| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 141 | Preparation of 1,4-diaminoanthraquinone-2,3-disulfonic acid and 1,4-diaminoanthraquinone-2,3-dinitrile | JP16781593 | 1993-07-07 | JPH06179647A | 1994-06-28 | MATEIASU DOUSUTO; UDO BERUKUMAN; GERUTO SHIYUBUANTEIE |
| PURPOSE: To easily and economically obtain the subject compound by allowing 1,4-diamino-2,3-dihalogenanthraquinone to react with boric acid and subsequently allowing it to react with an aqueous sulfite solution, using a specific non-polar solvent such as xylene. CONSTITUTION: In an inert organic solvent, 1,4-diamino-2,3- dihalogenanthraquinone is allowed to react with boric acid and subsequently allowed it to react with an aqueous sulfite solution without isolating the produced intermediate to obtain 1,4-diaminoanthraquinone-2,3-disulfonic acid of formula I. Here, an non-polar solvent having a boiling point of 130°C or higher and a density of 0.95/cm 3 or smaller, especially an aromatic hydrocarbon, specifically xylene, ethyl benzene, isopropyl benzene or the like, is used as the inert organic solvent. The compound of formula I obtained through the method is allowed to react with a cyanide to obtain 1,4-diaminoanthraquinone-2,4-dinitrile of formula II. The compounds of formula I and formula II are useful as synthetic intermediates for blue disperse dyes. This method gives a high yield and purity. COPYRIGHT: (C)1994,JPO | ||||||
| 142 | New derivative of 2-aminopentanedioic acid, preparation and intermediates thereof, use thereof as medicines and composition containing the same | JP3404890 | 1990-02-16 | JPH02264750A | 1990-10-29 | JIYANKUROODO GASUKU; DANIERU ANBEERU; MARIO BUKAN |
| NEW MATERIAL: All possible isomeric forms and mixtures thereof compounds of formula I (wherein R 2 is a group of formula II or III; R 1, Ar and Ar' are each 14C or less aryl, indolyl, pyridyl or the like; R 3 is H, or form together with NR 2R 3 a 5 to 7-membered carbon ring or the like; R 4 is H, 1-8C alkyl or the like; aryl nucleus, phenyl nucleus of formula III and the ring in R 3 can have a substituent such as 1-8C alkyl). EXAMPLE: (S)-4-[[(1H-Indol-2-yl)carbonyl]amino]-5-[[bis(4-methylphenyl) methyl]amino]-5-oxopentanoic acid. USE: Agonist or antagonist for cholecystokinin and dopamine useful for the treatment of some gastrointestinal disorders, adiposis, behavioral disordes, emotional disturbances, sex disorders, memory disorders and schizophrenia. PROCESS: A compd. of formula I is obtained from a compd. of formula IV [wherein BOC is (1,1-dimethylethoxy)carbonyl; and R 4' is a group of R 4 excluding H) through a compd. of formula V. COPYRIGHT: (C)1990,JPO | ||||||
| 143 | JPH0213660B2 - | JP5190482 | 1982-03-29 | JPH0213660B2 | 1990-04-04 | TAKIGAWA TETSUO; KINUHATA KOICHI; OKADA MASAFUMI; MIZUNO MASAO; NISHIDA TAKUJI |
| 144 | Production of diaminomaleonitrile and diaminoacrylonitrile derivative | JP16756988 | 1988-07-05 | JPH0217163A | 1990-01-22 | OZEKI TAKASHI; MITSUKUMA KATSUNORI; TAZAKI SEIJI; YAGIHARA TOMIO |
| PURPOSE: To advantageously obtain the title compound useful as an intermediate for medicine and agricultural chemical in mild conditions by reacting a dithiooxaldiimitate capable of readily producing and used as a raw material with hydrogen cyanide. CONSTITUTION: A dithiooxaldiimitate expressed by formula I (R and R 1 are organic groups) used as a starting raw material is reacted with hydrogen cyanide in an organic solvent such as acetonitrile or chloroform in the presence of a base such as triethylamine or pyridine nearly at 0°C to ambient temperature for 30min to several hr when diaminoacrylonitrile is produced or at ambient temperature to temperature up to boiling temperature of the solvent for 1-10 several hr when diaminomaleonitrile is produced to provide the diaminoacrylonitrile expressed by formula II and diaminomaleonitrile expressed by formula III and salt thereof. COPYRIGHT: (C)1990,JPO&Japio | ||||||
| 145 | JPS6312048B2 - | JP5334377 | 1977-05-10 | JPS6312048B2 | 1988-03-17 | SUGASAWA TSUTOMU; TOYODA TATSURO; SASAKURA KAZUYUKI; UEDA SHIRO; TAKASE AKIRA; OKUNO KATSUTO; ISHIZUKA ICHIRO; SUMIMOTO SHINZABURO |
| 146 | JPS6017781B2 - | JP2038377 | 1977-02-28 | JPS6017781B2 | 1985-05-07 | ROJAA AASAA SHERUDON; PEETERU BEEN; DERETSUKU AREGUZANDAA UTSUDO; RONARUDO FURANKU MEISON |
| 147 | Polyprenyl compound | JP5190482 | 1982-03-29 | JPS58167555A | 1983-10-03 | TAKIGAWA TETSUO; KINUHATA KOUICHI; OKADA MASAFUMI; MIZUNO MASAO; NISHIDA TAKUJI |
