| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 一种酯胺类季铵盐及其合成方法 | CN200410012215.1 | 2004-03-29 | CN1562960A | 2005-01-12 | 耿涛; 李秋小; 李运玲 |
| 一种酯胺类季铵盐的化学结构式为：采用将一定比例的脂肪酸和乙醇胺进行酯胺化反应，再用碳酸二甲酯和酯胺反应合成得到酯胺类季铵盐。本发明具有采用本合成方法，转化率高，选择性好，所得产品的活性物含量高，使用绿色无毒的碳酸二甲酯来替代有剧毒的硫酸二甲酯和氯甲烷进行季铵化反应，避免了产品中残留有未反应的剧毒品，降低了季铵盐产品对人体的毒害和对环境的污染。 | ||||||
| 2 | 一种酯胺类季铵盐及其合成方法 | CN200410012215.1 | 2004-03-29 | CN1255374C | 2006-05-10 | 耿涛; 李秋小; 李运玲 |
| 一种酯胺类季铵盐的化学结构式为：见右式，采用将一定比例的脂肪酸和乙醇胺进行酯胺化反应，再用碳酸二甲酯和酯胺反应合成得到酯胺类季铵盐。本发明具有采用本合成方法，转化率高，选择性好，所得产品的活性物含量高，使用绿色无毒的碳酸二甲酯来替代有剧毒的硫酸二甲酯和氯甲烷进行季铵化反应，避免了产品中残留有未反应的剧毒品，降低了季铵盐产品对人体的毒害和对环境的污染。 | ||||||
| 3 | 含有多氟化合物作为抗磨添加剂的润滑剂 | CN87103969 | 1987-05-30 | CN1015718B | 1992-03-04 | 多米尼克·巴塞; 皮埃尔·迪吕亚尔; 让-克劳德·法亚尔; 洛朗·热尔芒诺; 马克·埃尔芒 |
| 为了改进润滑剂的抗磨性，至少要加入下式所示的一种化合物，式中：Rf是全氟基，a＝0至10，b＝0或1(若a＝0和c＝1)，c＝1至4(若a≠0时c为2)，m＝0或1，n＝0或1，x是-芳基，Y是2-羟基-1-苯乙基，R1和R1′各代表氢原子或是烷基，环烷基或芳基，R2和R2′各代表氢原子或酰基，若a+m+n＝0，R1和R2中至少有一个不是H或CH3。 | ||||||
| 4 | Liposomal ceramide-related liposomes and the therapeutic use thereof | US545164 | 1995-10-19 | US5681589A | 1997-10-28 | Yong Wei; Eric Mayhew; Imran Ahmad; Andrew S. Janoff |
| This invention provides a compound having the formula R.sup.1 -Y.sup.1 --CHZ.sup.1 -CH(NY.sup.2 Y.sup.3)--CH.sub.2 -Z.sup.2, wherein: R.sup.1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y.sup.1 is --CH.dbd.CH--, --C.tbd.C-- or --CH(OH)CH(OH)--; Z.sup.1 is OH or a conversion-inhibiting group; Z.sup.2 is a conversion-inhibiting group; Y.sup.2 is H, a phenyl group, an alkyl-substituted phenyl group having from 1 to about 6 carbons in the alkyl chain, or an alkyl chain having from 1 to 6 carbons; Y.sup.3 is H or a group having the formula --C(O)R.sup.2 or --S(O).sub.2 R.sup.2 ; R.sup.2 is a straight-chained alkyl, alkenyl or alkynyl group having from 1 to 23 carbon atoms in the chain; and when Z.sup.2 is an amino, R.sup.2 is an aliphatic chain having from 1 to 9 or from 19 to 23 carbon atoms in the aliphatic chain. | ||||||
| 5 | Solvent free quaternization of tertiary amines with dimethylsulfate | US247804 | 1994-05-23 | US5463094A | 1995-10-31 | David M. Brown; Erich M. Gatter; Cheryl A. Littau |
| A process for a high temperature, solvent free quaternization of certain tertiary amines using dimethylsulfate to produce quaternary ammonium methyl sulfates which may be used in fabric softening and other applications, is disclosed. | ||||||
| 6 | Novel alpha-aminoacetophenones as photoinitiators | US501409 | 1990-03-28 | US5077402A | 1991-12-31 | Vincent Desobry; Kurt Dietliker; Rinaldo Husler; Werner Rutsch; Manfred Rembold; Franciszek Sitek |
| Compounds of the formula I, II, III and IIIa ##STR1## in which Ar.sup.1 is an unsubstituted or substituted aromatic radical and at least one of the radicals R.sup.1 and R.sup.2 is an alkenyl, cycloalkenyl or arylmethyl group, are effective photoinitiators for photopolymerization of unsaturated compounds. They are particularly suitable for photocuring of pigmented systems. | ||||||
