341 |
RETROVIRAL PROTEASE INHIBITORS |
GR970402230 |
1997-08-29 |
GR3024586T3 |
1997-12-31 |
DECRESCENZO GARY ANTHONY; FRESKOS JOHN NICHOLAS; GETMAN DANIEL PAUL; LIN KO-CHUNG; ROGIER DONALD JOSEPH JR; TALLEY JOHN JEFFREY |
|
342 |
|
PT9846491 |
1991-07-26 |
PT98464B |
1997-10-31 |
VORBRUGGEN HELMUT; KLAR ULRICH; REHWINKEL HARTMUT; THIERAUCH KARL-HEINZ; VERHALLEN PETER |
|
343 |
Retroviral protease inhibitors |
DK92901691 |
1991-11-18 |
DK0558657T3 |
1997-07-07 |
TALLEY JOHN JEFFREY; REED KATHRYN LEA |
|
344 |
Retroviral protease inhibitors |
DE69124110 |
1991-11-18 |
DE69124110T2 |
1997-06-05 |
REED KATHRYN; TALLEY JOHN |
|
345 |
Cyclopentane derivatives process for their production and their pharmaceutical use |
IE265591 |
1991-07-29 |
IE73476B1 |
1997-06-04 |
KLAR ULRICH DR; REHWINKEL HARTMUT DR; VORBRUGGEN HELMUET PROF; THIERAUCH KARL-HEINZ DR; VERHALLEN PETER DR |
|
346 |
Benzocycloalkene compounds with melatonine receptor binding affinity, their production and use |
AU6531296 |
1996-07-25 |
AU6531296A |
1997-02-26 |
OHKAWA SHIGENORI; UCHIKAWA OSAMU; FUKATSU KOHJI; MIYAMOTO MASAOMI |
|
347 |
Retroviral protease inhibitors |
DE69124110 |
1991-11-18 |
DE69124110D1 |
1997-02-20 |
REED KATHRYN; TALLEY JOHN |
|
348 |
UREIDS DERIVED FROM ALPHA, OMEGA-DIAMINO-ACIDS AND PROCESS FOR PRODUCING THEM |
HU9401821 |
1994-06-17 |
HUT71414A |
1995-11-28 |
CALLENS ROLAND; BLONDEEL GEORGES; ANTEUNIS MARC; BECU FRANK |
|
349 |
Cyclopentene derivatives, methods for their manufacture and their pharmaceutical use. |
DE59106490 |
1991-07-22 |
DE59106490D1 |
1995-10-19 |
KLAR ULRICH; REHWINKEL HARTMUT; VORBRUEGGEN HELMUT; THIERAUCH KARL-HEINZ; VERHALLEN PETER |
|
350 |
Cyclopentane derivatives, processes for their preparation and pharmaceutical use. |
ES91912997 |
1991-07-22 |
ES2074721T3 |
1995-09-16 |
KLAR ULRICH DR; REHWINKEL HARTMUT DR; VORBRUGGEN HELMUT PROF; THIERAUCH KARL-HEINZ DR; VERHALLEN PETER DR |
LA INVENCION SE REFIERE A DERIVADOS DEL CICLOPENTANO DE LA FORMULA (I) EN LA QUE HAY UN DOBLE ENLACE ENTRE LOS ATOMOS DE CARBONO DE CENTROS AB O CD, YA SUS SALES CON BASES TOLERABLES FISIOLOGICAMENTE, ASI COMO LOS CICLODEXTRINA CLATRATOS (ALFA), (BETA) OY, ASI COMO LOS COMPUESTOS ENCAPSULADOS CON LIPOSOMAS DE LA FORMULA (I), PROCESO PARA SU FABRICACION Y SU EMPLEO FARMACEUTICO. |
351 |
Retroviral protease inhibitors |
AU9133291 |
1991-11-18 |
AU662309B2 |
1995-08-31 |
REED KATHRYN LEA; TALLEY JOHN JEFFREY |
|
352 |
Use of urea-derivatives as crystallization inhibitors |
DE4341984 |
1993-12-09 |
DE4341984A1 |
1995-06-14 |
WIRTH WOLFGANG DIPL CHEM DR; WANGERMANN KLAUS DIPL PHYS DR; BOTTA ARTUR DIPL CHEM DR; REIZLEIN KARL DIPL CHEM DR; ROSENFELDT FRANK DIPL CHEM DR |
|
353 |
GLYCOSAMINOGLYCAN SALTS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
CA601668 |
1989-06-02 |
CA1335375C |
1995-04-25 |
DAL POZZO ALMA; ACQUASALIENTE MAURIZIO; SPORTOLETTI GIANCARLO; SARRET MONIQUE; FERRUTI PAOLO; DE SANTIS FRANCESCO |
