专利汇可以提供Mobile/transportable PET radioisotope system with omnidirectional self-shielding专利检索,专利查询,专利分析的服务。并且A linear accelerator system for producing PET radioisotopes, and taking the form of a beam-generation-to-target structure which includes form-fitting, self-contained, omnidirectional radiation shielding structure.,下面是Mobile/transportable PET radioisotope system with omnidirectional self-shielding专利的具体信息内容。
I claim:
This application claims priority to U.S. Provisional Patent Application Ser. No. 60/581,012, filed Jun. 17, 2004, for “Mobile/Transportable PET Radioisotope System with Omnidirectional Self-Shielding”. The entire content of that prior-filed, currently copending U.S. provisional application is hereby incorporated herein by reference.
This invention pertains to Positron Emission Tomography (PET), and more particularly to a unique, compact, self-shielding system for PET radioisotope production, and to the special form factor, or configuration, per se of such a system. PET radioisotopes play a widely recognized, growingly significant role in modem radiation therapies, and the present invention offers an appreciable new opportunity for making these therapies more widely accessible and available through enabling a more readily attainable, wide and economic distribution of PET radioisotope production capabilities.
In this context, and as will be seen, in addition to utilitarian uniqueness which is expressed in this invention through the special self-shielding nature of key, high-energy particle-accelerator and particle-beam-transport components which make up portions of the system of the invention, this special “nature” leads to a unique, compact system form factor (defined-configuration and shape). This form factor enables the system to be (a) easily transported by, and readily deployed in and from, various conventional kinds of transportation vehicles (land, water and air), (b) used in a very wide range of spatial orientations, and (c) disposed for use in very modest and inexpensive facilities which do not need to furnish conventional, building-structure-type, room-sized shielding structure.
The basic radioisotope production components of the proposed system are arranged in a straight-linear, elongate fashion, and progressing through the system from the low-energy end to the high-energy end, include: (a) an ion injector source; (b) a low-energy beam transport (LEBT); (c) a radio frequency quadrupole (RFQ); (d) a drift tube linear accelerator, or linac, (DTL); (e) a high-energy beam transport (HEBT); and (f) a target, or target structure.
To aid in appreciating certain technical background information which is helpful in understanding the nature of the present invention, reference is here made to two, currently living U.S. Pat. Nos. 5,179,350 and 5,315,120. To the extent that the disclosures in these two patents are useful regarding an understanding of the present invention, they are hereby incorporated by reference into this disclosure. U.S. Pat. No 5,179,350 discloses details of construction of a DTL which may be employed preferably in the practice of this invention. Similarly, U.S. Pat. No. 5,315,120 discloses certain core structure in an RFQ which also is preferably employable in the structure and practice of the present invention.
As it is well known to those generally skilled in this art, it is critical that an overall device like that which is disclosed in this patent application be very adequately shielded so as to prevent exposure to radiation with respect to people who work near and around such a system. In most instances, the conventional practice implemented to achieve shielding from such radiation involves the building, around a core accelerator device, of large room-like structures which are constructed with appropriate shielding. Such shielding structure is not part of the shielded device per se, but rather occupies, typically, considerable and costly space in a building structure. Given this prior art condition, it is also the case that installation of a PET radioisotope production system cannot be afforded in many areas where it might be useful and important, particularly because of the fact that the conventional approach to providing adequate shielding for such a system involves the constructing of a fairly robust and elaborate building structure with a room, or rooms, especially designed for radiation shielding.
As will be seen, the present invention offers a PET radioisotope production system which is highly mobile and transportable, relatively small in size, capable of being positioned for use in virtually any orientation, and self-contained with respect to shielding against harmful radiation. The shape, or form factor, of the proposed system is unique and very relevant to these considerations in that, effectively, all radiation shielding is built directly into the linear accelerator components themselves—an approach which results in the overall system being very compact in size, and easily transportable in a variety of ways (land, water, air). More specifically, the system proposed by this invention has what is referred to herein as a bulb-and-stem, or lollipop, physical configuration, wherein the stem part of the system takes the form of elongate, linearly aligned components leading up to the target structure, and the target structure is made as compactly as possible because of its bulblike, roughly spherical shape.