| 7 | Amino acid esters, pharmaceuticals containing them, and the use thereof in learning disorders | US340656 | 1989-04-20 | US5043346A | 1991-08-27 | Franz Hock; Josef Scholtholt; Hansjorg Urbach; Rainer Henning; Ulrich Lerch; Wolf-Ulrich Nickel; Wolfgang Ruger |
| The invention relates to amino acid esters of the formula I ##STR1## in which n is 2 and R, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meaning indicated in the description, to a process and intermediates for the preparation thereof, to agents containing them, and the use thereof. | ||||||
| 8 | Methods of treatment using pharmaceutically active ceramide-related compositions | US547688 | 1995-10-19 | US5677337A | 1997-10-14 | Yong Wei; Eric Mayhew; Imran Ahmad; Andrew S. Janoff |
| This invention provides a compound having the formula R.sup.1 --Y.sup.1 --CHZ.sup.1 --CH(NY.sup.2 Y.sup.3)--CH.sub.2 --Z.sup.2, wherein: R.sup.1 is a straight-chained alkyl, alkenyl or alkynyl group having from 8 to 19 carbon atoms in the aliphatic chain; Y.sup.1 is --CH.dbd.CH--, --C.tbd.C-- or --CH(OH)CH(OH)--; Z.sup.1 is OH or a conversion-inhibiting group; Z.sup.2 is a conversion-inhibiting group; Y.sup.2 is H, a phenyl group, an alkyl-substituted phenyl group having from 1 to about 6 carbons in the alkyl chain, or an alkyl chain having from 1 to 6 carbons; Y.sup.3 is H or a group having the formula --C(O)R.sup.2 or --S(O).sub.2 R.sup.2 ; R.sup.2 is a straight-chained alkyl, alkenyl or alkynyl group having from 1 to 23 carbon atoms in the chain; and when Z.sup.2 is an amino, R.sup.2 is an aliphatic chain having from 1 to 9 or from 19 to 23 carbon atoms in the aliphatic chain. | ||||||
| 9 | .alpha.-aminoacetophenones as photoinitiators | US432035 | 1995-05-01 | US5534629A | 1996-07-09 | Vincent Desobry; Kurt Dietliker; Rinaldo Husler; Werner Rutsch; Manfred Rembold; Franciszek Sitek |
| Compounds of the formula I, II, III and IIIa ##STR1## in which Ar.sup.1 is an unsubstituted or substituted aromatic radical and at least one of the radicals R.sup.1 and R.sup.2 is an alkenyl, cycloalkenyl or arylmethyl group, are effective photoinitiators for photopolymerization of unsaturated compounds. They are particularly suitable for photocuring of pigmented systems. | ||||||
| 10 | Acyloxypropanolamines | US285008 | 1988-12-15 | US4935422A | 1990-06-19 | Ghanshyam Patil; Khuong H. X. Mai |
| Compounds of the present invention, are represented by the general formula ##STR1## wherein R represents a straight or branched loweralkyl from 1 to about 6 carbon atoms, loweralkene from 2 to about 6 carbon atoms, or ##STR2## where m is o or 1 and n is 2, 3, 4, or 5 provided that when m is o, n is 2, 3, 4, or 5 and when m is 1, n is 3 or 4, and R.sub.1 is hydrogen, a straight, branched or cyclic loweralky from 1 to about 6 carbon atoms or loweralkoxy, phenyl or substituted phenyl, and