| NEW MATERIAL:A compound shown by the formulaI (group shown by the formula II is trans type isoprene unit; group shown by the formula III is cis type isoprene unit; n is 11W19; R is lower alkyl). USE: A raw material for drugs, cosmetics, etc. Especially useful as an intermediate for synthesizing a dolichol of mammals. PROCESS: A polyprenyl halide shown by the formula IV (X is halogen) is reacted with an acetoacetic ester shown by the formula V in the presence of a basic compound (e.g., sodium hydroxide, potassium hydroxide, etc.) to give a polyprenylketocarboxylic ester shown by the formula VI, which is hydrolyzed and decarboxylated to give a polyprenylacetone shown by the formula VII, which is reacted with a cyanoacetic acid lower alkyl ester in the presence of a base and/ or acid, to give a polyprenyl compound shown by the formulaI. COPYRIGHT: (C)1983,JPO&Japio | ||||||
| 148 | Production of acetonitrile and/or hydrogen cyanide from ammonia and methanol | US16469841 | 2018-02-01 | US11760718B2 | 2023-09-19 | Poul Erik Højlund Nielsen; Rasmus Munksgård Nielsen; Brian Kjærgaard Olsen |
| The invention relates to a process for producing a product gas comprising acetonitrile and/or hydrogen cyanide from a feed stream comprising ammonia and methanol over a solid catalyst comprising a support, a first metal and a second metal on the support, wherein the first metal and the second metal are in the form of a chemical compound, wherein the first metal is Fe, Ru or Co and the second metal is Sn, Zn, or Ge. The pressure is ambient pressure or higher and the temperature lies in a range from about 400° C. to about 700° C. Thus, the process for producing acetonitrile and/or hydrogen cyanide from ammonia and methanol may be catalyzed by a single catalyst and may be carried out in a single reactor. The invention also relates to a catalyst, a method for activating a catalyst and use of a catalyst for catalysing production of acetonitrile and/or hydrogen cyanide from ammonia and methanol. | ||||||
| 149 | Continuous flow synthesis of ibuprofen | US16500687 | 2018-04-06 | US11639326B2 | 2023-05-02 | Nathan Collins; Jeremiah Malerich; Judy Szeto; Joseph A. Kozocas |
| This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | ||||||
| 150 | PROCESS FOR MANUFACTURING AN AQUEOUS HYDROGEN PEROXIDE SOLUTION | US17637470 | 2020-09-11 | US20220274833A1 | 2022-09-01 | Karol LORENT |
| A process for manufacturing an aqueous hydrogen peroxide solution comprising the following steps:—hydrogenating a working solution which comprises an alkylanthraquinone and/or tetrahydroalkylanthraquinone and a mixture of a non-polar organic solvent and a polar organic solvent;—oxidizing the hydrogenated working solution to produce hydrogen peroxide; and—isolating the hydrogen peroxide, wherein the polar organic solvent is 5-methyl-2-isopropylcyclohexanecarbonitrile (C11F). | ||||||
| 151 | CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN | US16500687 | 2018-04-06 | US20210114962A1 | 2021-04-22 | Nathan Collins; Jeremiah Malerich; Judy Szeto; Joseph A. Kozocas |
| This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | ||||||
| 152 | USES OF CERTAIN PLATINOID ACCUMULATING PLANTS FOR USE IN ORGANIC CHEMICAL REACTIONS | US14905119 | 2014-07-15 | US20160159934A1 | 2016-06-09 | Claude GRISON; Vincent ESCANDE; Clemence BES; Brice-Loic RENARD |
| A composition derived from the acid treatment of ashes obtained after heat treatment of selected plants or plant material is provided. The selected plants accumulate metal from the platinum group (platinoids). The compositions can be used to produce catalysts for performing various organic synthesis reactions. | ||||||
| 153 | METHOD OF SYNTHESISING AMINO ACID BY METATHESIS, HYDROLYSIS, THEN HYDROGENATION | US14766956 | 2014-02-10 | US20160002147A1 | 2016-01-07 | Jean-Luc DUBOIS; Jean-Luc COUTURIER |
| A method of synthesising an amino acid from an unsaturated fatty compound I that includes at least the following steps: cross-metathesis with a short unsaturated compound II, one of compounds I or II comprising a nitrile function and the other of these compounds II or I an ester function, so as to obtain and recover at least one monounsaturated nitrile ester NEU; hydrolysis of the NEU in unsaturated acid nitrile NAU; hydrogenation of the NAU to saturated amino acid AA; and then purification of the AA, if applicable, in particular by crystallisation. Also, a polymer obtained by polymerisation using the amino acid synthesised according to the method. | ||||||
| 154 | Convergent synthesis of renin inhibitors and intermediates useful therein | US12810220 | 2008-12-19 | US08563279B2 | 2013-10-22 | Ben De Lange; Anna Maria Cornelia Francisca Castelijns; Johannes Gerardus De Vries; Andreas Hendrikus Maria De Vries; Jeroen Antonius Franciscus Boogers; Quirinus Bernardus Broxterman |
| Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3—6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10). | ||||||
