cross-link.
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| 146 | Fluoride substituted carbanilates | US3790619D | 1971-11-01 | US3790619A | 1974-02-05 | EDAMURA F; GIACOBBE T |
| COMPOUNDS USEFUL AS HERBICIDES AND FUNGICIDES DEFINED AS SUBSTITUTED (THIO-AND DITHIO-)CARBANILATE COMPOUNDS AND DERIVATIVES THEREOF.
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| 147 | 高分子化合物及びその製造方法、組成物及びその製造方法、樹脂組成物、潤滑油用添加剤並びに潤滑油 | PCT/JP2020/014187 | 2020-03-27 | WO2020203837A1 | 2020-10-08 | 茶谷 俊介; 宮原 由希; 新納 洋; 井川 雅資; 岡田 春樹; 藤江 史子 |
熱可塑性樹脂の耐熱性を向上させ、添加した溶液の高粘度化を抑制する効果を有する高分子化合物及びその製造方法の提供。 複数のポリマー鎖が２価以上の連結基で連結された高分子化合物であって、前記２価以上の連結基はチオール基と、チオエーテル構造及びチオウレタン構造の少なくとも一方とを有し、相対重量平均分子量に対する絶対重量平均分子量の比（絶対Ｍｗ／相対Ｍｗ）が１．２５以上である、高分子化合物、並びにその製造方法。 |
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| 148 | HYDROXYALKYLDITHIOCARBAMATE ESTERS AND BORATE ESTERS | PCT/US2005038082 | 2005-10-21 | WO2006047360A3 | 2006-06-29 | TEPPER RONALD; CHASE KEVIN J |
| A novel hydroxyalkyldithiocarbamate borate ester compound is presented according to the formula I: (I) where R=alkyl C1 to C25;R'=H or CO2 R; R"= (CH2)m,OH where m=1 to 8, or alkyl C1 to C25; n=1 to 8. The borate ester compound is prepared by reacting boric acid with a novel hydroxyalkyldithiocarbamate ester compound according to the formula, and optionally with an alcohol [formula II: (II)] where R, R', R" and n are as above. The hydroxyalkyldithiocarbamate ester is prepared by reacting a hydroxyalkylamine with CS2, and an acrylate or maleate compound. A lubricating composition is based on a major amount of lubricating oil and a minor amount of the hydroxyalkyldithiocarbamate borate ester. | ||||||
| 149 | TUNGSTEN DITHIOCARBAMATE COMPOSITIONS AND LUBRICATING COMPOSITIONS CONTAINING THE SAME | PCT/US2003/036463 | 2003-11-13 | WO2004043910A2 | 2004-05-27 | HSU, Shih-Ying; KRINKER, Randall; FACI, Hocine; ANSONG, Omari; PASTORE, William, M. |
This invention generally relates to a new tungsten dithiocarbamate compound and a process for making the same by the reaction of divalent metal tungstates with dithiocarbamates in an alkaline sodium sulfide and/or sodium hydrogen sulfide solution. The tungsten dithiocarbamate compounds of the present invention are useful as extreme pressure agents and exhibit anti-wear properties. |
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| 150 | PHARMACEUTICALLY ACTIVE SULFONYL AMINO ACID DERIVATIVES | PCT/IB2000/001382 | 2000-09-28 | WO01023379A1 | 2001-04-05 | |
| The present invention is related to sulfonyl amino acid derivatives of formula (I), notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl amino acid derivatives. Said sulfonyl amino acid are efficient modulators of the JNK pathway, they are in particular efficient inhibitors of JNK 2 and 33. The present invention is furthermore related to novel sulfonyl amino acid derivatives as well as to methods of their preparation. | ||||||
| 151 | OXYGEN, SULFUR AND NITROGEN SUBSTITUTED CYCLOHEXENE AND CYCLOHEXANE DERIVATIVES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | PCT/US2000/012162 | 2000-05-04 | WO00068191A1 | 2000-11-16 | |
| Compounds of Formula (1), Formula (2), Formula (3) and Formula (4) wherein the symbols have the meaning assigned to them in the disclosure have retinoid-like biological activity. | ||||||
| 152 | NOVEL AMPHETAMINE DERIVATIVES AND PROTEIN AND POLYPEPTIDE AMPHETAMINE DERIVATIVE CONJUGATES AND LABELS | PCT/US1993002961 | 1993-03-31 | WO1993020048A1 | 1993-10-14 | BIOSITE DIAGNOSTICS INCORPORATED; BUECHLER, Kenneth, Francis; NOAR, Joseph, Barry; MOI, Si, Shi |
| The invention is drawn to novel amphetamine derivatives set forth which are covalently attached to antigenic carrier proteins or polypeptides for the preparation of antibodies or receptors to amphetamine and amphetamine metabolites. Further, the novel amphetamine derivatives covalently attached to proteins, polypeptides or labels or the antibodies or receptors may be used in immunoassays of the amphetamine and/or amphetamine metabolites. | ||||||
| 153 | MACROMOLECULAR GSH-ACTIVATED GLYOXYLASE I INHIBITORS | PCT/US2005013361 | 2005-04-20 | WO2005115338A3 | 2006-02-16 | CREIGHTON DONALD J; ZHENG ZHE-BIN |
| This invention relates to macromolecular prodrugs having antitumor activity when activated by GSH, and methods for synthesizing and administering these to patients. More particularly, this invention relates to, inter alia, the synthesis and use of polyacrylamide carriers to target anticancer prodrugs to tumors, and to release active antitumor agents selectively in tumor cells. These active antitumor agents target the active site of the methylglyoxal-detoxifying enzyme glyoxalase I to thereby cause tumor regression. | ||||||