R.sub.2 represents a straight or branched loweralkyl from 1 to about 6 carbon atoms or W-B wherein W represents alkylene of from 1 to about 10 carbon atoms which may be substituted with loweralkyl of from 1 to about 4 carbon atoms; and B represents hydrogen, --NHCOR.sub.4, or --NHCONR.sub.3 R.sub.4, wherein R.sub.3 and R.sub.4 may be the same or diffrent and may be hydrogen, alkyl, alkoxyalkyl, cycloalkyl, alkenyl, alkynyl, phenyl or aralkyl wherein the alkyl group contains from 1 to about 6 carbon atoms and the aryl group represents phenyl which may be unsubstituted or substituted with lower alkyl from 1 to about 6 carbon atoms, alkoxy wherein the alkyl group contains from 1 to about 6 carbon atoms, halogen, acetamido, amino, hydroxy, hydroxyalkyl of from 1 to about 10 carbon atoms; thiophenyl, imidazole, oxazole or indole, furanyl, tetrahydrofuranyl or R.sub.3 and R.sub.4 may together with N form a pyrrolidino, piperidino, piperazino, or morpholino ring, or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment or prophylaxis of cardiac disorder or in the treatment of glaucoma. | ||||||
| 11 | Soft quaternary surface active agents exhibiting antibacterial activity | US615519 | 1975-09-22 | US3989711A | 1976-11-02 | Nicolae S. Bodor |
| Soft quaternary surface active agents having the formula: ##EQU1## wherein ##EQU2## represents a tertiary open chain or cyclic aliphatic amine; wherein ##EQU3## represents an aromatic amine; wherein R represents a member selected from the group consisting of a hydrogen atom, a C.sub.1 -C.sub.20 open chain or cyclo alkyl group, a C.sub.1 -C.sub.20 alkoxyalkyl group, a C.sub.1 -C.sub.20 acyloxyalkyl group, a C.sub.1 -C.sub.20 haloalkyl group, a C.sub.1 -C.sub.20 carboxyalkyl group, an aryl group, and a substituted aryl group, whose substituents are selected from the group consisting of a halogen atom, an O--C.sub.1 -C.sub.4 alkyl group, an O--C.sub.1 -C.sub.8 acyl group a nitro group, a carboxyl group, and a carboethoxy group; wherein R.sub.1 represents a C.sub.9 -C.sub.22 straight or branched alkyl group, a ##EQU4## group, wherein R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are each selected from the group consisting of a hydrogen atom, a methyl group or an ethyl group, a C.sub.0 -C.sub.22 straight or branched ##SPC1##Group, wherein n in each occurrence and m represent an integer of from 0 to 22, an ##SPC2##Group, wherein A represents a C.sub.0 -C.sub.22 straight or branched alkyl group as above or a -(CH.sub.2 CH.sub.2 O).sub.p group, wherein the p represents an integer of from 0 to 22, and the residue of any naturally occurring bile acid or synthetic derivative thereof; and wherein X represents a halogen atom or any other organic or inorganic movement anion are disclosed.All compounds encompassed within the above-described generic formulae find use as "soft" antibacterial agents of extremely low toxicity. | ||||||