| 155 | CONVERGENT SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES USEFUL THEREIN | US12810220 | 2008-12-19 | US20110008852A1 | 2011-01-13 | Ben De Lange; Anna Maria Cornelia Francisca Castelijns; Johannes Gerardus De Vries; Andreas Hendrikus Maria De Vries; Jeroen Antonius Boogers; Quirinus Bernardus Broxterman |
| Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3—6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10). | ||||||
| 156 | APPARATUS AND PROCESS FOR CONTINUOUSLY PREPARING ETHYLENE CYANOHYDRIN | US12296780 | 2007-03-14 | US20090163735A1 | 2009-06-25 | Volker Schleep; Benedikt Laux |
| The invention relates to an apparatus and to a process for continuously preparing ethylene cyanohydrin. | ||||||
| 157 | Process for preparing protected, enantiomer-enriched cyanohydrins by in-situ derivatization | US10325923 | 2002-12-23 | US06909011B2 | 2005-06-21 | Wolfgang Skranc; Peter Poechlauer; Irma Wirth; Rudolf Neuhofer; Herbert Mayrhofer |
| A process for preparing protected, enantiomer-enriched cyanohydrins of the formula where R1 and R2 independently of one another can be an unsubstituted, monosubstituted or polysubstituted C1-C20-alkyl, C5-C20-aryl, C5-C20-heteroaryl, C5-C20-alkaryl, C5-C20-alkylheteroaryl or C5-C20-aralkyl radical or an unsubstituted, monosubstituted or polysubstituted C5-C20-heterocycle, or C5-C20-alkylheterocycle or together can be an unsubstituted or substituted C4-C20-alkylene radical, which can contain one or more heteroatoms in the chain, or one of the radicals is hydrogen, and R3 can be an unsubstituted or substituted C1-C20-alkyl, C5-C20-aryl or C5-C20-heteroaryl radical, by reacting an aldehyde or ketone of the formula where R1 and R2 are defined as above, in the presence of an (R)- or (S)-hydroxynitrile lyase in an organic, aqueous or 2-phase system or in emulsion at a temperature of −5 to +40° C. with a carbonic ester nitrile of the formula where R3 is defined as above. | ||||||
| 158 | Process for the preparation of nitrile compounds | US10482381 | 2004-07-19 | US20040254391A1 | 2004-12-16 | Andrew John Blacker; Ian Nicholas Houson; Jonathan William Wiffen |
| A process is provided for the preparation of a compound of Formula (1) 1 wherein: R1 is H, optionally substituted acyl, optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl: R2 and R3 each independently are H or a hydroxy protecting group; comprising the steps: (a) reacting a compound of Formula (2) 2 in a solvent in the presence of a base with a compound of formula R4SO2X to give a compound of Formula (3); 3 wherein: R4 is an optionally substituted alkyl, optionally substituted aryl or optionally substituted heteroaryl group; and X is halogen: and (b) reacting the compound of Formula (3) with a cyanide source in the presence of a phase transfer catalyst. | ||||||
| 159 | Processes and compositions for the production of chiral amino-nitriles | US09967270 | 2001-09-28 | US20030065207A1 | 2003-04-03 | David Robert Allen; Crystal A. Achenbach-McCarthy |
| Processes for the efficient production of chiral amino nitrites are disclosed. Generally, the processes include the esterification of the alcohol of a amino protected alcohol followed by nucleophilic substitution of the ester with a cyano group. In an exemplary embodiment the chiral amino nitrile produced is (R)-3-aminopentanenitrile. | ||||||
| 160 | Intermediates for the preparation of peptide analogues | US866558 | 1997-05-30 | US5912352A | 1999-06-15 | Alexander Fassler; Guido Bold; Hans-Georg Capraro; Heinz Steiner |
| The invention relates to a novel process for the preparation of compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or a suitable amino-protecting group,R.sub.2 is unsubstituted or substituted alkyl,R.sub.3 is hydrogen, aryl, heterocyclyl, unsubstituted or substituted alkyl or unsubstituted or substituted cycloalkyl,R.sub.4, independently of R.sub.1, is hydrogen or a suitable amino-protecting group andm is a number from 1 to 7; and wherein further suitable protecting groups for functional groups may be present; which compounds are antivirally active or can be used as starting materials for pharmaceutically active, especially antiviral compounds.The precursor is an oxo compound,which is in turn prepared by hydrogenation with a suitable complex hydride or with hydrogen in the presence of a suitable catalyst and acyl migration starting from a hydrazone,which is in turn preferably prepared from a nitrile via an imino compound by means of hydrogenation and reaction with a hydrazine derivative,which is prepared from an aldehyde by reaction with a reactive derivative of a carboxylic acid in the presence of a cyanide salt;and the novel intermediates required therefor. | ||||||
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