序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
341 RETROVIRAL PROTEASE INHIBITORS GR970402230 1997-08-29 GR3024586T3 1997-12-31 DECRESCENZO GARY ANTHONY; FRESKOS JOHN NICHOLAS; GETMAN DANIEL PAUL; LIN KO-CHUNG; ROGIER DONALD JOSEPH JR; TALLEY JOHN JEFFREY
342 PT9846491 1991-07-26 PT98464B 1997-10-31 VORBRUGGEN HELMUT; KLAR ULRICH; REHWINKEL HARTMUT; THIERAUCH KARL-HEINZ; VERHALLEN PETER
343 Retroviral protease inhibitors DK92901691 1991-11-18 DK0558657T3 1997-07-07 TALLEY JOHN JEFFREY; REED KATHRYN LEA
344 Retroviral protease inhibitors DE69124110 1991-11-18 DE69124110T2 1997-06-05 REED KATHRYN; TALLEY JOHN
345 Cyclopentane derivatives process for their production and their pharmaceutical use IE265591 1991-07-29 IE73476B1 1997-06-04 KLAR ULRICH DR; REHWINKEL HARTMUT DR; VORBRUGGEN HELMUET PROF; THIERAUCH KARL-HEINZ DR; VERHALLEN PETER DR
346 Benzocycloalkene compounds with melatonine receptor binding affinity, their production and use AU6531296 1996-07-25 AU6531296A 1997-02-26 OHKAWA SHIGENORI; UCHIKAWA OSAMU; FUKATSU KOHJI; MIYAMOTO MASAOMI
347 Retroviral protease inhibitors DE69124110 1991-11-18 DE69124110D1 1997-02-20 REED KATHRYN; TALLEY JOHN
348 UREIDS DERIVED FROM ALPHA, OMEGA-DIAMINO-ACIDS AND PROCESS FOR PRODUCING THEM HU9401821 1994-06-17 HUT71414A 1995-11-28 CALLENS ROLAND; BLONDEEL GEORGES; ANTEUNIS MARC; BECU FRANK
349 Cyclopentene derivatives, methods for their manufacture and their pharmaceutical use. DE59106490 1991-07-22 DE59106490D1 1995-10-19 KLAR ULRICH; REHWINKEL HARTMUT; VORBRUEGGEN HELMUT; THIERAUCH KARL-HEINZ; VERHALLEN PETER
350 Cyclopentane derivatives, processes for their preparation and pharmaceutical use. ES91912997 1991-07-22 ES2074721T3 1995-09-16 KLAR ULRICH DR; REHWINKEL HARTMUT DR; VORBRUGGEN HELMUT PROF; THIERAUCH KARL-HEINZ DR; VERHALLEN PETER DR
LA INVENCION SE REFIERE A DERIVADOS DEL CICLOPENTANO DE LA FORMULA (I) EN LA QUE HAY UN DOBLE ENLACE ENTRE LOS ATOMOS DE CARBONO DE CENTROS AB O CD, YA SUS SALES CON BASES TOLERABLES FISIOLOGICAMENTE, ASI COMO LOS CICLODEXTRINA CLATRATOS (ALFA), (BETA) OY, ASI COMO LOS COMPUESTOS ENCAPSULADOS CON LIPOSOMAS DE LA FORMULA (I), PROCESO PARA SU FABRICACION Y SU EMPLEO FARMACEUTICO.
351 Retroviral protease inhibitors AU9133291 1991-11-18 AU662309B2 1995-08-31 REED KATHRYN LEA; TALLEY JOHN JEFFREY
352 Use of urea-derivatives as crystallization inhibitors DE4341984 1993-12-09 DE4341984A1 1995-06-14 WIRTH WOLFGANG DIPL CHEM DR; WANGERMANN KLAUS DIPL PHYS DR; BOTTA ARTUR DIPL CHEM DR; REIZLEIN KARL DIPL CHEM DR; ROSENFELDT FRANK DIPL CHEM DR
353 GLYCOSAMINOGLYCAN SALTS, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THEM CA601668 1989-06-02 CA1335375C 1995-04-25 DAL POZZO ALMA; ACQUASALIENTE MAURIZIO; SPORTOLETTI GIANCARLO; SARRET MONIQUE; FERRUTI PAOLO; DE SANTIS FRANCESCO
Salts of glycosaminoglycans (heparin, its fractions or fragments "supersulfatated", dermatan sulfate, heparan sulfate, modified heparins) with cations of formula I (I) wherein R1, R2, R3 and R4 represent for instance H, alkyl, cycloalkyl; R5 and R6 represent H, alkyl or aryl; R7 and R8 represent H or alkyl; n and m range from 1 to 4 whereas X = -O-CO-O-; -O-CO-; -NH-CO-; -NH-CO-NH- etc., show the typical pharmacological properties of the glycosaminoclycans themselves also by oral or rectal administration.