| 12 | PREPARATION OF CATIONIC SURFACTANT USEFUL FOR SOFTENING OR ANTI-STATIC AGENT FOR FIBERS | KR20060069147 | 2006-07-24 | KR100757049B1 | 2007-09-07 | NOH JAE SUNG |
| A method for preparing a cationic surfactant compound without hydrolysis, and a composition containing the compound useful as a fiber softening agent or an antistatic agent are provided to improve water absorption. A method for preparing a cationic surfactant compound comprises the steps of reacting a triglyceride-based fat directly with a tertiary amine for esterification or amidation; and obtaining a quaternary compound from the obtained product to prepare a compound represented by the formula 1 or 2, wherein R1 to R4 are independently a carboxyl group unsubstituted or substituted with a C1-C3 alkyl group, a hydroxyl group or a C12-C22 linear or branched or alkyl or alkenyl group; R5 is -CH2CHNHC(O)R; R is a C12-C22 linear or branched alkyl or alkenyl group; and X is a halogen atom or an alkyl sulfonate group. | ||||||
| 13 | Fragrance precursors | JP2009511350 | 2007-03-29 | JP5172827B2 | 2013-03-27 | オセス，マリア，ホセ ベルメヨ; ジラーメ，マルク アルデリウ; 裕 安倍 |
| 14 | α- aminoacetophenone derivative | JP6381697 | 1997-03-03 | JP3271052B2 | 2002-04-02 | デソブリ ヴィンセント; ルッチュ ヴェルナー; ディートリカー クルト; シテック フランシスセック; レンボルド マンフレッド; ヒュスラー リナルド |
| 15 | α- aminoacetophenone derivative | JP6381597 | 1997-03-03 | JP3182720B2 | 2001-07-03 | デソブリ ヴィンセント; ルッチュ ヴェルナー; ディートリカー クルト; シテック フランシスセック; レンボルド マンフレッド; ヒュスラー リナルド |
| 16 | Iridium - hydrogenation process of diphosphine complexes and imine | JP50718497 | 1996-07-17 | JPH11510146A | 1999-09-07 | アンソニー オズボーン，ジョン; サブロン，ラファエル; スピンドラー，フェリックス |
| (57)【要約】 式Ｉ、IaおよびIbの化合物、またはそれらの化合物の少なくとも２種の混合物。 （上式中、ＤＩＰはジ-tert-ジホスフィンであり、その２つのホスフィン基はＣ 2 −、Ｃ 3 −またはＣ 4 −炭素鎖に結合しており、その結果、上記ジホスフィンがＩｒ原子といっしょになって５〜７員環を形成しており、ＸはＣｌ、ＢｒまたはＩであり、Ｙは水素原子であり、ｑおよびｒは０、１または２であり、ｑ＋ｒの和は２であり、ｓおよびｔは０または１であり、ｓ＋ｔの和は１であり、そして、Ｚは有機オキシ酸のアニオンであって、そのアニオン中にＣ（＝Ｏ）Ｏ、Ｓ（＝Ｏ）Ｏ、Ｐ（＝Ｏ）Ｏの基を含む）上記化合物は、イミンの水素添加、特にプロキラルなイミンのエナンチオ選択的な水素添加用の優れた触媒である。 | ||||||
| 17 | Preparation of hydroxypropylated quaternary ammonium derivative containing fatty acid ester function group | JP34040197 | 1997-12-10 | JPH10175927A | 1998-06-30 | PHILIPPE MICHEL; CAMPOS ALAIN |
| PROBLEM TO BE SOLVED: To obtain the subject compound useful as a cosmetic material, etc., easily rapidly and safely in one step without using a highly toxic solvent, an alkylating agent, etc., by reacting a fatty aliphatic carboxylic acid, etc., with a specific compound under refluxing in an alcoholic solvent and under a base catalytic condition. SOLUTION: This hydroxypropylated quaternary ammonium derivative containing a fatty acid ester functional group of formula III is obtained by reacting a fatty aliphatic carboxylic acid: RCOOH (R is a 7-35C alkyl chain) (or a salt) with a compound of formula I [R 1 to R 3 are each a 1-8C alkyl; X - is formula II (R 4 is a 1-8C alkyl), etc.] in an alcoholic solvent such as 2- butanol under a reflux and a base catalytic condition preferably at 45-150°C for 4-8hr. COPYRIGHT: (C)1998,JPO | ||||||