| 154 | CARBODIIMIDES COMPRISING THIOCARBAMIDE ACID ESTER GROUPS | PCT/EP2005002293 | 2005-03-04 | WO2005087718A3 | 2005-11-10 | BURGHARDT ANDRE; HAEBERLE KARL; LICHT ULRIKE; SCHUMACHER KARL-HEINZ |
| The invention relates to thiocarbamides comprising at least one carbodiimide group and at least one thiocarbamide acid ester group of formula (I). | ||||||
| 155 | CARBAMATES AS HIV ANTI-VIRAL AGENTS | PCT/US2005/008170 | 2005-03-11 | WO2005090299A2 | 2005-09-29 | OLSON, Matthew, W.; DI GRANDI, Martin; PRASHAD, Amarnauth |
The present invention relates to carbamate derivatives having RNase H, polymerase and/or HIV reverse transcriptase modulatory, and particularly, inhibitory activity. Included in the invention are the carbamate derivatives, compositions containing the derivatives, methods of synthesis of the derivatives, screening methods to identify the derivatives, and methods of treatment using the carbamate derivatives, including the treatment of HIV, AIDS and retrovirus-associated cancer. |
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| 156 | METHOD FOR PREPARATION OF PHARMACEUTICAL-GRADE DITHIOCARBAMATE | PCT/US0003994 | 2000-02-16 | WO0048463A9 | 2001-11-01 | VASSILEV VASSIL P; LIAW WEI-CHENG; LAI CHING-SAN |
| The present invention provides methods for producing pharmaceutical-grade particulate dithiocarbamates from secondary amines by vigorously contacting at least one secondary amine and a pharmaceutically acceptable diluent that is a solvent for the carbon disulfide, but not for the secondary amine in an inert gas atmosphere, cooling the mixture so as to precipitate the dithiocarbamate therefrom, and separating the precipitated dithiocarbamate from the cooled mixture. The preferred solvent contains absolute ethanol. In alternative embodiments, the invention further provides methods for purifying a dithiocarbamate to obtain a pharmaceutical-grade dithiocarbamate particulate from a dithiocarbamate feed and methods for producing a sterile pharmaceutical-grade dithiocarbamate from a dithiocarbamate feed. | ||||||
| 157 | N-SUBSTITUTED DITHIOCARBAMATES FOR THE TREATMENT OF BIOLOGICAL DISORDERS | PCT/US2001/009037 | 2001-03-21 | WO01079164A2 | 2001-10-25 | |
| Methods and compositions for the treatment of proliferative cell diseases, such as cancer, are provided, using N-substituted dithiocarbamates. | ||||||
| 158 | METHOD FOR PREPARATION OF PHARMACEUTICAL-GRADE DITHIOCARBAMATE | PCT/US2000/003994 | 2000-02-16 | WO00048463A1 | 2000-08-24 | |
| The present invention provides methods for producing pharmaceutical-grade particulate dithiocarbamates from secondary amines by vigorously contacting at least one secondary amine and a pharmaceutically acceptable diluent that is a solvent for the carbon disulfide, but not for the secondary amine in an inert gas atmosphere, cooling the mixture so as to precipitate the dithiocarbamate therefrom, and separating the precipitated dithiocarbamate from the cooled mixture. The preferred solvent contains absolute ethanol. In alternative embodiments, the invention further provides methods for purifying a dithiocarbamate to obtain a pharmaceutical-grade dithiocarbamate particulate from a dithiocarbamate feed and methods for producing a sterile pharmaceutical-grade dithiocarbamate from a dithiocarbamate feed. | ||||||
| 159 | COMPETITIVE INHIBITORS OF GLYOXALASE I AND METHOD OF GENERATING SUCH COMPETITIVE INHIBITORS INSIDE TUMOR CELLS | PCT/US1999/000255 | 1999-01-07 | WO99035128A1 | 1999-07-15 | |
| The present invention provides a compound having structure (I) wherein S* is S=O or O=S=O; and wherein R1 is selected from the group consisting of (C1-C9) alkyl, (C3-C8) cycloalkyl, (C5-C7) cycloalkenyl, and (C6-C20) aryl substituted with halogen or (C1-C18) alkyl; and wherein R2 is selected from the group consisting of alkyl, (C1-C9) alkyl, (C3-C8) cycloalkyl, (C5-C7) cycloalkenyl, and (C6-C20) aryl substituted with hologen or (C1-C18) alkyl. Also provided are various methods of using the compositions of the present invention. | ||||||
| 160 | TRIAZINANE DERIVATIVES AND METHODS OF MAKING THEM | EP20768439.0 | 2020-08-26 | EP4021737A1 | 2022-07-06 | CHAPELET, Judicael Jacques; FORCINITI, Leandro; PENNEY, Jonathan Michael; FIELDS, Donald L., Jr. |
| The present invention is directed to compounds represented by the formula I: wherein R1comprises a hydrogen atom or an alkyl group having 1 to 2 carbon atoms; wherein R2 comprises an alkylene group, an arylene group, or a heterocyclic group; and wherein R3, R4, R5, R6, R7, and R8 are identical or different and comprise a hydrogen atom, an alkyl group, an aryl group, or an alkylaryl group. | ||||||
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