With this concept implemented by the system of this invention, the system can be installed virtually anywhere without any need for the construction of a special building space which itself is formed with radiation shielding structure. The compact form factor of this invention also yields a system, which as was just suggested above, is easily transportable over land, water, and by air.
The special features of this invention are focused (a) on the invention's proposed unique form factor, and (b) upon the fact that this form factor results from the direct incorporation of radiation shielding structure as component parts per se, of the different components in the system. The system embodies its own, self-contained, fully capable radiation shielding structure.
With the invention specifically having a focus on these features, it should be understood that the internal workings and details of construction of the various particle beam accelerator and transport components do not form any part of the present invention. Accordingly, such details are not described herein. Those generally skilled in the art will recognize, from the description which follows below, how it is possible to implement the present invention with various difference specific types of linear accelerator components properly assembled and employed. They will also recognize how various dimensions and materials selections may be varied to suit different specific applications.
The four radioisotopes which are most commonly used in Positron Emission Tomography, fluorine-18, carbon-11, nitrogen-13, oxygen 15, all decay rapidly, and have short lifetimes, with half lives ranging generally from about 2-minutes to about 110-minutes. Many facilities are now using mobile PET scanners in order to bring PET imaging techniques to remote areas, but they can practically only do these kinds of scans relatively near a site where an accelerator is located to produce the required PET radioisotopes. Because of the short half-lives of the desired isotopes, transportation times between production sites and use (scanning) sites must be extremely short, and this, as a practical matter, requires that production facilities be located physically quite close to use facilities. With longer distances between production and use sites, transportation costs simply become prohibitively high, and as a consequence, relatively remote, rural areas do not have ready access to this technology.
In this kind of a setting, it is obviously important to consider structural improvements in PET radioisotope production apparatus which will permit such apparatus easily to be brought and/or placed very close to sites where PET scanning activities are to take place.
As will be seen from the description of the invention set forth below, the system of the present invention directly and effectively addresses these important time and distance issues.
As will be seen, the system of the invention offers a very high degree of ready mobility, inasmuch as it is relatively small in size, light in weight, and configured easily to be transported in over-land trailers, as well as over the water and in the air. This significant size and mobility set of features of the invention allow it to be used, for example, as a local base of radioisotopes and labeled pharmaceuticals for several mobile PET or PET/CT scanner units that would allow their bases of operation to be moved easily into various rural areas of the country. Further, the system of the present invention can function as a fully mobile source of very short-lived PET radioisotopes, and thus, because of the ease of positioning and moving the system of this invention very closely near use facilities, allows these facilities ready access to employment of short half-life radioisotopes.
Additionally, the system of the invention may also be used as a temporary laboratory for a facility during construction of a new and more fixed (in place) PET radioisotope production facility.
The effective self-shielding nature of the system of this invention, travels, so-to-speak, as an integral unit with the system per se, and avoids the necessity of requiring the fabrication of expensive and large containment facilities. Very importantly, it allows the system of this invention to have its components oriented in any desired configuration in space without there being any concern for having to provide special external radiation shielding to accommodate such an orientation. Thus, and for example, a system of the present invention transported in an over-land trailer which may be brought to an area and parked in any one of a myriad of different orientations, raises no issue with respect to having to consider building specially oriented and sized external shielding walls, floor, ceilings, etc.
As will also become apparent to those skilled in the art, the various beam-creating and generating components of the system do not require extraordinary power, or other specialized utilities infrastructure, in order to be readily operable in substantially all areas of the country.
These and other features and advantages which are offered by the present invention will become more fully apparent as the description which now follows is read in conjunction with the accompanying drawings.