| 18 | Polyester polyquaternary compounds, compositions containing the same, and use thereof | JP14289797 | 1997-04-24 | JPH1087576A | 1998-04-07 | KEYS ROBERT O; FRIEDLI FLOYD E |
| PROBLEM TO BE SOLVED: To obtain a new polyesterified polyquaternary compound useful for fabric softeners, paper debonders, hair and skin conditioners, textile softeners, and a car wax sprays, and the like. SOLUTION: This polyester polyquaternary compound is represented by formula I [R* and R** are each independently a 2-12C alkyl; A<1> to A<5> are each independently a 2-4C strength or branched chain; R<1> to R<5> are each H or RAC(=O) (RA is an alkyl or alkenyl containing 9-21C and a C-C double bond); Q<1> to Q<3> are each H, CH3 , C2 H5 , etc.; (i), (j) and (k) are reach 0-1 with the proviso that (i+j+k) is 0-4; formula II, etc., are formula III; A is a monofunctional anion; (n) is the number of molecules of A]. The compound of formula I is obtained, for example, by starting from reacting 1,6- hexamethylenediamine with ethylene oxide and further quaternizing the product with dimethylsulfate. | ||||||
| 19 | Pharmacologically active compounds and liposomes and methods for their use | JP52079995 | 1995-02-02 | JPH09508900A | 1997-09-09 | アーマド，イムラン; ジャノフ，アンドリュー，エス; ペイ，ヨン−ウェイ; メイヤー，エリック |
| (57)【要約】 本発明は、式Ｒ 1 −Ｙ 1 −ＣＨＺ 1 −ＣＨ（ＮＹ 2 Ｙ 3 ）−ＣＨ 2 −Ｚ 2を有する化合物を提供する。 ここで、Ｒ 1は、脂肪族鎖中に８〜１９個の炭素原子を有する直鎖のアルキル、アルケニル又はアルキニル基、Ｙ 1は、−ＣＨ＝ＣＨ−、−Ｃ‖Ｃ−又は−ＣＨ（ＯＨ）ＣＨ（ＯＨ）、Ｚ 1は、ＯＨ又は変換抑制基であり、Ｚ 2は、変換抑制基、Ｙ 2は、Ｈ、フェニル基、アルキル鎖中に１〜６個の炭素を有するアルキル置換フェニル基又は１〜６個の炭素を有すアルキル鎖、Ｙ 3は、Ｈ又は式−Ｃ（Ｏ）Ｒ 2若しくは−Ｓ（Ｏ） 2 Ｒ 2 、Ｒ 2は、脂肪族鎖中に１〜２３個の炭素原子を有する直鎖のアルキル、アルケニル又はアルキニル基、Ｚ 2がアミノであるとき、Ｒ 2は、脂肪族鎖中に１〜９個又は１９〜２３個の炭素原子を有する脂肪族鎖である。 | ||||||
| 20 | Amino acid ester and its preparation | JP10034389 | 1989-04-21 | JPH01311100A | 1989-12-15 | FURANTSU HOTSUKU; YOOZEFU SHIYORUTOHORUTO; HANSUIERUKU URUBATSUHA; RAINAA HENINGU; URURITSUHI RERUHI; BUORUFUUURURITSUHI NIKERU; BUORUFUGANGU RIYUUGAA |
| NEW MATERIAL: Compd. of formula I [wherein n is 2; R is a 1-18C (substd.) aliph., a 3-20C (substd.) alicyclic and a 6-12C (substd.) arom.; R 1 is a (protected) side chain of a naturally existing α-amino acid of formula R 1-CH(NH 2)-COOH; R 2 is H, a 1-18C (substd.) aliph, a 7-20C (substd.) arom. aliph.; R 4 and R 5 form respectively a 3-15C monocyclic, dicyclic and tricyclic heterocyclic compd. together with atoms bonded with them]. EXAMPLE: n-octyl-2[N-(1S-ethoxycarbonyln-heptyl)-S-alanyl](1S,3S,5S)2- azabicyclo[3,3,0] octane-3-carboxylate. USE: A therapeutic agent for cognitive function disorder. PROCESS: A compd. of formula II (wherein Q 2 is R 2 and is not H and Q 3 is H) is reacted with a compd. of formula III (wherein Y is =N(+)=N(-) and Q is R 3 and is not H). COPYRIGHT: (C)1989,JPO | ||||||
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