Salts of glycosaminoglycans (heparin, its fractions or fragments "supersulfatated", dermatan sulfate, heparan sulfate, modified heparins) with cations of formula I (I) wherein R1, R2, R3 and R4 represent for instance H, alkyl, cycloalkyl; R5 and R6 represent H, alkyl or aryl; R7 and R8 represent H or alkyl; n and m range from 1 to 4 whereas X = -O-CO-O-; -O-CO-; -NH-CO-; -NH-CO-NH- etc., show the typical pharmacological properties of the glycosaminoclycans themselves also by oral or rectal administration. |
354 |
PROCESS FOR THE PREPARATION OF THALIDOMIDE |
CA2531868 |
1994-07-01 |
CA2531868A1 |
1995-01-12 |
MULLER GEORGE W |
The present invention relates to compounds which are useful for reducing levels of TNF.alpha. in a mammal. Examples of compounds include those of formula: See formula 1 wherein, for example, R7 is a cyclic alkyl, a substituted phenyl, etc ...; n is 1 and R12 is an alkoxy, a disubstituted amino, etc ...; those of formula: See formula 2 wherein, for example, Z is See formula 3 n is 1, 2 or 3; R1 is a divalent residue of 3,4-pyridine, pyrrolidine, etc ...; R2 is -CO- or -SO2-; R3 is a substituted phenyl, pyridyl, etc ...; and R4 is alanyl, argynyl, etc ...; or those of formula: wherein, for example, an optionally substituted o-phenylene, a divalent residue of pyridine, etc ...; R6 is -CO-, -CH2- or -SO2-; R7 is pyridyl, substituted phenyl etc ...; and R12 is -OH, alkoxy, etc ...; |
355 |
Retroviral protease inhibitors. |
ES92901068 |
1991-11-18 |
ES2059295T1 |
1994-11-16 |
CLARE MICHAEL; DECRESCENZO GARY ANTHONY; FRESKOS JOHN NICHOLAS; GETMAN DANIEL PAUL; HEINTZ ROBERT MARTIN; LIN KO-CHUNG; MUELLER RICHARD AUGUST; REED KATHRYN LEA; TALLEY JOHN JEFFREY; VAZQUEZ MICHAEL LAWRENCE; SUN ERIC TAK ON |
COMPUESTOS REPRESENTADOS POR LA FORMULA (I), DONDE A REPRESENTA RADICALES REPRESENTADOS POR LAS FORMULAS (A1,A2,A3), (VALORES PARA LAS VARIABLES DADAS AQUI), SON EFICACES COMO INHIBIDORES DE PROTEASA RETROVIRAL, Y EN PARTICULAR COMO INHIBIDORES DE PROTEASA HIV. |
356 |
Retroviral protease inhibitors. |
ES92900484 |
1991-11-18 |
ES2059289T1 |
1994-11-16 |
DECRESCENZO GARY ANTHONY; FRESKOS JOHN NICHOLAS; GETMAN DANIEL PAUL; LIN KO-CHUNG; ROGIER DONALD JOSEPH JR; TALLEY JOHN JEFFREY |
COMPUESTOS REPRESENTADOS POR LA FORMULA (I) EN LA QUE A REPRESENTA R, R13 Y RADICALES REPRESENTADOS POR LA FORMULA (II), B REPRESENTA R5 Y RADICALES REPRESENTADOS POR LA FORMULA (III) (VALORES PARA LAS VARIABLES DADAS AQUI), SON EFICACES COMO INHIBIDORES DE LA PROTEASA RETROVIRAL Y EN PARTICULAR COMO INHIBIDORES DE LA PROTEASA HIV. |
357 |
|
MX9102137 |
1991-11-19 |
MX9102137A |
1994-03-31 |
HEINTZ ROBERT MARTIN; LIN KO-CHUNG; ROGIER DONALD JOSEPH JR; TALLEY JOHN JEFFREY; DERTENSHAW DEBORAH ELIZABETH; FRESKOS JOHN NICHOLAS; GETMAN DANIEL PAUL |
|
358 |
|
MX9102136 |
1991-11-19 |
MX9102136A |
1994-01-31 |
REED KATHRYN LEA; TALLEY JOHN JEFFREY |
|
359 |
Selected difluoro derivatives |
IE151386 |
1986-06-06 |
IE59146B1 |
1994-01-12 |
|
|
360 |
INHIBITORS OF RETROVIRUS PROTEASE |
HU144593 |
1991-11-18 |
HU9301445D0 |
1993-11-29 |
REED KATHRYN LEA; TALLEY JOHN JEFFREY |
|