Turning attention now to the drawings, and referring first of all more particularly to
Important to notice particularly in
Support framework 12 put aside for the moment, the other components of system 10, as illustrated in isolated form in
Included in system 10, and effectively operating and generating ultimately a high-energy ion beam along a system axis shown at 10a, are an elongate ion source injector 16 having a long axis 16a which is coincident in axis 10a, an elongate, Low-Energy Beam Transport (LEBT) 17 having a long axis 17a which aligns with axes 10a, 16a, an elongate Radio Frequency Quadrupole (RFQ) 18 having a long axis 18a which is also coincident with system access 10a, an elongate Drift Tube Linac (DTL) 20 possessing a long axis 20a which is also coincident with this system axis 10a, an elongate High-Energy Beam Transport (HEBT) 22 having a long axis 22a which also aligns with system axis 10a, and finally, a target, or bulb, structure 23 having a target zone 24 which, as is indicated generally at 24a in
Helping to illustrate the small size, and generally the scale, of system 10, appearing adjacent the right side of
Ion source 16, LEBT 17, RFQ 18, and DTL 20 collectively form what is referred to herein as an ion-beam linear accelerator, or linac structure, and also as a stem. The left end of this structure in the figures is defined by ion source 16, and this end is referred to herein as an upstream end, or region, in the linac structure. The downstream end of the linac structure is defined by the far, or right, end of DTL 20, and is referred to herein both as the downstream end, or region, of the linac structure, and also as the discharge end of that structure. Ion source 16 is also referred to herein as an ion injector.
This arrangement (ion source 16 and LEBT 17) is generally well known to those skilled in the art, and does not require particular elaboration.
With reference made particularly to
RFQ 18 also has an elongate and somewhat cylindrical structure, including internal RFQ working structure 18A contained within an outside, wrap-around, radiation shielding body 18B, generally cylindrical in nature, and which is also referred to herein as being part of a first radiation-shielding substructure. The left end of RFQ 18 herein is referred to as its upstream end, and the right end of this RFQ structure is referred to as its downstream end. One can therefore see that the downstream end of ion injector 16 is operatively coupled directly to the upstream end of RFQ 18, with axes 16a, 18a in these two components in system 10 aligned with one another and with system axis 10a, as was mentioned earlier.
RFQ working structure 18A is made herein principally in accordance with teachings found in the '120 U.S. Patent mentioned above. Details of these features of the RFQ do not form any part of the present invention, and thus are not elaborated herein.
The form-fitting outer shielding body portion 18B of RFQ 18 defines an operating vacuum chamber for the RFQ, and is formed herein preferably of ⅜-inches stainless steel. This structure functions very effectively as, essentially, an omnidirectional radiation shield for and around the structure of the inner workings of RFQ 18.
Appropriately coupled to the high-energy (right) end of RFQ 18 in system 10 is previously mentioned DTL 20 which includes inner workings 20A (as described in U.S. Pat. No. 5,179,350), and integrated outer shield structure 20B whose configuration and make up will now be described. Shield 20B, which is also referred to herein as a cylindrical wrap-around structure, includes upper and lower planar elements 20B1, 20B2, respectively, which are formed preferably of about 2-inches to about 3-inches thick mild steel. Opposite lateral sides of shield structure 20B are arcuate, as can best be seen in
DTL outer body structure 20B, which performs integral shielding respecting radiation present within DTL 20, is shown herein best in
Elongate HEBT component 22 in system 10 is, with the exception of the presence of an integrated, wrap-around, omnidirectional, outside shield structure, entirely conventional with respect to its internal workings. It functions principally to transport and guide the high-energy ion beam exiting from the discharge end (the right end in the figures) of DTL 20 toward and into target zone 24 in target structure 23. In
Looking specifically at
The shield structure specifically shown in
In system 10 as illustrated and described, the overall assembled length of components 16, 17, 18, 20 and 22 is about 14-feet. The effective maximum vertical and lateral dimensions relative to and centered on axis 10a are roughly equivalent to that of a cylinder having an outside diameter of about 2-feet. These five components, 16, 17, 18, 20, 22 make up the “stem” portion of the previously referred to bulb-and-stem configuration for system 10.
Turning attention now to the target structure, the internal target region per se can be constructed in a number of different and entirely conventional ways which do not form any part of the present invention. Rather, the present invention is concerned with the construction and configuration generally of the target shield structure 26 which, as has been mentioned, can be thought of as possessing a bulb shape, and as having a generally cylindrical shape. The specific target shield configuration illustrated herein, also referred to as a second radiation-shielding substructure, has the form of an icosihexahedron, as is clearly visible in the drawings.