354 PROCESS FOR THE PREPARATION OF THALIDOMIDE CA2531868 1994-07-01 CA2531868A1 1995-01-12 MULLER GEORGE W
The present invention relates to compounds which are useful for reducing levels of TNF.alpha. in a mammal. Examples of compounds include those of formula: See formula 1 wherein, for example, R7 is a cyclic alkyl, a substituted phenyl, etc ...; n is 1 and R12 is an alkoxy, a disubstituted amino, etc ...; those of formula: See formula 2 wherein, for example, Z is See formula 3 n is 1, 2 or 3; R1 is a divalent residue of 3,4-pyridine, pyrrolidine, etc ...; R2 is -CO- or -SO2-; R3 is a substituted phenyl, pyridyl, etc ...; and R4 is alanyl, argynyl, etc ...; or those of formula: wherein, for example, an optionally substituted o-phenylene, a divalent residue of pyridine, etc ...; R6 is -CO-, -CH2- or -SO2-; R7 is pyridyl, substituted phenyl etc ...; and R12 is -OH, alkoxy, etc ...;
355 Retroviral protease inhibitors. ES92901068 1991-11-18 ES2059295T1 1994-11-16 CLARE MICHAEL; DECRESCENZO GARY ANTHONY; FRESKOS JOHN NICHOLAS; GETMAN DANIEL PAUL; HEINTZ ROBERT MARTIN; LIN KO-CHUNG; MUELLER RICHARD AUGUST; REED KATHRYN LEA; TALLEY JOHN JEFFREY; VAZQUEZ MICHAEL LAWRENCE; SUN ERIC TAK ON
COMPUESTOS REPRESENTADOS POR LA FORMULA (I), DONDE A REPRESENTA RADICALES REPRESENTADOS POR LAS FORMULAS (A1,A2,A3), (VALORES PARA LAS VARIABLES DADAS AQUI), SON EFICACES COMO INHIBIDORES DE PROTEASA RETROVIRAL, Y EN PARTICULAR COMO INHIBIDORES DE PROTEASA HIV.
356 Retroviral protease inhibitors. ES92900484 1991-11-18 ES2059289T1 1994-11-16 DECRESCENZO GARY ANTHONY; FRESKOS JOHN NICHOLAS; GETMAN DANIEL PAUL; LIN KO-CHUNG; ROGIER DONALD JOSEPH JR; TALLEY JOHN JEFFREY
COMPUESTOS REPRESENTADOS POR LA FORMULA (I) EN LA QUE A REPRESENTA R, R13 Y RADICALES REPRESENTADOS POR LA FORMULA (II), B REPRESENTA R5 Y RADICALES REPRESENTADOS POR LA FORMULA (III) (VALORES PARA LAS VARIABLES DADAS AQUI), SON EFICACES COMO INHIBIDORES DE LA PROTEASA RETROVIRAL Y EN PARTICULAR COMO INHIBIDORES DE LA PROTEASA HIV.
357 MX9102137 1991-11-19 MX9102137A 1994-03-31 HEINTZ ROBERT MARTIN; LIN KO-CHUNG; ROGIER DONALD JOSEPH JR; TALLEY JOHN JEFFREY; DERTENSHAW DEBORAH ELIZABETH; FRESKOS JOHN NICHOLAS; GETMAN DANIEL PAUL
358 MX9102136 1991-11-19 MX9102136A 1994-01-31 REED KATHRYN LEA; TALLEY JOHN JEFFREY
359 Selected difluoro derivatives IE151386 1986-06-06 IE59146B1 1994-01-12
360 INHIBITORS OF RETROVIRUS PROTEASE HU144593 1991-11-18 HU9301445D0 1993-11-29 REED KATHRYN LEA; TALLEY JOHN JEFFREY
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