Looking now at
Immediately surrounding target zone 24 is a lead jacket 32 having a wall thickness of about 5-inches, and immediately surrounding this lead jacket is another jacket-like enclosure 34 formed of borated polyethylene and having a wall thickness of about 6-inches. The space around enclosure 34 is filled with concrete 36 which is loaded appropriately with polyethylene beads and boron carbide powder. This concrete mix per se forms no part of the present invention. Finally, the outer portion of target shield 26 is formed of mild steel with a wall thickness of about ½-inches. Thinking of structure 26 as being generally spherical in nature, this structure can be described as having a diametral dimension in system 10 of about 7-feet.
Completing a description of what is shown in
Another very important feature of the system of this invention is brought to attention in
In
In
The basic features of system 10 have thus been described. Various materials and specific dimensions have been mentioned herein, but it should be understood that these specific material choices and dimensions may be changed in well known ways to accommodate different situations. In other words, specific dimensions and material selections are not per se any part of the present invention.
The system of this invention is extremely versatile in nature, and clearly addresses the concerns and considerations mentioned earlier herein with respect to issues associated with conventional PET radioisotope reduction facilities. The fact that is carries its own self shielding structure, and does so by form-fitting shielding componentry which results in the overall system having what has been referred to herein as a lollipop, or bulb-and-stem, configuration, means that the system of the invention can easily be employed in a host of remote sites where conventional facilities today can simply not, as a practical matter, be made available.
An important consequence of this unique form factor is that the overall size and weight of system 10 are relatively small, with the overall length of system 10 disclosed herein being about 20-feet, and the overall weight being about 13-tons.
Because of the unique nature of the system of this invention, it can be employed in any orientation desired. No separate external shielding structure is required. With respect to the self-shielding character of system 10, it should be understood that the term “omnidirectional” describes a condition which is that a person working with the system can stand anywhere near it when it is in full operation without any fear of receiving harmful radiation. In other words, the term “omnidirectional” is intended to mean a condition of radiation shielding with respect to any and all possible locations outside of the system where personnel may be positioned.
Accordingly, while a preferred embodiment, and certain modifications and variations have been suggested herein, it is appreciated that other modifications and variations may be made without departing from the spirit of the invention, and it is intended that all claims herein will be understood to read upon such other variations and modifications.
标题 | 发布/更新时间 | 阅读量 |
---|---|---|
能够自动换样的智能型低本底αβ测量仪 | 2020-05-08 | 394 |
一种具有综合屏蔽功能的钆不锈钢屏蔽材料及其制备方法 | 2020-05-13 | 997 |
一种面向室内的失控放射源自主搜寻机器人及其搜寻方法 | 2020-05-08 | 665 |
超导磁体装置 | 2020-05-12 | 291 |
一种放射性污染控制与清除材料及其制备方法 | 2020-05-08 | 92 |
一种LED背光连接线 | 2020-05-08 | 225 |
中子捕获治疗系统及用于支撑射束整形体的支撑模块 | 2020-05-11 | 172 |
用于便携式x射线医疗成像系统的辐射屏蔽帘 | 2020-05-11 | 903 |
一种集装箱空箱检测装置 | 2020-05-11 | 635 |
一种带有多层盖结构的多用途乏燃料组件用容器 | 2020-05-11 | 139 |
高效检索全球专利专利汇是专利免费检索,专利查询,专利分析-国家发明专利查询检索分析平台,是提供专利分析,专利查询,专利检索等数据服务功能的知识产权数据服务商。
我们的产品包含105个国家的1.26亿组数据,免费查、免费专利分析。
专利汇分析报告产品可以对行业情报数据进行梳理分析,涉及维度包括行业专利基本状况分析、地域分析、技术分析、发明人分析、申请人分析、专利权人分析、失效分析、核心专利分析、法律分析、研发重点分析、企业专利处境分析、技术处境分析、专利寿命分析、企业定位分析、引证分析等超过60个分析角度,系统通过AI智能系统对图表进行解读,只需1分钟,一键生成行业专利分析报告。